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The map label for this gene is adiC

Identifier: 187733448

GI number: 187733448

Start: 4303852

End: 4305189

Strand: Reverse

Name: adiC

Synonym: SbBS512_E4612

Alternate gene names: 187733448

Gene position: 4305189-4303852 (Counterclockwise)

Preceding gene: 187732783

Following gene: 187731674

Centisome position: 93.27

GC content: 53.74

Gene sequence:

>1338_bases
ATGTCTTCGGATGCTGATGCTCACAAAGTGGGCTTAATCCCCGTCACCCTGATGGTGTCGGGGAATATTATGGGGTCAGG
TGTTTTTCTGTTACCTGCAAACCTGGCCTCCACTGGCGGGATTGCCATTTATGGATGGTTGGTGACGATTATCGGTGCAC
TGGGGCTCTCGATGGTATACGCCAAAATGTCGTTCCTCGACCCAAGTCCTGGTGGTTCTTACGCTTACGCCCGCCGCTGC
TTTGGCCCGTTTCTCGGTTATCAAACCAACGTCCTCTACTGGCTGGCCTGCTGGATCGGCAATATCGCCATGGTGGTCAT
TGGCGTAGGATATTTAAGTTACTTCTTCACGATTCTGAAAGATCCATTGGTATTAACCATCACCTGCGTCGTGGTGCTGT
GGATCTTCGTCCTGCTGAACATTGTCGGTCCGAAAATGATCACCCGTGTGCAGGCAGTTGCCACCGTGCTGGCGCTGATC
CCCATCGTCGGGATTGCCGTATTTGGCTGGTTCTGGTTCCGTGGTGAAACCTATATGGCGGCATGGAACGTCAGCGGCCT
GGGCACCTTCGGTGCAATTCAAAGTACCCTTAACGTTACGCTGTGGTCGTTCATCGGTGTGGAAAGTGCCTCCGTTGCCG
CAGGTGTGGTGAAAAACCCGAAACGCAATGTCCCTATCGCCACCATTGGTGGGGTATTGATTGCCGCCGTTTGCTATGTA
CTTTCTACCACCGCGATTATGGGGATGATCCCTAATGCCGCACTGCGCGTTTCTGCTTCGCCATTCGGTGATGCCGCACG
GATGGCGTTGGGTGACACCGCCGGGGCCATTGTTTCCTTCTGCGCAGCTGCGGGTTGCTTAGGTTCACTGGGCGGCTGGA
CGTTGCTGGCGGGTCAAACGGCGAAAGCCGCTGCCGATGACGGACTGTTCCCACCGATTTTTGCCCGTGTAAATAAAGCG
GGTACGCCAGTGGCGGGGCTGATTATCGTCGGTATTTTGATGACCATCTTCCAGCTCAGCAGCATTTCACCAAACGCGAC
CAAAGAGTTCGGTCTGGTTTCTTCCGTCTCGGTCATCTTTACACTGGTGCCATATCTTTACACCTGTGCGGCGTTACTGC
TGCTCGGACACGGTCACTTTGGTAAAGCACGCCCGGCATATCTGGCAGTTACTACCATTGCCTTCCTCTACTGCATCTGG
GCCGTGGTGGGGTCCGGAGCGAAAGAGGTTATGTGGTCATTTGTCACCCTGATGGTCATCACCGCCATGTATGCGCTGAA
TTACAACCGGCTACATAAAAACCCGTATCCCTTAGATGCACCAATAAGCAAAGATTAA

Upstream 100 bases:

>100_bases
ATCAGCGATAACCCGGTCGATAATAATTCAACTATCGAATGCAGGCGTATGATATGACGTAATTTATTGTCACGAAGCTC
GCCTTCGCAGGAGTTTAATT

Downstream 100 bases:

>100_bases
TTCCCCTTAATCCAGCAAACATAAAAGCCAACCTTAAGAACTTAAGGTTGGCTTAATTTTGCTTTGCGAGCATATGCGCA
CTTTGTTCGATGGAAACACC

Product: arginine:agmatin antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 445; Mature: 444

Protein sequence:

>445_residues
MSSDADAHKVGLIPVTLMVSGNIMGSGVFLLPANLASTGGIAIYGWLVTIIGALGLSMVYAKMSFLDPSPGGSYAYARRC
FGPFLGYQTNVLYWLACWIGNIAMVVIGVGYLSYFFTILKDPLVLTITCVVVLWIFVLLNIVGPKMITRVQAVATVLALI
PIVGIAVFGWFWFRGETYMAAWNVSGLGTFGAIQSTLNVTLWSFIGVESASVAAGVVKNPKRNVPIATIGGVLIAAVCYV
LSTTAIMGMIPNAALRVSASPFGDAARMALGDTAGAIVSFCAAAGCLGSLGGWTLLAGQTAKAAADDGLFPPIFARVNKA
GTPVAGLIIVGILMTIFQLSSISPNATKEFGLVSSVSVIFTLVPYLYTCAALLLLGHGHFGKARPAYLAVTTIAFLYCIW
AVVGSGAKEVMWSFVTLMVITAMYALNYNRLHKNPYPLDAPISKD

Sequences:

>Translated_445_residues
MSSDADAHKVGLIPVTLMVSGNIMGSGVFLLPANLASTGGIAIYGWLVTIIGALGLSMVYAKMSFLDPSPGGSYAYARRC
FGPFLGYQTNVLYWLACWIGNIAMVVIGVGYLSYFFTILKDPLVLTITCVVVLWIFVLLNIVGPKMITRVQAVATVLALI
PIVGIAVFGWFWFRGETYMAAWNVSGLGTFGAIQSTLNVTLWSFIGVESASVAAGVVKNPKRNVPIATIGGVLIAAVCYV
LSTTAIMGMIPNAALRVSASPFGDAARMALGDTAGAIVSFCAAAGCLGSLGGWTLLAGQTAKAAADDGLFPPIFARVNKA
GTPVAGLIIVGILMTIFQLSSISPNATKEFGLVSSVSVIFTLVPYLYTCAALLLLGHGHFGKARPAYLAVTTIAFLYCIW
AVVGSGAKEVMWSFVTLMVITAMYALNYNRLHKNPYPLDAPISKD
>Mature_444_residues
SSDADAHKVGLIPVTLMVSGNIMGSGVFLLPANLASTGGIAIYGWLVTIIGALGLSMVYAKMSFLDPSPGGSYAYARRCF
GPFLGYQTNVLYWLACWIGNIAMVVIGVGYLSYFFTILKDPLVLTITCVVVLWIFVLLNIVGPKMITRVQAVATVLALIP
IVGIAVFGWFWFRGETYMAAWNVSGLGTFGAIQSTLNVTLWSFIGVESASVAAGVVKNPKRNVPIATIGGVLIAAVCYVL
STTAIMGMIPNAALRVSASPFGDAARMALGDTAGAIVSFCAAAGCLGSLGGWTLLAGQTAKAAADDGLFPPIFARVNKAG
TPVAGLIIVGILMTIFQLSSISPNATKEFGLVSSVSVIFTLVPYLYTCAALLLLGHGHFGKARPAYLAVTTIAFLYCIWA
VVGSGAKEVMWSFVTLMVITAMYALNYNRLHKNPYPLDAPISKD

Specific function: Major component of the acid-resistance (AR) system allowing enteric pathogens to survive the acidic environment in the stomach. Exchanges extracellular arginine for its intracellular decarboxylation product agmatine (Agm) thereby expelling intracellular p

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Escherichia coli, GI2367353, Length=445, Percent_Identity=99.7752808988764, Blast_Score=879, Evalue=0.0,
Organism=Escherichia coli, GI1790575, Length=447, Percent_Identity=38.0313199105145, Blast_Score=291, Evalue=7e-80,
Organism=Escherichia coli, GI1786908, Length=437, Percent_Identity=32.7231121281465, Blast_Score=255, Evalue=5e-69,
Organism=Escherichia coli, GI1787890, Length=431, Percent_Identity=29.2343387470998, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI87082250, Length=347, Percent_Identity=28.5302593659942, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI87081708, Length=410, Percent_Identity=24.6341463414634, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI48994972, Length=460, Percent_Identity=24.7826086956522, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1790653, Length=399, Percent_Identity=24.0601503759398, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786789, Length=371, Percent_Identity=21.5633423180593, Blast_Score=62, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI71995388, Length=412, Percent_Identity=25, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71995382, Length=412, Percent_Identity=25, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17540018, Length=341, Percent_Identity=24.3401759530792, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71993915, Length=403, Percent_Identity=24.0694789081886, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17532491, Length=359, Percent_Identity=26.7409470752089, Blast_Score=68, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI71982608, Length=410, Percent_Identity=23.4146341463415, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71982612, Length=410, Percent_Identity=23.4146341463415, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI32566699, Length=312, Percent_Identity=22.4358974358974, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI221331183, Length=452, Percent_Identity=24.7787610619469, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17647653, Length=452, Percent_Identity=24.7787610619469, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24664379, Length=452, Percent_Identity=24.7787610619469, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24641993, Length=386, Percent_Identity=23.3160621761658, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24641995, Length=386, Percent_Identity=23.3160621761658, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 46847; Mature: 46716

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSDADAHKVGLIPVTLMVSGNIMGSGVFLLPANLASTGGIAIYGWLVTIIGALGLSMVY
CCCCCCCCEECEEEEEEEEECCEEECCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHH
AKMSFLDPSPGGSYAYARRCFGPFLGYQTNVLYWLACWIGNIAMVVIGVGYLSYFFTILK
HHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DPLVLTITCVVVLWIFVLLNIVGPKMITRVQAVATVLALIPIVGIAVFGWFWFRGETYMA
CCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
AWNVSGLGTFGAIQSTLNVTLWSFIGVESASVAAGVVKNPKRNVPIATIGGVLIAAVCYV
EECCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
LSTTAIMGMIPNAALRVSASPFGDAARMALGDTAGAIVSFCAAAGCLGSLGGWTLLAGQT
HHHHHHHHHCCCCEEEEECCCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEECCC
AKAAADDGLFPPIFARVNKAGTPVAGLIIVGILMTIFQLSSISPNATKEFGLVSSVSVIF
HHHCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
TLVPYLYTCAALLLLGHGHFGKARPAYLAVTTIAFLYCIWAVVGSGAKEVMWSFVTLMVI
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
TAMYALNYNRLHKNPYPLDAPISKD
HHHHHHCHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
SSDADAHKVGLIPVTLMVSGNIMGSGVFLLPANLASTGGIAIYGWLVTIIGALGLSMVY
CCCCCCCEECEEEEEEEEECCEEECCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHH
AKMSFLDPSPGGSYAYARRCFGPFLGYQTNVLYWLACWIGNIAMVVIGVGYLSYFFTILK
HHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DPLVLTITCVVVLWIFVLLNIVGPKMITRVQAVATVLALIPIVGIAVFGWFWFRGETYMA
CCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
AWNVSGLGTFGAIQSTLNVTLWSFIGVESASVAAGVVKNPKRNVPIATIGGVLIAAVCYV
EECCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
LSTTAIMGMIPNAALRVSASPFGDAARMALGDTAGAIVSFCAAAGCLGSLGGWTLLAGQT
HHHHHHHHHCCCCEEEEECCCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEECCC
AKAAADDGLFPPIFARVNKAGTPVAGLIIVGILMTIFQLSSISPNATKEFGLVSSVSVIF
HHHCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
TLVPYLYTCAALLLLGHGHFGKARPAYLAVTTIAFLYCIWAVVGSGAKEVMWSFVTLMVI
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
TAMYALNYNRLHKNPYPLDAPISKD
HHHHHHCHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]