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The map label for this gene is moaA

Identifier: 187733362

GI number: 187733362

Start: 2371556

End: 2372545

Strand: Reverse

Name: moaA

Synonym: SbBS512_E2571

Alternate gene names: 187733362

Gene position: 2372545-2371556 (Counterclockwise)

Preceding gene: 187734131

Following gene: 187733260

Centisome position: 51.4

GC content: 53.94

Gene sequence:

>990_bases
ATGGCTTCACAACTGACTGATGCATTTGCGCGTAAGTTTTACTACTTGCGCCTGTCGATTACCGATGTGTGTAACTTTCG
TTGCACCTACTGCCTGCCGGATGGCTACAAACCGAGCGGCGTCACCAATAAAGGCTTTCTTACCGTCGATGAAATTCGCC
GGGTTACGCGCGCCTTCGCCAGTCTGGGCACCGAAAAAGTGCGCCTGACAGGAGGTGAGCCGTCTTTACGCCGCGACTTT
ACCGATATCATCGCCGCTGTGCGGGAAAACGACGCTATCCGCCAGATTGCGGTCACCACCAATGGTTACCGTCTGGAACG
CGATGTGGCGAACTGGCGCGATGCGGGACTTACTGGCATTAACGTCAGTGTCGACAGTCTGGACGCCCGCCAGTTTCACG
CTATTACCGGGCAGGATAAATTCAACCAGGTCATGGCAGGGATTGATGCTGCATTTGAGGCCGGTTTTGAGAAGGTCAAA
GTCAATACCGTGCTGATGCGTGATGTTAATCATCACCAGCTCGACACCTTTCTGAACTGGATCCAGCATCGCCCTATCCA
GCTGCGTTTCATCGAACTGATGGAAACGGGCGAGGGCAGCGAGCTCTTCCGTAAGCATCACATCTCTGGTCAGGTTCTGC
GTGACGAGCTACTGCGTCGCGGCTGGATCCACCAATTACGTCAACGCAGCGACGGTCCCGCGCAAGTCTTTTGCCATCCA
GATTACGCCGGAGAGATTGGCCTTATCATGCCGTATGAAAAAGACTTCTGCGCCACTTGCAACCGCCTGCGCGTTTCCTC
CATTGGTAAACTCTATCTCTGCCTGTTTGGTGAAGGCGGCGTTAACCTGCGCGATCTGCTGGAAGACGATACCCAGCAAC
AGGCGCTGGAAGCGCGTATTTCAGTGGCGCTGCGGGAGAAGAAACAGACCCATTTCCTGCATCAAAACAACACCGGTATT
ACGCAAAACTTATCGTACATTGGCGGCTAA

Upstream 100 bases:

>100_bases
GGTCAACTGATACGGTGCTTTGGCCGTGACAATGCTCGTAAAGATTGCCACCAGGGCGAAGGAAGAAATGACTTCGCCTC
CCGTATCTGGAAAGGTGTAC

Downstream 100 bases:

>100_bases
AACGTCAAAAGGAGAGATCAGATGAGTCAGGTAAGCACTGAATTTATCCCGACCCGTATTGCTATTCTTACGGTTTCTAA
TCGTCGCGGTGAAGAAGACG

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 329; Mature: 328

Protein sequence:

>329_residues
MASQLTDAFARKFYYLRLSITDVCNFRCTYCLPDGYKPSGVTNKGFLTVDEIRRVTRAFASLGTEKVRLTGGEPSLRRDF
TDIIAAVRENDAIRQIAVTTNGYRLERDVANWRDAGLTGINVSVDSLDARQFHAITGQDKFNQVMAGIDAAFEAGFEKVK
VNTVLMRDVNHHQLDTFLNWIQHRPIQLRFIELMETGEGSELFRKHHISGQVLRDELLRRGWIHQLRQRSDGPAQVFCHP
DYAGEIGLIMPYEKDFCATCNRLRVSSIGKLYLCLFGEGGVNLRDLLEDDTQQQALEARISVALREKKQTHFLHQNNTGI
TQNLSYIGG

Sequences:

>Translated_329_residues
MASQLTDAFARKFYYLRLSITDVCNFRCTYCLPDGYKPSGVTNKGFLTVDEIRRVTRAFASLGTEKVRLTGGEPSLRRDF
TDIIAAVRENDAIRQIAVTTNGYRLERDVANWRDAGLTGINVSVDSLDARQFHAITGQDKFNQVMAGIDAAFEAGFEKVK
VNTVLMRDVNHHQLDTFLNWIQHRPIQLRFIELMETGEGSELFRKHHISGQVLRDELLRRGWIHQLRQRSDGPAQVFCHP
DYAGEIGLIMPYEKDFCATCNRLRVSSIGKLYLCLFGEGGVNLRDLLEDDTQQQALEARISVALREKKQTHFLHQNNTGI
TQNLSYIGG
>Mature_328_residues
ASQLTDAFARKFYYLRLSITDVCNFRCTYCLPDGYKPSGVTNKGFLTVDEIRRVTRAFASLGTEKVRLTGGEPSLRRDFT
DIIAAVRENDAIRQIAVTTNGYRLERDVANWRDAGLTGINVSVDSLDARQFHAITGQDKFNQVMAGIDAAFEAGFEKVKV
NTVLMRDVNHHQLDTFLNWIQHRPIQLRFIELMETGEGSELFRKHHISGQVLRDELLRRGWIHQLRQRSDGPAQVFCHPD
YAGEIGLIMPYEKDFCATCNRLRVSSIGKLYLCLFGEGGVNLRDLLEDDTQQQALEARISVALREKKQTHFLHQNNTGIT
QNLSYIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=310, Percent_Identity=39.0322580645161, Blast_Score=218, Evalue=5e-57,
Organism=Homo sapiens, GI22027536, Length=310, Percent_Identity=39.0322580645161, Blast_Score=218, Evalue=6e-57,
Organism=Escherichia coli, GI1786999, Length=329, Percent_Identity=98.7841945288754, Blast_Score=677, Evalue=0.0,
Organism=Caenorhabditis elegans, GI32566331, Length=313, Percent_Identity=36.1022364217252, Blast_Score=201, Evalue=5e-52,
Organism=Caenorhabditis elegans, GI32566329, Length=308, Percent_Identity=36.3636363636364, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17561210, Length=307, Percent_Identity=35.1791530944625, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI28574490, Length=315, Percent_Identity=37.7777777777778, Blast_Score=212, Evalue=3e-55,
Organism=Drosophila melanogaster, GI28574488, Length=315, Percent_Identity=37.7777777777778, Blast_Score=212, Evalue=3e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 37359; Mature: 37228

Theoretical pI: Translated: 7.83; Mature: 7.83

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASQLTDAFARKFYYLRLSITDVCNFRCTYCLPDGYKPSGVTNKGFLTVDEIRRVTRAFA
CCCHHHHHHHHHEEEEEEEEEHHCCCEEEEECCCCCCCCCCCCCCCEEHHHHHHHHHHHH
SLGTEKVRLTGGEPSLRRDFTDIIAAVRENDAIRQIAVTTNGYRLERDVANWRDAGLTGI
HCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEEHHHHHHHHCCCEEE
NVSVDSLDARQFHAITGQDKFNQVMAGIDAAFEAGFEKVKVNTVLMRDVNHHQLDTFLNW
EEEECCCCCHHEEEECCCHHHHHHHHHHHHHHHCCCHHEEEEEEEEECCCHHHHHHHHHH
IQHRPIQLRFIELMETGEGSELFRKHHISGQVLRDELLRRGWIHQLRQRSDGPAQVFCHP
HHCCCEEEEEEEEHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECC
DYAGEIGLIMPYEKDFCATCNRLRVSSIGKLYLCLFGEGGVNLRDLLEDDTQQQALEARI
CCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHCCHHHHHHHHHHH
SVALREKKQTHFLHQNNTGITQNLSYIGG
HHHHHHHHHHHHEECCCCCCCCCCHHCCC
>Mature Secondary Structure 
ASQLTDAFARKFYYLRLSITDVCNFRCTYCLPDGYKPSGVTNKGFLTVDEIRRVTRAFA
CCHHHHHHHHHEEEEEEEEEHHCCCEEEEECCCCCCCCCCCCCCCEEHHHHHHHHHHHH
SLGTEKVRLTGGEPSLRRDFTDIIAAVRENDAIRQIAVTTNGYRLERDVANWRDAGLTGI
HCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEEHHHHHHHHCCCEEE
NVSVDSLDARQFHAITGQDKFNQVMAGIDAAFEAGFEKVKVNTVLMRDVNHHQLDTFLNW
EEEECCCCCHHEEEECCCHHHHHHHHHHHHHHHCCCHHEEEEEEEEECCCHHHHHHHHHH
IQHRPIQLRFIELMETGEGSELFRKHHISGQVLRDELLRRGWIHQLRQRSDGPAQVFCHP
HHCCCEEEEEEEEHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECC
DYAGEIGLIMPYEKDFCATCNRLRVSSIGKLYLCLFGEGGVNLRDLLEDDTQQQALEARI
CCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHCCHHHHHHHHHHH
SVALREKKQTHFLHQNNTGITQNLSYIGG
HHHHHHHHHHHHEECCCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA