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The map label for this gene is hcr

Identifier: 187733241

GI number: 187733241

Start: 2262369

End: 2263337

Strand: Direct

Name: hcr

Synonym: SbBS512_E2459

Alternate gene names: 187733241

Gene position: 2262369-2263337 (Clockwise)

Preceding gene: 187731053

Following gene: 187732619

Centisome position: 49.01

GC content: 55.31

Gene sequence:

>969_bases
ATGACGATGCCAACGAATCAATGCCCGTGGCGGATGCAGGTTCATCACATTACGCAAGAAACGCCGGATGTGTGGACGAT
TTCCCTGATTTGCCACGATTACTACCCATATCGCGCCGGGCAATATGCACTGGTCAGCGTGCGAAACTCAGCGGAAACGC
TGCGTGCTTACACCATTTCCTCCACGCCAGGCGTGAGTGAATATATCACCCTGACCGTGCGGCGGATTGATGACGGTGTC
GGCTCCCAGTGGCTGACGCGCGATGTAAAACGCGGTGATTATCTCTGGCTTTCGGACGCGATGGGGGAATTTACCTGCGA
CGATAAAGCAGAAGATAAATTCCTGTTGCTGGCGGCAGGCTGCGGCGTCACGCCGATTATGTCGATGCGTCGCTGGCTTG
CGAAGAACCGTCCACAGGCCGATGTGCGGGTGATCTACAACGTGCGTACGCCGCAGGATGTTATTTTCGCCGATGAGTGG
CGTAACTATCCGGTAACGCTGGTGGCAGAAAATAACGTTACCGAAGGCTTTATCGCTGGTCGTCTCACTCGCGAACTGCT
GGCAGGTGTACCTGACTTAGCTTCACGTACCGTGATGACCTGCGGCCCGGCTCCGTATATGGATTGGGTAGAGCAGGAAG
TGAAAGCGCTCGGCGTGACGCGTTTCTTTAAAGAGAAATTCTTCACCCCAGTAGCAGAAGCGGCGACCAGCGGTCTGAAA
TTCACCAAACTGCAACCGGCACGAGAATTTTACGCCCCGGTTGGCACCACGCTACTGGAGGCGCTGGAAAGCAATAACGT
TCCGGTTGTCGCTGCCTGCCGTGCGGGTGTTTGCGGCTGCTGTAAGACAAAAGTGGTTTCCGGTGAATATACGGTGAGCA
GTACAATGACGCTGACCGACGCCGAAATCGCTGAAGGTTACGTACTGGCCTGCTCCTGCCATCCGCAGGGGGATTTGGTT
CTCGCATAA

Upstream 100 bases:

>100_bases
CAGACCTGCTGGCGGTGCTGAACGAGAAATTCGGCCTGCGTTCTATCACCACTGTTGAAGAAGACATGAAGCAACTGTTG
AGCGCGTAAGGAGTTTGTCG

Downstream 100 bases:

>100_bases
TCGCCTTATGCCCGATGATATTCCTTTCATCGGGCTATTTAACCGTTAGTGCCTCCTTTCTCTCCCATCCCTTCCCCCTC
CGTCAGATGAACTAAACTTG

Product: HCP oxidoreductase, NADH-dependent

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 322; Mature: 321

Protein sequence:

>322_residues
MTMPTNQCPWRMQVHHITQETPDVWTISLICHDYYPYRAGQYALVSVRNSAETLRAYTISSTPGVSEYITLTVRRIDDGV
GSQWLTRDVKRGDYLWLSDAMGEFTCDDKAEDKFLLLAAGCGVTPIMSMRRWLAKNRPQADVRVIYNVRTPQDVIFADEW
RNYPVTLVAENNVTEGFIAGRLTRELLAGVPDLASRTVMTCGPAPYMDWVEQEVKALGVTRFFKEKFFTPVAEAATSGLK
FTKLQPAREFYAPVGTTLLEALESNNVPVVAACRAGVCGCCKTKVVSGEYTVSSTMTLTDAEIAEGYVLACSCHPQGDLV
LA

Sequences:

>Translated_322_residues
MTMPTNQCPWRMQVHHITQETPDVWTISLICHDYYPYRAGQYALVSVRNSAETLRAYTISSTPGVSEYITLTVRRIDDGV
GSQWLTRDVKRGDYLWLSDAMGEFTCDDKAEDKFLLLAAGCGVTPIMSMRRWLAKNRPQADVRVIYNVRTPQDVIFADEW
RNYPVTLVAENNVTEGFIAGRLTRELLAGVPDLASRTVMTCGPAPYMDWVEQEVKALGVTRFFKEKFFTPVAEAATSGLK
FTKLQPAREFYAPVGTTLLEALESNNVPVVAACRAGVCGCCKTKVVSGEYTVSSTMTLTDAEIAEGYVLACSCHPQGDLV
LA
>Mature_321_residues
TMPTNQCPWRMQVHHITQETPDVWTISLICHDYYPYRAGQYALVSVRNSAETLRAYTISSTPGVSEYITLTVRRIDDGVG
SQWLTRDVKRGDYLWLSDAMGEFTCDDKAEDKFLLLAAGCGVTPIMSMRRWLAKNRPQADVRVIYNVRTPQDVIFADEWR
NYPVTLVAENNVTEGFIAGRLTRELLAGVPDLASRTVMTCGPAPYMDWVEQEVKALGVTRFFKEKFFTPVAEAATSGLKF
TKLQPAREFYAPVGTTLLEALESNNVPVVAACRAGVCGCCKTKVVSGEYTVSSTMTLTDAEIAEGYVLACSCHPQGDLVL
A

Specific function: NADH oxidoreductase acting in concert with HCP

COG id: COG1018

COG function: function code C; Flavodoxin reductases (ferredoxin-NADPH reductases) family 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding FR-type domain

Homologues:

Organism=Escherichia coli, GI1787098, Length=322, Percent_Identity=100, Blast_Score=670, Evalue=0.0,
Organism=Escherichia coli, GI1787658, Length=338, Percent_Identity=28.1065088757396, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1788104, Length=289, Percent_Identity=27.681660899654, Blast_Score=86, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HCR_ECOLI (P75824)

Other databases:

- EMBL:   U00096
- EMBL:   AP009048
- PIR:   H64825
- RefSeq:   AP_001503.1
- RefSeq:   NP_415393.1
- ProteinModelPortal:   P75824
- STRING:   P75824
- EnsemblBacteria:   EBESCT00000001471
- EnsemblBacteria:   EBESCT00000001472
- EnsemblBacteria:   EBESCT00000017558
- GeneID:   947660
- GenomeReviews:   AP009048_GR
- GenomeReviews:   U00096_GR
- KEGG:   ecj:JW5117
- KEGG:   eco:b0872
- EchoBASE:   EB3455
- EcoGene:   EG13691
- eggNOG:   COG1018
- GeneTree:   EBGT00050000009403
- HOGENOM:   HBG483999
- OMA:   IMSMTRW
- ProtClustDB:   PRK10684
- BioCyc:   EcoCyc:G6456-MONOMER
- Genevestigator:   P75824
- GO:   GO:0006810
- InterPro:   IPR012675
- InterPro:   IPR017927
- InterPro:   IPR001041
- InterPro:   IPR008333
- InterPro:   IPR001433
- InterPro:   IPR000951
- InterPro:   IPR017938
- Gene3D:   G3DSA:3.10.20.30
- PRINTS:   PR00409

Pfam domain/function: PF00970 FAD_binding_6; PF00111 Fer2; PF00175 NAD_binding_1; SSF54292 Ferredoxin; SSF63380 Riboflavin_synthase_like_b-brl

EC number: 1.-.-.- [C]

Molecular weight: Translated: 35740; Mature: 35609

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS00197 2FE2S_FER_1; PS51085 2FE2S_FER_2; PS51384 FAD_FR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMPTNQCPWRMQVHHITQETPDVWTISLICHDYYPYRAGQYALVSVRNSAETLRAYTIS
CCCCCCCCCCEEEEEECCCCCCCEEEEEEEEECCCCCCCCCEEEEEECCCCCEEEEEEEC
STPGVSEYITLTVRRIDDGVGSQWLTRDVKRGDYLWLSDAMGEFTCDDKAEDKFLLLAAG
CCCCCCCEEEEEEEECCCCCCCHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCEEEEEEC
CGVTPIMSMRRWLAKNRPQADVRVIYNVRTPQDVIFADEWRNYPVTLVAENNVTEGFIAG
CCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEECCCCCCCEEEEECCCCCCHHHHH
RLTRELLAGVPDLASRTVMTCGPAPYMDWVEQEVKALGVTRFFKEKFFTPVAEAATSGLK
HHHHHHHCCCCCHHHCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCE
FTKLQPAREFYAPVGTTLLEALESNNVPVVAACRAGVCGCCKTKVVSGEYTVSSTMTLTD
EEECCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCEEECCCEEEEEEEEEEC
AEIAEGYVLACSCHPQGDLVLA
HHHCCCEEEEEEECCCCCEEEC
>Mature Secondary Structure 
TMPTNQCPWRMQVHHITQETPDVWTISLICHDYYPYRAGQYALVSVRNSAETLRAYTIS
CCCCCCCCCEEEEEECCCCCCCEEEEEEEEECCCCCCCCCEEEEEECCCCCEEEEEEEC
STPGVSEYITLTVRRIDDGVGSQWLTRDVKRGDYLWLSDAMGEFTCDDKAEDKFLLLAAG
CCCCCCCEEEEEEEECCCCCCCHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCEEEEEEC
CGVTPIMSMRRWLAKNRPQADVRVIYNVRTPQDVIFADEWRNYPVTLVAENNVTEGFIAG
CCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEECCCCCCCEEEEECCCCCCHHHHH
RLTRELLAGVPDLASRTVMTCGPAPYMDWVEQEVKALGVTRFFKEKFFTPVAEAATSGLK
HHHHHHHCCCCCHHHCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCE
FTKLQPAREFYAPVGTTLLEALESNNVPVVAACRAGVCGCCKTKVVSGEYTVSSTMTLTD
EEECCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCEEECCCEEEEEEEEEEC
AEIAEGYVLACSCHPQGDLVLA
HHHCCCEEEEEEECCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503; 10651802