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The map label for this gene is hemH

Identifier: 187732696

GI number: 187732696

Start: 396209

End: 397171

Strand: Direct

Name: hemH

Synonym: SbBS512_E0408

Alternate gene names: 187732696

Gene position: 396209-397171 (Clockwise)

Preceding gene: 187730448

Following gene: 187731286

Centisome position: 8.58

GC content: 54.0

Gene sequence:

>963_bases
ATGCGTCAGACTAAAACCGGTATCCTGCTGGCAAACCTGGGTACGCCCGATGCCCCCACACCTGAAGCGGTAAAACGCTA
TCTGAAACAATTTTTAAGCGACAGACGCGTGGTTGATACCTCACGGTTGTTATGGTGGCCATTGCTGCGCGGCGTTATTT
TGCCGCTGCGCTCGCCGCGTGTGGCGAAGCTGTATGCCTCTGTCTGGATGGAAGGTGGCTCGCCGCTGATGGTTTACAGC
CGCCAGCAACAGCAGGCGCTGGCACAACGTTTACCGGAGACGCCCGTAGCGCTGGGAATGAGCTACGGCTCGCCATCACT
GGAAAGCGCCGTCGATGAACTCCTGGCAGAGCATGTAGATCATATTGTGGTGCTGCCGCTTTATCCGCAATTCTCCTGTT
CTACGGTCGGTGCGGTATGGGATGAACTGGCACGCATTCTGGCGCGCAAACGTAGCATTCCGGGGATATCGTTTATTCGT
GATTACGCCGATAACCAGGATTACATTAATGCACTGGCGAACAGCGTACGCGCTTCTTTTGCCAAACATGGCGAACCGGA
TCTGCTGCTGCTCTCTTATCATGGCATTCCCCAGCGTTATGCAGATGAAGGCGATGATTACCCGCAACGTTGCCGCACAA
CGACTCGCGAACTGGCTTCCGCACTGGGGATGGCACCGGAAAAAGTGATGATGACCTTTCAGTCGCGCTTTGGCCGGGAA
CCCTGGCTGATGCCTTATACCGACGAAACGCTGAAAATGCTCGGAGAAAAAGGCGTAGGTTATATACAGGTGATGTGCCC
GGGCTTTGCTGCGGATTGTCTGGAGACGCTGGAAGAGATTGCCGAGCAAAACCGTGAGGTCTTCCTCGGTGCCGGTGGGA
AAAAATATGAATATATTCCAGCGCTTAATGCCACGCCAGAACATATCGAAATGATGGCTAATCTTGTTGCCGCGTATCGC
TAA

Upstream 100 bases:

>100_bases
TCTGCTCATCCACCTCAGGCAATACCTCTCACAGCAATTAGTTCTTCTTCCTCACTTTTCCGCTACAATTATCAACAAGT
TGAATCGATAAGAGGCGGTA

Downstream 100 bases:

>100_bases
AGCTGAGCGGTAAAGAACTGAGCGCCGTCGCGAAGAGCCTCGTCGGCGGTTTTCATCATTCGTGAATAATGCAAAAAGAC
ATGCAGCGTACCTGGGTAGA

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MRQTKTGILLANLGTPDAPTPEAVKRYLKQFLSDRRVVDTSRLLWWPLLRGVILPLRSPRVAKLYASVWMEGGSPLMVYS
RQQQQALAQRLPETPVALGMSYGSPSLESAVDELLAEHVDHIVVLPLYPQFSCSTVGAVWDELARILARKRSIPGISFIR
DYADNQDYINALANSVRASFAKHGEPDLLLLSYHGIPQRYADEGDDYPQRCRTTTRELASALGMAPEKVMMTFQSRFGRE
PWLMPYTDETLKMLGEKGVGYIQVMCPGFAADCLETLEEIAEQNREVFLGAGGKKYEYIPALNATPEHIEMMANLVAAYR

Sequences:

>Translated_320_residues
MRQTKTGILLANLGTPDAPTPEAVKRYLKQFLSDRRVVDTSRLLWWPLLRGVILPLRSPRVAKLYASVWMEGGSPLMVYS
RQQQQALAQRLPETPVALGMSYGSPSLESAVDELLAEHVDHIVVLPLYPQFSCSTVGAVWDELARILARKRSIPGISFIR
DYADNQDYINALANSVRASFAKHGEPDLLLLSYHGIPQRYADEGDDYPQRCRTTTRELASALGMAPEKVMMTFQSRFGRE
PWLMPYTDETLKMLGEKGVGYIQVMCPGFAADCLETLEEIAEQNREVFLGAGGKKYEYIPALNATPEHIEMMANLVAAYR
>Mature_320_residues
MRQTKTGILLANLGTPDAPTPEAVKRYLKQFLSDRRVVDTSRLLWWPLLRGVILPLRSPRVAKLYASVWMEGGSPLMVYS
RQQQQALAQRLPETPVALGMSYGSPSLESAVDELLAEHVDHIVVLPLYPQFSCSTVGAVWDELARILARKRSIPGISFIR
DYADNQDYINALANSVRASFAKHGEPDLLLLSYHGIPQRYADEGDDYPQRCRTTTRELASALGMAPEKVMMTFQSRFGRE
PWLMPYTDETLKMLGEKGVGYIQVMCPGFAADCLETLEEIAEQNREVFLGAGGKKYEYIPALNATPEHIEMMANLVAAYR

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499025, Length=334, Percent_Identity=26.3473053892216, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI60499021, Length=333, Percent_Identity=26.4264264264264, Blast_Score=101, Evalue=1e-21,
Organism=Escherichia coli, GI1786681, Length=320, Percent_Identity=99.0625, Blast_Score=655, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6324750, Length=339, Percent_Identity=28.023598820059, Blast_Score=102, Evalue=5e-23,
Organism=Drosophila melanogaster, GI17864156, Length=336, Percent_Identity=26.4880952380952, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24651774, Length=269, Percent_Identity=27.5092936802974, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 35872; Mature: 35872

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQTKTGILLANLGTPDAPTPEAVKRYLKQFLSDRRVVDTSRLLWWPLLRGVILPLRSPR
CCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCH
VAKLYASVWMEGGSPLMVYSRQQQQALAQRLPETPVALGMSYGSPSLESAVDELLAEHVD
HHHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCCCHHHCCCCCCCHHHHHHHHHHHHHCC
HIVVLPLYPQFSCSTVGAVWDELARILARKRSIPGISFIRDYADNQDYINALANSVRASF
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHH
AKHGEPDLLLLSYHGIPQRYADEGDDYPQRCRTTTRELASALGMAPEKVMMTFQSRFGRE
HHCCCCCEEEEEECCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
PWLMPYTDETLKMLGEKGVGYIQVMCPGFAADCLETLEEIAEQNREVFLGAGGKKYEYIP
CCCCCCCHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEC
ALNATPEHIEMMANLVAAYR
CCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRQTKTGILLANLGTPDAPTPEAVKRYLKQFLSDRRVVDTSRLLWWPLLRGVILPLRSPR
CCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCH
VAKLYASVWMEGGSPLMVYSRQQQQALAQRLPETPVALGMSYGSPSLESAVDELLAEHVD
HHHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCCCHHHCCCCCCCHHHHHHHHHHHHHCC
HIVVLPLYPQFSCSTVGAVWDELARILARKRSIPGISFIRDYADNQDYINALANSVRASF
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHH
AKHGEPDLLLLSYHGIPQRYADEGDDYPQRCRTTTRELASALGMAPEKVMMTFQSRFGRE
HHCCCCCEEEEEECCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
PWLMPYTDETLKMLGEKGVGYIQVMCPGFAADCLETLEEIAEQNREVFLGAGGKKYEYIP
CCCCCCCHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEC
ALNATPEHIEMMANLVAAYR
CCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA