Click here to switch to the map view.

The map label for this gene is ilvA [H]

Identifier: 187735091

GI number: 187735091

Start: 692337

End: 693953

Strand: Direct

Name: ilvA [H]

Synonym: Amuc_0585

Alternate gene names: 187735091

Gene position: 692337-693953 (Clockwise)

Preceding gene: 187735089

Following gene: 187735092

Centisome position: 25.99

GC content: 57.33

Gene sequence:

>1617_bases
ATGTTTTACTGGAAAAAGGGGTTGGACTTCAGTAGAATGGGGGCCAGCATTACAATCATGAGCATACTTTCGGACCGTCT
TTCCGAGGAAATACTGCAAGCCCGCCAGCGCGTCTATACCGTTGGCGAACCGACTCCTCTCCAGCGATTGAATCTGCCGG
GCATCAAGGCCCCGGTATACGCCAAAAGGGAGGATCTGGGGCCCATCCGGGCTTATAAGTGGCGCGGAGCGTTTAATTGC
ATGGCCGCATTGAGCCAGGAAGCCCGTGACAAAGGCATTGTGGCGGCTTCCGCCGGCAATCATGCCCAGGGCGTGGCGCT
GGCGGCCAGAGTGCTGAACTGCCATGCCACCATTTTCATGCCGCGCTCCACGCCGGAAGTGAAGCAGACGGAAGTGCGCC
GCCACGGCGGCAGGCATGTGAAGATCATGCTCCATGGGGACTGCTATGACGAGACGGCCGCAGCCGCCCATGAATACACG
GAAACCCACGGCTGCACTTTTGTCCATCCTTATGACGACCTGGTGACCATGGCCGGACAGGGAACGCTGGCGGACGAAGT
GGTGATGAGCGGAGAAGGCCCTTTTGACCGCGCGTACGTCGCCATCGGCGGCGGCGGCCTGGCCGCATCCGTGGCGTGCT
GGCTGAAAAAATTCTGGCCCCATATCAAGGTCATCGGCGTGGAAGGCATCGACCAGGCGTCCATGAAAACTTCCATTGAG
CAGGGACGCCGGGTGAATCTGGATTACGTGGATGTCTTCTGCGACGGCACAGCCGTCCACATCCCCGGAGAATTAACCTA
TCCCCTTTGCCGGGAACTGGTTGACGAGTTCGTGACCGTGACCAATAATGAGGTCTGCCAGGCCATCCGGGCCATGTGGG
AATCCTCCCGCGTCGTGCCGGAACCATCCGGAGCCATGAGCCTGGCAGGATTCCTGAAACAATGGAACCGGGGCGAAGTA
AAGCCGGAGGAAAAGAGTTTCGTGGTCATTTCCGGAGCCAATATGGATTTCACCCACCTTACCCAGATTGCCCGGCAGGC
GGGCATCGGCAACCATGAAACGCGCTATCTGCGCATTTCCATGGATTCCAAGCGCGGCCAGGTGCTTAAATACCTGCGCC
ACATTCCGCAGGATACGACGCTGGTGGATGTGCAATACGGCAAAACGGAGGGAAACACCCAGCACCCCGTGTTCGGCATT
GCCGCTTCCGATGAAGACCTGGATACCATCCGCACGACACTGAAAAAGAAAGGAATCGAATTCGAAGACATCAGCGAGGA
CGACGACGTGCGCTTCCGCATGATTCACTACCAGCCGGAACTGTGTCAACACCCCCTGTTCGTCCACATTGAATTTCCGG
AACGCGCCGGCGCCTTCCTTGACTTCATGGAACGCATCGCGGATCTGGCTTCCCTCTGTTATTTCAACTATACCTACACC
GGGGAACGCGTAGGCCGCGCCCTGGTGGGCATGGAATTTGATACAGCGGAAGACCGGGAAACCATCCGGAAACGCATGGG
CGCCTTTTCCAAAAACATTATCAGGTCCATTCGGGAAATTTCCCCCGAGGCTTTCCAGAGGATTATGGGAAGCAGACAGT
TGACAGGCAATCATTGA

Upstream 100 bases:

>100_bases
CGTCCGCTTCGCCACCTTGTTCAGGAAAAACAGCCGCCTCCGGGCGGCTTTTTTTTCGTCCAGAAAACCTGAATTCCAGA
AAACAGGCCGTCCTCCGGGA

Downstream 100 bases:

>100_bases
CAGCCCATCATCCAGGGAGCTTGAGAAAGATTGGCTCCCTGTTTTTCATGACCGCTTTTTTCTCCCATGATTCCCCCCGT
CATCCTGGCCTCCCAATCGC

Product: Pyridoxal-5'-phosphate-dependent protein beta subunit

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 538; Mature: 538

Protein sequence:

>538_residues
MFYWKKGLDFSRMGASITIMSILSDRLSEEILQARQRVYTVGEPTPLQRLNLPGIKAPVYAKREDLGPIRAYKWRGAFNC
MAALSQEARDKGIVAASAGNHAQGVALAARVLNCHATIFMPRSTPEVKQTEVRRHGGRHVKIMLHGDCYDETAAAAHEYT
ETHGCTFVHPYDDLVTMAGQGTLADEVVMSGEGPFDRAYVAIGGGGLAASVACWLKKFWPHIKVIGVEGIDQASMKTSIE
QGRRVNLDYVDVFCDGTAVHIPGELTYPLCRELVDEFVTVTNNEVCQAIRAMWESSRVVPEPSGAMSLAGFLKQWNRGEV
KPEEKSFVVISGANMDFTHLTQIARQAGIGNHETRYLRISMDSKRGQVLKYLRHIPQDTTLVDVQYGKTEGNTQHPVFGI
AASDEDLDTIRTTLKKKGIEFEDISEDDDVRFRMIHYQPELCQHPLFVHIEFPERAGAFLDFMERIADLASLCYFNYTYT
GERVGRALVGMEFDTAEDRETIRKRMGAFSKNIIRSIREISPEAFQRIMGSRQLTGNH

Sequences:

>Translated_538_residues
MFYWKKGLDFSRMGASITIMSILSDRLSEEILQARQRVYTVGEPTPLQRLNLPGIKAPVYAKREDLGPIRAYKWRGAFNC
MAALSQEARDKGIVAASAGNHAQGVALAARVLNCHATIFMPRSTPEVKQTEVRRHGGRHVKIMLHGDCYDETAAAAHEYT
ETHGCTFVHPYDDLVTMAGQGTLADEVVMSGEGPFDRAYVAIGGGGLAASVACWLKKFWPHIKVIGVEGIDQASMKTSIE
QGRRVNLDYVDVFCDGTAVHIPGELTYPLCRELVDEFVTVTNNEVCQAIRAMWESSRVVPEPSGAMSLAGFLKQWNRGEV
KPEEKSFVVISGANMDFTHLTQIARQAGIGNHETRYLRISMDSKRGQVLKYLRHIPQDTTLVDVQYGKTEGNTQHPVFGI
AASDEDLDTIRTTLKKKGIEFEDISEDDDVRFRMIHYQPELCQHPLFVHIEFPERAGAFLDFMERIADLASLCYFNYTYT
GERVGRALVGMEFDTAEDRETIRKRMGAFSKNIIRSIREISPEAFQRIMGSRQLTGNH
>Mature_538_residues
MFYWKKGLDFSRMGASITIMSILSDRLSEEILQARQRVYTVGEPTPLQRLNLPGIKAPVYAKREDLGPIRAYKWRGAFNC
MAALSQEARDKGIVAASAGNHAQGVALAARVLNCHATIFMPRSTPEVKQTEVRRHGGRHVKIMLHGDCYDETAAAAHEYT
ETHGCTFVHPYDDLVTMAGQGTLADEVVMSGEGPFDRAYVAIGGGGLAASVACWLKKFWPHIKVIGVEGIDQASMKTSIE
QGRRVNLDYVDVFCDGTAVHIPGELTYPLCRELVDEFVTVTNNEVCQAIRAMWESSRVVPEPSGAMSLAGFLKQWNRGEV
KPEEKSFVVISGANMDFTHLTQIARQAGIGNHETRYLRISMDSKRGQVLKYLRHIPQDTTLVDVQYGKTEGNTQHPVFGI
AASDEDLDTIRTTLKKKGIEFEDISEDDDVRFRMIHYQPELCQHPLFVHIEFPERAGAFLDFMERIADLASLCYFNYTYT
GERVGRALVGMEFDTAEDRETIRKRMGAFSKNIIRSIREISPEAFQRIMGSRQLTGNH

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=283, Percent_Identity=31.8021201413428, Blast_Score=128, Evalue=1e-29,
Organism=Escherichia coli, GI1790207, Length=481, Percent_Identity=33.6798336798337, Blast_Score=246, Evalue=4e-66,
Organism=Escherichia coli, GI1789505, Length=325, Percent_Identity=34.4615384615385, Blast_Score=154, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17508781, Length=285, Percent_Identity=27.3684210526316, Blast_Score=111, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI71991565, Length=285, Percent_Identity=28.4210526315789, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17537387, Length=391, Percent_Identity=26.3427109974425, Blast_Score=82, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6320930, Length=485, Percent_Identity=32.9896907216495, Blast_Score=245, Evalue=1e-65,
Organism=Saccharomyces cerevisiae, GI6322631, Length=314, Percent_Identity=32.1656050955414, Blast_Score=142, Evalue=1e-34,
Organism=Drosophila melanogaster, GI21355833, Length=280, Percent_Identity=29.6428571428571, Blast_Score=95, Evalue=2e-19,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 60293; Mature: 60293

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFYWKKGLDFSRMGASITIMSILSDRLSEEILQARQRVYTVGEPTPLQRLNLPGIKAPVY
CCEECCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHCCCCCCCCCCC
AKREDLGPIRAYKWRGAFNCMAALSQEARDKGIVAASAGNHAQGVALAARVLNCHATIFM
CCCCCCCCCCEEEECCHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHCEEEEEE
PRSTPEVKQTEVRRHGGRHVKIMLHGDCYDETAAAAHEYTETHGCTFVHPYDDLVTMAGQ
CCCCCCHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHCCEEEECCHHHHHHHCCC
GTLADEVVMSGEGPFDRAYVAIGGGGLAASVACWLKKFWPHIKVIGVEGIDQASMKTSIE
CCCHHHHEECCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHH
QGRRVNLDYVDVFCDGTAVHIPGELTYPLCRELVDEFVTVTNNEVCQAIRAMWESSRVVP
CCCCCCCEEEEEEECCEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCC
EPSGAMSLAGFLKQWNRGEVKPEEKSFVVISGANMDFTHLTQIARQAGIGNHETRYLRIS
CCCCHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCEEEEEEE
MDSKRGQVLKYLRHIPQDTTLVDVQYGKTEGNTQHPVFGIAASDEDLDTIRTTLKKKGIE
ECCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCC
FEDISEDDDVRFRMIHYQPELCQHPLFVHIEFPERAGAFLDFMERIADLASLCYFNYTYT
CCCCCCCCCCEEEEEEECHHHHCCCEEEEEECCHHCCHHHHHHHHHHHHHHHHHHCCEEC
GERVGRALVGMEFDTAEDRETIRKRMGAFSKNIIRSIREISPEAFQRIMGSRQLTGNH
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MFYWKKGLDFSRMGASITIMSILSDRLSEEILQARQRVYTVGEPTPLQRLNLPGIKAPVY
CCEECCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHCCCCCCCCCCC
AKREDLGPIRAYKWRGAFNCMAALSQEARDKGIVAASAGNHAQGVALAARVLNCHATIFM
CCCCCCCCCCEEEECCHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHCEEEEEE
PRSTPEVKQTEVRRHGGRHVKIMLHGDCYDETAAAAHEYTETHGCTFVHPYDDLVTMAGQ
CCCCCCHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHCCEEEECCHHHHHHHCCC
GTLADEVVMSGEGPFDRAYVAIGGGGLAASVACWLKKFWPHIKVIGVEGIDQASMKTSIE
CCCHHHHEECCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHH
QGRRVNLDYVDVFCDGTAVHIPGELTYPLCRELVDEFVTVTNNEVCQAIRAMWESSRVVP
CCCCCCCEEEEEEECCEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCC
EPSGAMSLAGFLKQWNRGEVKPEEKSFVVISGANMDFTHLTQIARQAGIGNHETRYLRIS
CCCCHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCEEEEEEE
MDSKRGQVLKYLRHIPQDTTLVDVQYGKTEGNTQHPVFGIAASDEDLDTIRTTLKKKGIE
ECCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCC
FEDISEDDDVRFRMIHYQPELCQHPLFVHIEFPERAGAFLDFMERIADLASLCYFNYTYT
CCCCCCCCCCEEEEEEECHHHHCCCEEEEEECCHHCCHHHHHHHHHHHHHHHHHHCCEEC
GERVGRALVGMEFDTAEDRETIRKRMGAFSKNIIRSIREISPEAFQRIMGSRQLTGNH
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA