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The map label for this gene is bioA [H]

Identifier: 187735000

GI number: 187735000

Start: 583467

End: 584816

Strand: Direct

Name: bioA [H]

Synonym: Amuc_0493

Alternate gene names: 187735000

Gene position: 583467-584816 (Clockwise)

Preceding gene: 187734999

Following gene: 187735001

Centisome position: 21.9

GC content: 56.3

Gene sequence:

>1350_bases
ATGAATCACTCCGACTGGTCAAAAAAAGATCTGGAATACATCTGGCATCCCTGTTCCCAGATGAAGGATTACGAAACGCT
GCCTCCTATCGTGGTCGACCACGGAAAAGGCGTCAACCTGTATGATGTGGACGGGAAACGCTATCTGGATGTGGTCAGCT
CCTGGTGGTGCAACCTGCTGGGCCATTCCCACCCCAAAATCAACCGTGCCATCAAGGAACAGCTTGATTCCCTGGAGCAT
GTCATCTTCGCCAACTTCTCACACAGGCCGGCTATCACTCTGTGTGAAGAACTGATGAAGAAAATTCCGCGGGGGCTCTG
CAAATTCAATTTCTCGGATAACGGTTCGGCATCCATCGAATCCGCCATGAAAATGAGTTTCCAATACCACTACCAGACCG
GAAACCGTCAGAAAGTACGTTTCATGTCCCTGAGCGACGCCTACCACGGAGAAACCCTGGGAGCCCTCTCCGCAGGAGGC
CTGGACCTTTATTCGGAACTCTACAAACCTCTTCTGCTGGACATCGTGCGCATTCCCGCTCCGGATTGCTACCGCTGCCC
CAAGGGGAACAAACGCGGCTGCTGCCAGGCGGAATGCATTGACGCGGCACAGGAGGCCTTTGCGCGCCATGGGGACGAAT
GCGCCGCCCTGCTGGTGGAACCCCTGCTCCAGGGCTCCGCAGGCATGCGGATGTATCCTCCCGCTTATCTGGCGAAACTG
CGTTCCCTGTGCGACGCCTACAACGTGCACCTCATTGCAGATGAAATCGCCACCGGTTTTGGCCGCACGGGGAGCATGTT
CGCCTGCGACCAGGCCGGCGTTTCCCCGGACATCATGTGCGTCTCCAAAGGGCTCACGGGCGGCTATATGCCCATGTCCA
TCACCATCACCACGCAGAAAATTTACGATGCCTTTTATGCGGACTACAGGGAAGGAAAAGCATTCATGCACAGCCATACC
TATTCCGGCAATCCGCTGGGGTGCTCCACAGCTCTCGCCGTGCTGAAGGTCCTGGACGAGGAACACATTATTCCCCGGGC
GCAGGAAAAAGCCCCTCTTTTCCGCCAGATGATCGTGGAGGCCCTGGGGGATCATCCCCACGTGGGGGAAATACGCAGCC
TGGGCCTGGTGAACGCCATTGAACTGGTGGAGAACAGGGAAACCAAAAAAAGCTTTCCGTCCGAGCAGAGGCTGGGGTAC
CGGATTTACAGGGAAGCCCTTAAACAGGGACTTCTGCTTCGCCCCCTGGGCGACGTCCTGTATTTCAATCCCCCCCTCGT
CATTTCTCCGGAGGAAATGGAGGAAGCCGTATCCATCTGCGCTTCCTGCATCCGCAAAGTGCTGGGATAA

Upstream 100 bases:

>100_bases
ACCGCCGGCGTCACCATCCGGGAAGACCTGGCCATGCTGGCGGAACTGGGATATGAAGTCCGCATGAAATAAGGTCCGTC
CCATTTTCGCGCCCTTTGCC

Downstream 100 bases:

>100_bases
ATGTTCATCCGGCACAACAAGACGAACTGTTTTTTCTTGAAGAAGATTGTGAACCACCAATATAGTGCAATTATAATTTG
ACAAAAGCCGGGATGCGGCA

Product: adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MNHSDWSKKDLEYIWHPCSQMKDYETLPPIVVDHGKGVNLYDVDGKRYLDVVSSWWCNLLGHSHPKINRAIKEQLDSLEH
VIFANFSHRPAITLCEELMKKIPRGLCKFNFSDNGSASIESAMKMSFQYHYQTGNRQKVRFMSLSDAYHGETLGALSAGG
LDLYSELYKPLLLDIVRIPAPDCYRCPKGNKRGCCQAECIDAAQEAFARHGDECAALLVEPLLQGSAGMRMYPPAYLAKL
RSLCDAYNVHLIADEIATGFGRTGSMFACDQAGVSPDIMCVSKGLTGGYMPMSITITTQKIYDAFYADYREGKAFMHSHT
YSGNPLGCSTALAVLKVLDEEHIIPRAQEKAPLFRQMIVEALGDHPHVGEIRSLGLVNAIELVENRETKKSFPSEQRLGY
RIYREALKQGLLLRPLGDVLYFNPPLVISPEEMEEAVSICASCIRKVLG

Sequences:

>Translated_449_residues
MNHSDWSKKDLEYIWHPCSQMKDYETLPPIVVDHGKGVNLYDVDGKRYLDVVSSWWCNLLGHSHPKINRAIKEQLDSLEH
VIFANFSHRPAITLCEELMKKIPRGLCKFNFSDNGSASIESAMKMSFQYHYQTGNRQKVRFMSLSDAYHGETLGALSAGG
LDLYSELYKPLLLDIVRIPAPDCYRCPKGNKRGCCQAECIDAAQEAFARHGDECAALLVEPLLQGSAGMRMYPPAYLAKL
RSLCDAYNVHLIADEIATGFGRTGSMFACDQAGVSPDIMCVSKGLTGGYMPMSITITTQKIYDAFYADYREGKAFMHSHT
YSGNPLGCSTALAVLKVLDEEHIIPRAQEKAPLFRQMIVEALGDHPHVGEIRSLGLVNAIELVENRETKKSFPSEQRLGY
RIYREALKQGLLLRPLGDVLYFNPPLVISPEEMEEAVSICASCIRKVLG
>Mature_449_residues
MNHSDWSKKDLEYIWHPCSQMKDYETLPPIVVDHGKGVNLYDVDGKRYLDVVSSWWCNLLGHSHPKINRAIKEQLDSLEH
VIFANFSHRPAITLCEELMKKIPRGLCKFNFSDNGSASIESAMKMSFQYHYQTGNRQKVRFMSLSDAYHGETLGALSAGG
LDLYSELYKPLLLDIVRIPAPDCYRCPKGNKRGCCQAECIDAAQEAFARHGDECAALLVEPLLQGSAGMRMYPPAYLAKL
RSLCDAYNVHLIADEIATGFGRTGSMFACDQAGVSPDIMCVSKGLTGGYMPMSITITTQKIYDAFYADYREGKAFMHSHT
YSGNPLGCSTALAVLKVLDEEHIIPRAQEKAPLFRQMIVEALGDHPHVGEIRSLGLVNAIELVENRETKKSFPSEQRLGY
RIYREALKQGLLLRPLGDVLYFNPPLVISPEEMEEAVSICASCIRKVLG

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=424, Percent_Identity=30.6603773584906, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI13994255, Length=440, Percent_Identity=28.4090909090909, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI284507298, Length=335, Percent_Identity=30.1492537313433, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI24119277, Length=426, Percent_Identity=27.4647887323944, Blast_Score=135, Evalue=9e-32,
Organism=Homo sapiens, GI37574042, Length=417, Percent_Identity=26.1390887290168, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI226442709, Length=386, Percent_Identity=26.4248704663212, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI226442705, Length=417, Percent_Identity=25.6594724220624, Blast_Score=116, Evalue=6e-26,
Organism=Homo sapiens, GI188536080, Length=440, Percent_Identity=22.0454545454545, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI38679950, Length=440, Percent_Identity=22.0454545454545, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI38679946, Length=440, Percent_Identity=22.0454545454545, Blast_Score=73, Evalue=5e-13,
Organism=Escherichia coli, GI1786991, Length=426, Percent_Identity=35.6807511737089, Blast_Score=270, Evalue=1e-73,
Organism=Escherichia coli, GI145693181, Length=405, Percent_Identity=31.1111111111111, Blast_Score=202, Evalue=3e-53,
Organism=Escherichia coli, GI1789016, Length=422, Percent_Identity=30.3317535545024, Blast_Score=199, Evalue=3e-52,
Organism=Escherichia coli, GI1789759, Length=415, Percent_Identity=29.1566265060241, Blast_Score=174, Evalue=7e-45,
Organism=Escherichia coli, GI1787560, Length=413, Percent_Identity=28.3292978208232, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1788044, Length=417, Percent_Identity=28.2973621103118, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI1786349, Length=338, Percent_Identity=25.7396449704142, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI32564660, Length=447, Percent_Identity=29.082774049217, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI25144271, Length=423, Percent_Identity=27.1867612293144, Blast_Score=149, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI71992977, Length=435, Percent_Identity=26.2068965517241, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI25144274, Length=233, Percent_Identity=31.7596566523605, Blast_Score=118, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6324386, Length=457, Percent_Identity=30.4157549234136, Blast_Score=218, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6323470, Length=449, Percent_Identity=28.2850779510022, Blast_Score=160, Evalue=6e-40,
Organism=Saccharomyces cerevisiae, GI6324432, Length=438, Percent_Identity=26.7123287671233, Blast_Score=132, Evalue=8e-32,
Organism=Drosophila melanogaster, GI21357415, Length=425, Percent_Identity=31.0588235294118, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI28574759, Length=449, Percent_Identity=30.2895322939866, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI161085790, Length=446, Percent_Identity=30.0448430493274, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI21356575, Length=437, Percent_Identity=27.6887871853547, Blast_Score=134, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 50171; Mature: 50171

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHSDWSKKDLEYIWHPCSQMKDYETLPPIVVDHGKGVNLYDVDGKRYLDVVSSWWCNLL
CCCCCCCHHHHHHHHCCHHHCCCCCCCCCEEEECCCCCEEEECCCHHHHHHHHHHHHHHH
GHSHPKINRAIKEQLDSLEHVIFANFSHRPAITLCEELMKKIPRGLCKFNFSDNGSASIE
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHEEECCCCCCCHHHH
SAMKMSFQYHYQTGNRQKVRFMSLSDAYHGETLGALSAGGLDLYSELYKPLLLDIVRIPA
HHHHHHHEEEEECCCCCEEEEEEECCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHCCC
PDCYRCPKGNKRGCCQAECIDAAQEAFARHGDECAALLVEPLLQGSAGMRMYPPAYLAKL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEECCHHHHHHH
RSLCDAYNVHLIADEIATGFGRTGSMFACDQAGVSPDIMCVSKGLTGGYMPMSITITTQK
HHHHHHHCCEEEHHHHHHCCCCCCCEEEECCCCCCCCCEEEECCCCCCCCEEEEEEEHHH
IYDAFYADYREGKAFMHSHTYSGNPLGCSTALAVLKVLDEEHIIPRAQEKAPLFRQMIVE
HHHHHHHHHHHCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHCCHHHHHHHHH
ALGDHPHVGEIRSLGLVNAIELVENRETKKSFPSEQRLGYRIYREALKQGLLLRPLGDVL
HHCCCCCCCHHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHCCCEECCCCCCE
YFNPPLVISPEEMEEAVSICASCIRKVLG
EECCCEEECHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MNHSDWSKKDLEYIWHPCSQMKDYETLPPIVVDHGKGVNLYDVDGKRYLDVVSSWWCNLL
CCCCCCCHHHHHHHHCCHHHCCCCCCCCCEEEECCCCCEEEECCCHHHHHHHHHHHHHHH
GHSHPKINRAIKEQLDSLEHVIFANFSHRPAITLCEELMKKIPRGLCKFNFSDNGSASIE
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHEEECCCCCCCHHHH
SAMKMSFQYHYQTGNRQKVRFMSLSDAYHGETLGALSAGGLDLYSELYKPLLLDIVRIPA
HHHHHHHEEEEECCCCCEEEEEEECCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHCCC
PDCYRCPKGNKRGCCQAECIDAAQEAFARHGDECAALLVEPLLQGSAGMRMYPPAYLAKL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEECCHHHHHHH
RSLCDAYNVHLIADEIATGFGRTGSMFACDQAGVSPDIMCVSKGLTGGYMPMSITITTQK
HHHHHHHCCEEEHHHHHHCCCCCCCEEEECCCCCCCCCEEEECCCCCCCCEEEEEEEHHH
IYDAFYADYREGKAFMHSHTYSGNPLGCSTALAVLKVLDEEHIIPRAQEKAPLFRQMIVE
HHHHHHHHHHHCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHCCHHHHHHHHH
ALGDHPHVGEIRSLGLVNAIELVENRETKKSFPSEQRLGYRIYREALKQGLLLRPLGDVL
HHCCCCCCCHHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHCCCEECCCCCCE
YFNPPLVISPEEMEEAVSICASCIRKVLG
EECCCEEECHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]