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The map label for this gene is coaC [H]

Identifier: 187734970

GI number: 187734970

Start: 550779

End: 551318

Strand: Direct

Name: coaC [H]

Synonym: Amuc_0463

Alternate gene names: 187734970

Gene position: 550779-551318 (Clockwise)

Preceding gene: 187734969

Following gene: 187734971

Centisome position: 20.67

GC content: 56.48

Gene sequence:

>540_bases
ATGGCCTGCATCATTCTGGGCGTCACCGGCTCCATTGCCGCATACAAAGCGGCGGATATCGCTTCCGCCCTGGTCAAATA
CGGTCATGAAGTGCACTGCGTCTGCACAGCCAAGGCCCTTGAATTCGTCACTCCCCTCACCCTGCACACGATTTCCCGCA
ACCCCGTCTTTTCCTCCTTTGAGGATGAAAAGACGGACTGGGTTCCCCCACACATCCAACTGGCCCAACGGGCGGATCTT
CTGCTTGTAGCCCCAGCCACGGCAAACACCATGGCCAATTTTGCCCATGGCTTCGCTCCGGACATGCTCAGTTCCCTCTA
CCTGGCTTGCCAGTCTCCGGTGCTTATTTGCCCAGCTATGAACGTCCACATGTGGGAACATGCGGCCACGCAGCAAAACG
CGGCCGTTCTGAAGCAAAGGAAGGATCATTACATCCTCGGCCCCAGTGAATCCGGAATTCTGGCCTGCGGAGCGGAAGGC
GCGGGAAAACTCATGCCGGTGGACAAGATTATTCAAAAAACACTCTCCCTTCTGCCGTAA

Upstream 100 bases:

>100_bases
CCGACTGCCGGGGAAGATGAAATCCTGAGCCAGTCCAAGCACTTCTGGAAACTTATCGACGAAGGCAAAAACGCCTCCAA
AGCCTGACCTTTTCCCATTC

Downstream 100 bases:

>100_bases
GGACGGCAAAAATCGCTCCATGCCTGTTTATTGGTTTGCCCCCGGAGAACTAAATCTTCTATCATGGACGCATATGAAAA
TGCTCCTGTTCCTCTTCAGT

Product: Phosphopantothenoylcysteine decarboxylase

Products: NA

Alternate protein names: PPCDC [H]

Number of amino acids: Translated: 179; Mature: 178

Protein sequence:

>179_residues
MACIILGVTGSIAAYKAADIASALVKYGHEVHCVCTAKALEFVTPLTLHTISRNPVFSSFEDEKTDWVPPHIQLAQRADL
LLVAPATANTMANFAHGFAPDMLSSLYLACQSPVLICPAMNVHMWEHAATQQNAAVLKQRKDHYILGPSESGILACGAEG
AGKLMPVDKIIQKTLSLLP

Sequences:

>Translated_179_residues
MACIILGVTGSIAAYKAADIASALVKYGHEVHCVCTAKALEFVTPLTLHTISRNPVFSSFEDEKTDWVPPHIQLAQRADL
LLVAPATANTMANFAHGFAPDMLSSLYLACQSPVLICPAMNVHMWEHAATQQNAAVLKQRKDHYILGPSESGILACGAEG
AGKLMPVDKIIQKTLSLLP
>Mature_178_residues
ACIILGVTGSIAAYKAADIASALVKYGHEVHCVCTAKALEFVTPLTLHTISRNPVFSSFEDEKTDWVPPHIQLAQRADLL
LVAPATANTMANFAHGFAPDMLSSLYLACQSPVLICPAMNVHMWEHAATQQNAAVLKQRKDHYILGPSESGILACGAEGA
GKLMPVDKIIQKTLSLLP

Specific function: Catalyzes the decarboxylation of 4'- phosphopantothenoylcysteine to 4'-phosphopantetheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=183, Percent_Identity=36.6120218579235, Blast_Score=92, Evalue=3e-19,
Organism=Escherichia coli, GI87082301, Length=162, Percent_Identity=42.5925925925926, Blast_Score=119, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI17560194, Length=179, Percent_Identity=30.7262569832402, Blast_Score=77, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6322762, Length=185, Percent_Identity=31.8918918918919, Blast_Score=68, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24657262, Length=185, Percent_Identity=28.6486486486486, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011847
- InterPro:   IPR003382 [H]

Pfam domain/function: PF02441 Flavoprotein [H]

EC number: =4.1.1.36 [H]

Molecular weight: Translated: 19178; Mature: 19046

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MACIILGVTGSIAAYKAADIASALVKYGHEVHCVCTAKALEFVTPLTLHTISRNPVFSSF
CEEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHCCHHEEECCCCCCCCCC
EDEKTDWVPPHIQLAQRADLLLVAPATANTMANFAHGFAPDMLSSLYLACQSPVLICPAM
CCCCCCCCCCCHHHHCCCCEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHCCCEEEECCC
NVHMWEHAATQQNAAVLKQRKDHYILGPSESGILACGAEGAGKLMPVDKIIQKTLSLLP
CCHHHHHHHHHHHHHHHHHCCCCEEECCCCCCEEEECCCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
ACIILGVTGSIAAYKAADIASALVKYGHEVHCVCTAKALEFVTPLTLHTISRNPVFSSF
EEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHCCHHEEECCCCCCCCCC
EDEKTDWVPPHIQLAQRADLLLVAPATANTMANFAHGFAPDMLSSLYLACQSPVLICPAM
CCCCCCCCCCCHHHHCCCCEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHCCCEEEECCC
NVHMWEHAATQQNAAVLKQRKDHYILGPSESGILACGAEGAGKLMPVDKIIQKTLSLLP
CCHHHHHHHHHHHHHHHHHCCCCEEECCCCCCEEEECCCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12397186; 8763945 [H]