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The map label for this gene is purM [H]

Identifier: 187734964

GI number: 187734964

Start: 545157

End: 546158

Strand: Direct

Name: purM [H]

Synonym: Amuc_0457

Alternate gene names: 187734964

Gene position: 545157-546158 (Clockwise)

Preceding gene: 187734963

Following gene: 187734965

Centisome position: 20.46

GC content: 56.39

Gene sequence:

>1002_bases
ATGTCCGGCAAACTAACCTACAAGCAATCGGGGGTCGATACCAAGGAAGCAGCCGCTTTTGTATCCGACATCAGCTCTCA
CGTTAAAAGAACGCAAAAGCAGAGATCTCTGCACCAGGCCTTTGGCCTTTTCGCCGCCGCCTATGATTTGAGCTCCTACA
AGGAACCGGTCATCGTCACCGGGTGCGACGGCGTAGGCACCAAGACGGAAATTCTTTTTGAACTGGACATGGTGGAAACC
GCCGGCAAAGACCTGGTGGCCATGAACGTCAACGACATTCTTACTACGGGCGGCGACCCTCTCCTTTTCCTGGATTATCT
GGGCATCTCCAATCTGGAACGGGAACGCTCCCGTATCACCCGCCTGGTGGCCGGCATGTGCGACTACCTGGAATCCTGCA
ACTGCATCCTGGCCGGCGGAGAAACGGCGGAAATGCCCGGCGTGGTGCCGGAATCCATCGTGGAACTCTCCGGCTTCTGC
ATCGGCTGCTGTGAAAAAAGCAAACTGATTGATCCGAAAACCGTCCAGCCCGGAGACGTATTCATCGGCTACAAATCCGA
CAGCTTCCATGCCAACGGCTGGAGCCTCATCCGCCGCATTCTGGAAGAAAATCCGGATGTAGTTGATGAAGAAGAACTCC
GCTCCCTCCTTCAGCCCACCCGTTTGTATCATGACGTAGTGGAAGATATGCGCCGCTTCAACGTCACCCCGAAAGCATAC
GCCCACATCACGGGGGGAGGCCTCCCGGAAAACCTGGAACGCTTCCTGGGCGACTACGGCGCAGACCTCTCCATTCCCTA
TTGGGACAACACCGCCGCCCAGAAAATCCTGAAGCATGTGGATCCTCAGGACCGCTTCAACACTTTTAACATGGGCATTG
GCTGGGTAGCCATCGTGAGGCCTGAAGACGCGGAAGCCGCATTGAAGGCAGGTCCGGGCGGCACGGTCATTGGCACGCTG
AGAGAAGGCCGCGGCATTCATGTCAAGGTACAGGGCGAATAA

Upstream 100 bases:

>100_bases
CAGTTCCTCCCGCGCGTCCTATGGCAAAAATACTTCTTTTTTCACTCGCCGCGGAAGGAGCCTTCCTCTAGGATGCTGGC
ACACCCAGTCCATCCGTTCA

Downstream 100 bases:

>100_bases
AAAACACCATCTCCTTGCAGCGGATACACCACACTTACAGGACAATCTTTTCATCATCATCCCATGAGCGATTTTCTTAA
ACACGAGTGCGGCGTAGCCG

Product: phosphoribosylformylglycinamidine cyclo-ligase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 333; Mature: 332

Protein sequence:

>333_residues
MSGKLTYKQSGVDTKEAAAFVSDISSHVKRTQKQRSLHQAFGLFAAAYDLSSYKEPVIVTGCDGVGTKTEILFELDMVET
AGKDLVAMNVNDILTTGGDPLLFLDYLGISNLERERSRITRLVAGMCDYLESCNCILAGGETAEMPGVVPESIVELSGFC
IGCCEKSKLIDPKTVQPGDVFIGYKSDSFHANGWSLIRRILEENPDVVDEEELRSLLQPTRLYHDVVEDMRRFNVTPKAY
AHITGGGLPENLERFLGDYGADLSIPYWDNTAAQKILKHVDPQDRFNTFNMGIGWVAIVRPEDAEAALKAGPGGTVIGTL
REGRGIHVKVQGE

Sequences:

>Translated_333_residues
MSGKLTYKQSGVDTKEAAAFVSDISSHVKRTQKQRSLHQAFGLFAAAYDLSSYKEPVIVTGCDGVGTKTEILFELDMVET
AGKDLVAMNVNDILTTGGDPLLFLDYLGISNLERERSRITRLVAGMCDYLESCNCILAGGETAEMPGVVPESIVELSGFC
IGCCEKSKLIDPKTVQPGDVFIGYKSDSFHANGWSLIRRILEENPDVVDEEELRSLLQPTRLYHDVVEDMRRFNVTPKAY
AHITGGGLPENLERFLGDYGADLSIPYWDNTAAQKILKHVDPQDRFNTFNMGIGWVAIVRPEDAEAALKAGPGGTVIGTL
REGRGIHVKVQGE
>Mature_332_residues
SGKLTYKQSGVDTKEAAAFVSDISSHVKRTQKQRSLHQAFGLFAAAYDLSSYKEPVIVTGCDGVGTKTEILFELDMVETA
GKDLVAMNVNDILTTGGDPLLFLDYLGISNLERERSRITRLVAGMCDYLESCNCILAGGETAEMPGVVPESIVELSGFCI
GCCEKSKLIDPKTVQPGDVFIGYKSDSFHANGWSLIRRILEENPDVVDEEELRSLLQPTRLYHDVVEDMRRFNVTPKAYA
HITGGGLPENLERFLGDYGADLSIPYWDNTAAQKILKHVDPQDRFNTFNMGIGWVAIVRPEDAEAALKAGPGGTVIGTLR
EGRGIHVKVQGE

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=322, Percent_Identity=38.1987577639752, Blast_Score=185, Evalue=5e-47,
Organism=Homo sapiens, GI209869995, Length=322, Percent_Identity=38.1987577639752, Blast_Score=185, Evalue=5e-47,
Organism=Homo sapiens, GI209869993, Length=322, Percent_Identity=38.1987577639752, Blast_Score=185, Evalue=5e-47,
Organism=Escherichia coli, GI1788845, Length=315, Percent_Identity=36.5079365079365, Blast_Score=179, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17567511, Length=324, Percent_Identity=34.8765432098765, Blast_Score=144, Evalue=9e-35,
Organism=Saccharomyces cerevisiae, GI6321203, Length=325, Percent_Identity=32.6153846153846, Blast_Score=150, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24582400, Length=338, Percent_Identity=31.3609467455621, Blast_Score=129, Evalue=2e-30,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 36494; Mature: 36363

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGKLTYKQSGVDTKEAAAFVSDISSHVKRTQKQRSLHQAFGLFAAAYDLSSYKEPVIVT
CCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
GCDGVGTKTEILFELDMVETAGKDLVAMNVNDILTTGGDPLLFLDYLGISNLERERSRIT
CCCCCCCCEEEEEEEHHHHHCCCCEEEEEHHHHHHCCCCCEEEEEHHCCCHHHHHHHHHH
RLVAGMCDYLESCNCILAGGETAEMPGVVPESIVELSGFCIGCCEKSKLIDPKTVQPGDV
HHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHCCCEEEECCCCCCCCCCCCCCCCE
FIGYKSDSFHANGWSLIRRILEENPDVVDEEELRSLLQPTRLYHDVVEDMRRFNVTPKAY
EEEECCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHE
AHITGGGLPENLERFLGDYGADLSIPYWDNTAAQKILKHVDPQDRFNTFNMGIGWVAIVR
EEECCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCHHHCCEEECCCEEEEEEC
PEDAEAALKAGPGGTVIGTLREGRGIHVKVQGE
CCCHHHHHHCCCCCCEEEEEECCCEEEEEEECC
>Mature Secondary Structure 
SGKLTYKQSGVDTKEAAAFVSDISSHVKRTQKQRSLHQAFGLFAAAYDLSSYKEPVIVT
CCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
GCDGVGTKTEILFELDMVETAGKDLVAMNVNDILTTGGDPLLFLDYLGISNLERERSRIT
CCCCCCCCEEEEEEEHHHHHCCCCEEEEEHHHHHHCCCCCEEEEEHHCCCHHHHHHHHHH
RLVAGMCDYLESCNCILAGGETAEMPGVVPESIVELSGFCIGCCEKSKLIDPKTVQPGDV
HHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHCCCEEEECCCCCCCCCCCCCCCCE
FIGYKSDSFHANGWSLIRRILEENPDVVDEEELRSLLQPTRLYHDVVEDMRRFNVTPKAY
EEEECCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHE
AHITGGGLPENLERFLGDYGADLSIPYWDNTAAQKILKHVDPQDRFNTFNMGIGWVAIVR
EEECCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCHHHCCEEECCCEEEEEEC
PEDAEAALKAGPGGTVIGTLREGRGIHVKVQGE
CCCHHHHHHCCCCCCEEEEEECCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376 [H]