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The map label for this gene is lpxD [H]

Identifier: 187734913

GI number: 187734913

Start: 486810

End: 487847

Strand: Direct

Name: lpxD [H]

Synonym: Amuc_0406

Alternate gene names: 187734913

Gene position: 486810-487847 (Clockwise)

Preceding gene: 187734912

Following gene: 187734917

Centisome position: 18.27

GC content: 57.9

Gene sequence:

>1038_bases
ATGAAGCTTACACTTGAAGCCGTGGCCGCCCTCACCGGGGGAAAAATCCTTTCCGGCGACCCCGAACTGACCGTATTCGG
GGTCGCTTCCCTTCTTGACGCATCCCGTGAAGAAGCCTCCTTCCTTGGCAATGAAAAATACTTCCAGGACTTCCTGCACA
CCTCTGCCGGAATCGTGCTGGTGCCGCCGGGCCTGCCTGCGTATCCAGAACACGCAGCCTTCGTGGAAGTGGACAACCCC
TCCATGGCATTCAACGCCCTGGTGAAATATTTCATGGCTTCCGCCTACCGGTTCACCCCCGGCATTCATCCCACAGCCAT
CATCGACCCCACGGCCAGCTTCAACCCGGACAAAATCCATGTAGGAGCCTATACCTGCATCGGGGCCCACTGCATAATCG
GAGACGGGACGGACATTGGCAACGGCTGCGATATCGGAGACGGCGTCACCATGGGGGAAAACTGCCGCCTGCATGCCCAT
GTTACCATCAGGGAACGCTGCAAACTCGGCAACAGGGTGACCATCCAGCCCGGAGCCGTCATCGGTTCCGACGGATTCGG
CTTCCTGATGGGAGACAATGGACGCTACGTGGGCATTGACCAGGTAGGCATTGTGGAACTGGGGGATGACGTGGACGTAG
GGGCCAACACCACTATTGACCGCGCCAGATTCGGGCGCACCATTGTGGGGGAAGGCACCAAAATAGACAACCTGATCCAG
CTCGGCCATAACGTCGTTGTCGGCAGGCATTGCATCATCGTCGCCCAATCCGGCATAGCCGGCAGCACCAAAGTGGGGGA
TTATGCCACCATCGCCGCCCAGGTCGGCATCTCAGGACACCTCAACATCGGTTCCAAATCCACGCTGGGCGCTAAAACGG
GAGTCCTCTCGGACATTCCGGAAAACTCTACTTACTGGGGCATGCCGGCTTTCCCCTACAAGGACGCTACCCGCCAATAC
GCCGCCCTCAAAAAACTTCCAGCACTGATTAAGGAAGTCCGCGCGCTCAAAAAGGAGCTGGATTCTTCCGGCAAATAA

Upstream 100 bases:

>100_bases
TGACCCCTCCAAGAAAAAGGCTCCGGCCGTCCCCGCCGCTCCCGCGGCCCCGGCCAACTAACCCTTGACATTACCCCCGG
GAAGGCGGAATCATATACCC

Downstream 100 bases:

>100_bases
CGGGCACCATATCGCCGGAACGCTCTGCAGCCCCTCTCCGTGTTTCTGTTTCCCGCCGCTTCAGGCCTGTCCTGTCCCCC
AGCGGCGGTGCAGAAACCGT

Product: UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MKLTLEAVAALTGGKILSGDPELTVFGVASLLDASREEASFLGNEKYFQDFLHTSAGIVLVPPGLPAYPEHAAFVEVDNP
SMAFNALVKYFMASAYRFTPGIHPTAIIDPTASFNPDKIHVGAYTCIGAHCIIGDGTDIGNGCDIGDGVTMGENCRLHAH
VTIRERCKLGNRVTIQPGAVIGSDGFGFLMGDNGRYVGIDQVGIVELGDDVDVGANTTIDRARFGRTIVGEGTKIDNLIQ
LGHNVVVGRHCIIVAQSGIAGSTKVGDYATIAAQVGISGHLNIGSKSTLGAKTGVLSDIPENSTYWGMPAFPYKDATRQY
AALKKLPALIKEVRALKKELDSSGK

Sequences:

>Translated_345_residues
MKLTLEAVAALTGGKILSGDPELTVFGVASLLDASREEASFLGNEKYFQDFLHTSAGIVLVPPGLPAYPEHAAFVEVDNP
SMAFNALVKYFMASAYRFTPGIHPTAIIDPTASFNPDKIHVGAYTCIGAHCIIGDGTDIGNGCDIGDGVTMGENCRLHAH
VTIRERCKLGNRVTIQPGAVIGSDGFGFLMGDNGRYVGIDQVGIVELGDDVDVGANTTIDRARFGRTIVGEGTKIDNLIQ
LGHNVVVGRHCIIVAQSGIAGSTKVGDYATIAAQVGISGHLNIGSKSTLGAKTGVLSDIPENSTYWGMPAFPYKDATRQY
AALKKLPALIKEVRALKKELDSSGK
>Mature_345_residues
MKLTLEAVAALTGGKILSGDPELTVFGVASLLDASREEASFLGNEKYFQDFLHTSAGIVLVPPGLPAYPEHAAFVEVDNP
SMAFNALVKYFMASAYRFTPGIHPTAIIDPTASFNPDKIHVGAYTCIGAHCIIGDGTDIGNGCDIGDGVTMGENCRLHAH
VTIRERCKLGNRVTIQPGAVIGSDGFGFLMGDNGRYVGIDQVGIVELGDDVDVGANTTIDRARFGRTIVGEGTKIDNLIQ
LGHNVVVGRHCIIVAQSGIAGSTKVGDYATIAAQVGISGHLNIGSKSTLGAKTGVLSDIPENSTYWGMPAFPYKDATRQY
AALKKLPALIKEVRALKKELDSSGK

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=329, Percent_Identity=33.7386018237082, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI1786378, Length=219, Percent_Identity=28.310502283105, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD [H]

EC number: 2.3.1.-

Molecular weight: Translated: 36362; Mature: 36362

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLTLEAVAALTGGKILSGDPELTVFGVASLLDASREEASFLGNEKYFQDFLHTSAGIVL
CEEEHHHHHHHCCCEEECCCCCEEEEEHHHHHHCCHHHHHHCCCHHHHHHHHHCCCCEEE
VPPGLPAYPEHAAFVEVDNPSMAFNALVKYFMASAYRFTPGIHPTAIIDPTASFNPDKIH
ECCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCEEE
VGAYTCIGAHCIIGDGTDIGNGCDIGDGVTMGENCRLHAHVTIRERCKLGNRVTIQPGAV
EEEEEEECCEEEEECCCCCCCCCCCCCCCEECCCCEEEEEEEEHHHHCCCCEEEECCCCE
IGSDGFGFLMGDNGRYVGIDQVGIVELGDDVDVGANTTIDRARFGRTIVGEGTKIDNLIQ
ECCCCCEEEECCCCCEEEECCEEEEEECCCCCCCCCCCHHHHHHCCEEECCCCCHHHHHH
LGHNVVVGRHCIIVAQSGIAGSTKVGDYATIAAQVGISGHLNIGSKSTLGAKTGVLSDIP
HCCCEEECCEEEEEEECCCCCCCCCCCEEEEEEEECCCEEECCCCCCCCCCCCCCCCCCC
ENSTYWGMPAFPYKDATRQYAALKKLPALIKEVRALKKELDSSGK
CCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKLTLEAVAALTGGKILSGDPELTVFGVASLLDASREEASFLGNEKYFQDFLHTSAGIVL
CEEEHHHHHHHCCCEEECCCCCEEEEEHHHHHHCCHHHHHHCCCHHHHHHHHHCCCCEEE
VPPGLPAYPEHAAFVEVDNPSMAFNALVKYFMASAYRFTPGIHPTAIIDPTASFNPDKIH
ECCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCEEE
VGAYTCIGAHCIIGDGTDIGNGCDIGDGVTMGENCRLHAHVTIRERCKLGNRVTIQPGAV
EEEEEEECCEEEEECCCCCCCCCCCCCCCEECCCCEEEEEEEEHHHHCCCCEEEECCCCE
IGSDGFGFLMGDNGRYVGIDQVGIVELGDDVDVGANTTIDRARFGRTIVGEGTKIDNLIQ
ECCCCCEEEECCCCCEEEECCEEEEEECCCCCCCCCCCHHHHHHCCEEECCCCCHHHHHH
LGHNVVVGRHCIIVAQSGIAGSTKVGDYATIAAQVGISGHLNIGSKSTLGAKTGVLSDIP
HCCCEEECCEEEEEEECCCCCCCCCCCEEEEEEEECCCEEECCCCCCCCCCCCCCCCCCC
ENSTYWGMPAFPYKDATRQYAALKKLPALIKEVRALKKELDSSGK
CCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA