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The map label for this gene is panC

Identifier: 187734911

GI number: 187734911

Start: 485179

End: 486024

Strand: Reverse

Name: panC

Synonym: Amuc_0404

Alternate gene names: 187734911

Gene position: 486024-485179 (Counterclockwise)

Preceding gene: 187734914

Following gene: 187734910

Centisome position: 18.24

GC content: 58.16

Gene sequence:

>846_bases
ATGCAAACATTTTCCACCAAGGCCCAGTTGAGGGCTGCCCTCCTCAAGCACCACCGCAAACATGACCATGTGGTTCTCGT
CCCCACAATGGGGGCCCTTCACGCCGGACACCGCGCTTTGCTGGAACAGGCGCGCAAGTTGGCCGGGGAGGATGGCGTGG
TGGTTGCCAGTATTTTCGTCAATCCTATCCAGTTTAACAATTCCTCCGACCTTCAGACTTATCCCCGGACTCCTGAAAAG
GATTTGGAGGTGTGCGAAGGTGCAGGCGTGGATTATGTGTTTTCCCCTGCTCCTGAAGAAATGTATTCCGGAGAACGCAG
CATTGCCGTGGAAGAAAGCTTTTTGTCCGCAACATTGTGCGGTGCGTCCCGCCCGGGGCATTTTTCCGGTGTCTGCACGG
TGCTTGCTAAACTGTTCAACCTGGTACAGCCCACGGACGCCATTTTCGGAAAGAAGGATTACCAGCAGCTTGCCATTATC
CGCCGCATGGTGCGCGACCTGGATTTTCCGGTGCGCATTCACGGGGCGGAGATTGTAAGGCATGGCAACGGTCTGGCCTA
TTCCTCCCGGAACGCCCGCCTGACGCCGGAGCAGAAGGAGCAGGCCGTGGTAATACGGCAGGCTATGCTTCAGGCCCGGG
ACGAGTTCCAGGCCGGGGCGGACGCCTCCAAGGTGAAGGAGCATGCCGCCGCCATGATTGAGGGTGTGCCCGGCACGCGC
ATCGATTATCTGGAGATTGTGGATGCGGAGACCATGCAGCCGGTGGCGGAGAACCGGAAGCCGGCCCTGATGGCCGCCGC
CGTCTATTTCGGCGACGTGCGTCTTATAGACAACATAGAACTTTAA

Upstream 100 bases:

>100_bases
GTCTTCTGACTTTACCAGTTTACATGTGGAATGGCATGCGTCAACCTTCTAGCAATATTTCAGGATTGAACTTTTGTCAT
CAAGGGGCCACTTTAGGCGC

Downstream 100 bases:

>100_bases
TACGGCAAGGATTTTCTTATACTGCGCCCGTGATTACCGCCTCCAACCTCCACCGCAGCTATTCCATCGGCAAGAAGTCC
ATTGAGATCCTGCATGGGGT

Product: pantoate/beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MQTFSTKAQLRAALLKHHRKHDHVVLVPTMGALHAGHRALLEQARKLAGEDGVVVASIFVNPIQFNNSSDLQTYPRTPEK
DLEVCEGAGVDYVFSPAPEEMYSGERSIAVEESFLSATLCGASRPGHFSGVCTVLAKLFNLVQPTDAIFGKKDYQQLAII
RRMVRDLDFPVRIHGAEIVRHGNGLAYSSRNARLTPEQKEQAVVIRQAMLQARDEFQAGADASKVKEHAAAMIEGVPGTR
IDYLEIVDAETMQPVAENRKPALMAAAVYFGDVRLIDNIEL

Sequences:

>Translated_281_residues
MQTFSTKAQLRAALLKHHRKHDHVVLVPTMGALHAGHRALLEQARKLAGEDGVVVASIFVNPIQFNNSSDLQTYPRTPEK
DLEVCEGAGVDYVFSPAPEEMYSGERSIAVEESFLSATLCGASRPGHFSGVCTVLAKLFNLVQPTDAIFGKKDYQQLAII
RRMVRDLDFPVRIHGAEIVRHGNGLAYSSRNARLTPEQKEQAVVIRQAMLQARDEFQAGADASKVKEHAAAMIEGVPGTR
IDYLEIVDAETMQPVAENRKPALMAAAVYFGDVRLIDNIEL
>Mature_281_residues
MQTFSTKAQLRAALLKHHRKHDHVVLVPTMGALHAGHRALLEQARKLAGEDGVVVASIFVNPIQFNNSSDLQTYPRTPEK
DLEVCEGAGVDYVFSPAPEEMYSGERSIAVEESFLSATLCGASRPGHFSGVCTVLAKLFNLVQPTDAIFGKKDYQQLAII
RRMVRDLDFPVRIHGAEIVRHGNGLAYSSRNARLTPEQKEQAVVIRQAMLQARDEFQAGADASKVKEHAAAMIEGVPGTR
IDYLEIVDAETMQPVAENRKPALMAAAVYFGDVRLIDNIEL

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=281, Percent_Identity=44.1281138790036, Blast_Score=212, Evalue=3e-56,
Organism=Saccharomyces cerevisiae, GI6322046, Length=312, Percent_Identity=34.2948717948718, Blast_Score=159, Evalue=4e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_AKKM8 (B2UND0)

Other databases:

- EMBL:   CP001071
- RefSeq:   YP_001877023.1
- ProteinModelPortal:   B2UND0
- SMR:   B2UND0
- GeneID:   6274820
- GenomeReviews:   CP001071_GR
- KEGG:   amu:Amuc_0404
- HOGENOM:   HBG428839
- OMA:   RLIDNFT
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 30918; Mature: 30918

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: ACT_SITE 37-37 BINDING 64-64 BINDING 64-64 BINDING 156-156 BINDING 179-179

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTFSTKAQLRAALLKHHRKHDHVVLVPTMGALHAGHRALLEQARKLAGEDGVVVASIFV
CCCCCHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEE
NPIQFNNSSDLQTYPRTPEKDLEVCEGAGVDYVFSPAPEEMYSGERSIAVEESFLSATLC
CEEEECCCCCCCCCCCCCHHHHHHHCCCCCCEEECCCCHHHHCCCCCEEHHHHHHHHHHH
GASRPGHFSGVCTVLAKLFNLVQPTDAIFGKKDYQQLAIIRRMVRDLDFPVRIHGAEIVR
CCCCCCCHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHCCCCEEECHHHHHC
HGNGLAYSSRNARLTPEQKEQAVVIRQAMLQARDEFQAGADASKVKEHAAAMIEGVPGTR
CCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCC
IDYLEIVDAETMQPVAENRKPALMAAAVYFGDVRLIDNIEL
CHHEEECCHHHHHHHHHCCCCHHHHHHHHHCCEEEECCCCC
>Mature Secondary Structure
MQTFSTKAQLRAALLKHHRKHDHVVLVPTMGALHAGHRALLEQARKLAGEDGVVVASIFV
CCCCCHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEE
NPIQFNNSSDLQTYPRTPEKDLEVCEGAGVDYVFSPAPEEMYSGERSIAVEESFLSATLC
CEEEECCCCCCCCCCCCCHHHHHHHCCCCCCEEECCCCHHHHCCCCCEEHHHHHHHHHHH
GASRPGHFSGVCTVLAKLFNLVQPTDAIFGKKDYQQLAIIRRMVRDLDFPVRIHGAEIVR
CCCCCCCHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHCCCCEEECHHHHHC
HGNGLAYSSRNARLTPEQKEQAVVIRQAMLQARDEFQAGADASKVKEHAAAMIEGVPGTR
CCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCC
IDYLEIVDAETMQPVAENRKPALMAAAVYFGDVRLIDNIEL
CHHEEECCHHHHHHHHHCCCCHHHHHHHHHCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA