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The map label for this gene is lacA [H]

Identifier: 187734892

GI number: 187734892

Start: 461377

End: 462018

Strand: Reverse

Name: lacA [H]

Synonym: Amuc_0384

Alternate gene names: 187734892

Gene position: 462018-461377 (Counterclockwise)

Preceding gene: 187734893

Following gene: 187734891

Centisome position: 17.34

GC content: 58.88

Gene sequence:

>642_bases
ATGGCCTCGAAGGACTGGAATAACATGCTGTCCGGGCGTTTATATCATGCCCAGGATTCTGAATTGGCTGCCGCCCGGCT
CAGGGCGCGCCGGCTTGTTTTCCGTTATAACCAGTCCGCTCCGGAAAATGAAAGCCTGCGCCGGGAATTGGCCCGGGAGC
TTTTCGGCCAAATGGGAGAGGGGTGTTATCTGGAACCTCCGCTGCGTTGTGATTACGGCTCCAATATACGGCTGGGGGAC
CGCGTGTATGTCAATTTCAACCTCGTGGTGCTGGACTGCGCTGCCGTTACCATTGGCAATGACGTGCTGATAGGTCCCAA
CGTGGGCATTTATACTGCCGGGCATCCCGTAGACCCGGGGCTGAGACGGCAGGGGCTGGAATTTGCTCTGCCCATTACCA
TTGAGGATGGAGTATGGATAGGCGGTCATGCGGTGATTGCCCCGGGCGTGCGTATTGGGAGAAATTCCGTGATAGGCGCG
GGCAGCGTGGTGACGAAGGACATCCCCGCCAATGTAGTGGCCGTGGGTAATCCCTGCCGTGTGGTTCGCCCCGTGACGGA
AAAGGACCGCGAAGTCTGGGACACCGGGGAAAATGGAGAGGGGCCGCTTTCCCAGGGACCGAAGGCAAATTCCCCGGGAT
GA

Upstream 100 bases:

>100_bases
TCCGTAAAAAAAGATGCCGCCGCCATGCCGTCTGTTGGAGAACAGAAAAACGGGCAGCTGCCTTTTTCTGAGGCGGACGC
TGTGACCCCCTCTTCATCCA

Downstream 100 bases:

>100_bases
CGAAATTTGAATTGCTTTTGGGGCTGGATGATGCATAGTTGGCGCCCTCACAGTGTCGATTAGCCGCTGCCACGAGCTAA
ATACATTCAAGGAAAACACT

Product: Maltose O-acetyltransferase

Products: NA

Alternate protein names: GAT; Thiogalactoside acetyltransferase [H]

Number of amino acids: Translated: 213; Mature: 212

Protein sequence:

>213_residues
MASKDWNNMLSGRLYHAQDSELAAARLRARRLVFRYNQSAPENESLRRELARELFGQMGEGCYLEPPLRCDYGSNIRLGD
RVYVNFNLVVLDCAAVTIGNDVLIGPNVGIYTAGHPVDPGLRRQGLEFALPITIEDGVWIGGHAVIAPGVRIGRNSVIGA
GSVVTKDIPANVVAVGNPCRVVRPVTEKDREVWDTGENGEGPLSQGPKANSPG

Sequences:

>Translated_213_residues
MASKDWNNMLSGRLYHAQDSELAAARLRARRLVFRYNQSAPENESLRRELARELFGQMGEGCYLEPPLRCDYGSNIRLGD
RVYVNFNLVVLDCAAVTIGNDVLIGPNVGIYTAGHPVDPGLRRQGLEFALPITIEDGVWIGGHAVIAPGVRIGRNSVIGA
GSVVTKDIPANVVAVGNPCRVVRPVTEKDREVWDTGENGEGPLSQGPKANSPG
>Mature_212_residues
ASKDWNNMLSGRLYHAQDSELAAARLRARRLVFRYNQSAPENESLRRELARELFGQMGEGCYLEPPLRCDYGSNIRLGDR
VYVNFNLVVLDCAAVTIGNDVLIGPNVGIYTAGHPVDPGLRRQGLEFALPITIEDGVWIGGHAVIAPGVRIGRNSVIGAG
SVVTKDIPANVVAVGNPCRVVRPVTEKDREVWDTGENGEGPLSQGPKANSPG

Specific function: May assist cellular detoxification by acetylating non- metabolizable pyranosides, thereby preventing their reentry into the cell [H]

COG id: COG0110

COG function: function code R; Acetyltransferase (isoleucine patch superfamily)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Escherichia coli, GI1786537, Length=183, Percent_Identity=48.6338797814208, Blast_Score=190, Evalue=6e-50,
Organism=Escherichia coli, GI1786664, Length=183, Percent_Identity=48.6338797814208, Blast_Score=188, Evalue=2e-49,
Organism=Escherichia coli, GI1788367, Length=151, Percent_Identity=31.1258278145695, Blast_Score=72, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6322243, Length=183, Percent_Identity=54.6448087431694, Blast_Score=205, Evalue=4e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00132 Hexapep [H]

EC number: =2.3.1.18 [H]

Molecular weight: Translated: 23030; Mature: 22899

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASKDWNNMLSGRLYHAQDSELAAARLRARRLVFRYNQSAPENESLRRELARELFGQMGE
CCCCCCHHHHCCEEEECCCCHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHCCC
GCYLEPPLRCDYGSNIRLGDRVYVNFNLVVLDCAAVTIGNDVLIGPNVGIYTAGHPVDPG
CCEECCCCCCCCCCCCEECCEEEEEEEEEEEEEEEEEECCEEEECCCCCEEECCCCCCCC
LRRQGLEFALPITIEDGVWIGGHAVIAPGVRIGRNSVIGAGSVVTKDIPANVVAVGNPCR
HHHCCCEEEEEEEECCCEEECCCEEEECCEEECCCCEECCCCEEECCCCCCEEEECCCCE
VVRPVTEKDREVWDTGENGEGPLSQGPKANSPG
EECCCCCCCHHHHCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ASKDWNNMLSGRLYHAQDSELAAARLRARRLVFRYNQSAPENESLRRELARELFGQMGE
CCCCCHHHHCCEEEECCCCHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHCCC
GCYLEPPLRCDYGSNIRLGDRVYVNFNLVVLDCAAVTIGNDVLIGPNVGIYTAGHPVDPG
CCEECCCCCCCCCCCCEECCEEEEEEEEEEEEEEEEEECCEEEECCCCCEEECCCCCCCC
LRRQGLEFALPITIEDGVWIGGHAVIAPGVRIGRNSVIGAGSVVTKDIPANVVAVGNPCR
HHHCCCEEEEEEEECCCEEECCCEEEECCEEECCCCEECCCCEEECCCCCCEEEECCCCE
VVRPVTEKDREVWDTGENGEGPLSQGPKANSPG
EECCCCCCCHHHHCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3922433; 3901000; 9278503; 6444453; 11937062 [H]