| Definition | Akkermansia muciniphila ATCC BAA-835, complete genome. |
|---|---|
| Accession | NC_010655 |
| Length | 2,664,102 |
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The map label for this gene is ftsH
Identifier: 187734856
GI number: 187734856
Start: 410440
End: 412878
Strand: Reverse
Name: ftsH
Synonym: Amuc_0348
Alternate gene names: 187734856
Gene position: 412878-410440 (Counterclockwise)
Preceding gene: 187734857
Following gene: 187734855
Centisome position: 15.5
GC content: 60.23
Gene sequence:
>2439_bases ATGCCACCCAGTCCTCCCCGTCCTCCCAAATTTCCCGGCTCCGGCAGGCCCGAATCCCCCAACTGGGGCGTGTGGGTCAT GGTACTTCTCATTGTAGGCGTCCTTGCGTTTGGCTTTTTCACCCCTGAATCTTTCGGGTTGGGCCCCCGCAAGGAAAATC TGGAATCCTTTGAAGCCCAGTATAAGGCGGGGCGCGTGGTGCTGAACGACCCCAAGGCCCCCGTGGAAGTGGTGCTGAGC GAGAACGGTTCCGAAGGCGTTATTCACGCGCTGGTGTACAGGAAGGAAATTCAGCCGAAGGTGGAAATGACCCCCTTTGC GCTGACTTATTCCATGTCCCTTCCGGACCGCGACAAGCCTTTGCTGAATGAACTTTCCGGCTACAGGGTGGTGGAGAGCC CGTACCGGACGGAAGAGGGAAAGAATGTTTCCCTCATTCCTGAGGGAGCTCAGAAGCTTTCCGTGCCAGAATTCAACCGC CTGGCCCTGGAAGGCCGCATCGCCGGAGGAAAGGACGGCATCATCCTGGCGGAAGACGGCAACCAGAACGTGCTGGTCGG ACAGATTGTCACCCGCATCTGGCCCGCGGCTACGGGAGACGCCTCCGTGGACAAACAGCGTTTTGAACGTGTGGAAGTGC CTTTTACCCTGGAGTTCCAGGGAGACCGCGTCAAGCAGCTGCTGGGGCCGGATACGAAGTTCAAGCGTGAATCCGGTTCC TGGGGCGGCATTCTGCTGAATCTGCTGCCCATCGTGCTCATTCTGGTGATTTTGTTCTTCATGTTCCGCGCGCAGAGCGG CGGGGCCCGGGGGGCCATGAGCTTCGGCAAAAGCCGGGCGCGCCTCATCTCCCCGGACAAGAACAAGGTGACGTTCAAGG ATGTGGCCGGTATCAGCGAAGCCAAGGAGGAAGTGTGGGAACTGGTGGAGTTTCTGCGCAATCCGGAAAAATTCCGCGAT CTGGGCGCCACCATTCCCCGCGGCGTGCTGATGGTCGGGGCGCCCGGTACGGGCAAGACTCTGCTGGCGCGTGCCATTGC CGGGGAGTCCAACGCTTCCTTCTATTCCATCAGCGGCTCGGATTTTGTGGAAATGTTCGTGGGGGTGGGGGCAAGCCGTG TCCGCGATATGTTTGAACAGGCCAAAAGGACGGCGCCCAGCCTGATTTTCATTGATGAAATTGACGCCGTGGGCCGCCAG CGCGGTTACGGCATGGGCGGCGGCAATGACGAGCGGGAACAAACGCTGAACGCCCTGCTGGTGGAGATGGACGGTTTTGA AAACAACTCCAATGTAATCGTGATTGCCGCCACCAACCGTGCGGACATTCTGGACCCGGCCCTGCTGCGTCCCGGCCGCT TCGACCGGCAGGTGGTGGTGAACCTGCCGGACGTCCGGGGGCGCGAACAGATCCTGCAGGTGCATGCCAGAAAAGTGAAG ATGGCGCCCGGAGTCAGCTTTGAGCGGATTGCCCGCGGCACGTCCGGCTTTTCCGGTGCCCAGCTGGCCAACCTGGTCAA TGAAGCCGCCCTGCTGGCCGCCCGCAAGGGGCTGAAGGAGATTACGGAGGCCGAATTGGAAGAAGCCCGCGACAAGGTCA GCTGGGGGCGTGAACGCCGCAGCCTGGCGATTAACGAACGGGGGCGCCGCATTACTGCCGTGCATGAGGCGGGGCATGCC ATCTGCCTGTTGAAAACACCGCACAGCGAGCCGCTGCACCGGGTGACCATTGTTCCCCGCGGCGGGGCCCTCGGCATGAC CATGTGGCTTCCTTCCGACGACAAGATGCACCAGCTCCGGTCCGAAATGCTGGACCAGCTCGTCGTGGCGATGGGCGGGC GCTGCGCCGAACAAATCGTTTTTGGTGATGTGACCAGCGGTGCTACCGGAGACATCAAGAGCGCCACCAACCTGGCGCGG CGCATGGTGTGCGAATTCGGCATGAGCGAAAAACTGGGGCTGATTGAGTACGGAGAACACCAGGGAGAAGTTTATATTGC CCGCGACCTGGGGACGCGTTCCCGCAATTATTCCGAATCCACGGCGGAGCTGATTGACTCGGAAGTCCGCTTCCTGGTGG ACAGCGCTTATGAACGCGCCATGGCCATCCTGACGGAAAACCGGGACAAGCTGGACATTCTGACGGAGGCCCTGATGGAG TTTGAAACGCTGGAAGGTTCCCAGGTCATGGATATTCTGGAATACGGGGAAATGAAAAACCCTCCCGCCAGGGTGACTCC GCCCCCCATGCCTTCCGAAGTGGAGGAACAGCCCGGGAAGGATGATTCCGGCCATAACGAGAAGAAAGAAGCTGAAGAGA CCCGCGCGGACGGCGCTGAAGAACGGAAGATGGAAGAGGAACTGGAACAGGCGGAACGGGCCCCCTTCTCCTACAATCCC GTTGATGAGTTCGGCAAGGACGGCGGAGAAAAGAAATAA
Upstream 100 bases:
>100_bases TATGGCATGTCTCGGAAAAAAGTTTTATTTTACAAGGACTCGCGTATCATGCCGCCCTATTCATTAACTTCTGTGTGCTA ACCACATTATGTCTGACAGA
Downstream 100 bases:
>100_bases TTCAATAGAAACGAATCGAATATGGTAGCCAACGATGCGATGGAACTGGCCAGGATGTGCGCCCGCGCCGCGGATGACGC CAAGGCCGAAAATGTGCGGG
Product: ATP-dependent metalloprotease FtsH
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 812; Mature: 811
Protein sequence:
>812_residues MPPSPPRPPKFPGSGRPESPNWGVWVMVLLIVGVLAFGFFTPESFGLGPRKENLESFEAQYKAGRVVLNDPKAPVEVVLS ENGSEGVIHALVYRKEIQPKVEMTPFALTYSMSLPDRDKPLLNELSGYRVVESPYRTEEGKNVSLIPEGAQKLSVPEFNR LALEGRIAGGKDGIILAEDGNQNVLVGQIVTRIWPAATGDASVDKQRFERVEVPFTLEFQGDRVKQLLGPDTKFKRESGS WGGILLNLLPIVLILVILFFMFRAQSGGARGAMSFGKSRARLISPDKNKVTFKDVAGISEAKEEVWELVEFLRNPEKFRD LGATIPRGVLMVGAPGTGKTLLARAIAGESNASFYSISGSDFVEMFVGVGASRVRDMFEQAKRTAPSLIFIDEIDAVGRQ RGYGMGGGNDEREQTLNALLVEMDGFENNSNVIVIAATNRADILDPALLRPGRFDRQVVVNLPDVRGREQILQVHARKVK MAPGVSFERIARGTSGFSGAQLANLVNEAALLAARKGLKEITEAELEEARDKVSWGRERRSLAINERGRRITAVHEAGHA ICLLKTPHSEPLHRVTIVPRGGALGMTMWLPSDDKMHQLRSEMLDQLVVAMGGRCAEQIVFGDVTSGATGDIKSATNLAR RMVCEFGMSEKLGLIEYGEHQGEVYIARDLGTRSRNYSESTAELIDSEVRFLVDSAYERAMAILTENRDKLDILTEALME FETLEGSQVMDILEYGEMKNPPARVTPPPMPSEVEEQPGKDDSGHNEKKEAEETRADGAEERKMEEELEQAERAPFSYNP VDEFGKDGGEKK
Sequences:
>Translated_812_residues MPPSPPRPPKFPGSGRPESPNWGVWVMVLLIVGVLAFGFFTPESFGLGPRKENLESFEAQYKAGRVVLNDPKAPVEVVLS ENGSEGVIHALVYRKEIQPKVEMTPFALTYSMSLPDRDKPLLNELSGYRVVESPYRTEEGKNVSLIPEGAQKLSVPEFNR LALEGRIAGGKDGIILAEDGNQNVLVGQIVTRIWPAATGDASVDKQRFERVEVPFTLEFQGDRVKQLLGPDTKFKRESGS WGGILLNLLPIVLILVILFFMFRAQSGGARGAMSFGKSRARLISPDKNKVTFKDVAGISEAKEEVWELVEFLRNPEKFRD LGATIPRGVLMVGAPGTGKTLLARAIAGESNASFYSISGSDFVEMFVGVGASRVRDMFEQAKRTAPSLIFIDEIDAVGRQ RGYGMGGGNDEREQTLNALLVEMDGFENNSNVIVIAATNRADILDPALLRPGRFDRQVVVNLPDVRGREQILQVHARKVK MAPGVSFERIARGTSGFSGAQLANLVNEAALLAARKGLKEITEAELEEARDKVSWGRERRSLAINERGRRITAVHEAGHA ICLLKTPHSEPLHRVTIVPRGGALGMTMWLPSDDKMHQLRSEMLDQLVVAMGGRCAEQIVFGDVTSGATGDIKSATNLAR RMVCEFGMSEKLGLIEYGEHQGEVYIARDLGTRSRNYSESTAELIDSEVRFLVDSAYERAMAILTENRDKLDILTEALME FETLEGSQVMDILEYGEMKNPPARVTPPPMPSEVEEQPGKDDSGHNEKKEAEETRADGAEERKMEEELEQAERAPFSYNP VDEFGKDGGEKK >Mature_811_residues PPSPPRPPKFPGSGRPESPNWGVWVMVLLIVGVLAFGFFTPESFGLGPRKENLESFEAQYKAGRVVLNDPKAPVEVVLSE NGSEGVIHALVYRKEIQPKVEMTPFALTYSMSLPDRDKPLLNELSGYRVVESPYRTEEGKNVSLIPEGAQKLSVPEFNRL ALEGRIAGGKDGIILAEDGNQNVLVGQIVTRIWPAATGDASVDKQRFERVEVPFTLEFQGDRVKQLLGPDTKFKRESGSW GGILLNLLPIVLILVILFFMFRAQSGGARGAMSFGKSRARLISPDKNKVTFKDVAGISEAKEEVWELVEFLRNPEKFRDL GATIPRGVLMVGAPGTGKTLLARAIAGESNASFYSISGSDFVEMFVGVGASRVRDMFEQAKRTAPSLIFIDEIDAVGRQR GYGMGGGNDEREQTLNALLVEMDGFENNSNVIVIAATNRADILDPALLRPGRFDRQVVVNLPDVRGREQILQVHARKVKM APGVSFERIARGTSGFSGAQLANLVNEAALLAARKGLKEITEAELEEARDKVSWGRERRSLAINERGRRITAVHEAGHAI CLLKTPHSEPLHRVTIVPRGGALGMTMWLPSDDKMHQLRSEMLDQLVVAMGGRCAEQIVFGDVTSGATGDIKSATNLARR MVCEFGMSEKLGLIEYGEHQGEVYIARDLGTRSRNYSESTAELIDSEVRFLVDSAYERAMAILTENRDKLDILTEALMEF ETLEGSQVMDILEYGEMKNPPARVTPPPMPSEVEEQPGKDDSGHNEKKEAEETRADGAEERKMEEELEQAERAPFSYNPV DEFGKDGGEKK
Specific function: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
COG id: COG0465
COG function: function code O; ATP-dependent Zn proteases
Gene ontology:
Cell location: Cell membrane; Multi-pass membrane protein; Cytoplasmic side
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the peptidase M41 family
Homologues:
Organism=Homo sapiens, GI300192933, Length=504, Percent_Identity=44.8412698412698, Blast_Score=444, Evalue=1e-124, Organism=Homo sapiens, GI7657689, Length=490, Percent_Identity=46.530612244898, Blast_Score=415, Evalue=1e-116, Organism=Homo sapiens, GI21327685, Length=490, Percent_Identity=46.530612244898, Blast_Score=415, Evalue=1e-116, Organism=Homo sapiens, GI4507173, Length=526, Percent_Identity=39.5437262357414, Blast_Score=372, Evalue=1e-103, Organism=Homo sapiens, GI21361144, Length=238, Percent_Identity=45.7983193277311, Blast_Score=223, Evalue=6e-58, Organism=Homo sapiens, GI4506209, Length=249, Percent_Identity=43.7751004016064, Blast_Score=210, Evalue=4e-54, Organism=Homo sapiens, GI24497435, Length=257, Percent_Identity=41.2451361867704, Blast_Score=209, Evalue=7e-54, Organism=Homo sapiens, GI24430151, Length=249, Percent_Identity=37.3493975903614, Blast_Score=200, Evalue=5e-51, Organism=Homo sapiens, GI6005942, Length=235, Percent_Identity=43.4042553191489, Blast_Score=195, Evalue=1e-49, Organism=Homo sapiens, GI89064750, Length=253, Percent_Identity=41.897233201581, Blast_Score=195, Evalue=2e-49, Organism=Homo sapiens, GI5729991, Length=253, Percent_Identity=41.897233201581, Blast_Score=195, Evalue=2e-49, Organism=Homo sapiens, GI24430155, Length=253, Percent_Identity=41.897233201581, Blast_Score=194, Evalue=2e-49, Organism=Homo sapiens, GI195539395, Length=257, Percent_Identity=38.9105058365759, Blast_Score=194, Evalue=3e-49, Organism=Homo sapiens, GI45643125, Length=252, Percent_Identity=40.0793650793651, Blast_Score=181, Evalue=3e-45, Organism=Homo sapiens, GI45643123, Length=252, Percent_Identity=40.0793650793651, Blast_Score=180, Evalue=4e-45, Organism=Homo sapiens, GI157671927, Length=243, Percent_Identity=38.2716049382716, Blast_Score=175, Evalue=1e-43, Organism=Homo sapiens, GI229577436, Length=258, Percent_Identity=38.7596899224806, Blast_Score=170, Evalue=5e-42, Organism=Homo sapiens, GI40806173, Length=199, Percent_Identity=45.2261306532663, Blast_Score=165, Evalue=1e-40, Organism=Homo sapiens, GI153792536, Length=272, Percent_Identity=38.2352941176471, Blast_Score=163, Evalue=6e-40, Organism=Homo sapiens, GI24497618, Length=239, Percent_Identity=38.4937238493724, Blast_Score=160, Evalue=4e-39, Organism=Homo sapiens, GI194018488, Length=244, Percent_Identity=37.7049180327869, Blast_Score=153, Evalue=7e-37, Organism=Homo sapiens, GI4505725, Length=226, Percent_Identity=36.283185840708, Blast_Score=151, Evalue=3e-36, Organism=Homo sapiens, GI5901990, Length=254, Percent_Identity=37.4015748031496, Blast_Score=146, Evalue=9e-35, Organism=Homo sapiens, GI14149767, Length=249, Percent_Identity=36.144578313253, Blast_Score=145, Evalue=1e-34, Organism=Homo sapiens, GI62177112, Length=249, Percent_Identity=36.144578313253, Blast_Score=145, Evalue=1e-34, Organism=Homo sapiens, GI156564401, Length=226, Percent_Identity=36.7256637168142, Blast_Score=137, Evalue=3e-32, Organism=Homo sapiens, GI310125282, Length=226, Percent_Identity=36.283185840708, Blast_Score=134, Evalue=3e-31, Organism=Homo sapiens, GI310125280, Length=226, Percent_Identity=36.283185840708, Blast_Score=134, Evalue=4e-31, Organism=Homo sapiens, GI226371754, Length=236, Percent_Identity=34.7457627118644, Blast_Score=131, Evalue=2e-30, Organism=Homo sapiens, GI11875211, Length=228, Percent_Identity=39.9122807017544, Blast_Score=129, Evalue=8e-30, Organism=Homo sapiens, GI40806170, Length=228, Percent_Identity=39.9122807017544, Blast_Score=129, Evalue=1e-29, Organism=Homo sapiens, GI31742536, Length=226, Percent_Identity=34.9557522123894, Blast_Score=129, Evalue=1e-29, Organism=Homo sapiens, GI112789543, Length=226, Percent_Identity=34.9557522123894, Blast_Score=129, Evalue=1e-29, Organism=Homo sapiens, GI7019569, Length=237, Percent_Identity=34.1772151898734, Blast_Score=126, Evalue=8e-29, Organism=Homo sapiens, GI17865802, Length=233, Percent_Identity=35.1931330472103, Blast_Score=125, Evalue=1e-28, Organism=Homo sapiens, GI31377644, Length=259, Percent_Identity=31.6602316602317, Blast_Score=117, Evalue=3e-26, Organism=Homo sapiens, GI64084766, Length=230, Percent_Identity=30.4347826086957, Blast_Score=94, Evalue=6e-19, Organism=Homo sapiens, GI116292174, Length=254, Percent_Identity=31.496062992126, Blast_Score=88, Evalue=3e-17, Organism=Homo sapiens, GI75677353, Length=249, Percent_Identity=28.5140562248996, Blast_Score=74, Evalue=6e-13, Organism=Homo sapiens, GI4757852, Length=202, Percent_Identity=30.6930693069307, Blast_Score=69, Evalue=2e-11, Organism=Homo sapiens, GI119964730, Length=202, Percent_Identity=30.6930693069307, Blast_Score=69, Evalue=2e-11, Organism=Homo sapiens, GI283436220, Length=210, Percent_Identity=28.0952380952381, Blast_Score=68, Evalue=3e-11, Organism=Homo sapiens, GI283436222, Length=210, Percent_Identity=28.0952380952381, Blast_Score=68, Evalue=4e-11, Organism=Homo sapiens, GI283436224, Length=249, Percent_Identity=26.9076305220884, Blast_Score=67, Evalue=5e-11, Organism=Escherichia coli, GI1789568, Length=503, Percent_Identity=58.2504970178926, Blast_Score=586, Evalue=1e-168, Organism=Caenorhabditis elegans, GI71994521, Length=536, Percent_Identity=42.7238805970149, Blast_Score=397, Evalue=1e-110, Organism=Caenorhabditis elegans, GI17554264, Length=483, Percent_Identity=45.5486542443064, Blast_Score=389, Evalue=1e-108, Organism=Caenorhabditis elegans, GI115534323, Length=454, Percent_Identity=42.9515418502203, Blast_Score=350, Evalue=2e-96, Organism=Caenorhabditis elegans, GI17554786, Length=257, Percent_Identity=42.4124513618677, Blast_Score=219, Evalue=5e-57, Organism=Caenorhabditis elegans, GI25144278, Length=257, Percent_Identity=42.4124513618677, Blast_Score=217, Evalue=2e-56, Organism=Caenorhabditis elegans, GI25144281, Length=257, Percent_Identity=42.4124513618677, Blast_Score=217, Evalue=3e-56, Organism=Caenorhabditis elegans, GI17508701, Length=239, Percent_Identity=42.2594142259414, Blast_Score=207, Evalue=2e-53, Organism=Caenorhabditis elegans, GI17563248, Length=257, Percent_Identity=42.4124513618677, Blast_Score=206, Evalue=4e-53, Organism=Caenorhabditis elegans, GI17563250, Length=246, Percent_Identity=39.0243902439024, Blast_Score=197, Evalue=1e-50, Organism=Caenorhabditis elegans, GI17505546, Length=251, Percent_Identity=41.0358565737052, Blast_Score=197, Evalue=2e-50, Organism=Caenorhabditis elegans, GI71987364, Length=249, Percent_Identity=40.1606425702811, Blast_Score=196, Evalue=6e-50, Organism=Caenorhabditis elegans, GI71987372, Length=249, Percent_Identity=40.1606425702811, Blast_Score=195, Evalue=6e-50, Organism=Caenorhabditis elegans, GI17532375, Length=250, Percent_Identity=39.6, Blast_Score=195, Evalue=8e-50, Organism=Caenorhabditis elegans, GI17531535, Length=235, Percent_Identity=41.2765957446808, Blast_Score=184, Evalue=1e-46, Organism=Caenorhabditis elegans, GI17554784, Length=260, Percent_Identity=40, Blast_Score=181, Evalue=1e-45, Organism=Caenorhabditis elegans, GI17508053, Length=231, Percent_Identity=40.6926406926407, Blast_Score=176, Evalue=6e-44, Organism=Caenorhabditis elegans, GI17537217, Length=231, Percent_Identity=37.6623376623377, Blast_Score=161, Evalue=1e-39, Organism=Caenorhabditis elegans, GI25153574, Length=274, Percent_Identity=34.6715328467153, Blast_Score=153, Evalue=3e-37, Organism=Caenorhabditis elegans, GI133931034, Length=242, Percent_Identity=38.0165289256198, Blast_Score=153, Evalue=3e-37, Organism=Caenorhabditis elegans, GI193206116, Length=242, Percent_Identity=38.0165289256198, Blast_Score=153, Evalue=3e-37, Organism=Caenorhabditis elegans, GI193206114, Length=242, Percent_Identity=38.0165289256198, Blast_Score=153, Evalue=3e-37, Organism=Caenorhabditis elegans, GI193209502, Length=273, Percent_Identity=34.4322344322344, Blast_Score=150, Evalue=2e-36, Organism=Caenorhabditis elegans, GI133901658, Length=218, Percent_Identity=41.2844036697248, Blast_Score=147, Evalue=2e-35, Organism=Caenorhabditis elegans, GI133901662, Length=218, Percent_Identity=41.2844036697248, Blast_Score=147, Evalue=3e-35, Organism=Caenorhabditis elegans, GI17570397, Length=185, Percent_Identity=42.7027027027027, Blast_Score=138, Evalue=1e-32, Organism=Caenorhabditis elegans, GI32566590, Length=185, Percent_Identity=42.7027027027027, Blast_Score=138, Evalue=1e-32, Organism=Caenorhabditis elegans, GI25146157, Length=236, Percent_Identity=37.7118644067797, Blast_Score=135, Evalue=1e-31, Organism=Caenorhabditis elegans, GI17562804, Length=257, Percent_Identity=34.6303501945525, Blast_Score=134, Evalue=2e-31, Organism=Caenorhabditis elegans, GI32563584, Length=250, Percent_Identity=34.4, Blast_Score=124, Evalue=2e-28, Organism=Caenorhabditis elegans, GI17508421, Length=242, Percent_Identity=35.1239669421488, Blast_Score=123, Evalue=4e-28, Organism=Caenorhabditis elegans, GI17560432, Length=230, Percent_Identity=35.6521739130435, Blast_Score=118, Evalue=1e-26, Organism=Caenorhabditis elegans, GI86561515, Length=237, Percent_Identity=32.4894514767932, Blast_Score=117, Evalue=2e-26, Organism=Caenorhabditis elegans, GI17541226, Length=194, Percent_Identity=35.0515463917526, Blast_Score=100, Evalue=4e-21, Organism=Caenorhabditis elegans, GI17541224, Length=194, Percent_Identity=35.0515463917526, Blast_Score=100, Evalue=4e-21, Organism=Caenorhabditis elegans, GI71990294, Length=218, Percent_Identity=30.2752293577982, Blast_Score=76, Evalue=7e-14, Organism=Saccharomyces cerevisiae, GI6320854, Length=550, Percent_Identity=42.5454545454545, Blast_Score=430, Evalue=1e-121, Organism=Saccharomyces cerevisiae, GI6323736, Length=509, Percent_Identity=44.2043222003929, Blast_Score=419, Evalue=1e-118, Organism=Saccharomyces cerevisiae, GI6325281, Length=450, Percent_Identity=44.4444444444444, Blast_Score=383, Evalue=1e-107, Organism=Saccharomyces cerevisiae, GI6321390, Length=255, Percent_Identity=40.3921568627451, Blast_Score=215, Evalue=3e-56, Organism=Saccharomyces cerevisiae, GI6324691, Length=254, Percent_Identity=42.1259842519685, Blast_Score=211, Evalue=4e-55, Organism=Saccharomyces cerevisiae, GI6322704, Length=257, Percent_Identity=42.4124513618677, Blast_Score=209, Evalue=2e-54, Organism=Saccharomyces cerevisiae, GI6320077, Length=240, Percent_Identity=42.0833333333333, Blast_Score=201, Evalue=3e-52, Organism=Saccharomyces cerevisiae, GI6320197, Length=253, Percent_Identity=37.5494071146245, Blast_Score=198, Evalue=3e-51, Organism=Saccharomyces cerevisiae, GI6320602, Length=246, Percent_Identity=43.0894308943089, Blast_Score=195, Evalue=2e-50, Organism=Saccharomyces cerevisiae, GI6324833, Length=254, Percent_Identity=40.9448818897638, Blast_Score=194, Evalue=6e-50, Organism=Saccharomyces cerevisiae, GI6321709, Length=243, Percent_Identity=40.3292181069959, Blast_Score=170, Evalue=8e-43, Organism=Saccharomyces cerevisiae, GI6323429, Length=240, Percent_Identity=39.1666666666667, Blast_Score=164, Evalue=6e-41, Organism=Saccharomyces cerevisiae, GI6322651, Length=274, Percent_Identity=32.8467153284672, Blast_Score=161, Evalue=3e-40, Organism=Saccharomyces cerevisiae, GI6322994, Length=232, Percent_Identity=36.2068965517241, Blast_Score=159, Evalue=1e-39, Organism=Saccharomyces cerevisiae, GI6324000, Length=238, Percent_Identity=36.9747899159664, Blast_Score=147, Evalue=5e-36, Organism=Saccharomyces cerevisiae, GI6321465, Length=247, Percent_Identity=37.246963562753, Blast_Score=138, Evalue=3e-33, Organism=Saccharomyces cerevisiae, GI6319554, Length=215, Percent_Identity=37.2093023255814, Blast_Score=136, Evalue=1e-32, Organism=Saccharomyces cerevisiae, GI6325431, Length=255, Percent_Identity=36.4705882352941, Blast_Score=131, Evalue=5e-31, Organism=Saccharomyces cerevisiae, GI6325183, Length=238, Percent_Identity=34.8739495798319, Blast_Score=128, Evalue=4e-30, Organism=Saccharomyces cerevisiae, GI6320887, Length=271, Percent_Identity=33.210332103321, Blast_Score=124, Evalue=5e-29, Organism=Saccharomyces cerevisiae, GI6320583, Length=182, Percent_Identity=28.021978021978, Blast_Score=70, Evalue=1e-12, Organism=Drosophila melanogaster, GI28574878, Length=504, Percent_Identity=44.2460317460317, Blast_Score=421, Evalue=1e-118, Organism=Drosophila melanogaster, GI24665814, Length=504, Percent_Identity=44.2460317460317, Blast_Score=419, Evalue=1e-117, Organism=Drosophila melanogaster, GI24658770, Length=501, Percent_Identity=44.9101796407186, Blast_Score=408, Evalue=1e-114, Organism=Drosophila melanogaster, GI24639391, Length=467, Percent_Identity=45.3961456102784, Blast_Score=400, Evalue=1e-111, Organism=Drosophila melanogaster, GI17738151, Length=239, Percent_Identity=42.6778242677824, Blast_Score=210, Evalue=4e-54, Organism=Drosophila melanogaster, GI17137738, Length=249, Percent_Identity=44.578313253012, Blast_Score=210, Evalue=4e-54, Organism=Drosophila melanogaster, GI19920408, Length=257, Percent_Identity=41.2451361867704, Blast_Score=209, Evalue=5e-54, Organism=Drosophila melanogaster, GI24651451, Length=255, Percent_Identity=41.1764705882353, Blast_Score=206, Evalue=6e-53, Organism=Drosophila melanogaster, GI161076486, Length=246, Percent_Identity=41.0569105691057, Blast_Score=202, Evalue=1e-51, Organism=Drosophila melanogaster, GI17137560, Length=246, Percent_Identity=41.0569105691057, Blast_Score=201, Evalue=1e-51, Organism=Drosophila melanogaster, GI161076488, Length=246, Percent_Identity=41.0569105691057, Blast_Score=201, Evalue=2e-51, Organism=Drosophila melanogaster, GI24649446, Length=249, Percent_Identity=37.3493975903614, Blast_Score=195, Evalue=1e-49, Organism=Drosophila melanogaster, GI24640100, Length=257, Percent_Identity=40.0778210116732, Blast_Score=194, Evalue=2e-49, Organism=Drosophila melanogaster, GI45554047, Length=182, Percent_Identity=53.2967032967033, Blast_Score=194, Evalue=2e-49, Organism=Drosophila melanogaster, GI18860063, Length=242, Percent_Identity=42.1487603305785, Blast_Score=193, Evalue=4e-49, Organism=Drosophila melanogaster, GI281361487, Length=253, Percent_Identity=39.5256916996047, Blast_Score=191, Evalue=1e-48, Organism=Drosophila melanogaster, GI24663015, Length=257, Percent_Identity=37.7431906614786, Blast_Score=181, Evalue=2e-45, Organism=Drosophila melanogaster, GI19921202, Length=239, Percent_Identity=40.5857740585774, Blast_Score=179, Evalue=6e-45, Organism=Drosophila melanogaster, GI24652279, Length=208, Percent_Identity=42.7884615384615, Blast_Score=178, Evalue=1e-44, Organism=Drosophila melanogaster, GI281365776, Length=233, Percent_Identity=40.343347639485, Blast_Score=178, Evalue=1e-44, Organism=Drosophila melanogaster, GI24660075, Length=233, Percent_Identity=40.343347639485, Blast_Score=178, Evalue=1e-44, Organism=Drosophila melanogaster, GI45552965, Length=233, Percent_Identity=40.343347639485, Blast_Score=177, Evalue=2e-44, Organism=Drosophila melanogaster, GI24656820, Length=256, Percent_Identity=35.546875, Blast_Score=156, Evalue=7e-38, Organism=Drosophila melanogaster, GI24656825, Length=256, Percent_Identity=35.546875, Blast_Score=156, Evalue=7e-38, Organism=Drosophila melanogaster, GI281363136, Length=266, Percent_Identity=36.8421052631579, Blast_Score=149, Evalue=5e-36, Organism=Drosophila melanogaster, GI78707192, Length=266, Percent_Identity=36.8421052631579, Blast_Score=149, Evalue=5e-36, Organism=Drosophila melanogaster, GI24644145, Length=246, Percent_Identity=35.3658536585366, Blast_Score=140, Evalue=5e-33, Organism=Drosophila melanogaster, GI28573010, Length=237, Percent_Identity=37.1308016877637, Blast_Score=138, Evalue=1e-32, Organism=Drosophila melanogaster, GI17864540, Length=238, Percent_Identity=36.9747899159664, Blast_Score=138, Evalue=2e-32, Organism=Drosophila melanogaster, GI281360136, Length=248, Percent_Identity=35.0806451612903, Blast_Score=135, Evalue=1e-31, Organism=Drosophila melanogaster, GI24644411, Length=248, Percent_Identity=35.0806451612903, Blast_Score=135, Evalue=1e-31, Organism=Drosophila melanogaster, GI281360144, Length=248, Percent_Identity=35.0806451612903, Blast_Score=135, Evalue=2e-31, Organism=Drosophila melanogaster, GI281360140, Length=248, Percent_Identity=35.0806451612903, Blast_Score=135, Evalue=2e-31, Organism=Drosophila melanogaster, GI281360142, Length=248, Percent_Identity=35.0806451612903, Blast_Score=134, Evalue=2e-31, Organism=Drosophila melanogaster, GI21357333, Length=248, Percent_Identity=35.0806451612903, Blast_Score=134, Evalue=2e-31, Organism=Drosophila melanogaster, GI281360146, Length=248, Percent_Identity=35.0806451612903, Blast_Score=134, Evalue=2e-31, Organism=Drosophila melanogaster, GI281360138, Length=248, Percent_Identity=35.0806451612903, Blast_Score=134, Evalue=2e-31, Organism=Drosophila melanogaster, GI21355121, Length=199, Percent_Identity=35.1758793969849, Blast_Score=134, Evalue=4e-31, Organism=Drosophila melanogaster, GI18859657, Length=240, Percent_Identity=35.4166666666667, Blast_Score=132, Evalue=1e-30, Organism=Drosophila melanogaster, GI20129529, Length=273, Percent_Identity=31.5018315018315, Blast_Score=131, Evalue=2e-30, Organism=Drosophila melanogaster, GI28571849, Length=273, Percent_Identity=35.8974358974359, Blast_Score=128, Evalue=1e-29, Organism=Drosophila melanogaster, GI28571847, Length=273, Percent_Identity=35.8974358974359, Blast_Score=128, Evalue=1e-29, Organism=Drosophila melanogaster, GI24581396, Length=237, Percent_Identity=36.2869198312236, Blast_Score=124, Evalue=2e-28, Organism=Drosophila melanogaster, GI20129423, Length=246, Percent_Identity=30.8943089430894, Blast_Score=110, Evalue=6e-24, Organism=Drosophila melanogaster, GI24639486, Length=239, Percent_Identity=30.5439330543933, Blast_Score=95, Evalue=2e-19,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): FTSH_AKKM8 (B2UMY1)
Other databases:
- EMBL: CP001071 - RefSeq: YP_001876968.1 - MEROPS: M41.001 - GeneID: 6274960 - GenomeReviews: CP001071_GR - KEGG: amu:Amuc_0348 - HOGENOM: HBG724153 - OMA: DECKEEL - GO: GO:0006508 - HAMAP: MF_01458 - InterPro: IPR003593 - InterPro: IPR003959 - InterPro: IPR003960 - InterPro: IPR005936 - InterPro: IPR000642 - SMART: SM00382 - TIGRFAMs: TIGR01241
Pfam domain/function: PF00004 AAA; PF01434 Peptidase_M41
EC number: 3.4.24.-
Molecular weight: Translated: 89456; Mature: 89325
Theoretical pI: Translated: 5.08; Mature: 5.08
Prosite motif: PS00674 AAA
Important sites: ACT_SITE 556-556
Signals:
None
Transmembrane regions:
HASH(0x19b82f48)-; HASH(0x1bb64e14)-;
Cys/Met content:
0.4 %Cys (Translated Protein) 3.1 %Met (Translated Protein) 3.4 %Cys+Met (Translated Protein) 0.4 %Cys (Mature Protein) 3.0 %Met (Mature Protein) 3.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MPPSPPRPPKFPGSGRPESPNWGVWVMVLLIVGVLAFGFFTPESFGLGPRKENLESFEAQ CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH YKAGRVVLNDPKAPVEVVLSENGSEGVIHALVYRKEIQPKVEMTPFALTYSMSLPDRDKP HHCCEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCH LLNELSGYRVVESPYRTEEGKNVSLIPEGAQKLSVPEFNRLALEGRIAGGKDGIILAEDG HHHHCCCCEEECCCCCCCCCCEEEEECCCHHHCCCCCCCCEEEEEEECCCCCCEEEEECC NQNVLVGQIVTRIWPAATGDASVDKQRFERVEVPFTLEFQGDRVKQLLGPDTKFKRESGS CCCEEHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHCCCCCCCCCCCC WGGILLNLLPIVLILVILFFMFRAQSGGARGAMSFGKSRARLISPDKNKVTFKDVAGISE CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCEEECCCCCCEEHHHHHCHHH AKEEVWELVEFLRNPEKFRDLGATIPRGVLMVGAPGTGKTLLARAIAGESNASFYSISGS HHHHHHHHHHHHHCHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHCCCCCCCEEEECCH DFVEMFVGVGASRVRDMFEQAKRTAPSLIFIDEIDAVGRQRGYGMGGGNDEREQTLNALL HHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEECHHHHHHHCCCCCCCCCCHHHHHHHHHH VEMDGFENNSNVIVIAATNRADILDPALLRPGRFDRQVVVNLPDVRGREQILQVHARKVK HEECCCCCCCCEEEEEECCCCCCCCHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHC MAPGVSFERIARGTSGFSGAQLANLVNEAALLAARKGLKEITEAELEEARDKVSWGRERR CCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH SLAINERGRRITAVHEAGHAICLLKTPHSEPLHRVTIVPRGGALGMTMWLPSDDKMHQLR CEEECCCCCEEEEEECCCCEEEEEECCCCCCCEEEEEEECCCCCEEEEECCCCHHHHHHH SEMLDQLVVAMGGRCAEQIVFGDVTSGATGDIKSATNLARRMVCEFGMSEKLGLIEYGEH HHHHHHHHHHHCCHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEECCC QGEVYIARDLGTRSRNYSESTAELIDSEVRFLVDSAYERAMAILTENRDKLDILTEALME CCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH FETLEGSQVMDILEYGEMKNPPARVTPPPMPSEVEEQPGKDDSGHNEKKEAEETRADGAE HHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHCCCHH ERKMEEELEQAERAPFSYNPVDEFGKDGGEKK HHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCH >Mature Secondary Structure PPSPPRPPKFPGSGRPESPNWGVWVMVLLIVGVLAFGFFTPESFGLGPRKENLESFEAQ CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH YKAGRVVLNDPKAPVEVVLSENGSEGVIHALVYRKEIQPKVEMTPFALTYSMSLPDRDKP HHCCEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCH LLNELSGYRVVESPYRTEEGKNVSLIPEGAQKLSVPEFNRLALEGRIAGGKDGIILAEDG HHHHCCCCEEECCCCCCCCCCEEEEECCCHHHCCCCCCCCEEEEEEECCCCCCEEEEECC NQNVLVGQIVTRIWPAATGDASVDKQRFERVEVPFTLEFQGDRVKQLLGPDTKFKRESGS CCCEEHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHCCCCCCCCCCCC WGGILLNLLPIVLILVILFFMFRAQSGGARGAMSFGKSRARLISPDKNKVTFKDVAGISE CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCEEECCCCCCEEHHHHHCHHH AKEEVWELVEFLRNPEKFRDLGATIPRGVLMVGAPGTGKTLLARAIAGESNASFYSISGS HHHHHHHHHHHHHCHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHCCCCCCCEEEECCH DFVEMFVGVGASRVRDMFEQAKRTAPSLIFIDEIDAVGRQRGYGMGGGNDEREQTLNALL HHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEECHHHHHHHCCCCCCCCCCHHHHHHHHHH VEMDGFENNSNVIVIAATNRADILDPALLRPGRFDRQVVVNLPDVRGREQILQVHARKVK HEECCCCCCCCEEEEEECCCCCCCCHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHC MAPGVSFERIARGTSGFSGAQLANLVNEAALLAARKGLKEITEAELEEARDKVSWGRERR CCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH SLAINERGRRITAVHEAGHAICLLKTPHSEPLHRVTIVPRGGALGMTMWLPSDDKMHQLR CEEECCCCCEEEEEECCCCEEEEEECCCCCCCEEEEEEECCCCCEEEEECCCCHHHHHHH SEMLDQLVVAMGGRCAEQIVFGDVTSGATGDIKSATNLARRMVCEFGMSEKLGLIEYGEH HHHHHHHHHHHCCHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEECCC QGEVYIARDLGTRSRNYSESTAELIDSEVRFLVDSAYERAMAILTENRDKLDILTEALME CCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH FETLEGSQVMDILEYGEMKNPPARVTPPPMPSEVEEQPGKDDSGHNEKKEAEETRADGAE HHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHCCCHH ERKMEEELEQAERAPFSYNPVDEFGKDGGEKK HHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCH
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Metalloendopeptidases [C]
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: NA