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The map label for this gene is der

Identifier: 187734830

GI number: 187734830

Start: 376065

End: 377459

Strand: Direct

Name: der

Synonym: Amuc_0319

Alternate gene names: 187734830

Gene position: 376065-377459 (Clockwise)

Preceding gene: 187734829

Following gene: 187734831

Centisome position: 14.12

GC content: 58.42

Gene sequence:

>1395_bases
ATGCAGCACGTCCCCACCATCGCCATCGTAGGCAGGCCCAATGTCGGGAAATCCGCCATTTTCAACAGAATGGCAGGCAG
GCGCATCGCCATCGTGCATGATGAACCCGGCGTCACCCGCGACCGCCTTTCCGCCCCCTGCAAGATTACGGACCGCGCCT
GTAAAATCATGGATACGGGCGGTATCGGCGCGCGCCTGAGCGACGGCTTTGCAGAACAGGTAGAGGCAGAGGCGGACATT
GCCATAAAAACGGCGGACCTCATCCTCTTCGTGCTGGACTGCCGGGATCACCTTACACCTATCGACCAGAGCATCGCGGA
CCACCTCCGCAAATCGGACATTCCCGTCATCCTCCTTCTTAACAAAGCCGACCACGAAAAACAGGACCTTAATCTGGGCG
AATTTGCCGGACTGGGTTTTGACGACCATATCTTTCTTTCCGCCGCCCACGGCAGAGGCTTTTCCGAATTAGCCTCCCGG
CTGGACGGTTTTCTCAAGCAAAAAGGGGCTCCGCTTAAAGAAGAACTGGAGGAAGAACCGGAAAACGGAGAGGAAACGGC
CCTTCCCATCAAGGTAGCCGTAGTGGGACGCCCCAACGCAGGCAAATCCTCCCTGGTCAACGCCATCCTCCGGGACAGGC
GCACCATTGTCTCCAATGTGGCGGGCACTACCCGCGATGCCATTGACGTCCCCTACCTGCACGACGGCCAGCCCTACGTG
CTGATTGACACCGCCGGCATGCGCCCACGCTCCCGTCGGGACACCTCCGTAGAAGTTTTCTCCGCCATGCGCAGTGAAAA
AGCCATCCGCCGGGCGGATATCTGCCTGCTGGTCATTGACATTGCGGCGGGCATCACGCAGCAGGACCGCCGCATTGCCG
GCATCATTGCGGAGGAAGGAAAACCCTGTATCATCATCGTCAACAAATTCGACCTCTTCCATCCGAATGCCTCCCGCAAG
GACCGCATGGCGGAAGTGGAGGAACAGGTGCGCAGGGAACTCTTCTTCATCAGCTACGCGCCTTTCATCGCCACCTCCGC
CAAAAAAGCGGAAGGCGTGGAAATCATCTTCAAAGTCATCACGCGCATCCGCCGGGAATCCCATAACCTGCCCACTACCG
GCCAGCTCAACCGCCTGATCCAGCTTGCCCAGCAGATGAATCCCCCCGGCGCCGCCAGCGGCTCTGCCAGAAGGTTGAAA
ATATATTACGCCACCACAGCGGTGGACCCCAAGTACAATACTATTCCCGTCCCGCGCTACGTTCTTTTCGTCAATGACAA
AAGCCTGCTCACGGACAGCTATTCCCAGTACCTGCGCAACAAAATAAGGGAAGCCTACCCCGCTCCCGGCATTCCGGTCA
TCTTCTCCGCCCGTTCACGCGTGCGCAACGACTGA

Upstream 100 bases:

>100_bases
CAAACGGGCCAAGCACAAAGGATAAGCCCCCGGCGGAAGCCCTTCCCGCTGGCGTGGAATTAGCTTTCACAGCATGGGAG
CTTCGGGTAACATGACGTGC

Downstream 100 bases:

>100_bases
TCATCCCTCCTTCTCCGCATGCTCTCCGTCAGGAACCTCAGCGCCTCCTTCCACACCAGGGCCGGCATTGTCCGGGCGGT
AAGGAACGTGTCCTTTGATG

Product: small GTP-binding protein

Products: NA

Alternate protein names: GTP-binding protein EngA

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MQHVPTIAIVGRPNVGKSAIFNRMAGRRIAIVHDEPGVTRDRLSAPCKITDRACKIMDTGGIGARLSDGFAEQVEAEADI
AIKTADLILFVLDCRDHLTPIDQSIADHLRKSDIPVILLLNKADHEKQDLNLGEFAGLGFDDHIFLSAAHGRGFSELASR
LDGFLKQKGAPLKEELEEEPENGEETALPIKVAVVGRPNAGKSSLVNAILRDRRTIVSNVAGTTRDAIDVPYLHDGQPYV
LIDTAGMRPRSRRDTSVEVFSAMRSEKAIRRADICLLVIDIAAGITQQDRRIAGIIAEEGKPCIIIVNKFDLFHPNASRK
DRMAEVEEQVRRELFFISYAPFIATSAKKAEGVEIIFKVITRIRRESHNLPTTGQLNRLIQLAQQMNPPGAASGSARRLK
IYYATTAVDPKYNTIPVPRYVLFVNDKSLLTDSYSQYLRNKIREAYPAPGIPVIFSARSRVRND

Sequences:

>Translated_464_residues
MQHVPTIAIVGRPNVGKSAIFNRMAGRRIAIVHDEPGVTRDRLSAPCKITDRACKIMDTGGIGARLSDGFAEQVEAEADI
AIKTADLILFVLDCRDHLTPIDQSIADHLRKSDIPVILLLNKADHEKQDLNLGEFAGLGFDDHIFLSAAHGRGFSELASR
LDGFLKQKGAPLKEELEEEPENGEETALPIKVAVVGRPNAGKSSLVNAILRDRRTIVSNVAGTTRDAIDVPYLHDGQPYV
LIDTAGMRPRSRRDTSVEVFSAMRSEKAIRRADICLLVIDIAAGITQQDRRIAGIIAEEGKPCIIIVNKFDLFHPNASRK
DRMAEVEEQVRRELFFISYAPFIATSAKKAEGVEIIFKVITRIRRESHNLPTTGQLNRLIQLAQQMNPPGAASGSARRLK
IYYATTAVDPKYNTIPVPRYVLFVNDKSLLTDSYSQYLRNKIREAYPAPGIPVIFSARSRVRND
>Mature_464_residues
MQHVPTIAIVGRPNVGKSAIFNRMAGRRIAIVHDEPGVTRDRLSAPCKITDRACKIMDTGGIGARLSDGFAEQVEAEADI
AIKTADLILFVLDCRDHLTPIDQSIADHLRKSDIPVILLLNKADHEKQDLNLGEFAGLGFDDHIFLSAAHGRGFSELASR
LDGFLKQKGAPLKEELEEEPENGEETALPIKVAVVGRPNAGKSSLVNAILRDRRTIVSNVAGTTRDAIDVPYLHDGQPYV
LIDTAGMRPRSRRDTSVEVFSAMRSEKAIRRADICLLVIDIAAGITQQDRRIAGIIAEEGKPCIIIVNKFDLFHPNASRK
DRMAEVEEQVRRELFFISYAPFIATSAKKAEGVEIIFKVITRIRRESHNLPTTGQLNRLIQLAQQMNPPGAASGSARRLK
IYYATTAVDPKYNTIPVPRYVLFVNDKSLLTDSYSQYLRNKIREAYPAPGIPVIFSARSRVRND

Specific function: GTPase that plays an essential role in the late steps of ribosome biogenesis

COG id: COG1160

COG function: function code R; Predicted GTPases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH-like domain

Homologues:

Organism=Escherichia coli, GI87082120, Length=471, Percent_Identity=36.7303609341826, Blast_Score=265, Evalue=6e-72,
Organism=Escherichia coli, GI2367268, Length=91, Percent_Identity=43.956043956044, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1788919, Length=158, Percent_Identity=32.2784810126582, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323665, Length=175, Percent_Identity=33.1428571428571, Blast_Score=86, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DER_AKKM8 (B2UMV5)

Other databases:

- EMBL:   CP001071
- RefSeq:   YP_001876942.1
- GeneID:   6275050
- GenomeReviews:   CP001071_GR
- KEGG:   amu:Amuc_0319
- HOGENOM:   HBG592135
- OMA:   TRDRTYQ
- GO:   GO:0005622
- HAMAP:   MF_00195
- InterPro:   IPR016484
- InterPro:   IPR015946
- InterPro:   IPR002917
- InterPro:   IPR001806
- InterPro:   IPR005225
- Gene3D:   G3DSA:3.30.300.20
- PIRSF:   PIRSF006485
- PRINTS:   PR00449
- TIGRFAMs:   TIGR03594
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF01926 MMR_HSR1

EC number: NA

Molecular weight: Translated: 51390; Mature: 51390

Theoretical pI: Translated: 9.08; Mature: 9.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQHVPTIAIVGRPNVGKSAIFNRMAGRRIAIVHDEPGVTRDRLSAPCKITDRACKIMDTG
CCCCCEEEEEECCCCCHHHHHHHHCCCEEEEEECCCCCCHHHCCCCCEECCCCEEEEECC
GIGARLSDGFAEQVEAEADIAIKTADLILFVLDCRDHLTPIDQSIADHLRKSDIPVILLL
CCCCCCCCCHHHHHCCCCCEEEEEHHHEEEEEHHHHHCCHHHHHHHHHHHHCCCCEEEEE
NKADHEKQDLNLGEFAGLGFDDHIFLSAAHGRGFSELASRLDGFLKQKGAPLKEELEEEP
ECCCCCHHCCCCHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCC
ENGEETALPIKVAVVGRPNAGKSSLVNAILRDRRTIVSNVAGTTRDAIDVPYLHDGQPYV
CCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCEE
LIDTAGMRPRSRRDTSVEVFSAMRSEKAIRRADICLLVIDIAAGITQQDRRIAGIIAEEG
EEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEEHHCCCCCCCCEEEEEEECCC
KPCIIIVNKFDLFHPNASRKDRMAEVEEQVRRELFFISYAPFIATSAKKAEGVEIIFKVI
CCEEEEEECEEEECCCCCCHHHHHHHHHHHHHHHHHEEECHHHHCCCCCCCCHHHHHHHH
TRIRRESHNLPTTGQLNRLIQLAQQMNPPGAASGSARRLKIYYATTAVDPKYNTIPVPRY
HHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEECCCCCCCCCCCEE
VLFVNDKSLLTDSYSQYLRNKIREAYPAPGIPVIFSARSRVRND
EEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCEEECCHHHCCCC
>Mature Secondary Structure
MQHVPTIAIVGRPNVGKSAIFNRMAGRRIAIVHDEPGVTRDRLSAPCKITDRACKIMDTG
CCCCCEEEEEECCCCCHHHHHHHHCCCEEEEEECCCCCCHHHCCCCCEECCCCEEEEECC
GIGARLSDGFAEQVEAEADIAIKTADLILFVLDCRDHLTPIDQSIADHLRKSDIPVILLL
CCCCCCCCCHHHHHCCCCCEEEEEHHHEEEEEHHHHHCCHHHHHHHHHHHHCCCCEEEEE
NKADHEKQDLNLGEFAGLGFDDHIFLSAAHGRGFSELASRLDGFLKQKGAPLKEELEEEP
ECCCCCHHCCCCHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCC
ENGEETALPIKVAVVGRPNAGKSSLVNAILRDRRTIVSNVAGTTRDAIDVPYLHDGQPYV
CCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCEE
LIDTAGMRPRSRRDTSVEVFSAMRSEKAIRRADICLLVIDIAAGITQQDRRIAGIIAEEG
EEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEEHHCCCCCCCCEEEEEEECCC
KPCIIIVNKFDLFHPNASRKDRMAEVEEQVRRELFFISYAPFIATSAKKAEGVEIIFKVI
CCEEEEEECEEEECCCCCCHHHHHHHHHHHHHHHHHEEECHHHHCCCCCCCCHHHHHHHH
TRIRRESHNLPTTGQLNRLIQLAQQMNPPGAASGSARRLKIYYATTAVDPKYNTIPVPRY
HHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEECCCCCCCCCCCEE
VLFVNDKSLLTDSYSQYLRNKIREAYPAPGIPVIFSARSRVRND
EEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCEEECCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA