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The map label for this gene is atoC [H]

Identifier: 187734823

GI number: 187734823

Start: 368029

End: 369420

Strand: Direct

Name: atoC [H]

Synonym: Amuc_0312

Alternate gene names: 187734823

Gene position: 368029-369420 (Clockwise)

Preceding gene: 187734822

Following gene: 187734824

Centisome position: 13.81

GC content: 57.69

Gene sequence:

>1392_bases
ATGAAGATGCCTGTTCTGCTGATTGTAGATGATGAAAAACCCACGCGCGACGCTCTGCGCATGGGTTTTCAGGATGATTA
TGAAGTGTACACCGCCGCCAATCTCTCCCAGGCTTCCGCCCTCCTGCAGGAAGAATCTCCGGACCTGGTTCTGACGGATC
TGAGACTGGGCGGGGAAAGCGGCATGGACGTGCTGAAAGCCGCTGCCTCCCTGCCCCACCCTCCGCAAAGCATCATGATG
ACTGCCTACGGCTCCGTGGATGCCGCCGTAGCAGCTATGAAAGAGGGAGCGTACGACTTCGTCACCAAACCTCTGAATCT
GGACGCCGTGGAGCTGGTGCTCAAACGGGCGCTCCATACCCGGAACCTGGAAACGGCCAACCAGGAACTCACCACCCGCA
TCCAGGCGGACTCCGGACTGCAAAAACTCCTGGGCAGATCCGCCGCCATGGAACACGTATTCTCCATTATTCGTCAGGTG
GCCCCCAGCAAAACGACTGTGCTGATTGAGGGGGAAAGCGGCACCGGGAAAGAACTCGTAGCCCAGGCCATCCATTCCCT
TTCCGGAAGGCCGGAAAATAAATTCGTGGCCGTCAACTGTGCGGCCCTTTCCCCCCAATTATTGGAAAGCGAGTTGTTCG
GCCATGAAAAAGGCTCCTTCACCGGAGCCGGACAACGCCGCATCGGCCGCTTTGAGCAGGCGGACGGCGGCACCATCTTT
CTGGATGAAATCGGGGAAATAGACGCCGGAACACAAGTCCGGCTGCTGCGGGTGCTGTCTGAACGGACCATTGAACGCGT
AGGGTCCAATGCATCCATTCCCGTCAATGTGCGCGTTATCGCGGCCACCAACAAATCATTGAAAAAGCTCGTGCAGGAAG
GAAAATTCCGGGAAGACCTCTACTTCCGCCTCAATGTGGTGCATATCCAGATGCCCCCCCTCCGGGACCGCCGTGAAGAC
ATCCCCCTGCTTGCCACCGCCTTTCTGAAGGAATTCGCCAGGGAAAACAACAAGGAATTCAAGCCCCTCTCCCGGGACGC
CCTTGAAGCCGCCCGGAATTACCAGTGGCCGGGAAACGTTCGTGAACTCCGCACGGCCATGGAACATGGCGTCGTCATGA
GCAATTCCGCCAGCATAGGCCTCCATCATCTTCCCCCGCAACTGCAGGATACTTCTCCGGAAGCCGCTCCACAGGAACGG
CCGGAGGACAATGCACCCAACACGCAGAATGGGCTTGTCCCGGCCGGGGTTTTGAATTTATCCTTGCTGGAACGGAATGC
CATCCAACAAGCGCTGGCCCAGTCAAACGGCAATAAAACGGCAGCAGCCCACCTGCTGGGCATCAGCCGGCGCACTCTTC
AACGCAAACTACAAGACATCCTCCATTCATGA

Upstream 100 bases:

>100_bases
CCATCACGCTGGCCAGCCAGCCGGGTCAGGGAACCACCATCACGGTCTTCCTGCCGCGCGTGGAACGCACCATCAGGCTC
CTGCCATCCTCCATTCCCTC

Downstream 100 bases:

>100_bases
ATGAGCCCTCCTCGGCATCCCGCACCCCTTTTATCATTATCCTTATCCTGCTGCTGGCAATCACGGGGGTGCAGTACTTT
TTCAACTTTAACGGGCTGGG

Product: Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MKMPVLLIVDDEKPTRDALRMGFQDDYEVYTAANLSQASALLQEESPDLVLTDLRLGGESGMDVLKAAASLPHPPQSIMM
TAYGSVDAAVAAMKEGAYDFVTKPLNLDAVELVLKRALHTRNLETANQELTTRIQADSGLQKLLGRSAAMEHVFSIIRQV
APSKTTVLIEGESGTGKELVAQAIHSLSGRPENKFVAVNCAALSPQLLESELFGHEKGSFTGAGQRRIGRFEQADGGTIF
LDEIGEIDAGTQVRLLRVLSERTIERVGSNASIPVNVRVIAATNKSLKKLVQEGKFREDLYFRLNVVHIQMPPLRDRRED
IPLLATAFLKEFARENNKEFKPLSRDALEAARNYQWPGNVRELRTAMEHGVVMSNSASIGLHHLPPQLQDTSPEAAPQER
PEDNAPNTQNGLVPAGVLNLSLLERNAIQQALAQSNGNKTAAAHLLGISRRTLQRKLQDILHS

Sequences:

>Translated_463_residues
MKMPVLLIVDDEKPTRDALRMGFQDDYEVYTAANLSQASALLQEESPDLVLTDLRLGGESGMDVLKAAASLPHPPQSIMM
TAYGSVDAAVAAMKEGAYDFVTKPLNLDAVELVLKRALHTRNLETANQELTTRIQADSGLQKLLGRSAAMEHVFSIIRQV
APSKTTVLIEGESGTGKELVAQAIHSLSGRPENKFVAVNCAALSPQLLESELFGHEKGSFTGAGQRRIGRFEQADGGTIF
LDEIGEIDAGTQVRLLRVLSERTIERVGSNASIPVNVRVIAATNKSLKKLVQEGKFREDLYFRLNVVHIQMPPLRDRRED
IPLLATAFLKEFARENNKEFKPLSRDALEAARNYQWPGNVRELRTAMEHGVVMSNSASIGLHHLPPQLQDTSPEAAPQER
PEDNAPNTQNGLVPAGVLNLSLLERNAIQQALAQSNGNKTAAAHLLGISRRTLQRKLQDILHS
>Mature_463_residues
MKMPVLLIVDDEKPTRDALRMGFQDDYEVYTAANLSQASALLQEESPDLVLTDLRLGGESGMDVLKAAASLPHPPQSIMM
TAYGSVDAAVAAMKEGAYDFVTKPLNLDAVELVLKRALHTRNLETANQELTTRIQADSGLQKLLGRSAAMEHVFSIIRQV
APSKTTVLIEGESGTGKELVAQAIHSLSGRPENKFVAVNCAALSPQLLESELFGHEKGSFTGAGQRRIGRFEQADGGTIF
LDEIGEIDAGTQVRLLRVLSERTIERVGSNASIPVNVRVIAATNKSLKKLVQEGKFREDLYFRLNVVHIQMPPLRDRRED
IPLLATAFLKEFARENNKEFKPLSRDALEAARNYQWPGNVRELRTAMEHGVVMSNSASIGLHHLPPQLQDTSPEAAPQER
PEDNAPNTQNGLVPAGVLNLSLLERNAIQQALAQSNGNKTAAAHLLGISRRTLQRKLQDILHS

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=459, Percent_Identity=43.1372549019608, Blast_Score=359, Evalue=1e-100,
Organism=Escherichia coli, GI1790437, Length=456, Percent_Identity=45.8333333333333, Blast_Score=358, Evalue=1e-100,
Organism=Escherichia coli, GI1790299, Length=471, Percent_Identity=41.1889596602972, Blast_Score=325, Evalue=4e-90,
Organism=Escherichia coli, GI1788905, Length=453, Percent_Identity=37.9690949227373, Blast_Score=285, Evalue=4e-78,
Organism=Escherichia coli, GI87082117, Length=347, Percent_Identity=42.9394812680115, Blast_Score=271, Evalue=6e-74,
Organism=Escherichia coli, GI1789087, Length=262, Percent_Identity=49.618320610687, Blast_Score=256, Evalue=2e-69,
Organism=Escherichia coli, GI1789233, Length=323, Percent_Identity=42.4148606811146, Blast_Score=243, Evalue=1e-65,
Organism=Escherichia coli, GI1786524, Length=367, Percent_Identity=42.7792915531335, Blast_Score=240, Evalue=1e-64,
Organism=Escherichia coli, GI87082152, Length=323, Percent_Identity=43.6532507739938, Blast_Score=223, Evalue=3e-59,
Organism=Escherichia coli, GI87081872, Length=324, Percent_Identity=40.4320987654321, Blast_Score=221, Evalue=1e-58,
Organism=Escherichia coli, GI1787583, Length=233, Percent_Identity=42.9184549356223, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI87081858, Length=301, Percent_Identity=33.8870431893688, Blast_Score=148, Evalue=6e-37,
Organism=Escherichia coli, GI1789828, Length=311, Percent_Identity=33.4405144694534, Blast_Score=145, Evalue=7e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50715; Mature: 50715

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMPVLLIVDDEKPTRDALRMGFQDDYEVYTAANLSQASALLQEESPDLVLTDLRLGGES
CCCCEEEEECCCCCHHHHHHCCCCCCCCEEEECCHHHHHHHHHCCCCCEEEEEEEECCCC
GMDVLKAAASLPHPPQSIMMTAYGSVDAAVAAMKEGAYDFVTKPLNLDAVELVLKRALHT
CHHHHHHHHCCCCCCHHHHEEECCCHHHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHHHH
RNLETANQELTTRIQADSGLQKLLGRSAAMEHVFSIIRQVAPSKTTVLIEGESGTGKELV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHH
AQAIHSLSGRPENKFVAVNCAALSPQLLESELFGHEKGSFTGAGQRRIGRFEQADGGTIF
HHHHHHHCCCCCCCEEEEEEHHCCHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCCEEE
LDEIGEIDAGTQVRLLRVLSERTIERVGSNASIPVNVRVIAATNKSLKKLVQEGKFREDL
EECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCHHHHHHHHCCCCCCCE
YFRLNVVHIQMPPLRDRREDIPLLATAFLKEFARENNKEFKPLSRDALEAARNYQWPGNV
EEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCH
RELRTAMEHGVVMSNSASIGLHHLPPQLQDTSPEAAPQERPEDNAPNTQNGLVPAGVLNL
HHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
SLLERNAIQQALAQSNGNKTAAAHLLGISRRTLQRKLQDILHS
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKMPVLLIVDDEKPTRDALRMGFQDDYEVYTAANLSQASALLQEESPDLVLTDLRLGGES
CCCCEEEEECCCCCHHHHHHCCCCCCCCEEEECCHHHHHHHHHCCCCCEEEEEEEECCCC
GMDVLKAAASLPHPPQSIMMTAYGSVDAAVAAMKEGAYDFVTKPLNLDAVELVLKRALHT
CHHHHHHHHCCCCCCHHHHEEECCCHHHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHHHH
RNLETANQELTTRIQADSGLQKLLGRSAAMEHVFSIIRQVAPSKTTVLIEGESGTGKELV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHH
AQAIHSLSGRPENKFVAVNCAALSPQLLESELFGHEKGSFTGAGQRRIGRFEQADGGTIF
HHHHHHHCCCCCCCEEEEEEHHCCHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCCEEE
LDEIGEIDAGTQVRLLRVLSERTIERVGSNASIPVNVRVIAATNKSLKKLVQEGKFREDL
EECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCHHHHHHHHCCCCCCCE
YFRLNVVHIQMPPLRDRREDIPLLATAFLKEFARENNKEFKPLSRDALEAARNYQWPGNV
EEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCH
RELRTAMEHGVVMSNSASIGLHHLPPQLQDTSPEAAPQERPEDNAPNTQNGLVPAGVLNL
HHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
SLLERNAIQQALAQSNGNKTAAAHLLGISRRTLQRKLQDILHS
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]