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The map label for this gene is tdh [H]

Identifier: 187734745

GI number: 187734745

Start: 291556

End: 292593

Strand: Reverse

Name: tdh [H]

Synonym: Amuc_0233

Alternate gene names: 187734745

Gene position: 292593-291556 (Counterclockwise)

Preceding gene: 187734748

Following gene: 187734743

Centisome position: 10.98

GC content: 54.05

Gene sequence:

>1038_bases
ATGGGGGGCATGAAAGCTCTTGTAAAAACGCAGGCTGGCCCCGGTTTGGAATTGATGGATGTTCCTATGCCGGAAGTCGG
CCCGAATGACGTCCTGATCAAAATTCATAAAACAGCCATTTGCGGCACGGATCTTCATATTTGGAATTGGGATAAATGGG
CCCAGCAGACCATTCCGGTAGGGATGCATGTGGGCCATGAGTTCTGCGGCGTGATTGAGTCCGTAGGTTCTTCCGTGACG
GAATACAAGCCCGGGGAGATTGTTTCCGGTGAGGGGCATATTGTCTGCGGCCATTGCCGCAGCTGCCGTTCAGGGCAGAA
GCACTTGTGCCCCAACACAAAGGGTGTGGGAGTCAACAGGCCCGGCTGCTTTGCGGAGTACCTTTCCATTCCGCAGGATA
ACGTGGTGCGCATCCACAAGAGCATTCCGATGGAAATCGCCTCCATTTTTGACCCGCTGGGCAACGCCGTCCATACGGCT
TTGTCCTGGGATCTGGTGGGCGAGGACGTACTGATTACGGGAGCCGGGGTTATCGGCTGCATGGCTGCCGCCGTCTGCAA
GAAGGCCGGAGCCAAGACGGTGGTTATTACGGACATCAATGATTTCCGCCTGGGTCTTGCCAAAACGCTGGGGGCGGACC
GAACCGTGAACGTGACCCGTGAAAAGCTGGAAGACGTGATGAAGGAACTGGAAATGACGGAGGGATTTGACGTGTGCCTG
GAAATGAGCGGCGCTCCGTCCTGCCTGAAGGACATCATCGACAATTCCCGCAACGGAGCCAACATTTCCCTGCTGGGGAT
TCAGCCCGATGGTTCCAGCATCGAGTGGAATAAGTTCATTTGGAAAGGGTTGAAGATGAAAGGCATTTATGGCCGTGAAA
TTTTTGAAACTTGGCATAAAATGGATTCCATGATCCGCAGTGGCTTGAATGTGGCGCCCATCATCACGCACCGTCTGCCC
TACACGGAATTCCGGGAAGGGTTTGAAGCCATGAATTCGGGAAAATCCGGCAAGGTTGTTCTGGACTGGATTGTTTGA

Upstream 100 bases:

>100_bases
ATGGGAAGGGAAGGGGGGGGCGGAAGCCTCCGTTCCCTAGGCTTTTTCGGCGCTCCGAAATGAATTTTGAGCTTGCCGAC
GCAGGGGAAAAAGAGCATGA

Downstream 100 bases:

>100_bases
TTCTCTCTTTTTCTTTCCATGTGATTATGGATGCCCCGGTTTCCTGGAGGGAGACCGGGGCGTTTTTTAGGGAAGGGCAG
TAAAAGGGGGGATAGGTTTG

Product: L-threonine 3-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MGGMKALVKTQAGPGLELMDVPMPEVGPNDVLIKIHKTAICGTDLHIWNWDKWAQQTIPVGMHVGHEFCGVIESVGSSVT
EYKPGEIVSGEGHIVCGHCRSCRSGQKHLCPNTKGVGVNRPGCFAEYLSIPQDNVVRIHKSIPMEIASIFDPLGNAVHTA
LSWDLVGEDVLITGAGVIGCMAAAVCKKAGAKTVVITDINDFRLGLAKTLGADRTVNVTREKLEDVMKELEMTEGFDVCL
EMSGAPSCLKDIIDNSRNGANISLLGIQPDGSSIEWNKFIWKGLKMKGIYGREIFETWHKMDSMIRSGLNVAPIITHRLP
YTEFREGFEAMNSGKSGKVVLDWIV

Sequences:

>Translated_345_residues
MGGMKALVKTQAGPGLELMDVPMPEVGPNDVLIKIHKTAICGTDLHIWNWDKWAQQTIPVGMHVGHEFCGVIESVGSSVT
EYKPGEIVSGEGHIVCGHCRSCRSGQKHLCPNTKGVGVNRPGCFAEYLSIPQDNVVRIHKSIPMEIASIFDPLGNAVHTA
LSWDLVGEDVLITGAGVIGCMAAAVCKKAGAKTVVITDINDFRLGLAKTLGADRTVNVTREKLEDVMKELEMTEGFDVCL
EMSGAPSCLKDIIDNSRNGANISLLGIQPDGSSIEWNKFIWKGLKMKGIYGREIFETWHKMDSMIRSGLNVAPIITHRLP
YTEFREGFEAMNSGKSGKVVLDWIV
>Mature_344_residues
GGMKALVKTQAGPGLELMDVPMPEVGPNDVLIKIHKTAICGTDLHIWNWDKWAQQTIPVGMHVGHEFCGVIESVGSSVTE
YKPGEIVSGEGHIVCGHCRSCRSGQKHLCPNTKGVGVNRPGCFAEYLSIPQDNVVRIHKSIPMEIASIFDPLGNAVHTAL
SWDLVGEDVLITGAGVIGCMAAAVCKKAGAKTVVITDINDFRLGLAKTLGADRTVNVTREKLEDVMKELEMTEGFDVCLE
MSGAPSCLKDIIDNSRNGANISLLGIQPDGSSIEWNKFIWKGLKMKGIYGREIFETWHKMDSMIRSGLNVAPIITHRLPY
TEFREGFEAMNSGKSGKVVLDWIV

Specific function: Threonine catabolism; first step. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=347, Percent_Identity=30.2593659942363, Blast_Score=162, Evalue=4e-40,
Organism=Homo sapiens, GI4501929, Length=358, Percent_Identity=27.6536312849162, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI34577061, Length=375, Percent_Identity=26.6666666666667, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI4501933, Length=358, Percent_Identity=26.8156424581006, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI262073058, Length=356, Percent_Identity=26.4044943820225, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI71743840, Length=356, Percent_Identity=26.4044943820225, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI71565152, Length=378, Percent_Identity=25.6613756613757, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI156523966, Length=374, Percent_Identity=25.1336898395722, Blast_Score=95, Evalue=9e-20,
Organism=Homo sapiens, GI4501939, Length=368, Percent_Identity=25.2717391304348, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI71565154, Length=380, Percent_Identity=26.5789473684211, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1790045, Length=340, Percent_Identity=61.4705882352941, Blast_Score=442, Evalue=1e-125,
Organism=Escherichia coli, GI1788075, Length=367, Percent_Identity=30.5177111716621, Blast_Score=144, Evalue=6e-36,
Organism=Escherichia coli, GI1788073, Length=335, Percent_Identity=26.2686567164179, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1788407, Length=337, Percent_Identity=28.486646884273, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1787863, Length=279, Percent_Identity=30.1075268817204, Blast_Score=111, Evalue=7e-26,
Organism=Escherichia coli, GI1790718, Length=320, Percent_Identity=26.25, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI226510992, Length=315, Percent_Identity=26.6666666666667, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI87082125, Length=355, Percent_Identity=28.7323943661972, Blast_Score=104, Evalue=7e-24,
Organism=Escherichia coli, GI87081918, Length=323, Percent_Identity=27.5541795665635, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1786552, Length=374, Percent_Identity=25.668449197861, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1786825, Length=383, Percent_Identity=26.1096605744125, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1786518, Length=349, Percent_Identity=28.9398280802292, Blast_Score=79, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17562876, Length=332, Percent_Identity=31.0240963855422, Blast_Score=161, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17562878, Length=334, Percent_Identity=27.8443113772455, Blast_Score=128, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI71988145, Length=350, Percent_Identity=25.4285714285714, Blast_Score=94, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI25146526, Length=378, Percent_Identity=24.3386243386243, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI71997431, Length=367, Percent_Identity=24.5231607629428, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17562582, Length=291, Percent_Identity=28.1786941580756, Blast_Score=78, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17562584, Length=149, Percent_Identity=28.8590604026846, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322619, Length=330, Percent_Identity=26.6666666666667, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6319955, Length=330, Percent_Identity=26.6666666666667, Blast_Score=124, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6323099, Length=328, Percent_Identity=28.0487804878049, Blast_Score=118, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6320033, Length=378, Percent_Identity=28.3068783068783, Blast_Score=116, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6319258, Length=272, Percent_Identity=28.6764705882353, Blast_Score=99, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6323729, Length=361, Percent_Identity=27.9778393351801, Blast_Score=86, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6323961, Length=355, Percent_Identity=27.3239436619718, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319621, Length=224, Percent_Identity=30.3571428571429, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319257, Length=250, Percent_Identity=26.4, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324486, Length=343, Percent_Identity=27.1137026239067, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI17737897, Length=332, Percent_Identity=27.4096385542169, Blast_Score=121, Evalue=6e-28,
Organism=Drosophila melanogaster, GI17137530, Length=332, Percent_Identity=26.2048192771084, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI17737895, Length=378, Percent_Identity=26.7195767195767, Blast_Score=111, Evalue=6e-25,
Organism=Drosophila melanogaster, GI45551930, Length=187, Percent_Identity=30.4812834224599, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221457811, Length=187, Percent_Identity=30.4812834224599, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45550770, Length=187, Percent_Identity=30.4812834224599, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.103 [H]

Molecular weight: Translated: 37544; Mature: 37413

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGMKALVKTQAGPGLELMDVPMPEVGPNDVLIKIHKTAICGTDLHIWNWDKWAQQTIPV
CCCHHHHHHHCCCCCCEEEECCCCCCCCCCEEEEEEEEEEECCCEEEECCHHHHHHCCCC
GMHVGHEFCGVIESVGSSVTEYKPGEIVSGEGHIVCGHCRSCRSGQKHLCPNTKGVGVNR
HHHHHHHHHHHHHHHCCHHHCCCCCCEECCCCCEEECCCCCCCCCCCCCCCCCCCCCCCC
PGCFAEYLSIPQDNVVRIHKSIPMEIASIFDPLGNAVHTALSWDLVGEDVLITGAGVIGC
CCHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHEECCCCEEEECCHHHHH
MAAAVCKKAGAKTVVITDINDFRLGLAKTLGADRTVNVTREKLEDVMKELEMTEGFDVCL
HHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHCCCCEEEE
EMSGAPSCLKDIIDNSRNGANISLLGIQPDGSSIEWNKFIWKGLKMKGIYGREIFETWHK
ECCCCHHHHHHHHCCCCCCCEEEEEEECCCCCCCCHHHHHHHCCEECCCCHHHHHHHHHH
MDSMIRSGLNVAPIITHRLPYTEFREGFEAMNSGKSGKVVLDWIV
HHHHHHCCCCEEEHHHCCCCHHHHHHHHHHHHCCCCCCEEEEEEC
>Mature Secondary Structure 
GGMKALVKTQAGPGLELMDVPMPEVGPNDVLIKIHKTAICGTDLHIWNWDKWAQQTIPV
CCHHHHHHHCCCCCCEEEECCCCCCCCCCEEEEEEEEEEECCCEEEECCHHHHHHCCCC
GMHVGHEFCGVIESVGSSVTEYKPGEIVSGEGHIVCGHCRSCRSGQKHLCPNTKGVGVNR
HHHHHHHHHHHHHHHCCHHHCCCCCCEECCCCCEEECCCCCCCCCCCCCCCCCCCCCCCC
PGCFAEYLSIPQDNVVRIHKSIPMEIASIFDPLGNAVHTALSWDLVGEDVLITGAGVIGC
CCHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHEECCCCEEEECCHHHHH
MAAAVCKKAGAKTVVITDINDFRLGLAKTLGADRTVNVTREKLEDVMKELEMTEGFDVCL
HHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHCCCCEEEE
EMSGAPSCLKDIIDNSRNGANISLLGIQPDGSSIEWNKFIWKGLKMKGIYGREIFETWHK
ECCCCHHHHHHHHCCCCCCCEEEEEEECCCCCCCCHHHHHHHCCEECCCCHHHHHHHHHH
MDSMIRSGLNVAPIITHRLPYTEFREGFEAMNSGKSGKVVLDWIV
HHHHHHCCCCEEEHHHCCCCHHHHHHHHHHHHCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500782 [H]