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The map label for this gene is csd [H]

Identifier: 187734706

GI number: 187734706

Start: 242365

End: 243591

Strand: Direct

Name: csd [H]

Synonym: Amuc_0193

Alternate gene names: 187734706

Gene position: 242365-243591 (Clockwise)

Preceding gene: 187734705

Following gene: 187734707

Centisome position: 9.1

GC content: 60.39

Gene sequence:

>1227_bases
ATGCTTGACACAGCAACCATTCGCCCGCAGTTCCCCATTCTGGAAACCAGCGTGCACGGCAAGCCTCTCATTTACCTGGA
TAATGCGGCCACTACGCAAAAACCCCTGGCCGTGCTGGACGCCATCCGTCACTACTACGATACGGAGAACGCCAATGTGC
ACCGCGGCTCCCACTACCTGAGCCAGCTCGCGACGGAAGCGCATGAAGAATCGCGGGAAACGGTGGCGCGGTTCATCAAC
GCGCCGGAAACGGCGGAAGTCCTGTTCACCTCCGGCTGTACGATGGGCATCAACCTGGCGGCGGATACCATCGCCGGGTC
CGGCATGGTCAAACCGGGAGACGAAGTCATCGTAACCGCTTCCGAACACCATTCCAATATCGTTCCCTGGCAAATGCTGT
GCGAACGCACGGGCGCCGTCCTGAAAGCGGTTCCCCTGACGCCGGGCCAGACCCTGGACATGGAAGCTTACCGGAACATG
CTTTCCCCACGCACCCGCATCGTAGCTGTGGGACACGTTTCCAATACGCTGGGAACGGTTAATCCCGTGAGGGAAATGGC
CGCGCTCGCCAAGGAGAACAGGCAGGAAACCATCGTGCTGATTGACGGAGCCCAGGCTGTTTCCCATATGAATGTGGACG
TTCAGGAACTGGGCTGCGACCTGTATGCCTTTTCCGGCCACAAGCTGTACGCACCCACCGGCATCGGCGCGCTGTGGGGA
AAAAGGGAGCTGCTGGAAAAACTGCCGCCGTGGATGGGCGGCGGGGAAATGATCAAGGAAGTCACCTTTGAAAAAACCGT
TTACAACGACATCCCGTTCAAATATGAAGCGGGAACGCCCAACATTGGCGGGGCAGTGGGTCTGGCGGCCGCCATCCGCT
ACGTCTCCGGGCTGGGTCTGGACAACATTGCCGCCCATGAACAGAAACTGACGGATATGGCGGTGGAAGGCCTGAAGGCC
ATGCCGCGCCTGACCGTACTGGCCCCGGACGTGCCGCACAGCGCCGTGGTCTCCGTCCTGGCGGAGGGCGTCCACCACTA
TGACCTGGGTACGCTGCTGGACCAGATGGGAATTGCCGTAAGAACCGGGCACCATTGCTGCCAGCCGCTCATGTGCGCCC
TGGGCACCACCGGGACTACCCGCGCCTCCTTTGCCCTGTACAATACGGAAGAGGAAGTGCAGACCTTCCTCAAATCCATG
AACCGGGCGCTGGACATGCTCTCCTGA

Upstream 100 bases:

>100_bases
ATGAACTGAAAAAGCCGGAATACGGCATCCGCGCGCCCATTTTCATTCTGGAAGGAGGCTGGGATGAATTGCGCAAAGAA
CCCTCACTAGTACCATAGCC

Downstream 100 bases:

>100_bases
ATCCCCCTCCCTTCCCTGCTTATTGACACCGCGCATCATGAAAACGGTTTCCATCCTTCTCTTAGGACTGGCCATAGGCC
TTTCCGGCTGTTCCCTGCAC

Product: cysteine desulfurase, SufS subfamily

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MLDTATIRPQFPILETSVHGKPLIYLDNAATTQKPLAVLDAIRHYYDTENANVHRGSHYLSQLATEAHEESRETVARFIN
APETAEVLFTSGCTMGINLAADTIAGSGMVKPGDEVIVTASEHHSNIVPWQMLCERTGAVLKAVPLTPGQTLDMEAYRNM
LSPRTRIVAVGHVSNTLGTVNPVREMAALAKENRQETIVLIDGAQAVSHMNVDVQELGCDLYAFSGHKLYAPTGIGALWG
KRELLEKLPPWMGGGEMIKEVTFEKTVYNDIPFKYEAGTPNIGGAVGLAAAIRYVSGLGLDNIAAHEQKLTDMAVEGLKA
MPRLTVLAPDVPHSAVVSVLAEGVHHYDLGTLLDQMGIAVRTGHHCCQPLMCALGTTGTTRASFALYNTEEEVQTFLKSM
NRALDMLS

Sequences:

>Translated_408_residues
MLDTATIRPQFPILETSVHGKPLIYLDNAATTQKPLAVLDAIRHYYDTENANVHRGSHYLSQLATEAHEESRETVARFIN
APETAEVLFTSGCTMGINLAADTIAGSGMVKPGDEVIVTASEHHSNIVPWQMLCERTGAVLKAVPLTPGQTLDMEAYRNM
LSPRTRIVAVGHVSNTLGTVNPVREMAALAKENRQETIVLIDGAQAVSHMNVDVQELGCDLYAFSGHKLYAPTGIGALWG
KRELLEKLPPWMGGGEMIKEVTFEKTVYNDIPFKYEAGTPNIGGAVGLAAAIRYVSGLGLDNIAAHEQKLTDMAVEGLKA
MPRLTVLAPDVPHSAVVSVLAEGVHHYDLGTLLDQMGIAVRTGHHCCQPLMCALGTTGTTRASFALYNTEEEVQTFLKSM
NRALDMLS
>Mature_408_residues
MLDTATIRPQFPILETSVHGKPLIYLDNAATTQKPLAVLDAIRHYYDTENANVHRGSHYLSQLATEAHEESRETVARFIN
APETAEVLFTSGCTMGINLAADTIAGSGMVKPGDEVIVTASEHHSNIVPWQMLCERTGAVLKAVPLTPGQTLDMEAYRNM
LSPRTRIVAVGHVSNTLGTVNPVREMAALAKENRQETIVLIDGAQAVSHMNVDVQELGCDLYAFSGHKLYAPTGIGALWG
KRELLEKLPPWMGGGEMIKEVTFEKTVYNDIPFKYEAGTPNIGGAVGLAAAIRYVSGLGLDNIAAHEQKLTDMAVEGLKA
MPRLTVLAPDVPHSAVVSVLAEGVHHYDLGTLLDQMGIAVRTGHHCCQPLMCALGTTGTTRASFALYNTEEEVQTFLKSM
NRALDMLS

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=253, Percent_Identity=28.4584980237154, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI156713448, Length=271, Percent_Identity=28.4132841328413, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1787970, Length=403, Percent_Identity=49.1315136476427, Blast_Score=383, Evalue=1e-108,
Organism=Escherichia coli, GI1789175, Length=407, Percent_Identity=40.2948402948403, Blast_Score=328, Evalue=3e-91,
Organism=Escherichia coli, GI48994898, Length=235, Percent_Identity=30.6382978723404, Blast_Score=97, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI25143064, Length=399, Percent_Identity=25.062656641604, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI193211090, Length=374, Percent_Identity=24.8663101604278, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6319831, Length=405, Percent_Identity=26.6666666666667, Blast_Score=124, Evalue=2e-29,
Organism=Drosophila melanogaster, GI20129463, Length=246, Percent_Identity=32.9268292682927, Blast_Score=114, Evalue=9e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR022471
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 44141; Mature: 44141

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDTATIRPQFPILETSVHGKPLIYLDNAATTQKPLAVLDAIRHYYDTENANVHRGSHYL
CCCCCCCCCCCCEEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHH
SQLATEAHEESRETVARFINAPETAEVLFTSGCTMGINLAADTIAGSGMVKPGDEVIVTA
HHHHHHHHHHHHHHHHHHHCCCCHHHEEEECCCCEEEEEHHHHHCCCCCCCCCCCEEEEE
SEHHSNIVPWQMLCERTGAVLKAVPLTPGQTLDMEAYRNMLSPRTRIVAVGHVSNTLGTV
CCCCCCCCHHHHHHHHHCCEEEEECCCCCCCCCHHHHHHHHCCCEEEEEEECCCCCCCCH
NPVREMAALAKENRQETIVLIDGAQAVSHMNVDVQELGCDLYAFSGHKLYAPTGIGALWG
HHHHHHHHHHHCCCCCEEEEEECHHHHHHCCCCHHHHCCCEEEECCCEEECCCCCHHHHH
KRELLEKLPPWMGGGEMIKEVTFEKTVYNDIPFKYEAGTPNIGGAVGLAAAIRYVSGLGL
HHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCC
DNIAAHEQKLTDMAVEGLKAMPRLTVLAPDVPHSAVVSVLAEGVHHYDLGTLLDQMGIAV
CHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEE
RTGHHCCQPLMCALGTTGTTRASFALYNTEEEVQTFLKSMNRALDMLS
ECCHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLDTATIRPQFPILETSVHGKPLIYLDNAATTQKPLAVLDAIRHYYDTENANVHRGSHYL
CCCCCCCCCCCCEEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHH
SQLATEAHEESRETVARFINAPETAEVLFTSGCTMGINLAADTIAGSGMVKPGDEVIVTA
HHHHHHHHHHHHHHHHHHHCCCCHHHEEEECCCCEEEEEHHHHHCCCCCCCCCCCEEEEE
SEHHSNIVPWQMLCERTGAVLKAVPLTPGQTLDMEAYRNMLSPRTRIVAVGHVSNTLGTV
CCCCCCCCHHHHHHHHHCCEEEEECCCCCCCCCHHHHHHHHCCCEEEEEEECCCCCCCCH
NPVREMAALAKENRQETIVLIDGAQAVSHMNVDVQELGCDLYAFSGHKLYAPTGIGALWG
HHHHHHHHHHHCCCCCEEEEEECHHHHHHCCCCHHHHCCCEEEECCCEEECCCCCHHHHH
KRELLEKLPPWMGGGEMIKEVTFEKTVYNDIPFKYEAGTPNIGGAVGLAAAIRYVSGLGL
HHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCC
DNIAAHEQKLTDMAVEGLKAMPRLTVLAPDVPHSAVVSVLAEGVHHYDLGTLLDQMGIAV
CHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEE
RTGHHCCQPLMCALGTTGTTRASFALYNTEEEVQTFLKSMNRALDMLS
ECCHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]