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The map label for this gene is lpxA

Identifier: 187734693

GI number: 187734693

Start: 227570

End: 228349

Strand: Reverse

Name: lpxA

Synonym: Amuc_0180

Alternate gene names: 187734693

Gene position: 228349-227570 (Counterclockwise)

Preceding gene: 187734694

Following gene: 187734692

Centisome position: 8.57

GC content: 55.26

Gene sequence:

>780_bases
ATGCCAGAAATACACCCAACGGCAGTAGTGCATCCTGCTGCAGAGATCGCGGATGATGTTAAAATCGGTCCCTTTTGCGT
TGTCGGGGAACATGTCAAACTGGGGCCCGGCTGCGTGCTGCACAGCCATGTGGTTATAGACGGTCCTTCTTCCTTCGGCA
GCGGCAACGAATTTTTCCCGTTTTCCGTCATCGGCCTGAAAAGCCAGGATTTGAAATACAAGGGAGAGCCGACTTATCTG
GAAGTGGGGGATAACAACGTCTTCCGTGAAAACGCCACCATCAACCGGGCTACGGACATTGGCGGCGCAACGCGGATAGG
GAATAACAACCTTTTCCTGGTTTCCTGCCATGCCGGGCACGATTGCCAGATCGGCAATCATGTGATTTTCTCCGGGTTCG
CTACCGCCGCCGGCCATGTTACGGTGGGGGATTACGCCATCCTGGCGGGATGTTGCGCCGTACACCAGTTTGTGAGCATC
GGGGAACATGCCATGGTGGGAGCAATGGCCCGCGTGAGCCAGGATGTCCTGCCGTACACGATCGTGGAGGGCCACCCGGC
CGTAACGCGTTCCGTTAACTCCATCGGCATGCAGAGGCGCGGCTTTTCCGAAGAAGACCTGAAAGCCGTGCGCATGTGCT
ATAAAAAGCTTTTCGTCAATAAAAAGCTGACCGTTCATGAAGCTCTGGAGGAACTGCGGCATTCGGGGTATGCGGAAAAT
GCCTGCCTGAGGAGAATCATCCAATTCGTGGAAACTTCCGAACGGGGGTTCTGCCATTGA

Upstream 100 bases:

>100_bases
GGAGGCTTATGCGGCCGCTTCCGGCCAAATGTGATAAAAAGACGGCCCTGTGGGGTTTAGGCTTTTAATCACCTGAATTT
GTTTCATACTTGTTTCAGCC

Downstream 100 bases:

>100_bases
ATCCATGAAAACGGGTTTTGTCTTTGACCTGGACGGGACGCTGGTGGACTCTATTCCCGGTATCGCCCGCGGCCTGAATC
TGGCCTTGAAAGCGCTGGGG

Product: acyl-(acyl-carrier-protein)--UDP-N- acetylglucosamine O-acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase

Number of amino acids: Translated: 259; Mature: 258

Protein sequence:

>259_residues
MPEIHPTAVVHPAAEIADDVKIGPFCVVGEHVKLGPGCVLHSHVVIDGPSSFGSGNEFFPFSVIGLKSQDLKYKGEPTYL
EVGDNNVFRENATINRATDIGGATRIGNNNLFLVSCHAGHDCQIGNHVIFSGFATAAGHVTVGDYAILAGCCAVHQFVSI
GEHAMVGAMARVSQDVLPYTIVEGHPAVTRSVNSIGMQRRGFSEEDLKAVRMCYKKLFVNKKLTVHEALEELRHSGYAEN
ACLRRIIQFVETSERGFCH

Sequences:

>Translated_259_residues
MPEIHPTAVVHPAAEIADDVKIGPFCVVGEHVKLGPGCVLHSHVVIDGPSSFGSGNEFFPFSVIGLKSQDLKYKGEPTYL
EVGDNNVFRENATINRATDIGGATRIGNNNLFLVSCHAGHDCQIGNHVIFSGFATAAGHVTVGDYAILAGCCAVHQFVSI
GEHAMVGAMARVSQDVLPYTIVEGHPAVTRSVNSIGMQRRGFSEEDLKAVRMCYKKLFVNKKLTVHEALEELRHSGYAEN
ACLRRIIQFVETSERGFCH
>Mature_258_residues
PEIHPTAVVHPAAEIADDVKIGPFCVVGEHVKLGPGCVLHSHVVIDGPSSFGSGNEFFPFSVIGLKSQDLKYKGEPTYLE
VGDNNVFRENATINRATDIGGATRIGNNNLFLVSCHAGHDCQIGNHVIFSGFATAAGHVTVGDYAILAGCCAVHQFVSIG
EHAMVGAMARVSQDVLPYTIVEGHPAVTRSVNSIGMQRRGFSEEDLKAVRMCYKKLFVNKKLTVHEALEELRHSGYAENA
CLRRIIQFVETSERGFCH

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily

Homologues:

Organism=Escherichia coli, GI1786378, Length=257, Percent_Identity=45.5252918287938, Blast_Score=220, Evalue=6e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXA_AKKM8 (B2ULY0)

Other databases:

- EMBL:   CP001071
- RefSeq:   YP_001876805.1
- ProteinModelPortal:   B2ULY0
- SMR:   B2ULY0
- GeneID:   6275375
- GenomeReviews:   CP001071_GR
- KEGG:   amu:Amuc_0180
- HOGENOM:   HBG659295
- OMA:   SSTRGIT
- GO:   GO:0005737
- HAMAP:   MF_00387
- InterPro:   IPR001451
- InterPro:   IPR010137
- InterPro:   IPR011004
- PIRSF:   PIRSF000456
- TIGRFAMs:   TIGR01852

Pfam domain/function: PF00132 Hexapep; SSF51161 Trimer_LpxA_like

EC number: =2.3.1.129

Molecular weight: Translated: 28059; Mature: 27928

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
3.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEIHPTAVVHPAAEIADDVKIGPFCVVGEHVKLGPGCVLHSHVVIDGPSSFGSGNEFFP
CCCCCCCEEECCHHHHHCCCCCCCEEEECCCEECCCCEEEEEEEEEECCCCCCCCCCCCC
FSVIGLKSQDLKYKGEPTYLEVGDNNVFRENATINRATDIGGATRIGNNNLFLVSCHAGH
EEEEECCCCCCEECCCCCEEEECCCCEEECCCCCCCHHCCCCCEEECCCCEEEEEECCCC
DCQIGNHVIFSGFATAAGHVTVGDYAILAGCCAVHQFVSIGEHAMVGAMARVSQDVLPYT
CCCCCCEEEEECHHHCCCCEEECHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEE
IVEGHPAVTRSVNSIGMQRRGFSEEDLKAVRMCYKKLFVNKKLTVHEALEELRHSGYAEN
EECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCH
ACLRRIIQFVETSERGFCH
HHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
PEIHPTAVVHPAAEIADDVKIGPFCVVGEHVKLGPGCVLHSHVVIDGPSSFGSGNEFFP
CCCCCCEEECCHHHHHCCCCCCCEEEECCCEECCCCEEEEEEEEEECCCCCCCCCCCCC
FSVIGLKSQDLKYKGEPTYLEVGDNNVFRENATINRATDIGGATRIGNNNLFLVSCHAGH
EEEEECCCCCCEECCCCCEEEECCCCEEECCCCCCCHHCCCCCEEECCCCEEEEEECCCC
DCQIGNHVIFSGFATAAGHVTVGDYAILAGCCAVHQFVSIGEHAMVGAMARVSQDVLPYT
CCCCCCEEEEECHHHCCCCEEECHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEE
IVEGHPAVTRSVNSIGMQRRGFSEEDLKAVRMCYKKLFVNKKLTVHEALEELRHSGYAEN
EECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCH
ACLRRIIQFVETSERGFCH
HHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA