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The map label for this gene is degP [H]

Identifier: 187734689

GI number: 187734689

Start: 221610

End: 222614

Strand: Reverse

Name: degP [H]

Synonym: Amuc_0176

Alternate gene names: 187734689

Gene position: 222614-221610 (Counterclockwise)

Preceding gene: 187734692

Following gene: 187734688

Centisome position: 8.36

GC content: 59.5

Gene sequence:

>1005_bases
ATGACGAGTTTTTGTTGCTTGGTCGTTGGGGGGCTTGTGTCCCTGCTGTCAGGGGGGGCGAGCCTTGCGGGGAATGTTTC
TTCCATGGCGGATTTGCAGAAACATGTGCATGAGGTGGCCTCCAGGGTTACGGCTGCTACGGTGGCTCTGGTTTCCGACG
GGGGAGAGACGGGCAGCGGCGTCATTGTCTCTCCGCGGGGCCTGATTTTGACGGCGGCCCACGTCGTGGGCGGCGATGAA
ATCATGCGTGTGGTCTTTGCCGACGGGCGCGTGGTAAAGGGACGGGTGCTGGGCGCCAACTTCACGCGGGATGCCGCCAT
GGTGCAAATCATGGACGGAGGAAACTATCCTCATGTGGAACTGGGGGAATCCGACGGTCTTCATGTGGGGGATTTTGTGG
TGGCTCTGGGCCATTCCAAGGGATTTGACCCGGAACGCCGCGCGCCCATCCGCATGGGAAGATTGTGCACGGACGGAAAG
CAGCGCTTCCTTATTTCGGAATGTACGCTGATTGGCGGAGATTCCGGCGGTCCCCTCTTTGACCTGTCCGGCAAGTTGGT
TGGCATCCATTCCTCCATTGGCCCTATGTTGAAAATCAACAACCATGTCCCTGTTTCCGTTTTCAGGAGAGACTGGGACA
AACTGCTCTCCGGCAGGCATTGGGGCCAGCTGGGCCTTCATCCCATGGCGGACCCCGAATCTCCTGTGCTCGGGTTTGCC
ATGATGGATGTGCTGGGCGTGGACGGCGTGGTGGTGGAAGACGTTGTGGTGAATTCTCCGGCGGATACCGCCGGCATCCA
GCCGGGGGACGTCATTACCCATATGGACAGCCGGAGCCTGCGTTCCGTGCGGGATATGCTCCGTGAACTGGGCAGGCACC
GTCCGGGGGAAACCGTTCCATTGGTGGTGGTGAGGAAAGGTACGGCTTACAAGGCGGATCTTACATTCGGCAGGCGCGGC
GACCTGATGTCCGGCCTGAAATACCAGGAACAAACTCAAGGATGA

Upstream 100 bases:

>100_bases
GTCGCAATCCATAGACAAAATTCTGCCGTTTTGAACGTTTATACAGTAGGGTATGTCCTATCATTCGATTATCGGTAATT
TCATGATATCACTATTGAGA

Downstream 100 bases:

>100_bases
TGATGAAATATTTATGGGCGGCATTTGCGGCGGCTTCCGCGTATGCCCAGGAAATAGCTTCCCCGCTGCCTCCGGAGCAG
ATGATTGCCCCGGAGGACAA

Product: peptidase S1 and S6 chymotrypsin/Hap

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MTSFCCLVVGGLVSLLSGGASLAGNVSSMADLQKHVHEVASRVTAATVALVSDGGETGSGVIVSPRGLILTAAHVVGGDE
IMRVVFADGRVVKGRVLGANFTRDAAMVQIMDGGNYPHVELGESDGLHVGDFVVALGHSKGFDPERRAPIRMGRLCTDGK
QRFLISECTLIGGDSGGPLFDLSGKLVGIHSSIGPMLKINNHVPVSVFRRDWDKLLSGRHWGQLGLHPMADPESPVLGFA
MMDVLGVDGVVVEDVVVNSPADTAGIQPGDVITHMDSRSLRSVRDMLRELGRHRPGETVPLVVVRKGTAYKADLTFGRRG
DLMSGLKYQEQTQG

Sequences:

>Translated_334_residues
MTSFCCLVVGGLVSLLSGGASLAGNVSSMADLQKHVHEVASRVTAATVALVSDGGETGSGVIVSPRGLILTAAHVVGGDE
IMRVVFADGRVVKGRVLGANFTRDAAMVQIMDGGNYPHVELGESDGLHVGDFVVALGHSKGFDPERRAPIRMGRLCTDGK
QRFLISECTLIGGDSGGPLFDLSGKLVGIHSSIGPMLKINNHVPVSVFRRDWDKLLSGRHWGQLGLHPMADPESPVLGFA
MMDVLGVDGVVVEDVVVNSPADTAGIQPGDVITHMDSRSLRSVRDMLRELGRHRPGETVPLVVVRKGTAYKADLTFGRRG
DLMSGLKYQEQTQG
>Mature_333_residues
TSFCCLVVGGLVSLLSGGASLAGNVSSMADLQKHVHEVASRVTAATVALVSDGGETGSGVIVSPRGLILTAAHVVGGDEI
MRVVFADGRVVKGRVLGANFTRDAAMVQIMDGGNYPHVELGESDGLHVGDFVVALGHSKGFDPERRAPIRMGRLCTDGKQ
RFLISECTLIGGDSGGPLFDLSGKLVGIHSSIGPMLKINNHVPVSVFRRDWDKLLSGRHWGQLGLHPMADPESPVLGFAM
MDVLGVDGVVVEDVVVNSPADTAGIQPGDVITHMDSRSLRSVRDMLRELGRHRPGETVPLVVVRKGTAYKADLTFGRRGD
LMSGLKYQEQTQG

Specific function: Serine protease that is required at high temperature. Involved in the degradation of damaged proteins. Shared specificity with hhoA/degQ [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=285, Percent_Identity=25.2631578947368, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI24308541, Length=255, Percent_Identity=27.843137254902, Blast_Score=79, Evalue=4e-15,
Organism=Escherichia coli, GI1786356, Length=268, Percent_Identity=29.4776119402985, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1789629, Length=273, Percent_Identity=27.4725274725275, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1789630, Length=275, Percent_Identity=28.3636363636364, Blast_Score=92, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24646839, Length=279, Percent_Identity=27.2401433691756, Blast_Score=88, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 35336; Mature: 35205

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSFCCLVVGGLVSLLSGGASLAGNVSSMADLQKHVHEVASRVTAATVALVSDGGETGSG
CCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCC
VIVSPRGLILTAAHVVGGDEIMRVVFADGRVVKGRVLGANFTRDAAMVQIMDGGNYPHVE
EEECCCCEEEEEEHHHCHHHEEEEEEECCEEEEEEEECCCCCCCEEEEEEEECCCCCEEE
LGESDGLHVGDFVVALGHSKGFDPERRAPIRMGRLCTDGKQRFLISECTLIGGDSGGPLF
ECCCCCCCHHHEEEEECCCCCCCCCCCCCHHHCCCCCCCCCEEEEEEEEEEECCCCCCEE
DLSGKLVGIHSSIGPMLKINNHVPVSVFRRDWDKLLSGRHWGQLGLHPMADPESPVLGFA
ECCCCEEEEECCCCCEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHH
MMDVLGVDGVVVEDVVVNSPADTAGIQPGDVITHMDSRSLRSVRDMLRELGRHRPGETVP
HHHHHCCCCEEEEHEEECCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHCCCCCCCEE
LVVVRKGTAYKADLTFGRRGDLMSGLKYQEQTQG
EEEEECCCEEEEEECCCCCCCHHHCCCCHHHCCC
>Mature Secondary Structure 
TSFCCLVVGGLVSLLSGGASLAGNVSSMADLQKHVHEVASRVTAATVALVSDGGETGSG
CHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCC
VIVSPRGLILTAAHVVGGDEIMRVVFADGRVVKGRVLGANFTRDAAMVQIMDGGNYPHVE
EEECCCCEEEEEEHHHCHHHEEEEEEECCEEEEEEEECCCCCCCEEEEEEEECCCCCEEE
LGESDGLHVGDFVVALGHSKGFDPERRAPIRMGRLCTDGKQRFLISECTLIGGDSGGPLF
ECCCCCCCHHHEEEEECCCCCCCCCCCCCHHHCCCCCCCCCEEEEEEEEEEECCCCCCEE
DLSGKLVGIHSSIGPMLKINNHVPVSVFRRDWDKLLSGRHWGQLGLHPMADPESPVLGFA
ECCCCEEEEECCCCCEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHH
MMDVLGVDGVVVEDVVVNSPADTAGIQPGDVITHMDSRSLRSVRDMLRELGRHRPGETVP
HHHHHCCCCEEEEHEEECCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHCCCCCCCEE
LVVVRKGTAYKADLTFGRRGDLMSGLKYQEQTQG
EEEEECCCEEEEEECCCCCCCHHHCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1645840; 11677609 [H]