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The map label for this gene is pgcA [H]

Identifier: 187734668

GI number: 187734668

Start: 190556

End: 192511

Strand: Reverse

Name: pgcA [H]

Synonym: Amuc_0155

Alternate gene names: 187734668

Gene position: 192511-190556 (Counterclockwise)

Preceding gene: 187734669

Following gene: 187734667

Centisome position: 7.23

GC content: 58.44

Gene sequence:

>1956_bases
ATGATGTACTATTCCGCCAGCATGAATATACTGGACGAATCCCTGATGAATGCCGTTAAAGAAGGGAAGCTTTTGGAGTC
TTCCCGGACCAATATCCGCCTTCTGCTGGATGGAACCAAATCCCCCATAGCACGCGAGGCCGTAGAGGAACTGGCTGCCG
CCGGGGAATGGCAGGAGTTGAACGACCGTTTTTACAAAACGCTGGCCTTCGGAACGGGGGGGCTGCGGGGACGCACCATC
GGCAGCATCGTAACCCGGGCCGAGCAGGGGAACGGCGGCGTGAACGGCCGCCCGGAATATCCCTGCGTGGGAACCGCCTG
CATGAACTACTTCAATGTTGGGCGGGCAATGCGGGGCCTGATTATTTATGTGAAAAAGCATGTGGAGGCTACGGACCCGG
GCAGGAAGCCCCGCCTGGTCATCGGACACGACACGCGCCACTTTTCCCGTGACTTTGCCGAATTCTGCGCAAAAATCGGC
ACGGACCTGGGTTGTGACATTTACTTGTTCGACAGTCCTCGCGCCACGCCTGAAATCTCCTTTGCTATCCGGGAACTCCA
TGCGGATTCCGGTGTGGTGCTGACCGCCAGCCACAACCCCTCCCATGACAATGGTTTCAAGGCTTACTTCAATGATGGGG
CCCAGCTTGTGCCTCCGCATGACAAGGCCGTGATCAAGGAGGTCAATTCCCTGACTTCCGAAGAATATGAGCCGTTGCCG
GAAGACCGGCGCGGAACCCTTCATGTGCTGGATTCCTCCTTTGACCGTATTTACATGGACCGCTTGAAAACCGTGCTGCT
CCGTCCGGAGCTTTTCAACAGGGGAGGGGCTAAGATCGTTTATTCCAACCTCCACGGGACGGGCGGCCATATCATCGTGC
CCCTGTTGAAGGAACTGGGCTGCAACGTGCAGACCGTGGCGGCGCAGGATGTGCAGGACGGCCGTTTCCCGACGGTTGCT
TCCCCCAACCCGGAAAATCCGCCGGCTCTGGCCCTGGCCATTGAACAGGCGGATGCTTCTGGGGCGGATATCGTCATCGC
CACGGACCCGGATGCGGACCGCATGGGGGTGGCTGTGCGCGGGGAAGACGGCAAAATGCACCTGCTGACCGGCAACCAGA
TCGGCTCCCTGCTGGCGTGGTACCGCTGCATGAGCATGTCCGAGCTTGGCATCATCAATGACTCCAACCGTTCCCGTGCC
GTGATGGTGAAAACCTTTGTAACGACGGGGCTTCAGGATGCCATCGGCCACCACTTCGGTTATGAAGTGGTCAACGTGCT
CACGGGGTTCAAGTATATTGCCCAGAAACTCGGTAAATATGAACAGGCCATTCCGGCGGAAAAACGGGAAGGCTACCGCA
GGATGAGCGAGGAACAAACGCGTGCCCTGCGCCTGGAATACAGCCGTTACTTTGTCTTCGGCGGGGAGGAAAGCTACGGC
TACCTGGCCCAGGACTTTGTGCGGGACAAGGATGCCAACTCCGCCGCCATCATTTTTGCGGAATTGGCCGCTTATGCGGA
AAGCATCGGCAAGAGCCTTCTAGAACTGCTGCATGAACTCTTTGAGCAGTTCGGTGTGTATTTGGAAATGGGCAAATCAC
TGGTGATGGAAGGCGCAGACGGCGCGGCCAGAATCGCCGCCCTTGCCGCCTCCTATTCCTCCAATCCTCCCACGGAAGTG
GACGGCGTAACCGTCAGCGGCATCCGGGATTTTTCCAGAGGCGACCTGGTGGACGCGGAAGGCGATCCCATTCCGGCGGA
AAAAATGATTTTTGTGGATCTGGCGGACGGCCGCAGTTTTGCGGTGCGCCCCTCCGGAACGGAACCCAAGATTAAATACT
ACCTCTTCGGGCACGGGAAACCGGGCGCCCCTGTGAAGGAAGCATTGACGGAGGTCCAGGCCTCCCTGGACTCCCTGTGG
GCGGCTGTGGAGAAGGATGCCCACAGCCGTTCCTAG

Upstream 100 bases:

>100_bases
AAGGGGACGGGAAGGAAAGCGTTCCCTGCGCCCGCACCGGGATGAATATGGCGTTTTTTTCTCAGGCCATGATGGAAAGA
GCTATTGTCAAACAAGGGGC

Downstream 100 bases:

>100_bases
GGCTAAATATTGCTGATTTCTTTCCCCCGTCTACCATGTAATGTGGACGGGGGAAATTTATTTTCTTGCCAAGGGGGCGG
GAATTCCGCAGTTTATAATT

Product: phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I

Products: NA

Alternate protein names: PGM; Alpha-phosphoglucomutase; Glucose phosphomutase [H]

Number of amino acids: Translated: 651; Mature: 651

Protein sequence:

>651_residues
MMYYSASMNILDESLMNAVKEGKLLESSRTNIRLLLDGTKSPIAREAVEELAAAGEWQELNDRFYKTLAFGTGGLRGRTI
GSIVTRAEQGNGGVNGRPEYPCVGTACMNYFNVGRAMRGLIIYVKKHVEATDPGRKPRLVIGHDTRHFSRDFAEFCAKIG
TDLGCDIYLFDSPRATPEISFAIRELHADSGVVLTASHNPSHDNGFKAYFNDGAQLVPPHDKAVIKEVNSLTSEEYEPLP
EDRRGTLHVLDSSFDRIYMDRLKTVLLRPELFNRGGAKIVYSNLHGTGGHIIVPLLKELGCNVQTVAAQDVQDGRFPTVA
SPNPENPPALALAIEQADASGADIVIATDPDADRMGVAVRGEDGKMHLLTGNQIGSLLAWYRCMSMSELGIINDSNRSRA
VMVKTFVTTGLQDAIGHHFGYEVVNVLTGFKYIAQKLGKYEQAIPAEKREGYRRMSEEQTRALRLEYSRYFVFGGEESYG
YLAQDFVRDKDANSAAIIFAELAAYAESIGKSLLELLHELFEQFGVYLEMGKSLVMEGADGAARIAALAASYSSNPPTEV
DGVTVSGIRDFSRGDLVDAEGDPIPAEKMIFVDLADGRSFAVRPSGTEPKIKYYLFGHGKPGAPVKEALTEVQASLDSLW
AAVEKDAHSRS

Sequences:

>Translated_651_residues
MMYYSASMNILDESLMNAVKEGKLLESSRTNIRLLLDGTKSPIAREAVEELAAAGEWQELNDRFYKTLAFGTGGLRGRTI
GSIVTRAEQGNGGVNGRPEYPCVGTACMNYFNVGRAMRGLIIYVKKHVEATDPGRKPRLVIGHDTRHFSRDFAEFCAKIG
TDLGCDIYLFDSPRATPEISFAIRELHADSGVVLTASHNPSHDNGFKAYFNDGAQLVPPHDKAVIKEVNSLTSEEYEPLP
EDRRGTLHVLDSSFDRIYMDRLKTVLLRPELFNRGGAKIVYSNLHGTGGHIIVPLLKELGCNVQTVAAQDVQDGRFPTVA
SPNPENPPALALAIEQADASGADIVIATDPDADRMGVAVRGEDGKMHLLTGNQIGSLLAWYRCMSMSELGIINDSNRSRA
VMVKTFVTTGLQDAIGHHFGYEVVNVLTGFKYIAQKLGKYEQAIPAEKREGYRRMSEEQTRALRLEYSRYFVFGGEESYG
YLAQDFVRDKDANSAAIIFAELAAYAESIGKSLLELLHELFEQFGVYLEMGKSLVMEGADGAARIAALAASYSSNPPTEV
DGVTVSGIRDFSRGDLVDAEGDPIPAEKMIFVDLADGRSFAVRPSGTEPKIKYYLFGHGKPGAPVKEALTEVQASLDSLW
AAVEKDAHSRS
>Mature_651_residues
MMYYSASMNILDESLMNAVKEGKLLESSRTNIRLLLDGTKSPIAREAVEELAAAGEWQELNDRFYKTLAFGTGGLRGRTI
GSIVTRAEQGNGGVNGRPEYPCVGTACMNYFNVGRAMRGLIIYVKKHVEATDPGRKPRLVIGHDTRHFSRDFAEFCAKIG
TDLGCDIYLFDSPRATPEISFAIRELHADSGVVLTASHNPSHDNGFKAYFNDGAQLVPPHDKAVIKEVNSLTSEEYEPLP
EDRRGTLHVLDSSFDRIYMDRLKTVLLRPELFNRGGAKIVYSNLHGTGGHIIVPLLKELGCNVQTVAAQDVQDGRFPTVA
SPNPENPPALALAIEQADASGADIVIATDPDADRMGVAVRGEDGKMHLLTGNQIGSLLAWYRCMSMSELGIINDSNRSRA
VMVKTFVTTGLQDAIGHHFGYEVVNVLTGFKYIAQKLGKYEQAIPAEKREGYRRMSEEQTRALRLEYSRYFVFGGEESYG
YLAQDFVRDKDANSAAIIFAELAAYAESIGKSLLELLHELFEQFGVYLEMGKSLVMEGADGAARIAALAASYSSNPPTEV
DGVTVSGIRDFSRGDLVDAEGDPIPAEKMIFVDLADGRSFAVRPSGTEPKIKYYLFGHGKPGAPVKEALTEVQASLDSLW
AAVEKDAHSRS

Specific function: Catalyzes the interconversion between glucose-6- phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in B.subtilis membrane, which is also used

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI63055049, Length=638, Percent_Identity=28.5266457680251, Blast_Score=239, Evalue=8e-63,
Organism=Homo sapiens, GI31377548, Length=612, Percent_Identity=27.6143790849673, Blast_Score=208, Evalue=1e-53,
Organism=Escherichia coli, GI1788361, Length=506, Percent_Identity=24.901185770751, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1789566, Length=247, Percent_Identity=29.1497975708502, Blast_Score=67, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71993870, Length=521, Percent_Identity=31.4779270633397, Blast_Score=214, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI71993878, Length=227, Percent_Identity=37.8854625550661, Blast_Score=142, Evalue=8e-34,
Organism=Saccharomyces cerevisiae, GI6323934, Length=624, Percent_Identity=28.525641025641, Blast_Score=206, Evalue=1e-53,
Organism=Drosophila melanogaster, GI20129809, Length=627, Percent_Identity=27.4322169059011, Blast_Score=221, Evalue=1e-57,
Organism=Drosophila melanogaster, GI24651977, Length=514, Percent_Identity=28.2101167315175, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24653722, Length=631, Percent_Identity=26.148969889065, Blast_Score=173, Evalue=3e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 71243; Mature: 71243

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMYYSASMNILDESLMNAVKEGKLLESSRTNIRLLLDGTKSPIAREAVEELAAAGEWQEL
CEEEECHHHHHHHHHHHHHHCCCEECCCCCCEEEEEECCCCCHHHHHHHHHHHCCCHHHH
NDRFYKTLAFGTGGLRGRTIGSIVTRAEQGNGGVNGRPEYPCVGTACMNYFNVGRAMRGL
HHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
IIYVKKHVEATDPGRKPRLVIGHDTRHFSRDFAEFCAKIGTDLGCDIYLFDSPRATPEIS
EEEEEHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHH
FAIRELHADSGVVLTASHNPSHDNGFKAYFNDGAQLVPPHDKAVIKEVNSLTSEEYEPLP
HHHHHHCCCCCEEEEECCCCCCCCCCEEEECCCCEECCCCHHHHHHHHHHHHHHCCCCCC
EDRRGTLHVLDSSFDRIYMDRLKTVLLRPELFNRGGAKIVYSNLHGTGGHIIVPLLKELG
CCCCCEEEEECCCHHHHHHHHHHHHHHCHHHHCCCCCEEEEECCCCCCCEEHHHHHHHHC
CNVQTVAAQDVQDGRFPTVASPNPENPPALALAIEQADASGADIVIATDPDADRMGVAVR
CCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCEEEEEECCCCCCCEEEEE
GEDGKMHLLTGNQIGSLLAWYRCMSMSELGIINDSNRSRAVMVKTFVTTGLQDAIGHHFG
CCCCCEEEEECCHHHHHHHHHHHHCCCCCCEEECCCCCCEEEEHHHHHHCHHHHHHHHHH
YEVVNVLTGFKYIAQKLGKYEQAIPAEKREGYRRMSEEQTRALRLEYSRYFVFGGEESYG
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEEEEEEEEEECCCCCC
YLAQDFVRDKDANSAAIIFAELAAYAESIGKSLLELLHELFEQFGVYLEMGKSLVMEGAD
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEECCCC
GAARIAALAASYSSNPPTEVDGVTVSGIRDFSRGDLVDAEGDPIPAEKMIFVDLADGRSF
CHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCEECCCCCCCCCCCEEEEEECCCCEE
AVRPSGTEPKIKYYLFGHGKPGAPVKEALTEVQASLDSLWAAVEKDAHSRS
EECCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MMYYSASMNILDESLMNAVKEGKLLESSRTNIRLLLDGTKSPIAREAVEELAAAGEWQEL
CEEEECHHHHHHHHHHHHHHCCCEECCCCCCEEEEEECCCCCHHHHHHHHHHHCCCHHHH
NDRFYKTLAFGTGGLRGRTIGSIVTRAEQGNGGVNGRPEYPCVGTACMNYFNVGRAMRGL
HHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
IIYVKKHVEATDPGRKPRLVIGHDTRHFSRDFAEFCAKIGTDLGCDIYLFDSPRATPEIS
EEEEEHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHH
FAIRELHADSGVVLTASHNPSHDNGFKAYFNDGAQLVPPHDKAVIKEVNSLTSEEYEPLP
HHHHHHCCCCCEEEEECCCCCCCCCCEEEECCCCEECCCCHHHHHHHHHHHHHHCCCCCC
EDRRGTLHVLDSSFDRIYMDRLKTVLLRPELFNRGGAKIVYSNLHGTGGHIIVPLLKELG
CCCCCEEEEECCCHHHHHHHHHHHHHHCHHHHCCCCCEEEEECCCCCCCEEHHHHHHHHC
CNVQTVAAQDVQDGRFPTVASPNPENPPALALAIEQADASGADIVIATDPDADRMGVAVR
CCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCEEEEEECCCCCCCEEEEE
GEDGKMHLLTGNQIGSLLAWYRCMSMSELGIINDSNRSRAVMVKTFVTTGLQDAIGHHFG
CCCCCEEEEECCHHHHHHHHHHHHCCCCCCEEECCCCCCEEEEHHHHHHCHHHHHHHHHH
YEVVNVLTGFKYIAQKLGKYEQAIPAEKREGYRRMSEEQTRALRLEYSRYFVFGGEESYG
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEEEEEEEEEECCCCCC
YLAQDFVRDKDANSAAIIFAELAAYAESIGKSLLELLHELFEQFGVYLEMGKSLVMEGAD
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEECCCC
GAARIAALAASYSSNPPTEVDGVTVSGIRDFSRGDLVDAEGDPIPAEKMIFVDLADGRSF
CHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCEECCCCCCCCCCCEEEEEECCCCEE
AVRPSGTEPKIKYYLFGHGKPGAPVKEALTEVQASLDSLWAAVEKDAHSRS
EECCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 2127799 [H]