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The map label for this gene is parC [H]

Identifier: 187734641

GI number: 187734641

Start: 158875

End: 160968

Strand: Direct

Name: parC [H]

Synonym: Amuc_0128

Alternate gene names: 187734641

Gene position: 158875-160968 (Clockwise)

Preceding gene: 187734640

Following gene: 187734642

Centisome position: 5.96

GC content: 54.68

Gene sequence:

>2094_bases
ATGTATGCCGACTACTTTCTGGATTACGCCTCGTATGTCATTCTGGAACGGGCCGTACCCAAGATCAATGACGGGTTTAA
ACCTGTGCAGCGCCGTATTCTGCACGCCATGGACCGCCTGGACGACGGGCGTTATAATAAAGTGGCTAATATCGTGGGAG
ACACGATGAAATTCCATCCGCACGGCGACCGTTCCATTGCAGACGCGCTGGTGGGGCTGGGACAAAAAGGGCTGCTTATC
GACACGCAGGGGAACTGGGGCAATATTCTGACAGGCGACCCCGCAGCGGCTTCCCGCTATATTGAAGCCCGCTTTACCTC
CTTTGCGCGTGATGTAGTATTCAGCCCCAAGGTCACGGAATGGCAGCTCTCCTATGACGGCAGGAACAAGGAACCGGTCA
GCCTTCCCGTCAAATTTCCCCTGCTTCTCGCTCAGGGAGCGGAAGGCATCGCCGTGGGGCTTTCCAGTAAAATTCTTCCC
CACAACTTCAATGAGTTGATTGAAGCCTCCATCGCCTACTTGCGCGGCCAGCCCTTCCAGCTTCTGCCGGACTTTCCGAC
CGGAGGCGTGATGGATGCCACCAACTACCGTGACGGAGAACGAGGAACGGGCCGCGTCCGCATCAGGGCGCGCATCCTCA
CGGAATCGAAGAAACTTCTCCGCATCACGGAAATCCCGTTCGGCGTCACCACGGAAATCTTAATTGATTCCATTGTCTCC
GCTGCGGAAAAGGGAAAAATTAAAATCGCCCGCATTGAGGACAATACGGCCCAGCATGTGGACATCCTGGTCCATCTCCC
GGCCGGAGCGGATCCGGAGCAGACGAGGAAAGCCCTGTTTGCCTTCTCCGCCTGTGAAGTCAGCATCTCCCCGAATGCCT
GCGTCATTGTGGAGGAAAAACCCAGGTTCATGTGTGTTAGCGACATCCTGCGCTACAATACGGACTCCACCAAGGAAATC
CTGCGCCAGGAGCAGGAAATCCGACTCAAGGAACTGAACGAGGCGTGGCACCAGGCCAGCCTGGAAAAAATATTCATTGA
AAACCGCATCTACCTCTCCATAGAAGATTCCGAAACGTGGGAAGAAGTGCTCGGCACCATTGACCGGGAATTGCAGCCGT
TTGCATCCCGGCTGCGCGCCCCCATTACCAGGGACGACCTGGTAAGGCTGACGGAAATCAAAATCAAGCGGATTTCCAAA
TTTGACGCTTTCAAGGCGGACCAGCACATCCGCCAGCTTGAAGAGGACATCGAACAAACGCAGAAGAACCTCAACCAGCT
TACCAAATTCACTATCCGCTGGTTTGAAGCCCTGCGTAAAAAATACGGCGCCGCCTATCCGCGGAAAACGGAAATTTCCT
CCTTCGGCTCCGTAAACCGCGCGCAGGTGGCTGTTGCCAATGAAACATTGTATATTGATGACGAAGGCTTTGCCGGTTAC
GGTGTCAAGAAGGGAAACCCTGTCTGCAAATGCTCCACGCTGGATGACGTGTTGATCATTGACAATGCAGGCGTGCTCAA
AATCGTGCGGATTCAGGACAAATTTTTCGCTGGTAAAAATCCCCTTTATATTTCCGTCATCAAAAAAGGGGACGACCCCG
TGTTCAACCTGATTTACCGGGACGGAAAAGACGGCCCCGTGTACGCCAAGCGTTTCCGCATAGGAGGGTTCACCAGGGAC
AAGGAATATCCGCTTACCCGAGGCGCAAAGGGAACGCGCATCTTCCACTTCTCCGTGCATGAAACGGAGGAAAACAGTTC
CCAGATAAGCGTAAACGTTTATCTGAAAGCCGTTCTGAAACTCCGTAACCTGATCAGGCCCTTCCATTTCGCGGACCTGA
GAATCAAAAACCGCGGTGCCCAGGGAAATATCATTACCAGGCATCCTGTGGAACGCGTCTCCCGCATCATGCCTCCGGCC
AAGTCCGGAAATGAGGAAACGGAAGGGCCAACAACCGCTCCTTCCGCAACAGCGGAACGGACGGAAGGCTCACCCGCCCC
CTCCGCGGAAACGCTGCATCCTGAAACAGCCCCACATTTGGAGGAACCGCCTGCCGATCCGCCGCTGGAACAGGGCTCCC
TGTTTGACTCCTGA

Upstream 100 bases:

>100_bases
TTACGGAGATCGCGCTTGCCCCCCCGGAACAATTCCTTTAATATCCGCCGTCGTGACTCAACCCGCCCACATTGCTCCCG
CGAGTCAGTCTGTGGAAGGC

Downstream 100 bases:

>100_bases
AACGTTTTCAATCTCTTAAAATGGAAATATCCATGCCTGACTATCCATTTTCGGCTTGCCACAACGGGCCATCTTCTGTA
GATATGGGCCACCTCATTAC

Product: DNA topoisomerase (ATP-hydrolyzing)

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 697; Mature: 697

Protein sequence:

>697_residues
MYADYFLDYASYVILERAVPKINDGFKPVQRRILHAMDRLDDGRYNKVANIVGDTMKFHPHGDRSIADALVGLGQKGLLI
DTQGNWGNILTGDPAAASRYIEARFTSFARDVVFSPKVTEWQLSYDGRNKEPVSLPVKFPLLLAQGAEGIAVGLSSKILP
HNFNELIEASIAYLRGQPFQLLPDFPTGGVMDATNYRDGERGTGRVRIRARILTESKKLLRITEIPFGVTTEILIDSIVS
AAEKGKIKIARIEDNTAQHVDILVHLPAGADPEQTRKALFAFSACEVSISPNACVIVEEKPRFMCVSDILRYNTDSTKEI
LRQEQEIRLKELNEAWHQASLEKIFIENRIYLSIEDSETWEEVLGTIDRELQPFASRLRAPITRDDLVRLTEIKIKRISK
FDAFKADQHIRQLEEDIEQTQKNLNQLTKFTIRWFEALRKKYGAAYPRKTEISSFGSVNRAQVAVANETLYIDDEGFAGY
GVKKGNPVCKCSTLDDVLIIDNAGVLKIVRIQDKFFAGKNPLYISVIKKGDDPVFNLIYRDGKDGPVYAKRFRIGGFTRD
KEYPLTRGAKGTRIFHFSVHETEENSSQISVNVYLKAVLKLRNLIRPFHFADLRIKNRGAQGNIITRHPVERVSRIMPPA
KSGNEETEGPTTAPSATAERTEGSPAPSAETLHPETAPHLEEPPADPPLEQGSLFDS

Sequences:

>Translated_697_residues
MYADYFLDYASYVILERAVPKINDGFKPVQRRILHAMDRLDDGRYNKVANIVGDTMKFHPHGDRSIADALVGLGQKGLLI
DTQGNWGNILTGDPAAASRYIEARFTSFARDVVFSPKVTEWQLSYDGRNKEPVSLPVKFPLLLAQGAEGIAVGLSSKILP
HNFNELIEASIAYLRGQPFQLLPDFPTGGVMDATNYRDGERGTGRVRIRARILTESKKLLRITEIPFGVTTEILIDSIVS
AAEKGKIKIARIEDNTAQHVDILVHLPAGADPEQTRKALFAFSACEVSISPNACVIVEEKPRFMCVSDILRYNTDSTKEI
LRQEQEIRLKELNEAWHQASLEKIFIENRIYLSIEDSETWEEVLGTIDRELQPFASRLRAPITRDDLVRLTEIKIKRISK
FDAFKADQHIRQLEEDIEQTQKNLNQLTKFTIRWFEALRKKYGAAYPRKTEISSFGSVNRAQVAVANETLYIDDEGFAGY
GVKKGNPVCKCSTLDDVLIIDNAGVLKIVRIQDKFFAGKNPLYISVIKKGDDPVFNLIYRDGKDGPVYAKRFRIGGFTRD
KEYPLTRGAKGTRIFHFSVHETEENSSQISVNVYLKAVLKLRNLIRPFHFADLRIKNRGAQGNIITRHPVERVSRIMPPA
KSGNEETEGPTTAPSATAERTEGSPAPSAETLHPETAPHLEEPPADPPLEQGSLFDS
>Mature_697_residues
MYADYFLDYASYVILERAVPKINDGFKPVQRRILHAMDRLDDGRYNKVANIVGDTMKFHPHGDRSIADALVGLGQKGLLI
DTQGNWGNILTGDPAAASRYIEARFTSFARDVVFSPKVTEWQLSYDGRNKEPVSLPVKFPLLLAQGAEGIAVGLSSKILP
HNFNELIEASIAYLRGQPFQLLPDFPTGGVMDATNYRDGERGTGRVRIRARILTESKKLLRITEIPFGVTTEILIDSIVS
AAEKGKIKIARIEDNTAQHVDILVHLPAGADPEQTRKALFAFSACEVSISPNACVIVEEKPRFMCVSDILRYNTDSTKEI
LRQEQEIRLKELNEAWHQASLEKIFIENRIYLSIEDSETWEEVLGTIDRELQPFASRLRAPITRDDLVRLTEIKIKRISK
FDAFKADQHIRQLEEDIEQTQKNLNQLTKFTIRWFEALRKKYGAAYPRKTEISSFGSVNRAQVAVANETLYIDDEGFAGY
GVKKGNPVCKCSTLDDVLIIDNAGVLKIVRIQDKFFAGKNPLYISVIKKGDDPVFNLIYRDGKDGPVYAKRFRIGGFTRD
KEYPLTRGAKGTRIFHFSVHETEENSSQISVNVYLKAVLKLRNLIRPFHFADLRIKNRGAQGNIITRHPVERVSRIMPPA
KSGNEETEGPTTAPSATAERTEGSPAPSAETLHPETAPHLEEPPADPPLEQGSLFDS

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=319, Percent_Identity=26.0188087774295, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI19913406, Length=333, Percent_Identity=26.4264264264264, Blast_Score=84, Evalue=4e-16,
Organism=Escherichia coli, GI1788562, Length=360, Percent_Identity=31.3888888888889, Blast_Score=176, Evalue=4e-45,
Organism=Escherichia coli, GI1789396, Length=472, Percent_Identity=29.0254237288136, Blast_Score=160, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17535065, Length=278, Percent_Identity=25.1798561151079, Blast_Score=69, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=331, Percent_Identity=27.7945619335347, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17136538, Length=284, Percent_Identity=28.5211267605634, Blast_Score=84, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760 [H]

Pfam domain/function: PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 78278; Mature: 78278

Theoretical pI: Translated: 7.69; Mature: 7.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYADYFLDYASYVILERAVPKINDGFKPVQRRILHAMDRLDDGRYNKVANIVGDTMKFHP
CCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEECC
HGDRSIADALVGLGQKGLLIDTQGNWGNILTGDPAAASRYIEARFTSFARDVVFSPKVTE
CCCHHHHHHHHCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEECCCCEE
WQLSYDGRNKEPVSLPVKFPLLLAQGAEGIAVGLSSKILPHNFNELIEASIAYLRGQPFQ
EEEEECCCCCCCCEECEEEEEEEECCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCCCCE
LLPDFPTGGVMDATNYRDGERGTGRVRIRARILTESKKLLRITEIPFGVTTEILIDSIVS
ECCCCCCCCCEECCCCCCCCCCCCEEEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHH
AAEKGKIKIARIEDNTAQHVDILVHLPAGADPEQTRKALFAFSACEVSISPNACVIVEEK
HHHCCCEEEEEECCCCCCEEEEEEECCCCCCHHHHHHHHHEEEEEEEEECCCEEEEEECC
PRFMCVSDILRYNTDSTKEILRQEQEIRLKELNEAWHQASLEKIFIENRIYLSIEDSETW
CCEEEHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCEEEEEECCCHHH
EEVLGTIDRELQPFASRLRAPITRDDLVRLTEIKIKRISKFDAFKADQHIRQLEEDIEQT
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKNLNQLTKFTIRWFEALRKKYGAAYPRKTEISSFGSVNRAQVAVANETLYIDDEGFAGY
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCEEEEEECCEEEEECCCCCCC
GVKKGNPVCKCSTLDDVLIIDNAGVLKIVRIQDKFFAGKNPLYISVIKKGDDPVFNLIYR
CCCCCCCEEEECCCCCEEEEECCCEEEEEEEEHHHHCCCCCEEEEEEECCCCCEEEEEEE
DGKDGPVYAKRFRIGGFTRDKEYPLTRGAKGTRIFHFSVHETEENSSQISVNVYLKAVLK
CCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCEEEEHHHHHHHHH
LRNLIRPFHFADLRIKNRGAQGNIITRHPVERVSRIMPPAKSGNEETEGPTTAPSATAER
HHHHHCCCEEEEEEEECCCCCCCEEECCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
TEGSPAPSAETLHPETAPHLEEPPADPPLEQGSLFDS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MYADYFLDYASYVILERAVPKINDGFKPVQRRILHAMDRLDDGRYNKVANIVGDTMKFHP
CCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEECC
HGDRSIADALVGLGQKGLLIDTQGNWGNILTGDPAAASRYIEARFTSFARDVVFSPKVTE
CCCHHHHHHHHCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEECCCCEE
WQLSYDGRNKEPVSLPVKFPLLLAQGAEGIAVGLSSKILPHNFNELIEASIAYLRGQPFQ
EEEEECCCCCCCCEECEEEEEEEECCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCCCCE
LLPDFPTGGVMDATNYRDGERGTGRVRIRARILTESKKLLRITEIPFGVTTEILIDSIVS
ECCCCCCCCCEECCCCCCCCCCCCEEEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHH
AAEKGKIKIARIEDNTAQHVDILVHLPAGADPEQTRKALFAFSACEVSISPNACVIVEEK
HHHCCCEEEEEECCCCCCEEEEEEECCCCCCHHHHHHHHHEEEEEEEEECCCEEEEEECC
PRFMCVSDILRYNTDSTKEILRQEQEIRLKELNEAWHQASLEKIFIENRIYLSIEDSETW
CCEEEHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCEEEEEECCCHHH
EEVLGTIDRELQPFASRLRAPITRDDLVRLTEIKIKRISKFDAFKADQHIRQLEEDIEQT
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKNLNQLTKFTIRWFEALRKKYGAAYPRKTEISSFGSVNRAQVAVANETLYIDDEGFAGY
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCEEEEEECCEEEEECCCCCCC
GVKKGNPVCKCSTLDDVLIIDNAGVLKIVRIQDKFFAGKNPLYISVIKKGDDPVFNLIYR
CCCCCCCEEEECCCCCEEEEECCCEEEEEEEEHHHHCCCCCEEEEEEECCCCCEEEEEEE
DGKDGPVYAKRFRIGGFTRDKEYPLTRGAKGTRIFHFSVHETEENSSQISVNVYLKAVLK
CCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCEEEEHHHHHHHHH
LRNLIRPFHFADLRIKNRGAQGNIITRHPVERVSRIMPPAKSGNEETEGPTTAPSATAER
HHHHHCCCEEEEEEEECCCCCCCEEECCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
TEGSPAPSAETLHPETAPHLEEPPADPPLEQGSLFDS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9403685 [H]