Click here to switch to the map view.

The map label for this gene is aslA [H]

Identifier: 187734635

GI number: 187734635

Start: 149378

End: 150958

Strand: Direct

Name: aslA [H]

Synonym: Amuc_0121

Alternate gene names: 187734635

Gene position: 149378-150958 (Clockwise)

Preceding gene: 187734634

Following gene: 187734636

Centisome position: 5.61

GC content: 57.56

Gene sequence:

>1581_bases
ATGAATAAATCCGCATTACACCTGATGCTTGCCATGGCGGCGGCAGCGGCCTGCCCGGCCGCAGTCACGCCAACGGTCAA
GCCACCCAAGGCCATCGTCATGATTTACGCTGACGACCTCGGCTATGGAGACGTAGGCTGCTATGGAGCCAAGGGAATTC
CCACCCCCGCCATCGACAAGCTTGCCGAGCAGGGCTGCCGCTTCACGGACGCCTATTCCACCACATCCGTCTGCACCCCT
TCCCGCTATGCCCTGTTCACAGGGGAATATCCGTGGCGCAAGGAAGGCACGGGCATCCTGCCGGGAGATGCCGCCCTCAT
TATCGATACCAAGAAGCCCACCCTGCCCAAGATGCTCCAATCCCACGGCTACAAAACCTACATGATAGGCAAATGGCACC
TGGGCCTGGGGGAAAAGGGGAAGAAGATTGACTGGAACAAACATATCTCCCCCAGCCCGAACGAAATCGGATTTGACGAG
AGCTTTATCTTCGCCGCTACGGGCGACCGCGTTCCCTGCGTGATTCTGGAAAACGGCAATGTCCGCAACCTGGACCCGAA
CGACCCCATTGAAGTATCCTACAAGCACAACTTCCCCGGGCTTCCCAATGGCAAGGATAATAAGGACCAGCTCAAACTCA
TGTGGAGCCACGGACACAACCAGGCTATTATCAATGGGATCGGACGCATCGGGTTCATGAAGGGCGGCAGAAGCGCCTTG
TGGAAGGATGAGGAAAACGCCGATATCATTACGGATAAGGCCATTGAATACATTCAAAAAAGCGCCAAAGCCAAGGAACC
GTTTTTCCTGATGTTCGCCACGCATGACATCCACGTGCCGCGCTGCCCGGAAAAACGCTTTGTGGGCAAGAGCCGGCACG
GCGTGCGCGGTGACGTGACCGTGGAACTGGATGACTGTGTGCGCCGCATTACAGAGGCTCTGCAACAGGCCGGTCTGGAA
AAAGACGCCCTGGTGATCTTCTCCAGCGACAACGGTCCCGTGCTGGATGACGGCTACAGGGATTTCGCCGTCCGGGACAA
CGCCACCCATTCCCCCGCCGGCCCCTTCCGCGCAGGCAAATACAGCATTCTGGAAGGAGGTTCCCGCATTCCGTTTATCG
TCAAATGGCCCGGCGTGATCAAACCCGGAACCACGAGCAAAGCCCTGCTCAATCAAATGGATTTGGGGGCCTCCCTGGAA
CAGCTGCTGGCCCCCGGCAAGGCCAATTCCTTCCGCGACTCTGAAAACGTGATGCCCGCCCTTCTGGGCAAATCCGCCAA
GGGGCGTGACTACCATGTCATCAACAGCACCGGCAAGGCATTGGCGATTCGCCACGGCAAATGGAAATTCATTCCCGCCG
GCGTGGCCATTCGCGACGGCATCAACGGAGCCTCCGCAAAAATGAGCAAGTCCCCGGAAGGAGGAAGCCTCTTTGACCTG
GAAAAAGACCCGAAGGAACTTGACAACGTAGCCTCCCAGCATCCGGACATTTGCGAACAGATGAAAGCCAAGCTTGAGGA
AATCCGCCAGAGGCCCGAAACCAAGGCTGACCAGGAGGACCTGCTTCCCTTGGACGACTAA

Upstream 100 bases:

>100_bases
AACAGCCTCCGGACCCCCCCGAAGGTTCGGCCCACGCTTAAACAACGGCATCCTTCCGACCATCTTTTCCGGAAAATTAT
AATCACACACACCTGACAAC

Downstream 100 bases:

>100_bases
CATCCATTCGGGCCAGATCATGAGAGAATCCGCCACATGCTCCCAATGCGGCCACGGGTACACCTACCCGGCCGGACTGG
ACGCCAAAACCGGCATGCGC

Product: sulfatase

Products: NA

Alternate protein names: AS; Aryl-sulfate sulphohydrolase [H]

Number of amino acids: Translated: 526; Mature: 526

Protein sequence:

>526_residues
MNKSALHLMLAMAAAAACPAAVTPTVKPPKAIVMIYADDLGYGDVGCYGAKGIPTPAIDKLAEQGCRFTDAYSTTSVCTP
SRYALFTGEYPWRKEGTGILPGDAALIIDTKKPTLPKMLQSHGYKTYMIGKWHLGLGEKGKKIDWNKHISPSPNEIGFDE
SFIFAATGDRVPCVILENGNVRNLDPNDPIEVSYKHNFPGLPNGKDNKDQLKLMWSHGHNQAIINGIGRIGFMKGGRSAL
WKDEENADIITDKAIEYIQKSAKAKEPFFLMFATHDIHVPRCPEKRFVGKSRHGVRGDVTVELDDCVRRITEALQQAGLE
KDALVIFSSDNGPVLDDGYRDFAVRDNATHSPAGPFRAGKYSILEGGSRIPFIVKWPGVIKPGTTSKALLNQMDLGASLE
QLLAPGKANSFRDSENVMPALLGKSAKGRDYHVINSTGKALAIRHGKWKFIPAGVAIRDGINGASAKMSKSPEGGSLFDL
EKDPKELDNVASQHPDICEQMKAKLEEIRQRPETKADQEDLLPLDD

Sequences:

>Translated_526_residues
MNKSALHLMLAMAAAAACPAAVTPTVKPPKAIVMIYADDLGYGDVGCYGAKGIPTPAIDKLAEQGCRFTDAYSTTSVCTP
SRYALFTGEYPWRKEGTGILPGDAALIIDTKKPTLPKMLQSHGYKTYMIGKWHLGLGEKGKKIDWNKHISPSPNEIGFDE
SFIFAATGDRVPCVILENGNVRNLDPNDPIEVSYKHNFPGLPNGKDNKDQLKLMWSHGHNQAIINGIGRIGFMKGGRSAL
WKDEENADIITDKAIEYIQKSAKAKEPFFLMFATHDIHVPRCPEKRFVGKSRHGVRGDVTVELDDCVRRITEALQQAGLE
KDALVIFSSDNGPVLDDGYRDFAVRDNATHSPAGPFRAGKYSILEGGSRIPFIVKWPGVIKPGTTSKALLNQMDLGASLE
QLLAPGKANSFRDSENVMPALLGKSAKGRDYHVINSTGKALAIRHGKWKFIPAGVAIRDGINGASAKMSKSPEGGSLFDL
EKDPKELDNVASQHPDICEQMKAKLEEIRQRPETKADQEDLLPLDD
>Mature_526_residues
MNKSALHLMLAMAAAAACPAAVTPTVKPPKAIVMIYADDLGYGDVGCYGAKGIPTPAIDKLAEQGCRFTDAYSTTSVCTP
SRYALFTGEYPWRKEGTGILPGDAALIIDTKKPTLPKMLQSHGYKTYMIGKWHLGLGEKGKKIDWNKHISPSPNEIGFDE
SFIFAATGDRVPCVILENGNVRNLDPNDPIEVSYKHNFPGLPNGKDNKDQLKLMWSHGHNQAIINGIGRIGFMKGGRSAL
WKDEENADIITDKAIEYIQKSAKAKEPFFLMFATHDIHVPRCPEKRFVGKSRHGVRGDVTVELDDCVRRITEALQQAGLE
KDALVIFSSDNGPVLDDGYRDFAVRDNATHSPAGPFRAGKYSILEGGSRIPFIVKWPGVIKPGTTSKALLNQMDLGASLE
QLLAPGKANSFRDSENVMPALLGKSAKGRDYHVINSTGKALAIRHGKWKFIPAGVAIRDGINGASAKMSKSPEGGSLFDL
EKDPKELDNVASQHPDICEQMKAKLEEIRQRPETKADQEDLLPLDD

Specific function: Unknown

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI146229331, Length=490, Percent_Identity=31.0204081632653, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI146229329, Length=490, Percent_Identity=31.0204081632653, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI6005990, Length=490, Percent_Identity=31.0204081632653, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI146229324, Length=490, Percent_Identity=31.0204081632653, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI53831991, Length=558, Percent_Identity=28.3154121863799, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI58743319, Length=526, Percent_Identity=29.0874524714829, Blast_Score=148, Evalue=9e-36,
Organism=Homo sapiens, GI4503899, Length=538, Percent_Identity=26.9516728624535, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI71852584, Length=507, Percent_Identity=28.2051282051282, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI157266309, Length=559, Percent_Identity=25.9391771019678, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI31742482, Length=550, Percent_Identity=26.3636363636364, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI59797060, Length=526, Percent_Identity=26.8060836501901, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI38569405, Length=535, Percent_Identity=26.3551401869159, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI45430057, Length=513, Percent_Identity=26.1208576998051, Blast_Score=122, Evalue=8e-28,
Organism=Homo sapiens, GI38569407, Length=397, Percent_Identity=28.9672544080605, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI146229327, Length=398, Percent_Identity=27.3869346733668, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI71852586, Length=309, Percent_Identity=28.8025889967638, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI109389362, Length=539, Percent_Identity=23.9332096474954, Blast_Score=104, Evalue=3e-22,
Organism=Escherichia coli, GI1790233, Length=520, Percent_Identity=27.8846153846154, Blast_Score=152, Evalue=7e-38,
Organism=Escherichia coli, GI1790112, Length=258, Percent_Identity=25.5813953488372, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI87081924, Length=274, Percent_Identity=26.2773722627737, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI115533416, Length=508, Percent_Identity=24.6062992125984, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI115533418, Length=494, Percent_Identity=24.2914979757085, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17559078, Length=301, Percent_Identity=28.5714285714286, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI281363223, Length=567, Percent_Identity=23.1040564373898, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI281366397, Length=472, Percent_Identity=26.0593220338983, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI281366395, Length=472, Percent_Identity=26.0593220338983, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24666163, Length=472, Percent_Identity=26.0593220338983, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24666175, Length=596, Percent_Identity=22.8187919463087, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24666109, Length=449, Percent_Identity=22.9398663697105, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.1 [H]

Molecular weight: Translated: 57459; Mature: 57459

Theoretical pI: Translated: 8.03; Mature: 8.03

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00523 SULFATASE_1 ; PS00149 SULFATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKSALHLMLAMAAAAACPAAVTPTVKPPKAIVMIYADDLGYGDVGCYGAKGIPTPAIDK
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHH
LAEQGCRFTDAYSTTSVCTPSRYALFTGEYPWRKEGTGILPGDAALIIDTKKPTLPKMLQ
HHHCCCCEECCCCCCCCCCCCCEEEEECCCCCCCCCCEECCCCEEEEEECCCCCHHHHHH
SHGYKTYMIGKWHLGLGEKGKKIDWNKHISPSPNEIGFDESFIFAATGDRVPCVILENGN
HCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCEEEECCCC
VRNLDPNDPIEVSYKHNFPGLPNGKDNKDQLKLMWSHGHNQAIINGIGRIGFMKGGRSAL
CCCCCCCCCEEEEEECCCCCCCCCCCCHHHEEEEECCCCCHHHHHHHCCEEEECCCCCCC
WKDEENADIITDKAIEYIQKSAKAKEPFFLMFATHDIHVPRCPEKRFVGKSRHGVRGDVT
CCCCCCCCEEHHHHHHHHHHHHCCCCCEEEEEEECCEECCCCCHHHHCCCCCCCCCCEEE
VELDDCVRRITEALQQAGLEKDALVIFSSDNGPVLDDGYRDFAVRDNATHSPAGPFRAGK
EEHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCEEECCCCCCCCCCCCCCCC
YSILEGGSRIPFIVKWPGVIKPGTTSKALLNQMDLGASLEQLLAPGKANSFRDSENVMPA
CCEECCCCCCCEEEECCCCCCCCCCHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCHHH
LLGKSAKGRDYHVINSTGKALAIRHGKWKFIPAGVAIRDGINGASAKMSKSPEGGSLFDL
HHCCCCCCCEEEEECCCCCEEEEECCCEEEEECCEEEECCCCCCCCCCCCCCCCCCEECC
EKDPKELDNVASQHPDICEQMKAKLEEIRQRPETKADQEDLLPLDD
CCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCC
>Mature Secondary Structure
MNKSALHLMLAMAAAAACPAAVTPTVKPPKAIVMIYADDLGYGDVGCYGAKGIPTPAIDK
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHH
LAEQGCRFTDAYSTTSVCTPSRYALFTGEYPWRKEGTGILPGDAALIIDTKKPTLPKMLQ
HHHCCCCEECCCCCCCCCCCCCEEEEECCCCCCCCCCEECCCCEEEEEECCCCCHHHHHH
SHGYKTYMIGKWHLGLGEKGKKIDWNKHISPSPNEIGFDESFIFAATGDRVPCVILENGN
HCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCEEEECCCC
VRNLDPNDPIEVSYKHNFPGLPNGKDNKDQLKLMWSHGHNQAIINGIGRIGFMKGGRSAL
CCCCCCCCCEEEEEECCCCCCCCCCCCHHHEEEEECCCCCHHHHHHHCCEEEECCCCCCC
WKDEENADIITDKAIEYIQKSAKAKEPFFLMFATHDIHVPRCPEKRFVGKSRHGVRGDVT
CCCCCCCCEEHHHHHHHHHHHHCCCCCEEEEEEECCEECCCCCHHHHCCCCCCCCCCEEE
VELDDCVRRITEALQQAGLEKDALVIFSSDNGPVLDDGYRDFAVRDNATHSPAGPFRAGK
EEHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCEEECCCCCCCCCCCCCCCC
YSILEGGSRIPFIVKWPGVIKPGTTSKALLNQMDLGASLEQLLAPGKANSFRDSENVMPA
CCEECCCCCCCEEEECCCCCCCCCCHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCHHH
LLGKSAKGRDYHVINSTGKALAIRHGKWKFIPAGVAIRDGINGASAKMSKSPEGGSLFDL
HHCCCCCCCEEEEECCCCCEEEEECCCEEEEECCEEEECCCCCCCCCCCCCCCCCCEECC
EKDPKELDNVASQHPDICEQMKAKLEEIRQRPETKADQEDLLPLDD
CCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1379743; 9278503 [H]