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The map label for this gene is hemC [H]

Identifier: 187734604

GI number: 187734604

Start: 117979

End: 118956

Strand: Reverse

Name: hemC [H]

Synonym: Amuc_0090

Alternate gene names: 187734604

Gene position: 118956-117979 (Counterclockwise)

Preceding gene: 187734605

Following gene: 187734601

Centisome position: 4.47

GC content: 60.12

Gene sequence:

>978_bases
ATGACCAGTAAAAATACCCTCATCATCGGCACCCGCGGGAGCGCCCTGGCCCTGGCCCAGGCGGATATGGTCCGTGCTGC
CCTTTCCCTCCGTTATCCGGAACTGGACGTGCGCTGTGAAATCATCCATACTATTGGGGACCGCCGCACGGATGTTCCTC
TGGCGGATGTGGCCCGCGTTTCCGGCATGGTGGACAAGGGGATCTTCATTAAGGAACTGGAGACCGCCCTCCGGGATGGC
CGCATTGACGTAGCGGTGCACAGCCTCAAAGATGTGCCGAGCGAGCTTGCAGCCGGCTTCACGCTGGCCGCCGTCTTGCC
CCGTGCTGCCGTGGAGGATGTGCTTATCACGAAAGAACCGGACTGGAACGGTTCTGGAACGCTGGCTACCGGAAGCGTGC
GCCGACGCCTGATGGCGCGCACGTACTGGGGTTCCGGCCTGCGGTTTGAAAACCTGCGGGGGAATGTGCCTACGCGTTTG
GGAAAGCTGGTGGAACATCCCGGCTGGGATGCCGTGATTCTGGCCAGGGCCGGTTTGGAACGCCTGGGGCTGTACGCGCC
GGAAACCCTTGTGGAAGGAAGAAAACTTTACATGCGTCCCTTGCCGGTGGAAGTTTTTATTCCTGCTGTGGGGCAGGGCA
TCGTTGGAATGGAATGCCGTTCCTCGGACAGGGAGACGGCGGAAATGCTGGAAGGCATCAATGATCCGGAGTCTTTTGCC
TGTGCGCTGGCGGAACGGGCTTTCCTGGTACGTCTGGGTGCGAACTGTTCCACGCCCGTGGGTGTTTACGCCCATCCGGA
TGGAGAGGAACTGGTTCTGCGGGCTGCGTATTACGTTCCGGGCAGGGAAGAGCCTTTTGCCGTTGTGATTCGCGGAGACC
GGAAAGCCCCTGAAGCGCTGGGCCTTCGGGCTTTTGAAGAATTGGGCCTGAGTGGATGGCGGAAGACTTCCTCGTGTTCC
GGATGCGGAGAAAAATAA

Upstream 100 bases:

>100_bases
CTGGCGGATGAAGCCAAGCGCAGCCGGAAGCAGGAGGTTTCCCGGTGCGAGGCCATCATCCGGGACAGCATCTCCAGATA
TTTTCCGGATTCCGCTCTTT

Downstream 100 bases:

>100_bases
AAAGGCTCCGGACCGGATCCGGAGCCTGAATCAGGCGAAAAACTCGCGGGCATTAATGTTTTTCCTTGGAGCCTGAGCTT
TTATCGCTCATAAACTGCCC

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MTSKNTLIIGTRGSALALAQADMVRAALSLRYPELDVRCEIIHTIGDRRTDVPLADVARVSGMVDKGIFIKELETALRDG
RIDVAVHSLKDVPSELAAGFTLAAVLPRAAVEDVLITKEPDWNGSGTLATGSVRRRLMARTYWGSGLRFENLRGNVPTRL
GKLVEHPGWDAVILARAGLERLGLYAPETLVEGRKLYMRPLPVEVFIPAVGQGIVGMECRSSDRETAEMLEGINDPESFA
CALAERAFLVRLGANCSTPVGVYAHPDGEELVLRAAYYVPGREEPFAVVIRGDRKAPEALGLRAFEELGLSGWRKTSSCS
GCGEK

Sequences:

>Translated_325_residues
MTSKNTLIIGTRGSALALAQADMVRAALSLRYPELDVRCEIIHTIGDRRTDVPLADVARVSGMVDKGIFIKELETALRDG
RIDVAVHSLKDVPSELAAGFTLAAVLPRAAVEDVLITKEPDWNGSGTLATGSVRRRLMARTYWGSGLRFENLRGNVPTRL
GKLVEHPGWDAVILARAGLERLGLYAPETLVEGRKLYMRPLPVEVFIPAVGQGIVGMECRSSDRETAEMLEGINDPESFA
CALAERAFLVRLGANCSTPVGVYAHPDGEELVLRAAYYVPGREEPFAVVIRGDRKAPEALGLRAFEELGLSGWRKTSSCS
GCGEK
>Mature_324_residues
TSKNTLIIGTRGSALALAQADMVRAALSLRYPELDVRCEIIHTIGDRRTDVPLADVARVSGMVDKGIFIKELETALRDGR
IDVAVHSLKDVPSELAAGFTLAAVLPRAAVEDVLITKEPDWNGSGTLATGSVRRRLMARTYWGSGLRFENLRGNVPTRLG
KLVEHPGWDAVILARAGLERLGLYAPETLVEGRKLYMRPLPVEVFIPAVGQGIVGMECRSSDRETAEMLEGINDPESFAC
ALAERAFLVRLGANCSTPVGVYAHPDGEELVLRAAYYVPGREEPFAVVIRGDRKAPEALGLRAFEELGLSGWRKTSSCSG
CGEK

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=321, Percent_Identity=33.3333333333333, Blast_Score=145, Evalue=4e-35,
Organism=Homo sapiens, GI66933009, Length=321, Percent_Identity=33.3333333333333, Blast_Score=145, Evalue=4e-35,
Organism=Escherichia coli, GI48994974, Length=318, Percent_Identity=39.622641509434, Blast_Score=163, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6319996, Length=284, Percent_Identity=33.4507042253521, Blast_Score=130, Evalue=3e-31,
Organism=Drosophila melanogaster, GI20130425, Length=281, Percent_Identity=33.8078291814947, Blast_Score=134, Evalue=6e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 35241; Mature: 35110

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSKNTLIIGTRGSALALAQADMVRAALSLRYPELDVRCEIIHTIGDRRTDVPLADVARV
CCCCCEEEEECCCCEEEHHHHHHHHHHHHHCCCCCCCEEEEEEHHCCCCCCCCHHHHHHH
SGMVDKGIFIKELETALRDGRIDVAVHSLKDVPSELAAGFTLAAVLPRAAVEDVLITKEP
HHHHHCCCHHHHHHHHHHCCCEEEEHHHHHHCHHHHHCCHHHHHHHHHHHHHHEEEECCC
DWNGSGTLATGSVRRRLMARTYWGSGLRFENLRGNVPTRLGKLVEHPGWDAVILARAGLE
CCCCCCCEEHHHHHHHHHHHHHCCCCCEECCCCCCCHHHHHHHHHCCCCCEEEEEHHCHH
RLGLYAPETLVEGRKLYMRPLPVEVFIPAVGQGIVGMECRSSDRETAEMLEGINDPESFA
HHCCCCCHHHHCCCCEEECCCCCEEEECCCCCCEEEECCCCCCHHHHHHHHCCCCHHHHH
CALAERAFLVRLGANCSTPVGVYAHPDGEELVLRAAYYVPGREEPFAVVIRGDRKAPEAL
HHHHHHHEEEEECCCCCCCEEEEECCCCHHEEEEEEEECCCCCCCEEEEEECCCCCCHHH
GLRAFEELGLSGWRKTSSCSGCGEK
HHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TSKNTLIIGTRGSALALAQADMVRAALSLRYPELDVRCEIIHTIGDRRTDVPLADVARV
CCCCEEEEECCCCEEEHHHHHHHHHHHHHCCCCCCCEEEEEEHHCCCCCCCCHHHHHHH
SGMVDKGIFIKELETALRDGRIDVAVHSLKDVPSELAAGFTLAAVLPRAAVEDVLITKEP
HHHHHCCCHHHHHHHHHHCCCEEEEHHHHHHCHHHHHCCHHHHHHHHHHHHHHEEEECCC
DWNGSGTLATGSVRRRLMARTYWGSGLRFENLRGNVPTRLGKLVEHPGWDAVILARAGLE
CCCCCCCEEHHHHHHHHHHHHHCCCCCEECCCCCCCHHHHHHHHHCCCCCEEEEEHHCHH
RLGLYAPETLVEGRKLYMRPLPVEVFIPAVGQGIVGMECRSSDRETAEMLEGINDPESFA
HHCCCCCHHHHCCCCEEECCCCCEEEECCCCCCEEEECCCCCCHHHHHHHHCCCCHHHHH
CALAERAFLVRLGANCSTPVGVYAHPDGEELVLRAAYYVPGREEPFAVVIRGDRKAPEAL
HHHHHHHEEEEECCCCCCCEEEEECCCCHHEEEEEEEECCCCCCCEEEEEECCCCCCHHH
GLRAFEELGLSGWRKTSSCSGCGEK
HHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA