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The map label for this gene is prkC [H]

Identifier: 187734592

GI number: 187734592

Start: 101329

End: 103947

Strand: Direct

Name: prkC [H]

Synonym: Amuc_0078

Alternate gene names: 187734592

Gene position: 101329-103947 (Clockwise)

Preceding gene: 187734591

Following gene: 187734593

Centisome position: 3.8

GC content: 59.53

Gene sequence:

>2619_bases
ATGCCCGGCGGCAACCTGCCGACGCTGCCCGTCAAGCGGGTGGTGCGTCCCACTCCCTCCATTCCGGACCATGAAGTTGT
ACGCCAGATAGGGAGCGGCGCGTACGGAGAAGTATGGCTGGCAAAATCCCTGACCGGGGCGTGGCGCGCCGTCAAAATCG
TATGGAGGGAGGATTTTGAAGACGAGCGCTCTTTCAACCGGGAATTTGAGGGCATTCTCCAGTATGAACCCATCGCCCGC
AACCATCCGGGGCTGGTCCATATCCTGCATGTAGGGAGGCATGACCAGGATTCCCCGTTTTATTATTACGTCATGGAACT
GGGCGACGACGCCCGCACCGGAGTTCATATTACACCGGACGAATATATTCCGCGCACGCTCCAGACGGACAAGAAGTTTT
CCGGCAACAAGCCTCTTCCCCTGGATTACTGCCTGGAGGTAGGCAGCCAGCTGGCCCACGCCCTGCTGTACCTGCACAGC
AAGAACCTGACGCACCGGGACATCAAGCCGGCGAACGTCATCTTTGTCAACGGGCGCCCCAAACTGGCGGACATAGGCCT
GGTGGCCCATCTGGACCAGCGCAGCTTTGTAGGGACGGAGGGATTCATCCCCCCCGACGGCCCCGGCACCCGGCGGGCGG
ACGTTTACGCGCTGGCCAAGGTTCTGTATGAAATCAGCACGGGAAAGGACCGCATGGATTTTCCCGAACTCCCGGATGAC
TTGCCGGAAGGCACCGTGCGCAAGAAATGGCAGGCCTTCAACACCATCATTTGCCAGGCGGCGGAACCCCGCATTGAAGA
ATGCTCCATTGATTCCGCAGAGGAGCTGGCGGAAAAAATAGACGCCCTCCGGGGGTATGAAGTGCCTTCCCGTTTCCGTC
TTCAGAAGAAAAAGAAACGCCGCAAACTCAGACGGGCCCTCCAACTTCTGGCTGCAGCCGCCGCCGGAGCCCTGACTGCC
TACTGGGGGGCTTTATGGCTCAACAACAGCCAGCATCCGCCGGAGGAACCTGCCTCGGATATTCATCCGGATATCCACTC
ATCCGCTCCGGAAGAAGAATCCCGGACCGGATACGTGCTGGTGACCAGCTCCCCGGCGGGAGCGTCCGTGTATGATGCGG
ACGGCAACTATCTGGATGAAACTCCCTACGGCCCCATTGAACTGCCTTCCGGCTCCCCGGTAGCCTATACCATCAAGAAA
TCGGGGTTTGCGGACAAGGAAGAGGCGGGAACCGTCAAAGGAGGGTCCACGCTGGCCCTGGGCGGCGTGCTGAAAGAGTA
CCATCCCCCTACGGACAGCCAGCCCTGGAAGGATACGGAGGGTGTTACGTACCTGCCCGCAGAAACGCGCCATGTGGCGC
AAGGCCCCCTTACCGCCGCCCTGTTCAACAAATTTCTGAAGGAGGACCGCCAGAAAGGGAACTTCCAGATGAAAAGGGAA
CAGACGGAACCGGGGCATCCGGAGAAGGATGTGGCCCTGCTCACGCAGGACGGCATCACGGCCTACCTGGCGTGGCTGAA
CAAGAAATGCGAGCGGGAGGGGCTGCTGGGCAAGGAATTTTCCATCAATGCGGATCCGCTTCCGCAGGCTTCCGGCAGCA
CGGAAAACCACAATGCCTACGTCCTGAACGTCACCCGCGTGTTCCAGGTGCCCATTACCGTCACCACCAATCCGCCGGGA
GCCAGCGTTTTTTTCAATAACAGGCTCATCGGGCGTACCCCCATTGAAGAATACGTCAACCAGGTTCCCTACGTCATTGA
AATCAAACTGCCGGGGCACGCCACCATGCGTCGCAGGGGGCTGGATCCGCAGGACTTATACCTTTCCCTGCAGTTGGAAC
CGGACAAGTCTGTCGTTTTTGGCTCGCCCTGGACCAACAGCCTGGGCATCAAACTGGTCCCTGTGGGTGGGAATGCTCTG
GTCATGACCCACGAAGTGCGCGTAAAGGACTTTCAGGAATTCCTGAAAGCTACCGGAAGGAAAGCTCCGGCCCGGCCCGG
CTTTCCCCAGGGAGAAGACCACCCGGTGGTGAATGTCAGCAGGCAGGATGCGCGCGCCTTCGCCAGATGGCTTACCAGCA
AAGAGCGGGCCCTGGGCCTGATTGATCAGCACGACTCCTACCGTCTTCCCAAGGATGAGGAATGGAGTTCCTGGGTGCGT
CTGACGGATGAACAGGGAGCCTCCCCCTATGAAAAGACGCTGCCTCATGAAAACTCCCGGGAAGCCTTCCCGTGGGGGTA
TTCATGGCCGCCGCCTGATAAAACGGGAAATTTTGCGGACCAGTCCGCCCTGATTTACCTGCCGTCCTCCCGCGTTATCG
TAGGATATAACGACGGACAGCCGTATACGGCCCCCGTAAAAACCTTTCCGCCCAACCACCTGGGCCTGTACGACCTGGAA
GGAAACGTCATGGAATGGGTAGACGATTCCTACGGGGGGCCGGAATCCCTCCCCATCCGCAACTACGGCGTCGCCCGCGG
AGGCAGCTACCTGTCCTTCCGCCCCAAACAGCTCACCACTTCCATCCGCACTCCCCTGCCGGAAAATACGAGGGATAACG
CGCTGGGCTTCCGTCTTATCCTGTCTTCCGAACGCCCCGCCATTCCAACAGCTCCCTGA

Upstream 100 bases:

>100_bases
AACAGCTGGACAAGGCGATTGAGGCCTTCTGCAAGGTAGGTAAAAACCTGGGCGTTATTTCCTGATTCCCGCGCTTTCCA
TGGCTTCGGACGCATCACCC

Downstream 100 bases:

>100_bases
CGCCGTATCTGCGGCAGCGGTTTTCCCCGCTCTTTCCCCCTCTGAAACACACCGCCCCCCAAGGGGGAAAACCCTGAGGC
TTGAGAGAGCTTCCGGCTCT

Product: serine/threonine protein kinase

Products: NA

Alternate protein names: Ser/Thr-protein kinase PrkC [H]

Number of amino acids: Translated: 872; Mature: 871

Protein sequence:

>872_residues
MPGGNLPTLPVKRVVRPTPSIPDHEVVRQIGSGAYGEVWLAKSLTGAWRAVKIVWREDFEDERSFNREFEGILQYEPIAR
NHPGLVHILHVGRHDQDSPFYYYVMELGDDARTGVHITPDEYIPRTLQTDKKFSGNKPLPLDYCLEVGSQLAHALLYLHS
KNLTHRDIKPANVIFVNGRPKLADIGLVAHLDQRSFVGTEGFIPPDGPGTRRADVYALAKVLYEISTGKDRMDFPELPDD
LPEGTVRKKWQAFNTIICQAAEPRIEECSIDSAEELAEKIDALRGYEVPSRFRLQKKKKRRKLRRALQLLAAAAAGALTA
YWGALWLNNSQHPPEEPASDIHPDIHSSAPEEESRTGYVLVTSSPAGASVYDADGNYLDETPYGPIELPSGSPVAYTIKK
SGFADKEEAGTVKGGSTLALGGVLKEYHPPTDSQPWKDTEGVTYLPAETRHVAQGPLTAALFNKFLKEDRQKGNFQMKRE
QTEPGHPEKDVALLTQDGITAYLAWLNKKCEREGLLGKEFSINADPLPQASGSTENHNAYVLNVTRVFQVPITVTTNPPG
ASVFFNNRLIGRTPIEEYVNQVPYVIEIKLPGHATMRRRGLDPQDLYLSLQLEPDKSVVFGSPWTNSLGIKLVPVGGNAL
VMTHEVRVKDFQEFLKATGRKAPARPGFPQGEDHPVVNVSRQDARAFARWLTSKERALGLIDQHDSYRLPKDEEWSSWVR
LTDEQGASPYEKTLPHENSREAFPWGYSWPPPDKTGNFADQSALIYLPSSRVIVGYNDGQPYTAPVKTFPPNHLGLYDLE
GNVMEWVDDSYGGPESLPIRNYGVARGGSYLSFRPKQLTTSIRTPLPENTRDNALGFRLILSSERPAIPTAP

Sequences:

>Translated_872_residues
MPGGNLPTLPVKRVVRPTPSIPDHEVVRQIGSGAYGEVWLAKSLTGAWRAVKIVWREDFEDERSFNREFEGILQYEPIAR
NHPGLVHILHVGRHDQDSPFYYYVMELGDDARTGVHITPDEYIPRTLQTDKKFSGNKPLPLDYCLEVGSQLAHALLYLHS
KNLTHRDIKPANVIFVNGRPKLADIGLVAHLDQRSFVGTEGFIPPDGPGTRRADVYALAKVLYEISTGKDRMDFPELPDD
LPEGTVRKKWQAFNTIICQAAEPRIEECSIDSAEELAEKIDALRGYEVPSRFRLQKKKKRRKLRRALQLLAAAAAGALTA
YWGALWLNNSQHPPEEPASDIHPDIHSSAPEEESRTGYVLVTSSPAGASVYDADGNYLDETPYGPIELPSGSPVAYTIKK
SGFADKEEAGTVKGGSTLALGGVLKEYHPPTDSQPWKDTEGVTYLPAETRHVAQGPLTAALFNKFLKEDRQKGNFQMKRE
QTEPGHPEKDVALLTQDGITAYLAWLNKKCEREGLLGKEFSINADPLPQASGSTENHNAYVLNVTRVFQVPITVTTNPPG
ASVFFNNRLIGRTPIEEYVNQVPYVIEIKLPGHATMRRRGLDPQDLYLSLQLEPDKSVVFGSPWTNSLGIKLVPVGGNAL
VMTHEVRVKDFQEFLKATGRKAPARPGFPQGEDHPVVNVSRQDARAFARWLTSKERALGLIDQHDSYRLPKDEEWSSWVR
LTDEQGASPYEKTLPHENSREAFPWGYSWPPPDKTGNFADQSALIYLPSSRVIVGYNDGQPYTAPVKTFPPNHLGLYDLE
GNVMEWVDDSYGGPESLPIRNYGVARGGSYLSFRPKQLTTSIRTPLPENTRDNALGFRLILSSERPAIPTAP
>Mature_871_residues
PGGNLPTLPVKRVVRPTPSIPDHEVVRQIGSGAYGEVWLAKSLTGAWRAVKIVWREDFEDERSFNREFEGILQYEPIARN
HPGLVHILHVGRHDQDSPFYYYVMELGDDARTGVHITPDEYIPRTLQTDKKFSGNKPLPLDYCLEVGSQLAHALLYLHSK
NLTHRDIKPANVIFVNGRPKLADIGLVAHLDQRSFVGTEGFIPPDGPGTRRADVYALAKVLYEISTGKDRMDFPELPDDL
PEGTVRKKWQAFNTIICQAAEPRIEECSIDSAEELAEKIDALRGYEVPSRFRLQKKKKRRKLRRALQLLAAAAAGALTAY
WGALWLNNSQHPPEEPASDIHPDIHSSAPEEESRTGYVLVTSSPAGASVYDADGNYLDETPYGPIELPSGSPVAYTIKKS
GFADKEEAGTVKGGSTLALGGVLKEYHPPTDSQPWKDTEGVTYLPAETRHVAQGPLTAALFNKFLKEDRQKGNFQMKREQ
TEPGHPEKDVALLTQDGITAYLAWLNKKCEREGLLGKEFSINADPLPQASGSTENHNAYVLNVTRVFQVPITVTTNPPGA
SVFFNNRLIGRTPIEEYVNQVPYVIEIKLPGHATMRRRGLDPQDLYLSLQLEPDKSVVFGSPWTNSLGIKLVPVGGNALV
MTHEVRVKDFQEFLKATGRKAPARPGFPQGEDHPVVNVSRQDARAFARWLTSKERALGLIDQHDSYRLPKDEEWSSWVRL
TDEQGASPYEKTLPHENSREAFPWGYSWPPPDKTGNFADQSALIYLPSSRVIVGYNDGQPYTAPVKTFPPNHLGLYDLEG
NVMEWVDDSYGGPESLPIRNYGVARGGSYLSFRPKQLTTSIRTPLPENTRDNALGFRLILSSERPAIPTAP

Specific function: Protein kinase that is responsible for triggering spore germination in response to muropeptides, signaling bacteria to exit dormancy. PrkC is thus a germination receptor that binds peptidoglycan fragments containing m-Dpm (meso-diaminopimelate), which act

COG id: COG0515

COG function: function code RTKL; Serine/threonine protein kinase

Gene ontology:

Cell location: Spore core membrane; Single-pass type II membrane protein. Note=Is associated with the inner membrane of the spore [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain [H]

Homologues:

Organism=Homo sapiens, GI38327572, Length=222, Percent_Identity=27.9279279279279, Blast_Score=71, Evalue=5e-12,
Organism=Homo sapiens, GI38327570, Length=222, Percent_Identity=27.9279279279279, Blast_Score=71, Evalue=5e-12,
Organism=Homo sapiens, GI38327568, Length=222, Percent_Identity=27.9279279279279, Blast_Score=71, Evalue=5e-12,
Organism=Homo sapiens, GI38327566, Length=222, Percent_Identity=27.9279279279279, Blast_Score=71, Evalue=5e-12,
Organism=Homo sapiens, GI38327564, Length=222, Percent_Identity=27.9279279279279, Blast_Score=71, Evalue=5e-12,
Organism=Homo sapiens, GI38327562, Length=222, Percent_Identity=27.9279279279279, Blast_Score=71, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17505246, Length=222, Percent_Identity=28.3783783783784, Blast_Score=76, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011009
- InterPro:   IPR005543
- InterPro:   IPR000719
- InterPro:   IPR017441
- InterPro:   IPR017442
- InterPro:   IPR008271
- InterPro:   IPR002290 [H]

Pfam domain/function: PF03793 PASTA; PF00069 Pkinase [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 97120; Mature: 96989

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00107 PROTEIN_KINASE_ATP ; PS00108 PROTEIN_KINASE_ST ; PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGGNLPTLPVKRVVRPTPSIPDHEVVRQIGSGAYGEVWLAKSLTGAWRAVKIVWREDFE
CCCCCCCCCCHHHHHCCCCCCCCHHHHHHHCCCCCCEEEEHHHHCCCCCEEEEEECCCCC
DERSFNREFEGILQYEPIARNHPGLVHILHVGRHDQDSPFYYYVMELGDDARTGVHITPD
HHHHHHHHHHHHEEECCCCCCCCCEEEEEEECCCCCCCCEEEEEEEECCCCCCCEEECCH
EYIPRTLQTDKKFSGNKPLPLDYCLEVGSQLAHALLYLHSKNLTHRDIKPANVIFVNGRP
HHCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCC
KLADIGLVAHLDQRSFVGTEGFIPPDGPGTRRADVYALAKVLYEISTGKDRMDFPELPDD
CEECCCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
LPEGTVRKKWQAFNTIICQAAEPRIEECSIDSAEELAEKIDALRGYEVPSRFRLQKKKKR
CCCCHHHHHHHHHHHHEECCCCCCHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHH
RKLRRALQLLAAAAAGALTAYWGALWLNNSQHPPEEPASDIHPDIHSSAPEEESRTGYVL
HHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCHHHCCCCCCCCCCCCCCCCCEEE
VTSSPAGASVYDADGNYLDETPYGPIELPSGSPVAYTIKKSGFADKEEAGTVKGGSTLAL
EECCCCCCEEEECCCCCCCCCCCCCEECCCCCCEEEEEECCCCCCCHHCCCCCCCCEEEH
GGVLKEYHPPTDSQPWKDTEGVTYLPAETRHVAQGPLTAALFNKFLKEDRQKGNFQMKRE
HHHHHHCCCCCCCCCCCCCCCEEECCCCCCHHCCCCHHHHHHHHHHHHHHHCCCEEEEEC
QTEPGHPEKDVALLTQDGITAYLAWLNKKCEREGLLGKEFSINADPLPQASGSTENHNAY
CCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCEE
VLNVTRVFQVPITVTTNPPGASVFFNNRLIGRTPIEEYVNQVPYVIEIKLPGHATMRRRG
EEEEEEEEEEEEEEECCCCCCEEEECCEECCCCCHHHHHHHCCEEEEEEECCCHHHHHCC
LDPQDLYLSLQLEPDKSVVFGSPWTNSLGIKLVPVGGNALVMTHEVRVKDFQEFLKATGR
CCHHHEEEEEEECCCCCEEECCCCCCCCCEEEEEECCCEEEEEEEHHHHHHHHHHHHCCC
KAPARPGFPQGEDHPVVNVSRQDARAFARWLTSKERALGLIDQHDSYRLPKDEEWSSWVR
CCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHCCEECCCCCCCCCCCCCCHHEE
LTDEQGASPYEKTLPHENSREAFPWGYSWPPPDKTGNFADQSALIYLPSSRVIVGYNDGQ
ECCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEECCCC
PYTAPVKTFPPNHLGLYDLEGNVMEWVDDSYGGPESLPIRNYGVARGGSYLSFRPKQLTT
CEECCCCCCCCCCCEEEECCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECHHHHHH
SIRTPLPENTRDNALGFRLILSSERPAIPTAP
HHCCCCCCCCCCCCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
PGGNLPTLPVKRVVRPTPSIPDHEVVRQIGSGAYGEVWLAKSLTGAWRAVKIVWREDFE
CCCCCCCCCHHHHHCCCCCCCCHHHHHHHCCCCCCEEEEHHHHCCCCCEEEEEECCCCC
DERSFNREFEGILQYEPIARNHPGLVHILHVGRHDQDSPFYYYVMELGDDARTGVHITPD
HHHHHHHHHHHHEEECCCCCCCCCEEEEEEECCCCCCCCEEEEEEEECCCCCCCEEECCH
EYIPRTLQTDKKFSGNKPLPLDYCLEVGSQLAHALLYLHSKNLTHRDIKPANVIFVNGRP
HHCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCC
KLADIGLVAHLDQRSFVGTEGFIPPDGPGTRRADVYALAKVLYEISTGKDRMDFPELPDD
CEECCCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
LPEGTVRKKWQAFNTIICQAAEPRIEECSIDSAEELAEKIDALRGYEVPSRFRLQKKKKR
CCCCHHHHHHHHHHHHEECCCCCCHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHH
RKLRRALQLLAAAAAGALTAYWGALWLNNSQHPPEEPASDIHPDIHSSAPEEESRTGYVL
HHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCHHHCCCCCCCCCCCCCCCCCEEE
VTSSPAGASVYDADGNYLDETPYGPIELPSGSPVAYTIKKSGFADKEEAGTVKGGSTLAL
EECCCCCCEEEECCCCCCCCCCCCCEECCCCCCEEEEEECCCCCCCHHCCCCCCCCEEEH
GGVLKEYHPPTDSQPWKDTEGVTYLPAETRHVAQGPLTAALFNKFLKEDRQKGNFQMKRE
HHHHHHCCCCCCCCCCCCCCCEEECCCCCCHHCCCCHHHHHHHHHHHHHHHCCCEEEEEC
QTEPGHPEKDVALLTQDGITAYLAWLNKKCEREGLLGKEFSINADPLPQASGSTENHNAY
CCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCEE
VLNVTRVFQVPITVTTNPPGASVFFNNRLIGRTPIEEYVNQVPYVIEIKLPGHATMRRRG
EEEEEEEEEEEEEEECCCCCCEEEECCEECCCCCHHHHHHHCCEEEEEEECCCHHHHHCC
LDPQDLYLSLQLEPDKSVVFGSPWTNSLGIKLVPVGGNALVMTHEVRVKDFQEFLKATGR
CCHHHEEEEEEECCCCCEEECCCCCCCCCEEEEEECCCEEEEEEEHHHHHHHHHHHHCCC
KAPARPGFPQGEDHPVVNVSRQDARAFARWLTSKERALGLIDQHDSYRLPKDEEWSSWVR
CCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHCCEECCCCCCCCCCCCCCHHEE
LTDEQGASPYEKTLPHENSREAFPWGYSWPPPDKTGNFADQSALIYLPSSRVIVGYNDGQ
ECCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEECCCC
PYTAPVKTFPPNHLGLYDLEGNVMEWVDDSYGGPESLPIRNYGVARGGSYLSFRPKQLTT
CEECCCCCCCCCCCEEEECCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECHHHHHH
SIRTPLPENTRDNALGFRLILSSERPAIPTAP
HHCCCCCCCCCCCCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]