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The map label for this gene is pgsA [H]

Identifier: 187734528

GI number: 187734528

Start: 16460

End: 17068

Strand: Direct

Name: pgsA [H]

Synonym: Amuc_0012

Alternate gene names: 187734528

Gene position: 16460-17068 (Clockwise)

Preceding gene: 187734527

Following gene: 187734529

Centisome position: 0.62

GC content: 60.59

Gene sequence:

>609_bases
ATGCTGAACCTGCCCAATGCCATTACCCTGACGCGTATTGCCCTGGTAGTCGTCTTTACGGCAGCAGTCAGCGTCGCGGA
CCGGTATTCCTGGGGATACCTGGCTGCGCTGGTCACGTTCATTCTGGCTGCCTGCACGGACTGGCTGGACGGCTACCTGG
CCCGCCGCCTGAATCAGGTCACCACCTTCGGCAAGCTGATTGACCCCCTGGCGGATAAAATAGCCGTCTCCGCTGCCTTC
ATTTACCTGACGGGCGAAGGGCTCTGCCCCGCCTGGATTACCATTCTCATCATCAGCAGGGAATTCTTGGTCACCGGACT
GCGCCAGATTGCGCAGGATCATGGCGTCATCATCCCTGCGGGAACGTCCGGCAAATGGAAAACCGCCTTCCAGCTGGCCT
TCTGCATCGCCTGCCTGCTGGCCCTGACATGGACGCATACGCCGGAATACCTGCCTTCCATCACGGACCGGCTGGCCGCG
CTCTGCCTGTGGCACGGTTCCGGCGCTTCCAACTTGCTGTACCAGGTTACACTGTGGGGTTCCGTCATCCTGACCGTTTA
TTCCGGAGCCGTTTACTGCGCGGGCGCCCGCAAATTCCTGCAGCGTTGA

Upstream 100 bases:

>100_bases
TCCCTTCGCTTTTTTCCGTGCGCCGTTTTCCGGAAATTTCATTCCCGAATCCAGCAAAAAAGCTTGCTACGGGCAGCCAT
CTGTCCCCTAATAAACCGGT

Downstream 100 bases:

>100_bases
AAATTGCCTTTTCCCCCATCCGTCCGGAGACAGAGGCAACATTGTTCATTCTCCGGGACATTTCATATACCGGGAGCATG
ATTTCATTCCGCCGGGTTCC

Product: CDP-diacylglycerol/glycerol-3-phosphate 3-phosphatidyltransferase

Products: NA

Alternate protein names: Phosphatidylglycerophosphate synthase; PGP synthase [H]

Number of amino acids: Translated: 202; Mature: 202

Protein sequence:

>202_residues
MLNLPNAITLTRIALVVVFTAAVSVADRYSWGYLAALVTFILAACTDWLDGYLARRLNQVTTFGKLIDPLADKIAVSAAF
IYLTGEGLCPAWITILIISREFLVTGLRQIAQDHGVIIPAGTSGKWKTAFQLAFCIACLLALTWTHTPEYLPSITDRLAA
LCLWHGSGASNLLYQVTLWGSVILTVYSGAVYCAGARKFLQR

Sequences:

>Translated_202_residues
MLNLPNAITLTRIALVVVFTAAVSVADRYSWGYLAALVTFILAACTDWLDGYLARRLNQVTTFGKLIDPLADKIAVSAAF
IYLTGEGLCPAWITILIISREFLVTGLRQIAQDHGVIIPAGTSGKWKTAFQLAFCIACLLALTWTHTPEYLPSITDRLAA
LCLWHGSGASNLLYQVTLWGSVILTVYSGAVYCAGARKFLQR
>Mature_202_residues
MLNLPNAITLTRIALVVVFTAAVSVADRYSWGYLAALVTFILAACTDWLDGYLARRLNQVTTFGKLIDPLADKIAVSAAF
IYLTGEGLCPAWITILIISREFLVTGLRQIAQDHGVIIPAGTSGKWKTAFQLAFCIACLLALTWTHTPEYLPSITDRLAA
LCLWHGSGASNLLYQVTLWGSVILTVYSGAVYCAGARKFLQR

Specific function: This protein catalyzes the committed step to the synthesis of the acidic phospholipids [H]

COG id: COG0558

COG function: function code I; Phosphatidylglycerophosphate synthase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CDP-alcohol phosphatidyltransferase class-I family [H]

Homologues:

Organism=Homo sapiens, GI188536108, Length=102, Percent_Identity=39.2156862745098, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI10092647, Length=102, Percent_Identity=39.2156862745098, Blast_Score=65, Evalue=3e-11,
Organism=Escherichia coli, GI1788220, Length=136, Percent_Identity=36.7647058823529, Blast_Score=80, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000462
- InterPro:   IPR004570 [H]

Pfam domain/function: PF01066 CDP-OH_P_transf [H]

EC number: =2.7.8.5 [H]

Molecular weight: Translated: 22015; Mature: 22015

Theoretical pI: Translated: 8.58; Mature: 8.58

Prosite motif: PS00379 CDP_ALCOHOL_P_TRANSF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNLPNAITLTRIALVVVFTAAVSVADRYSWGYLAALVTFILAACTDWLDGYLARRLNQV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TTFGKLIDPLADKIAVSAAFIYLTGEGLCPAWITILIISREFLVTGLRQIAQDHGVIIPA
HHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEC
GTSGKWKTAFQLAFCIACLLALTWTHTPEYLPSITDRLAALCLWHGSGASNLLYQVTLWG
CCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
SVILTVYSGAVYCAGARKFLQR
HHHHHHHCCHHHHHHHHHHHCC
>Mature Secondary Structure
MLNLPNAITLTRIALVVVFTAAVSVADRYSWGYLAALVTFILAACTDWLDGYLARRLNQV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TTFGKLIDPLADKIAVSAAFIYLTGEGLCPAWITILIISREFLVTGLRQIAQDHGVIIPA
HHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEC
GTSGKWKTAFQLAFCIACLLALTWTHTPEYLPSITDRLAALCLWHGSGASNLLYQVTLWG
CCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
SVILTVYSGAVYCAGARKFLQR
HHHHHHHCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7750561; 9384377 [H]