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The map label for this gene is hemE [H]

Identifier: 186477769

GI number: 186477769

Start: 3395980

End: 3397116

Strand: Reverse

Name: hemE [H]

Synonym: Bphy_3023

Alternate gene names: 186477769

Gene position: 3397116-3395980 (Counterclockwise)

Preceding gene: 186477771

Following gene: 186477768

Centisome position: 97.64

GC content: 63.32

Gene sequence:

>1137_bases
ATGCGCTTTTGCCTTCCTTCAGTCGCGAGCAACGTGGCCCACAACCTCCTCAACGACACCTTTCTACGCGCGTTGATGCG
CGAGCCGACCGAGTACACGCCGATCTGGCTGATGCGCCAGGCGGGACGTTATCTGCCGGAATACAACGCGACGCGTAGCC
GCGCGGGGAGCTTCCTCGGGCTGGCGAAGAACCCCGACTACGCGACGGAAGTTACGCTGCAGCCGCTCGAGCGCTATCCG
CTCGACGCCGCCATTCTTTTTTCCGACATTCTGACCGTCCCCGACGCAATGGGCCTGGGTCTGGACTTCCAGGTCGGCGA
AGGGCCGAAGTTTGCGCACCCGGTACGCACTGAAGAAGATGTCGCGCGCCTCACCGTGCCGGACATCGATGCCACTCTGC
GCTATGTGACGGATGCCGTGCGCCAGATCCGCACCGCGCTGACCGACGCGCAAGGCCGTCAGCGCGTGCCGTTGATCGGC
TTCTCGGGAAGTCCGTGGACGCTCGCCTGCTACATGGTCGAAGGCGGCGGCTCCGATGATTTCCGCACCGTAAAGTCGAT
GCTCTATGGCCGCCCTGACCTGATGCATCGCATCCTGGAGGTCAACGCGAAGGCCGTAGCTGCCTATCTGAACGCGCAGA
TCGAAGCAGGCGCGCAAGCCGTGATGATTTTCGACACGTGGGGCGGGGCGCTCGCTGATGGCATCTATCAACGCTTTTCG
CTGCACTACATCCAGCAGGTCGTGCGCCAGTTGAAGCGCGAACACGACGGCAATCGCGTGCCAGTCATTACCTTCACGAA
GGGCGGCGGCCTGTGGCTCGAAGAAATCGCGGCGACGGGCGTCGATGCCGTCGGTCTCGACTGGACCGTGAATCTGGGCA
AGGCGCGCGAGCGCGTCGGCGGACAAGTCGCGCTTCAGGGCAATATCGATCCGTCCGTGCTGTTCGCGCCACCGTCTACG
ATTCGCATCGAAGCTCGCGCGGTGCTCGACAGCTTCGGCAACCATCCGGGCCACGTTTTCAATCTCGGACATGGCATCTC
ACAGTTCACCCCGCCGGAACATGTGGCGGAACTGGTCGACGAAGTGCATCGGCATAGCCGTGCGATTCGCGCGACAGGCG
GCAGGGGCGCCGCGTAA

Upstream 100 bases:

>100_bases
TCATAGTCCGCGCAACTGTCCGTGACCATTGATCTAAGGGCATAGGACAAATAGCAATTGCCAGGATTACCAAGGCGGCG
CCCGACGCTCACCGGGTAAA

Downstream 100 bases:

>100_bases
AGCTGCGGTGTGTATGACGTTTGTGTTGCAATGCAGCGACGCGGTCTGCCGGCCGAAGGGGAAAATTGCGTTCCAAAGGC
CGTCGCAAGGCTCTCTTCGC

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MRFCLPSVASNVAHNLLNDTFLRALMREPTEYTPIWLMRQAGRYLPEYNATRSRAGSFLGLAKNPDYATEVTLQPLERYP
LDAAILFSDILTVPDAMGLGLDFQVGEGPKFAHPVRTEEDVARLTVPDIDATLRYVTDAVRQIRTALTDAQGRQRVPLIG
FSGSPWTLACYMVEGGGSDDFRTVKSMLYGRPDLMHRILEVNAKAVAAYLNAQIEAGAQAVMIFDTWGGALADGIYQRFS
LHYIQQVVRQLKREHDGNRVPVITFTKGGGLWLEEIAATGVDAVGLDWTVNLGKARERVGGQVALQGNIDPSVLFAPPST
IRIEARAVLDSFGNHPGHVFNLGHGISQFTPPEHVAELVDEVHRHSRAIRATGGRGAA

Sequences:

>Translated_378_residues
MRFCLPSVASNVAHNLLNDTFLRALMREPTEYTPIWLMRQAGRYLPEYNATRSRAGSFLGLAKNPDYATEVTLQPLERYP
LDAAILFSDILTVPDAMGLGLDFQVGEGPKFAHPVRTEEDVARLTVPDIDATLRYVTDAVRQIRTALTDAQGRQRVPLIG
FSGSPWTLACYMVEGGGSDDFRTVKSMLYGRPDLMHRILEVNAKAVAAYLNAQIEAGAQAVMIFDTWGGALADGIYQRFS
LHYIQQVVRQLKREHDGNRVPVITFTKGGGLWLEEIAATGVDAVGLDWTVNLGKARERVGGQVALQGNIDPSVLFAPPST
IRIEARAVLDSFGNHPGHVFNLGHGISQFTPPEHVAELVDEVHRHSRAIRATGGRGAA
>Mature_378_residues
MRFCLPSVASNVAHNLLNDTFLRALMREPTEYTPIWLMRQAGRYLPEYNATRSRAGSFLGLAKNPDYATEVTLQPLERYP
LDAAILFSDILTVPDAMGLGLDFQVGEGPKFAHPVRTEEDVARLTVPDIDATLRYVTDAVRQIRTALTDAQGRQRVPLIG
FSGSPWTLACYMVEGGGSDDFRTVKSMLYGRPDLMHRILEVNAKAVAAYLNAQIEAGAQAVMIFDTWGGALADGIYQRFS
LHYIQQVVRQLKREHDGNRVPVITFTKGGGLWLEEIAATGVDAVGLDWTVNLGKARERVGGQVALQGNIDPSVLFAPPST
IRIEARAVLDSFGNHPGHVFNLGHGISQFTPPEHVAELVDEVHRHSRAIRATGGRGAA

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=360, Percent_Identity=48.0555555555556, Blast_Score=323, Evalue=2e-88,
Organism=Escherichia coli, GI2367337, Length=352, Percent_Identity=61.3636363636364, Blast_Score=444, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6320252, Length=359, Percent_Identity=35.933147632312, Blast_Score=244, Evalue=2e-65,
Organism=Drosophila melanogaster, GI221330099, Length=352, Percent_Identity=38.6363636363636, Blast_Score=250, Evalue=1e-66,
Organism=Drosophila melanogaster, GI19921920, Length=352, Percent_Identity=38.6363636363636, Blast_Score=250, Evalue=1e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 41455; Mature: 41455

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2 ; PS00867 CPSASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFCLPSVASNVAHNLLNDTFLRALMREPTEYTPIWLMRQAGRYLPEYNATRSRAGSFLG
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCHHHHCCCEEE
LAKNPDYATEVTLQPLERYPLDAAILFSDILTVPDAMGLGLDFQVGEGPKFAHPVRTEED
ECCCCCCCCEEEECHHHHCCCHHHHHHHHHHHCCHHHCCCCEEEECCCCCCCCCCCCHHH
VARLTVPDIDATLRYVTDAVRQIRTALTDAQGRQRVPLIGFSGSPWTLACYMVEGGGSDD
HHEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCEEEEEEEEECCCCHH
FRTVKSMLYGRPDLMHRILEVNAKAVAAYLNAQIEAGAQAVMIFDTWGGALADGIYQRFS
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHH
LHYIQQVVRQLKREHDGNRVPVITFTKGGGLWLEEIAATGVDAVGLDWTVNLGKARERVG
HHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHCCCCEECCEEEEECCHHHHHCC
GQVALQGNIDPSVLFAPPSTIRIEARAVLDSFGNHPGHVFNLGHGISQFTPPEHVAELVD
CEEEEECCCCCCEEECCCCCEEEHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHH
EVHRHSRAIRATGGRGAA
HHHHHHHHEEECCCCCCC
>Mature Secondary Structure
MRFCLPSVASNVAHNLLNDTFLRALMREPTEYTPIWLMRQAGRYLPEYNATRSRAGSFLG
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCHHHHCCCEEE
LAKNPDYATEVTLQPLERYPLDAAILFSDILTVPDAMGLGLDFQVGEGPKFAHPVRTEED
ECCCCCCCCEEEECHHHHCCCHHHHHHHHHHHCCHHHCCCCEEEECCCCCCCCCCCCHHH
VARLTVPDIDATLRYVTDAVRQIRTALTDAQGRQRVPLIGFSGSPWTLACYMVEGGGSDD
HHEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCEEEEEEEEECCCCHH
FRTVKSMLYGRPDLMHRILEVNAKAVAAYLNAQIEAGAQAVMIFDTWGGALADGIYQRFS
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHH
LHYIQQVVRQLKREHDGNRVPVITFTKGGGLWLEEIAATGVDAVGLDWTVNLGKARERVG
HHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHCCCCEECCEEEEECCHHHHHCC
GQVALQGNIDPSVLFAPPSTIRIEARAVLDSFGNHPGHVFNLGHGISQFTPPEHVAELVD
CEEEEECCCCCCEEECCCCCEEEHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHH
EVHRHSRAIRATGGRGAA
HHHHHHHHEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA