Click here to switch to the map view.

The map label for this gene is pyrE [H]

Identifier: 186477619

GI number: 186477619

Start: 3226347

End: 3227033

Strand: Direct

Name: pyrE [H]

Synonym: Bphy_2871

Alternate gene names: 186477619

Gene position: 3226347-3227033 (Clockwise)

Preceding gene: 186477616

Following gene: 186477621

Centisome position: 92.73

GC content: 61.28

Gene sequence:

>687_bases
ATGACAGGCTTCGATCGCCAGACGATCTCCGACACGACCGCCAAAATGCTGCTGGAAGTCCAGGCAGTGCATTTCAATGC
GGAAAAACCGTACATCTTCACTTCCGGCTGGGCGAGCCCGGTGTACATCGACTGCCGGAAGCTGATTTCGTATCCGCGCG
TGCGCCGCGGCCTGATGGAAATGGCGGAGGCGACGCTCCTGCGCGACGTCGGCTACGAGCAGATCGACGCCGTAGCCGGC
GGTGAAACGGCAGGCATTCCGTTCGCCGCATGGCTGTCGGACCGCCTGATGGTGCCGATGCAATATGTGCGCAAGAAGCC
GAAGGGGTTCGGCCGCAACGCGCAGATCGAAGGTCTGCTGACGGAAGGCCAGCGCGTGCTGCTGGTCGAAGACCTGACCA
CCGACAGCCGCAGCAAGATCAACTTCATCAACGCGCTGCGCACGGCGGGCGCGCAGGTGAATCACTGCTTCGTGCTGTTC
CACTACAACATCTTCAAGGAAAGCGTGTCCGTGCTGAAGGACATCGACGTTGACCTGCACGCGCTCGCCACGTGGTGGGA
CGTGCTGCGGGTCGCGAAGCAACAGGGCTATTTTGAAACGAAGACGCTCGACGAAGTCGAGAAATTCCTGCATGCACCGG
CTGAGTGGTCAGCGGCACATGGCGGCGCGACGGCGGCACCACAATAA

Upstream 100 bases:

>100_bases
CGTCCGGCATGTTTCGCCCACTAGGGCGCGAAACGTTACGCCTGCTGCGCCATCGGGCCGCGCGCCCGCCTCCCCGCTCA
CCACACCGAAGGATTCGCCC

Downstream 100 bases:

>100_bases
GCGCGCTACCCGCACCGGCGTCTCGCGCACAGTCGGGCCTGCATACGAAAACGCCGCCTGTCTTGAAGACAGGCGGCGTT
TTTTATTGCGTATGCACCTT

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 228; Mature: 227

Protein sequence:

>228_residues
MTGFDRQTISDTTAKMLLEVQAVHFNAEKPYIFTSGWASPVYIDCRKLISYPRVRRGLMEMAEATLLRDVGYEQIDAVAG
GETAGIPFAAWLSDRLMVPMQYVRKKPKGFGRNAQIEGLLTEGQRVLLVEDLTTDSRSKINFINALRTAGAQVNHCFVLF
HYNIFKESVSVLKDIDVDLHALATWWDVLRVAKQQGYFETKTLDEVEKFLHAPAEWSAAHGGATAAPQ

Sequences:

>Translated_228_residues
MTGFDRQTISDTTAKMLLEVQAVHFNAEKPYIFTSGWASPVYIDCRKLISYPRVRRGLMEMAEATLLRDVGYEQIDAVAG
GETAGIPFAAWLSDRLMVPMQYVRKKPKGFGRNAQIEGLLTEGQRVLLVEDLTTDSRSKINFINALRTAGAQVNHCFVLF
HYNIFKESVSVLKDIDVDLHALATWWDVLRVAKQQGYFETKTLDEVEKFLHAPAEWSAAHGGATAAPQ
>Mature_227_residues
TGFDRQTISDTTAKMLLEVQAVHFNAEKPYIFTSGWASPVYIDCRKLISYPRVRRGLMEMAEATLLRDVGYEQIDAVAGG
ETAGIPFAAWLSDRLMVPMQYVRKKPKGFGRNAQIEGLLTEGQRVLLVEDLTTDSRSKINFINALRTAGAQVNHCFVLFH
YNIFKESVSVLKDIDVDLHALATWWDVLRVAKQQGYFETKTLDEVEKFLHAPAEWSAAHGGATAAPQ

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507835, Length=207, Percent_Identity=26.5700483091787, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17508631, Length=119, Percent_Identity=36.9747899159664, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI17933654, Length=198, Percent_Identity=28.2828282828283, Blast_Score=68, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004467
- InterPro:   IPR023031
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 25568; Mature: 25436

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGFDRQTISDTTAKMLLEVQAVHFNAEKPYIFTSGWASPVYIDCRKLISYPRVRRGLME
CCCCCCCHHHHHHHHHHHHHHHHEECCCCCEEEECCCCCCHHHHHHHHHCCHHHHHHHHH
MAEATLLRDVGYEQIDAVAGGETAGIPFAAWLSDRLMVPMQYVRKKPKGFGRNAQIEGLL
HHHHHHHHHCCHHHHHHHCCCCCCCCCHHHHHHCCCHHHHHHHHCCCCCCCCCCEEEEEE
TEGQRVLLVEDLTTDSRSKINFINALRTAGAQVNHCFVLFHYNIFKESVSVLKDIDVDLH
CCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEEEHHHHHHHHHHHHHCCCHHH
ALATWWDVLRVAKQQGYFETKTLDEVEKFLHAPAEWSAAHGGATAAPQ
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TGFDRQTISDTTAKMLLEVQAVHFNAEKPYIFTSGWASPVYIDCRKLISYPRVRRGLME
CCCCCCHHHHHHHHHHHHHHHHEECCCCCEEEECCCCCCHHHHHHHHHCCHHHHHHHHH
MAEATLLRDVGYEQIDAVAGGETAGIPFAAWLSDRLMVPMQYVRKKPKGFGRNAQIEGLL
HHHHHHHHHCCHHHHHHHCCCCCCCCCHHHHHHCCCHHHHHHHHCCCCCCCCCCEEEEEE
TEGQRVLLVEDLTTDSRSKINFINALRTAGAQVNHCFVLFHYNIFKESVSVLKDIDVDLH
CCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEEEHHHHHHHHHHHHHCCCHHH
ALATWWDVLRVAKQQGYFETKTLDEVEKFLHAPAEWSAAHGGATAAPQ
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA