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The map label for this gene is hisC [H]

Identifier: 186477506

GI number: 186477506

Start: 3108683

End: 3109753

Strand: Reverse

Name: hisC [H]

Synonym: Bphy_2758

Alternate gene names: 186477506

Gene position: 3109753-3108683 (Counterclockwise)

Preceding gene: 186477507

Following gene: 186477505

Centisome position: 89.38

GC content: 63.21

Gene sequence:

>1071_bases
ATGACGACACCACAAGACATCATTCGCCGCGACGTGCTCGCGATGACGAGTTATCCCGTTGCCGACGCGACGGGCCTCGT
GAAGCTCGACGCGATGGAGAATCCGTTCCCGCTGCCTGCAGCGCTCGCTGCGCAGCTCGGCGAGCATCTGGCGGGCGTCG
CGCTGAACCGCTATCCGGCGCCGCGTCCGCAGGCGTTGCTTGACAAGCTCAAGCGTGTGATGAACGTGCCGGCGAATTGT
GAAGTGCTGCTCGGCAACGGCTCTGACGAACTGATCAGCATGATTTCGATGGCCTGCGCGACGCCGGGCGCGAAGGTGCT
GGCGCCCGTGCCAGGCTTCGTGATGTATGCGATGTCGGCGAAGCTCGCCAACATGGAATTCGTCGGAGTGCCGTTGAAGG
CCGATCTCACGCTCGACACGCAAGCCATGCTCGCCGCGATCGCCGAACATCGGCCGGCCGTCATCTATCTCGCGTATCCG
AACAACCCGACGGGCACGCTGTACGACGCCGCGGACATGGAGCGCATCATTGCCGCGGCGAGCAGGAGTCTCGTCGTGAT
CGACGAAGCGTATCAGCCGTTCGCGCAGCAGAGCTGGATGCCGCGCGCGGGCGAGTTCGACAATGTCGTCGTGATGCGCA
CGGTGTCGAAGCTGGGCCTCGCGGGCATCCGTCTCGGCTACATGGCGGGCCGCACGGAATGGATCAACGAACTCGACAAG
GTGCGTCCGCCGTACAACATCAACGTGCTCACGCAAGCGACGGCCGATTTTCTGCTCGATCACATCGACGTGCTCGATGC
GCAGGCCGCGCAACTGCGCGCGGAGCGCACGAAGCTGGCGCAGGCGGTAGCCGCGCTGCCGGGCGCCGAGGTATTCCCGA
GCGCGGGCAATTTCCTGCTGGTGCGCGTGCCCGATGCGTCGGCGACGTTCGAAACCTTGCTCACAGCGCGGGTTTTGATC
AAAAACGTGAGTAAAATGCACCCATTGCTCGCGAATTGCGTGCGTTTGACAGTCGGTTCGCCGGATGAAAACGGTCAGAT
GCTCGCTGCACTGAAACTCGTGCTGAACTGA

Upstream 100 bases:

>100_bases
CTGCGTTTTCGCGAGTTTTCGCGAGAGACAGAGAATCCAACCCGGGGCGGCCGCGAGCCGCCCCAATTGCGCCGCGACTG
CGATAGGCGCGCCCCACGCC

Downstream 100 bases:

>100_bases
AAGCGGCACTTTTCCAACCCAATACTTTTCAAAGTCAGATTCGAGGAATTGCCATGCGCCTTGCGGAAGTCGTTCGCAAC
ACCAGCGAAACGCAGATCCG

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 356; Mature: 355

Protein sequence:

>356_residues
MTTPQDIIRRDVLAMTSYPVADATGLVKLDAMENPFPLPAALAAQLGEHLAGVALNRYPAPRPQALLDKLKRVMNVPANC
EVLLGNGSDELISMISMACATPGAKVLAPVPGFVMYAMSAKLANMEFVGVPLKADLTLDTQAMLAAIAEHRPAVIYLAYP
NNPTGTLYDAADMERIIAAASRSLVVIDEAYQPFAQQSWMPRAGEFDNVVVMRTVSKLGLAGIRLGYMAGRTEWINELDK
VRPPYNINVLTQATADFLLDHIDVLDAQAAQLRAERTKLAQAVAALPGAEVFPSAGNFLLVRVPDASATFETLLTARVLI
KNVSKMHPLLANCVRLTVGSPDENGQMLAALKLVLN

Sequences:

>Translated_356_residues
MTTPQDIIRRDVLAMTSYPVADATGLVKLDAMENPFPLPAALAAQLGEHLAGVALNRYPAPRPQALLDKLKRVMNVPANC
EVLLGNGSDELISMISMACATPGAKVLAPVPGFVMYAMSAKLANMEFVGVPLKADLTLDTQAMLAAIAEHRPAVIYLAYP
NNPTGTLYDAADMERIIAAASRSLVVIDEAYQPFAQQSWMPRAGEFDNVVVMRTVSKLGLAGIRLGYMAGRTEWINELDK
VRPPYNINVLTQATADFLLDHIDVLDAQAAQLRAERTKLAQAVAALPGAEVFPSAGNFLLVRVPDASATFETLLTARVLI
KNVSKMHPLLANCVRLTVGSPDENGQMLAALKLVLN
>Mature_355_residues
TTPQDIIRRDVLAMTSYPVADATGLVKLDAMENPFPLPAALAAQLGEHLAGVALNRYPAPRPQALLDKLKRVMNVPANCE
VLLGNGSDELISMISMACATPGAKVLAPVPGFVMYAMSAKLANMEFVGVPLKADLTLDTQAMLAAIAEHRPAVIYLAYPN
NPTGTLYDAADMERIIAAASRSLVVIDEAYQPFAQQSWMPRAGEFDNVVVMRTVSKLGLAGIRLGYMAGRTEWINELDKV
RPPYNINVLTQATADFLLDHIDVLDAQAAQLRAERTKLAQAVAALPGAEVFPSAGNFLLVRVPDASATFETLLTARVLIK
NVSKMHPLLANCVRLTVGSPDENGQMLAALKLVLN

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=363, Percent_Identity=31.6804407713499, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI1788722, Length=283, Percent_Identity=25.4416961130742, Blast_Score=68, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6322075, Length=383, Percent_Identity=27.9373368146214, Blast_Score=125, Evalue=8e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 38270; Mature: 38139

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPQDIIRRDVLAMTSYPVADATGLVKLDAMENPFPLPAALAAQLGEHLAGVALNRYPA
CCCHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
PRPQALLDKLKRVMNVPANCEVLLGNGSDELISMISMACATPGAKVLAPVPGFVMYAMSA
CCHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHH
KLANMEFVGVPLKADLTLDTQAMLAAIAEHRPAVIYLAYPNNPTGTLYDAADMERIIAAA
HHCCCEEEECCEEECCEECHHHHHHHHHHCCCEEEEEEECCCCCCCEECHHHHHHHHHHC
SRSLVVIDEAYQPFAQQSWMPRAGEFDNVVVMRTVSKLGLAGIRLGYMAGRTEWINELDK
CCCEEEEEHHHCHHHHHCCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHCCCHHHHHHHHH
VRPPYNINVLTQATADFLLDHIDVLDAQAAQLRAERTKLAQAVAALPGAEVFPSAGNFLL
CCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEE
VRVPDASATFETLLTARVLIKNVSKMHPLLANCVRLTVGSPDENGQMLAALKLVLN
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
TTPQDIIRRDVLAMTSYPVADATGLVKLDAMENPFPLPAALAAQLGEHLAGVALNRYPA
CCHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
PRPQALLDKLKRVMNVPANCEVLLGNGSDELISMISMACATPGAKVLAPVPGFVMYAMSA
CCHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHH
KLANMEFVGVPLKADLTLDTQAMLAAIAEHRPAVIYLAYPNNPTGTLYDAADMERIIAAA
HHCCCEEEECCEEECCEECHHHHHHHHHHCCCEEEEEEECCCCCCCEECHHHHHHHHHHC
SRSLVVIDEAYQPFAQQSWMPRAGEFDNVVVMRTVSKLGLAGIRLGYMAGRTEWINELDK
CCCEEEEEHHHCHHHHHCCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHCCCHHHHHHHHH
VRPPYNINVLTQATADFLLDHIDVLDAQAAQLRAERTKLAQAVAALPGAEVFPSAGNFLL
CCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEE
VRVPDASATFETLLTARVLIKNVSKMHPLLANCVRLTVGSPDENGQMLAALKLVLN
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12754231 [H]