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The map label for this gene is trpC

Identifier: 186477449

GI number: 186477449

Start: 3054545

End: 3055330

Strand: Direct

Name: trpC

Synonym: Bphy_2701

Alternate gene names: 186477449

Gene position: 3054545-3055330 (Clockwise)

Preceding gene: 186477448

Following gene: 186477450

Centisome position: 87.79

GC content: 63.49

Gene sequence:

>786_bases
ATGAGCGATATTCTCGACCGCATCATCGACGTCAAGCGCCAAGAAGTGCGCGCCGCGCAGCAAAGCGCGCCGCTCGAAGA
ACTGCGTCTCCAGGCATCCACACGCGATCTGCGCGATTTCGTCGGCGCAATCCGCGCCAAGCACGAGGCCGGTCTCGCGG
CCGTGATCGCCGAGGTCAAGAAGGCGAGCCCGTCGAAAGGCGTGCTGCGCGAGCACTTCGTCCCCGCCGATATCGCGCGT
TCGTATGCCAATCATGGCGCAGCATGTCTGTCCGTGCTGACCGACGTGCAGTTCTTCAAGGGCAGCGCACAGTATCTGGA
AGAAGCGCGCGCCGCCTGCCAGTTGCCCGTGCTGCGCAAGGACTTCATCGTCGATCCGTATCAGATCCTCGAAGCGCGCG
CGATGGGCGCCGACGCGATCCTGCTGATCGTCGCAGCACTCGAAACCTCGCAGATGCAGGACCTCGAAGCGTACGCGCAC
TCGCTCGGTCTCGCGGTGCTCGTCGAAGTGCACGACAAGGACGAACTGGTCGAAGCGCTGACGCTGAAGACGCCGCTGAT
CGGCGTGAACAACCGCAATCTGCGCACGTTCGAAACTTCGATCGACACGACGCTCGGCCTGCTCGACATGATGCCGGACG
ACCGCATCGTCGTGACCGAATCCGGCATTCTGTCGCGCACCGACGTCGAGCGGATGCGCGCGATGGACGTGAACACGTTC
CTCGTCGGCGAGGCGTTCATGCGTGCCGACGAGCCGGGCGTGGAACTTGCGCGGATGTTCTTCTGA

Upstream 100 bases:

>100_bases
GGCGCGTGAGGCGATCGCGAGCGGCAAGGCACGCGCGAAAGTCGACGAACTGGTCCGCTTCACGCAGCAGTTCAAGCATT
GATCAAGTAACGGAAATCAC

Downstream 100 bases:

>100_bases
GCCGGCGAACCTCATAAGCGAGTCAAGCGATGGGCATGGAACACGAGATCAAGCTCGCGCTGCCGACCGACCAGGTCGGC
GCGGCGACACAATGGTTCAT

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 261; Mature: 260

Protein sequence:

>261_residues
MSDILDRIIDVKRQEVRAAQQSAPLEELRLQASTRDLRDFVGAIRAKHEAGLAAVIAEVKKASPSKGVLREHFVPADIAR
SYANHGAACLSVLTDVQFFKGSAQYLEEARAACQLPVLRKDFIVDPYQILEARAMGADAILLIVAALETSQMQDLEAYAH
SLGLAVLVEVHDKDELVEALTLKTPLIGVNNRNLRTFETSIDTTLGLLDMMPDDRIVVTESGILSRTDVERMRAMDVNTF
LVGEAFMRADEPGVELARMFF

Sequences:

>Translated_261_residues
MSDILDRIIDVKRQEVRAAQQSAPLEELRLQASTRDLRDFVGAIRAKHEAGLAAVIAEVKKASPSKGVLREHFVPADIAR
SYANHGAACLSVLTDVQFFKGSAQYLEEARAACQLPVLRKDFIVDPYQILEARAMGADAILLIVAALETSQMQDLEAYAH
SLGLAVLVEVHDKDELVEALTLKTPLIGVNNRNLRTFETSIDTTLGLLDMMPDDRIVVTESGILSRTDVERMRAMDVNTF
LVGEAFMRADEPGVELARMFF
>Mature_260_residues
SDILDRIIDVKRQEVRAAQQSAPLEELRLQASTRDLRDFVGAIRAKHEAGLAAVIAEVKKASPSKGVLREHFVPADIARS
YANHGAACLSVLTDVQFFKGSAQYLEEARAACQLPVLRKDFIVDPYQILEARAMGADAILLIVAALETSQMQDLEAYAHS
LGLAVLVEVHDKDELVEALTLKTPLIGVNNRNLRTFETSIDTTLGLLDMMPDDRIVVTESGILSRTDVERMRAMDVNTFL
VGEAFMRADEPGVELARMFF

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=253, Percent_Identity=39.1304347826087, Blast_Score=158, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6322638, Length=261, Percent_Identity=38.6973180076628, Blast_Score=163, Evalue=3e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_BURP8 (B2JHI8)

Other databases:

- EMBL:   CP001043
- RefSeq:   YP_001858919.1
- ProteinModelPortal:   B2JHI8
- SMR:   B2JHI8
- GeneID:   6244184
- GenomeReviews:   CP001043_GR
- KEGG:   bph:Bphy_2701
- HOGENOM:   HBG540956
- OMA:   VDLPLLC
- ProtClustDB:   PRK00278
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 28825; Mature: 28693

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDILDRIIDVKRQEVRAAQQSAPLEELRLQASTRDLRDFVGAIRAKHEAGLAAVIAEVK
CHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KASPSKGVLREHFVPADIARSYANHGAACLSVLTDVQFFKGSAQYLEEARAACQLPVLRK
HCCCCCCHHHHHCCCHHHHHHHHHCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHH
DFIVDPYQILEARAMGADAILLIVAALETSQMQDLEAYAHSLGLAVLVEVHDKDELVEAL
HHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHH
TLKTPLIGVNNRNLRTFETSIDTTLGLLDMMPDDRIVVTESGILSRTDVERMRAMDVNTF
HHCCCEEECCCCCCEEEHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHCCHHH
LVGEAFMRADEPGVELARMFF
HHHHHHHHCCCCCHHHHHHCC
>Mature Secondary Structure 
SDILDRIIDVKRQEVRAAQQSAPLEELRLQASTRDLRDFVGAIRAKHEAGLAAVIAEVK
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KASPSKGVLREHFVPADIARSYANHGAACLSVLTDVQFFKGSAQYLEEARAACQLPVLRK
HCCCCCCHHHHHCCCHHHHHHHHHCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHH
DFIVDPYQILEARAMGADAILLIVAALETSQMQDLEAYAHSLGLAVLVEVHDKDELVEAL
HHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHH
TLKTPLIGVNNRNLRTFETSIDTTLGLLDMMPDDRIVVTESGILSRTDVERMRAMDVNTF
HHCCCEEECCCCCCEEEHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHCCHHH
LVGEAFMRADEPGVELARMFF
HHHHHHHHCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA