Click here to switch to the map view.

The map label for this gene is mltA [H]

Identifier: 186477442

GI number: 186477442

Start: 3047564

End: 3048796

Strand: Reverse

Name: mltA [H]

Synonym: Bphy_2694

Alternate gene names: 186477442

Gene position: 3048796-3047564 (Counterclockwise)

Preceding gene: 186477443

Following gene: 186477436

Centisome position: 87.63

GC content: 64.4

Gene sequence:

>1233_bases
ATGAAAATCAGCAGGGAAAGCGCGAGGAGCGACTCCAGCGCGAAGATGAGCATCGGGTATTCGTCGAGCAGATCAGACAT
GGCAGTTTCCATCGAGAACAATCATTGTATGCGCTTTGTCCGCCGGGCCGCGAGCTGGGCGGGAGCACTATCCGTTGCCG
TGCTGCTTGCGTCGTGCGGCGGCGGCGGTGTGGTGCGGCCTTCCGTTTCGCCGCCGATGGGCGCCGCGATCATCCCCGGC
CAGATTGCTTCACAACGGCTGACGGCTGTAGCCTGGCAGCAGGTGCCGGGCTGGCAGGACGATTCGCTGATCGGCGCTGC
TGCCGCGCTGCGCCAGAACTGCGCACGCCTCGCAAGCCAGGCGACATGGCGGCGTGCCTGCGCTGCGGCGCTGATGCTGG
ACGATCTCGACGTGGCTAGCGCACGCGCCTTTTTCGAAACCTACTTCACACCATTCCAGTTCGCGAACACGGACGGCACG
CTGGACGGACTGGTGACAGGCTACTACGAGCCGTTGCTACGGGGTTCGCGCGTGCGTCGCGGCGTGTATCAGACAGCCCT
GTACCGTTGGCCGCCCGCTTACCGCCCCGGTTCGCCGATGCCCGCGCGCGCGCAGCTCGAGCGTTCCGGCGTGCTGAACG
GCAATGAACTGGTGTGGGTCGACGATCCCATCGAGGCTTTTTTCCTGCAGGTGCAAGGCTCGGGACGCATCGTGATGGAA
GACGGCAGTGTGATGCGGGTCGGCTTCGGCGGCACGAACAATCAACCGTACAAGTCGATCGGCCGCTGGCTGCTCGATCG
CGGTGAACTCACGCCAGCACAGGCGACCATGCAAGGCATCAAGGCTTGGGCGCGCGCGAACCCGACGCGTGTCGATGCGC
TGCTCGATACGAATCCGCGCTTCGTGTTTTTCCGCGAGATGGCGTCGAACGAACCGATGCCGGCGGGTGGCGCCGACGGG
CCGATTGGTGCGCTTGGCGTGCCGCTGACGCCGGAGCGGTCGATTGCCGTCGATCCGTCGTCGATTCCGCTCGGGACGCC
CGTCTTCCTGCAGACGACCCGTCCAATGACGAACGCACCGATGAATCGCCTGGTGTTTGCGCAAGACACCGGGTCGGCGA
TCAAGGGTGGCGTACGTGCCGACTATTTCTGGGGACTCGGCGATGAAGCTGGCGATCTGGCAGGCAAGATGAAGCAGGCG
GGTCGGATGTGGTTGCTGCTGCCCAATTCTTGA

Upstream 100 bases:

>100_bases
AGTCTGTTAGCGACGCGGCTGACGTTGCGGCGGGACCTGGTTTGCGTCCTGCTTCTGGCGTGCGGCATTCTTTTTCTTGC
CGGACGCTGTCCACACAACG

Downstream 100 bases:

>100_bases
GGTCGTCGTGAGAATGGGGCGCGCTTCAGCCGTTGCCTGAACTGGAAAGCCCGACGGCTGTCATCACCGCCGTCGGGCTT
TCGTTTTTGTCAGCCGGCAG

Product: MltA domain-containing protein

Products: Muramic Acid Residue [C]

Alternate protein names: Mlt38; Murein hydrolase A [H]

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MKISRESARSDSSAKMSIGYSSSRSDMAVSIENNHCMRFVRRAASWAGALSVAVLLASCGGGGVVRPSVSPPMGAAIIPG
QIASQRLTAVAWQQVPGWQDDSLIGAAAALRQNCARLASQATWRRACAAALMLDDLDVASARAFFETYFTPFQFANTDGT
LDGLVTGYYEPLLRGSRVRRGVYQTALYRWPPAYRPGSPMPARAQLERSGVLNGNELVWVDDPIEAFFLQVQGSGRIVME
DGSVMRVGFGGTNNQPYKSIGRWLLDRGELTPAQATMQGIKAWARANPTRVDALLDTNPRFVFFREMASNEPMPAGGADG
PIGALGVPLTPERSIAVDPSSIPLGTPVFLQTTRPMTNAPMNRLVFAQDTGSAIKGGVRADYFWGLGDEAGDLAGKMKQA
GRMWLLLPNS

Sequences:

>Translated_410_residues
MKISRESARSDSSAKMSIGYSSSRSDMAVSIENNHCMRFVRRAASWAGALSVAVLLASCGGGGVVRPSVSPPMGAAIIPG
QIASQRLTAVAWQQVPGWQDDSLIGAAAALRQNCARLASQATWRRACAAALMLDDLDVASARAFFETYFTPFQFANTDGT
LDGLVTGYYEPLLRGSRVRRGVYQTALYRWPPAYRPGSPMPARAQLERSGVLNGNELVWVDDPIEAFFLQVQGSGRIVME
DGSVMRVGFGGTNNQPYKSIGRWLLDRGELTPAQATMQGIKAWARANPTRVDALLDTNPRFVFFREMASNEPMPAGGADG
PIGALGVPLTPERSIAVDPSSIPLGTPVFLQTTRPMTNAPMNRLVFAQDTGSAIKGGVRADYFWGLGDEAGDLAGKMKQA
GRMWLLLPNS
>Mature_410_residues
MKISRESARSDSSAKMSIGYSSSRSDMAVSIENNHCMRFVRRAASWAGALSVAVLLASCGGGGVVRPSVSPPMGAAIIPG
QIASQRLTAVAWQQVPGWQDDSLIGAAAALRQNCARLASQATWRRACAAALMLDDLDVASARAFFETYFTPFQFANTDGT
LDGLVTGYYEPLLRGSRVRRGVYQTALYRWPPAYRPGSPMPARAQLERSGVLNGNELVWVDDPIEAFFLQVQGSGRIVME
DGSVMRVGFGGTNNQPYKSIGRWLLDRGELTPAQATMQGIKAWARANPTRVDALLDTNPRFVFFREMASNEPMPAGGADG
PIGALGVPLTPERSIAVDPSSIPLGTPVFLQTTRPMTNAPMNRLVFAQDTGSAIKGGVRADYFWGLGDEAGDLAGKMKQA
GRMWLLLPNS

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Degrades murein glycan strands and insoluble, high-molecular weight murein sacculi [H]

COG id: COG2821

COG function: function code M; Membrane-bound lytic murein transglycosylase

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789179, Length=261, Percent_Identity=34.4827586206897, Blast_Score=133, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010611
- InterPro:   IPR014733
- InterPro:   IPR005300 [H]

Pfam domain/function: PF06725 3D; PF03562 MltA [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 44096; Mature: 44096

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKISRESARSDSSAKMSIGYSSSRSDMAVSIENNHCMRFVRRAASWAGALSVAVLLASCG
CCCCCHHCCCCCCCEEEECCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCC
GGGVVRPSVSPPMGAAIIPGQIASQRLTAVAWQQVPGWQDDSLIGAAAALRQNCARLASQ
CCCEECCCCCCCCCCEECCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
ATWRRACAAALMLDDLDVASARAFFETYFTPFQFANTDGTLDGLVTGYYEPLLRGSRVRR
HHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHH
GVYQTALYRWPPAYRPGSPMPARAQLERSGVLNGNELVWVDDPIEAFFLQVQGSGRIVME
HHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCCEEEEEECCCEEEEEEECCCCEEEEE
DGSVMRVGFGGTNNQPYKSIGRWLLDRGELTPAQATMQGIKAWARANPTRVDALLDTNPR
CCCEEEEECCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCC
FVFFREMASNEPMPAGGADGPIGALGVPLTPERSIAVDPSSIPLGTPVFLQTTRPMTNAP
EEEEEEHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCEEEEECCCCCCCC
MNRLVFAQDTGSAIKGGVRADYFWGLGDEAGDLAGKMKQAGRMWLLLPNS
CCCEEEEECCCHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCEEEEECCC
>Mature Secondary Structure
MKISRESARSDSSAKMSIGYSSSRSDMAVSIENNHCMRFVRRAASWAGALSVAVLLASCG
CCCCCHHCCCCCCCEEEECCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCC
GGGVVRPSVSPPMGAAIIPGQIASQRLTAVAWQQVPGWQDDSLIGAAAALRQNCARLASQ
CCCEECCCCCCCCCCEECCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
ATWRRACAAALMLDDLDVASARAFFETYFTPFQFANTDGTLDGLVTGYYEPLLRGSRVRR
HHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHH
GVYQTALYRWPPAYRPGSPMPARAQLERSGVLNGNELVWVDDPIEAFFLQVQGSGRIVME
HHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCCEEEEEECCCEEEEEEECCCCEEEEE
DGSVMRVGFGGTNNQPYKSIGRWLLDRGELTPAQATMQGIKAWARANPTRVDALLDTNPR
CCCEEEEECCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCC
FVFFREMASNEPMPAGGADGPIGALGVPLTPERSIAVDPSSIPLGTPVFLQTTRPMTNAP
EEEEEEHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCEEEEECCCCCCCC
MNRLVFAQDTGSAIKGGVRADYFWGLGDEAGDLAGKMKQAGRMWLLLPNS
CCCEEEEECCCHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]