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The map label for this gene is ffh [H]

Identifier: 186477391

GI number: 186477391

Start: 2983475

End: 2984842

Strand: Direct

Name: ffh [H]

Synonym: Bphy_2643

Alternate gene names: 186477391

Gene position: 2983475-2984842 (Clockwise)

Preceding gene: 186477383

Following gene: 186477392

Centisome position: 85.75

GC content: 63.82

Gene sequence:

>1368_bases
ATGCTCGACAACCTCACTCAACGGATGGCGCGCGTCGTCAAGACGCTGCGCGGCGAAGCCCGGCTCACCGAGGCGAACAC
CCAGGAGATGCTGCGCGAAGTGCGCCTCGCACTCCTTGAAGCGGACGTGGCGCTGCCCGTCGTGCGCGACTTCATCTCGA
AGGTGAAGGAAAAGGCGCTCGGCGAGGAAGTGATCGGCAGCCTGTCGCCTGGCCAGGCGCTCGTCGGCGTCGTGCAGCGC
GAGCTGACGGCCGTGATCGGCGGCGACTACGAAGGCAAGGCCGCCGAGCTGAATCTTAGCGTGACGCCCCCCGCCATCAT
CCTGATGGCGGGTCTGCAGGGCGCCGGCAAGACAACCACGGTCGGCAAGCTCGCGAAGCTCCTGCGCGAGAAGTACAAGA
AGAAAGTGCTGACGGTGTCGTGCGACGTGTATCGCCCGGCCGCTATCGCGCAGCTGAAGACGGTGACTGAACAGGTCGGC
GCCGACTTCTTCCCTTCGCAGCCGGACCAGAAGCCTGTCGATATCGCGCGTGCCGCCGTCGACTGGGCCAAGCGCCACTA
TCACGATGTGCTGCTCGTCGACACGGCCGGCCGTCTCGGCATCGACGAGGCGATGATGAATGAAATCGCCGCGCTGCATA
AGGAACTGAACCCTGCGGAGACGCTGTTCGTCGTCGATGCGATGCTCGGCCAGGACGCGGTGAACACCGCCAAGGCGTTC
AACGACACGCTGCCACTCACAGGGGTCGTGCTAACCAAGCTCGACGGCGACTCGCGCGGTGGCGCGGCGCTCTCAGTGCG
TCATGTGACGGGCAAACCGATCAAGTTCGTCGGCGTCGCAGAAAAGCTCGACGGCCTGGAAATCTTCTATCCGGACCGCA
TGGCGAACCGGATTCTCGGCATGGGCGACATCCTCGCGCTTGTTGAAGAAGCACAACGCGGCGTCGACGTTCAGGCCGCG
CAAAAGCTCGCGGACAAGGTGAAGAAAGGCGGCGACTTCGATCTGAACGATTTCCGCGCGCAGCTCTCACAGATGAAGAA
GATGGGCGGCCTGTCGTCGCTGATGGACAAGCTGCCCGCGCAGTTCCAGCAGGCCGCGTCGAATGCCGACATGGGCCAGG
CCGAAAAGCAGATGCGCCGCATGGAAGGCATCATCAATTCGATGACGGCCGCCGAGCGCGCCAAGCCCGAGCTGATCAAG
GCGACGCGCAAGCGCCGTATCGCTGCCGGCGCCGGCGTGCAGGTGCAGGAAGTCAACCGGCTGCTGAACCAGTACGAGCA
GATGCGCACCATGATGAAGAAGCTCAAGGGCGGCAACCTGCAAAAGATGATGCGCGGCATGAAGGGCATGATGCCGGGCA
TGCGCTGA

Upstream 100 bases:

>100_bases
GCATACAGTACAATATCCATATTGGAAGTTTACACCAGGCCCTCCAAAGTCCGCCGCTCTCGCGCTGTGACGGGAATGGC
CGCACTGCTCACCGCCCCCC

Downstream 100 bases:

>100_bases
TGCGCTTTGCTGCCGTCGCGCGGCGCCACGCATCTGAGCGCACGACGGCCAACACGGCCCGGCGCGTATGCCGGATCAAG
GCGCGGGTATTTGCTGTAGC

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MLDNLTQRMARVVKTLRGEARLTEANTQEMLREVRLALLEADVALPVVRDFISKVKEKALGEEVIGSLSPGQALVGVVQR
ELTAVIGGDYEGKAAELNLSVTPPAIILMAGLQGAGKTTTVGKLAKLLREKYKKKVLTVSCDVYRPAAIAQLKTVTEQVG
ADFFPSQPDQKPVDIARAAVDWAKRHYHDVLLVDTAGRLGIDEAMMNEIAALHKELNPAETLFVVDAMLGQDAVNTAKAF
NDTLPLTGVVLTKLDGDSRGGAALSVRHVTGKPIKFVGVAEKLDGLEIFYPDRMANRILGMGDILALVEEAQRGVDVQAA
QKLADKVKKGGDFDLNDFRAQLSQMKKMGGLSSLMDKLPAQFQQAASNADMGQAEKQMRRMEGIINSMTAAERAKPELIK
ATRKRRIAAGAGVQVQEVNRLLNQYEQMRTMMKKLKGGNLQKMMRGMKGMMPGMR

Sequences:

>Translated_455_residues
MLDNLTQRMARVVKTLRGEARLTEANTQEMLREVRLALLEADVALPVVRDFISKVKEKALGEEVIGSLSPGQALVGVVQR
ELTAVIGGDYEGKAAELNLSVTPPAIILMAGLQGAGKTTTVGKLAKLLREKYKKKVLTVSCDVYRPAAIAQLKTVTEQVG
ADFFPSQPDQKPVDIARAAVDWAKRHYHDVLLVDTAGRLGIDEAMMNEIAALHKELNPAETLFVVDAMLGQDAVNTAKAF
NDTLPLTGVVLTKLDGDSRGGAALSVRHVTGKPIKFVGVAEKLDGLEIFYPDRMANRILGMGDILALVEEAQRGVDVQAA
QKLADKVKKGGDFDLNDFRAQLSQMKKMGGLSSLMDKLPAQFQQAASNADMGQAEKQMRRMEGIINSMTAAERAKPELIK
ATRKRRIAAGAGVQVQEVNRLLNQYEQMRTMMKKLKGGNLQKMMRGMKGMMPGMR
>Mature_455_residues
MLDNLTQRMARVVKTLRGEARLTEANTQEMLREVRLALLEADVALPVVRDFISKVKEKALGEEVIGSLSPGQALVGVVQR
ELTAVIGGDYEGKAAELNLSVTPPAIILMAGLQGAGKTTTVGKLAKLLREKYKKKVLTVSCDVYRPAAIAQLKTVTEQVG
ADFFPSQPDQKPVDIARAAVDWAKRHYHDVLLVDTAGRLGIDEAMMNEIAALHKELNPAETLFVVDAMLGQDAVNTAKAF
NDTLPLTGVVLTKLDGDSRGGAALSVRHVTGKPIKFVGVAEKLDGLEIFYPDRMANRILGMGDILALVEEAQRGVDVQAA
QKLADKVKKGGDFDLNDFRAQLSQMKKMGGLSSLMDKLPAQFQQAASNADMGQAEKQMRRMEGIINSMTAAERAKPELIK
ATRKRRIAAGAGVQVQEVNRLLNQYEQMRTMMKKLKGGNLQKMMRGMKGMMPGMR

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=458, Percent_Identity=30.5676855895196, Blast_Score=198, Evalue=8e-51,
Organism=Homo sapiens, GI226371618, Length=349, Percent_Identity=31.8051575931232, Blast_Score=178, Evalue=9e-45,
Organism=Homo sapiens, GI89061728, Length=165, Percent_Identity=33.3333333333333, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI295424842, Length=202, Percent_Identity=32.6732673267327, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI23308697, Length=202, Percent_Identity=32.6732673267327, Blast_Score=99, Evalue=8e-21,
Organism=Escherichia coli, GI1788963, Length=452, Percent_Identity=64.6017699115044, Blast_Score=561, Evalue=1e-161,
Organism=Escherichia coli, GI1789874, Length=269, Percent_Identity=33.457249070632, Blast_Score=130, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17539958, Length=461, Percent_Identity=29.9349240780911, Blast_Score=204, Evalue=8e-53,
Organism=Caenorhabditis elegans, GI193206261, Length=202, Percent_Identity=34.1584158415842, Blast_Score=96, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6325345, Length=446, Percent_Identity=30.2690582959641, Blast_Score=184, Evalue=3e-47,
Organism=Drosophila melanogaster, GI17647949, Length=445, Percent_Identity=30.1123595505618, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24641198, Length=271, Percent_Identity=30.6273062730627, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49578; Mature: 49578

Theoretical pI: Translated: 10.15; Mature: 10.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDNLTQRMARVVKTLRGEARLTEANTQEMLREVRLALLEADVALPVVRDFISKVKEKAL
CCCHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GEEVIGSLSPGQALVGVVQRELTAVIGGDYEGKAAELNLSVTPPAIILMAGLQGAGKTTT
HHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHCCCCCCCCHH
VGKLAKLLREKYKKKVLTVSCDVYRPAAIAQLKTVTEQVGADFFPSQPDQKPVDIARAAV
HHHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
DWAKRHYHDVLLVDTAGRLGIDEAMMNEIAALHKELNPAETLFVVDAMLGQDAVNTAKAF
HHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHH
NDTLPLTGVVLTKLDGDSRGGAALSVRHVTGKPIKFVGVAEKLDGLEIFYPDRMANRILG
CCCCCCHHEEEEEECCCCCCCCEEEEEECCCCCEEEEEHHHHCCCCEEECCHHHHHHHHC
MGDILALVEEAQRGVDVQAAQKLADKVKKGGDFDLNDFRAQLSQMKKMGGLSSLMDKLPA
HHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHH
QFQQAASNADMGQAEKQMRRMEGIINSMTAAERAKPELIKATRKRRIAAGAGVQVQEVNR
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHH
LLNQYEQMRTMMKKLKGGNLQKMMRGMKGMMPGMR
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MLDNLTQRMARVVKTLRGEARLTEANTQEMLREVRLALLEADVALPVVRDFISKVKEKAL
CCCHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GEEVIGSLSPGQALVGVVQRELTAVIGGDYEGKAAELNLSVTPPAIILMAGLQGAGKTTT
HHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHCCCCCCCCHH
VGKLAKLLREKYKKKVLTVSCDVYRPAAIAQLKTVTEQVGADFFPSQPDQKPVDIARAAV
HHHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
DWAKRHYHDVLLVDTAGRLGIDEAMMNEIAALHKELNPAETLFVVDAMLGQDAVNTAKAF
HHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHH
NDTLPLTGVVLTKLDGDSRGGAALSVRHVTGKPIKFVGVAEKLDGLEIFYPDRMANRILG
CCCCCCHHEEEEEECCCCCCCCEEEEEECCCCCEEEEEHHHHCCCCEEECCHHHHHHHHC
MGDILALVEEAQRGVDVQAAQKLADKVKKGGDFDLNDFRAQLSQMKKMGGLSSLMDKLPA
HHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHH
QFQQAASNADMGQAEKQMRRMEGIINSMTAAERAKPELIKATRKRRIAAGAGVQVQEVNR
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHH
LLNQYEQMRTMMKKLKGGNLQKMMRGMKGMMPGMR
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]