Click here to switch to the map view.

The map label for this gene is proA

Identifier: 186477333

GI number: 186477333

Start: 2921635

End: 2922906

Strand: Reverse

Name: proA

Synonym: Bphy_2585

Alternate gene names: 186477333

Gene position: 2922906-2921635 (Counterclockwise)

Preceding gene: 186477334

Following gene: 186477332

Centisome position: 84.01

GC content: 64.78

Gene sequence:

>1272_bases
ATGGATATCGACCAGTACATGACCGACCTCGGGCGCCGTGCGCGCCACGCTTCGCGTGCGATGGCGCGCGCCTCGACGGC
AGCGAAGAACGCCGCGCTCGAAGCCGTGGCCGTCGCCATCGAGCGGGAAGCGGATACGCTCAGGCAAGCGAATGCACGCG
ACCTCGCACGCGCACGCGACAAGGGGCACGATGCCGCTTTCATCGACCGTTTGACGCTGTCGGACAAGGCACTGAAGACG
ATGGTCGAAGGATTGCGGCAGGTGGCCGCGCTCGCCGACCCGATCGGCGAAATCAGCAATCTCAAGTTCCGGCCGAGCGG
CATCCAGGTCGGCCAGATGCGCGTGCCGCTGGGTGTGATAGGCATCATCTACGAGTCCCGCCCGAACGTGACGATCGATG
CTGCAGCGCTATGCCTGAAGTCCGGCAACGCGACCATCCTGCGCGGGGGATCGGAAGCGCTCGAATGCAACACGGCACTC
GCGAGGCTGATCGGCGAGGGGCTGGACAAGGCGGGCTTGCCGCAGGAGGCGGTGCAGGTAGTCGAGACGTCGGACCGCGC
CGCTGTCGGCAAGCTGATTACGATGACCGACTACGTCGACGTCATCGTGCCGCGCGGCGGCAAGAGCCTAATCGCGCGGC
TGATGGAAGAATCGCGCGTGCCGATGATCAAGCATCTGGACGGCATCTGTCATGTGTACGTGGATGACCGCGCGGATGTC
GCCAAGGCGCTGAACGTGTGCGACAACGCGAAGACGCATCGCTACGGGACGTGCAACACGATGGAGACATTGCTCGTGGC
GCGCGGCATTGCGGCACACGTGCTGCCGGCGCTCGGCAAGCTCTATCGCGAGAAGGAGGTCGAATTGCGCGTCGATTCAG
CTGCGCGCGCGGTCCTGACGGAGGCGGGCGTCGCACCGCTCGTCGATGCGACGGAAGAAGACTGGCGCACCGAGTATCTC
GCGCCCGTGCTCGCGGTGAAGGTGGTGGACGGCATCGACGACGCAATCGGCCATATCAACGAATATGGATCGCACCACAC
CGACGCCATCGTCACCGAAGACCACGACCGCGCGATGCGTTTCCTTCGCGAAGTGGACTCGGCGAGCGTGATGGTCAACG
CATCGACGCGTTTTGCGGACGGCTTCGAGTTCGGCCTGGGCGCCGAGATCGGCATTTCCAACGACAAGCTGCACGCACGC
GGGCCCGTCGGTCTCGAAGGGCTGACGTCGCTGAAGTATGTCGTGCTGGGCCACGGGGAAGGCCGTCAGTAA

Upstream 100 bases:

>100_bases
GGCCGCCGCGCAACGCGCAAAGGTCGCGCAGCATACAATCGACACATCTTTCATCGGCACGCGTCGCCGCGTGCGGCAGG
GCGGCACAATGGGAATCACC

Downstream 100 bases:

>100_bases
ATTCGAATATCGAGAAAAACAAGATTATGGCGATGCTGTGGATCAAGACGTTTCACATCGTTCTGGTGGCTTCGTGGTTT
GCGGGTCTGTTCTACCTGCC

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MDIDQYMTDLGRRARHASRAMARASTAAKNAALEAVAVAIEREADTLRQANARDLARARDKGHDAAFIDRLTLSDKALKT
MVEGLRQVAALADPIGEISNLKFRPSGIQVGQMRVPLGVIGIIYESRPNVTIDAAALCLKSGNATILRGGSEALECNTAL
ARLIGEGLDKAGLPQEAVQVVETSDRAAVGKLITMTDYVDVIVPRGGKSLIARLMEESRVPMIKHLDGICHVYVDDRADV
AKALNVCDNAKTHRYGTCNTMETLLVARGIAAHVLPALGKLYREKEVELRVDSAARAVLTEAGVAPLVDATEEDWRTEYL
APVLAVKVVDGIDDAIGHINEYGSHHTDAIVTEDHDRAMRFLREVDSASVMVNASTRFADGFEFGLGAEIGISNDKLHAR
GPVGLEGLTSLKYVVLGHGEGRQ

Sequences:

>Translated_423_residues
MDIDQYMTDLGRRARHASRAMARASTAAKNAALEAVAVAIEREADTLRQANARDLARARDKGHDAAFIDRLTLSDKALKT
MVEGLRQVAALADPIGEISNLKFRPSGIQVGQMRVPLGVIGIIYESRPNVTIDAAALCLKSGNATILRGGSEALECNTAL
ARLIGEGLDKAGLPQEAVQVVETSDRAAVGKLITMTDYVDVIVPRGGKSLIARLMEESRVPMIKHLDGICHVYVDDRADV
AKALNVCDNAKTHRYGTCNTMETLLVARGIAAHVLPALGKLYREKEVELRVDSAARAVLTEAGVAPLVDATEEDWRTEYL
APVLAVKVVDGIDDAIGHINEYGSHHTDAIVTEDHDRAMRFLREVDSASVMVNASTRFADGFEFGLGAEIGISNDKLHAR
GPVGLEGLTSLKYVVLGHGEGRQ
>Mature_423_residues
MDIDQYMTDLGRRARHASRAMARASTAAKNAALEAVAVAIEREADTLRQANARDLARARDKGHDAAFIDRLTLSDKALKT
MVEGLRQVAALADPIGEISNLKFRPSGIQVGQMRVPLGVIGIIYESRPNVTIDAAALCLKSGNATILRGGSEALECNTAL
ARLIGEGLDKAGLPQEAVQVVETSDRAAVGKLITMTDYVDVIVPRGGKSLIARLMEESRVPMIKHLDGICHVYVDDRADV
AKALNVCDNAKTHRYGTCNTMETLLVARGIAAHVLPALGKLYREKEVELRVDSAARAVLTEAGVAPLVDATEEDWRTEYL
APVLAVKVVDGIDDAIGHINEYGSHHTDAIVTEDHDRAMRFLREVDSASVMVNASTRFADGFEFGLGAEIGISNDKLHAR
GPVGLEGLTSLKYVVLGHGEGRQ

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI62912457, Length=410, Percent_Identity=37.8048780487805, Blast_Score=256, Evalue=3e-68,
Organism=Homo sapiens, GI21361368, Length=410, Percent_Identity=37.8048780487805, Blast_Score=256, Evalue=3e-68,
Organism=Escherichia coli, GI1786438, Length=411, Percent_Identity=46.9586374695864, Blast_Score=367, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17569969, Length=417, Percent_Identity=35.0119904076739, Blast_Score=252, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI17569967, Length=417, Percent_Identity=35.0119904076739, Blast_Score=252, Evalue=3e-67,
Organism=Saccharomyces cerevisiae, GI6324899, Length=434, Percent_Identity=37.7880184331797, Blast_Score=287, Evalue=2e-78,
Organism=Drosophila melanogaster, GI21357643, Length=413, Percent_Identity=37.2881355932203, Blast_Score=258, Evalue=6e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_BURP8 (B2JGX3)

Other databases:

- EMBL:   CP001043
- RefSeq:   YP_001858803.1
- ProteinModelPortal:   B2JGX3
- SMR:   B2JGX3
- GeneID:   6244068
- GenomeReviews:   CP001043_GR
- KEGG:   bph:Bphy_2585
- HOGENOM:   HBG318080
- OMA:   QYPAACN
- ProtClustDB:   PRK00197
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 45516; Mature: 45516

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIDQYMTDLGRRARHASRAMARASTAAKNAALEAVAVAIEREADTLRQANARDLARARD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
KGHDAAFIDRLTLSDKALKTMVEGLRQVAALADPIGEISNLKFRPSGIQVGQMRVPLGVI
CCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCEECEEECCCEEE
GIIYESRPNVTIDAAALCLKSGNATILRGGSEALECNTALARLIGEGLDKAGLPQEAVQV
EEEEECCCCEEEHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
VETSDRAAVGKLITMTDYVDVIVPRGGKSLIARLMEESRVPMIKHLDGICHVYVDDRADV
HHCCCHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHCCCCHHHHCCCEEEEEECCHHHH
AKALNVCDNAKTHRYGTCNTMETLLVARGIAAHVLPALGKLYREKEVELRVDSAARAVLT
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECHHHHHHHH
EAGVAPLVDATEEDWRTEYLAPVLAVKVVDGIDDAIGHINEYGSHHTDAIVTEDHDRAMR
HCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHH
FLREVDSASVMVNASTRFADGFEFGLGAEIGISNDKLHARGPVGLEGLTSLKYVVLGHGE
HHHHCCCCEEEEECCCCCCCCCCCCCCCEECCCCCCEECCCCCCCCHHCCEEEEEEECCC
GRQ
CCC
>Mature Secondary Structure
MDIDQYMTDLGRRARHASRAMARASTAAKNAALEAVAVAIEREADTLRQANARDLARARD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
KGHDAAFIDRLTLSDKALKTMVEGLRQVAALADPIGEISNLKFRPSGIQVGQMRVPLGVI
CCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCEECEEECCCEEE
GIIYESRPNVTIDAAALCLKSGNATILRGGSEALECNTALARLIGEGLDKAGLPQEAVQV
EEEEECCCCEEEHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
VETSDRAAVGKLITMTDYVDVIVPRGGKSLIARLMEESRVPMIKHLDGICHVYVDDRADV
HHCCCHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHCCCCHHHHCCCEEEEEECCHHHH
AKALNVCDNAKTHRYGTCNTMETLLVARGIAAHVLPALGKLYREKEVELRVDSAARAVLT
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECHHHHHHHH
EAGVAPLVDATEEDWRTEYLAPVLAVKVVDGIDDAIGHINEYGSHHTDAIVTEDHDRAMR
HCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHH
FLREVDSASVMVNASTRFADGFEFGLGAEIGISNDKLHARGPVGLEGLTSLKYVVLGHGE
HHHHCCCCEEEEECCCCCCCCCCCCCCCEECCCCCCEECCCCCCCCHHCCEEEEEEECCC
GRQ
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA