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The map label for this gene is edd [H]

Identifier: 186477328

GI number: 186477328

Start: 2900861

End: 2902774

Strand: Reverse

Name: edd [H]

Synonym: Bphy_2580

Alternate gene names: 186477328

Gene position: 2902774-2900861 (Counterclockwise)

Preceding gene: 186477330

Following gene: 186477327

Centisome position: 83.43

GC content: 65.73

Gene sequence:

>1914_bases
ATGGTTTCCCCGCATTCGCAACTGATGAAAGTCACGCAACGCGTGATCGAACGCAGCAAGCCGACGCGCGAAGCGTACCT
GGCGCGCATCGACCAGGCGCAGGGCAAGTTCCCGGCGCGCGGCGCGCTCTCTTGCGCGAACCTCGCGCATGGCTTCGCCG
GCCTCGAGGGCAACGACAAGCTCGTCATCAAACAGATCCGGCAGCCGAACATCGGCATCGTCTCGTCGTACAACGAGATG
CTGTCGGCACATGCGCCGTACAAGGACTTCCCCGACATCATCAAGGCTGCCGCGCGTGAGAACGGCGGCGTCGCGCAGTT
CGCGGGCGGTGTACCGGCGATGTGCGACGGCGTCACGCAGGGCAACGCGGGCATGGAACTGTCGCTGTTTTCGCGCGAAG
TGATTGCGATGAGCACGGCCGTCGCGCTCACGCACAACATGTTCGACGCGGCGCTGTGCCTCGGCGTGTGCGACAAGATC
GTGCCGGGCCTGCTGATCGGCGCGCTGCAATTTGGCCATCTGCCGACCATTTTCGTGCCCGCTGGACCGATGACGAGCGG
CATCTCGAACGACGCGAAGGCGAAGGTGCGCCAGGAGTTCGCGACGGGCCAGTGCGGACGCGACGCACTGCTCGAATCCG
AAGCGGCCGCGTATCACGGCCACGGCACCTGCACGTTCTACGGCACGGCCAACAGCAACCAGATGCTGATGGAGATCATG
GGCCTGCATTTGCCGGGCTCGGCGTTCGTGCATCCGCATACGCCACTGCGTGACGCGTTGACCGCGCAGGCCGCGCGCCG
CGTGCTCGACCTCACAGTGGAGCGCGGCAACTACATGCCGATCGGCCATGTGATCGACGAGAAGGCGATCGTCAACGGCA
TCGTCGGCCTGCTCGCGACGGGCGGCTCGACCAATCACACCTTGCACCTCGTGGCGATTGCGCGCGCGGCGGGGATCATC
ATCGACTGGGACGACTTCGACACGCTGTCGGCGTCCGTGCCGCTGCTCGCCAAGGTGTATCCGAACGGCAAGGCCGACGT
GAACCATTTCCACGCGGCGGGCGGCATGGCGTTCCTGACGCGCAACCTGCTCGAAGGCGGCCTGCTGCACGACGACGTGA
ACACGGTCGCCGGCAAGGGCCTGTCGCACTACACCGAGGAGCCGAAGCTGCTCGACGGCAAGCTGACGTGGGTGCCGGGC
GTCAGCGAAAGCCAGGACAGCGCCGTTCTGCGCCGCATAGACGAGCCGTTCCAGCCGGACGGCGGTCTGCGTCTGATGCA
AGGCAAGCTGGGCCGTGGCGTCATCAAGATTTCGGCCGTCGCGAAGCAGCATCGCACGGTGAAGGCGCCTGCCATCGTGT
TCGATTCACAGGAAGCCGTGCAGGAAGCATTCGATAACGGCGAACTGAAACGCGATTTCATCGCCGTCGTGCGTTTCCAG
GGCGCGCGGGCAAACGGCATGCCCGAACTGCATCGTTTGACGCCGCTGCTTGGCGTGTTGCAGGATCAAGGTTTCCATGT
CGCGCTGGTCACGGATGGTCGTATGTCCGGTGCATCGGGCAAGGTGCCCGCCGTGATTCACGTGTCGCCGGAAGCTCTGC
TGCAGGGACCGCTCGGCAAGGTGCGCACGGGCGACATGCTGGTGATCGATGCGGAAGCGGGCCTGCTGGACGTCGAGATG
GATGCCGCTGAATGGGCCGCGCGTCCGATTGCGGTATCGCAGCATCAGGCGGAAAACGAAGTGGGCTTCGGCCGCGAGCT
GTTCGGTGTGTTCCGTGCAGCGGCCGCGCCGGCGGAACTGGGCGCATCGGTGTTCGGGCCGCTGGTCGGCGAAGCGGCGA
GCGCCGCGCAGCATGCGGCGTCGCAACCGGCCAGCGCCGAGGCGCGCGAAGCCCGTCACGCAATGCACAAATGA

Upstream 100 bases:

>100_bases
TTCTACTAATATCCCGTTTGCCGGCTTTCCATGCCGTTCCCTGCGATACCAATCTGGCGCAACGCGCATCTCAGCGCGAG
CCAGCGACGAAGGAGCATCG

Downstream 100 bases:

>100_bases
GCGAAGGAGTTTGAAGATGACGTCGAAAACAGTCAGCGAAATCGTGCGCCTCGGACCGGTGATCCCCGTCCTCGCATTCG
ATACCGTCGAGCAGGGCGAA

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 637; Mature: 637

Protein sequence:

>637_residues
MVSPHSQLMKVTQRVIERSKPTREAYLARIDQAQGKFPARGALSCANLAHGFAGLEGNDKLVIKQIRQPNIGIVSSYNEM
LSAHAPYKDFPDIIKAAARENGGVAQFAGGVPAMCDGVTQGNAGMELSLFSREVIAMSTAVALTHNMFDAALCLGVCDKI
VPGLLIGALQFGHLPTIFVPAGPMTSGISNDAKAKVRQEFATGQCGRDALLESEAAAYHGHGTCTFYGTANSNQMLMEIM
GLHLPGSAFVHPHTPLRDALTAQAARRVLDLTVERGNYMPIGHVIDEKAIVNGIVGLLATGGSTNHTLHLVAIARAAGII
IDWDDFDTLSASVPLLAKVYPNGKADVNHFHAAGGMAFLTRNLLEGGLLHDDVNTVAGKGLSHYTEEPKLLDGKLTWVPG
VSESQDSAVLRRIDEPFQPDGGLRLMQGKLGRGVIKISAVAKQHRTVKAPAIVFDSQEAVQEAFDNGELKRDFIAVVRFQ
GARANGMPELHRLTPLLGVLQDQGFHVALVTDGRMSGASGKVPAVIHVSPEALLQGPLGKVRTGDMLVIDAEAGLLDVEM
DAAEWAARPIAVSQHQAENEVGFGRELFGVFRAAAAPAELGASVFGPLVGEAASAAQHAASQPASAEAREARHAMHK

Sequences:

>Translated_637_residues
MVSPHSQLMKVTQRVIERSKPTREAYLARIDQAQGKFPARGALSCANLAHGFAGLEGNDKLVIKQIRQPNIGIVSSYNEM
LSAHAPYKDFPDIIKAAARENGGVAQFAGGVPAMCDGVTQGNAGMELSLFSREVIAMSTAVALTHNMFDAALCLGVCDKI
VPGLLIGALQFGHLPTIFVPAGPMTSGISNDAKAKVRQEFATGQCGRDALLESEAAAYHGHGTCTFYGTANSNQMLMEIM
GLHLPGSAFVHPHTPLRDALTAQAARRVLDLTVERGNYMPIGHVIDEKAIVNGIVGLLATGGSTNHTLHLVAIARAAGII
IDWDDFDTLSASVPLLAKVYPNGKADVNHFHAAGGMAFLTRNLLEGGLLHDDVNTVAGKGLSHYTEEPKLLDGKLTWVPG
VSESQDSAVLRRIDEPFQPDGGLRLMQGKLGRGVIKISAVAKQHRTVKAPAIVFDSQEAVQEAFDNGELKRDFIAVVRFQ
GARANGMPELHRLTPLLGVLQDQGFHVALVTDGRMSGASGKVPAVIHVSPEALLQGPLGKVRTGDMLVIDAEAGLLDVEM
DAAEWAARPIAVSQHQAENEVGFGRELFGVFRAAAAPAELGASVFGPLVGEAASAAQHAASQPASAEAREARHAMHK
>Mature_637_residues
MVSPHSQLMKVTQRVIERSKPTREAYLARIDQAQGKFPARGALSCANLAHGFAGLEGNDKLVIKQIRQPNIGIVSSYNEM
LSAHAPYKDFPDIIKAAARENGGVAQFAGGVPAMCDGVTQGNAGMELSLFSREVIAMSTAVALTHNMFDAALCLGVCDKI
VPGLLIGALQFGHLPTIFVPAGPMTSGISNDAKAKVRQEFATGQCGRDALLESEAAAYHGHGTCTFYGTANSNQMLMEIM
GLHLPGSAFVHPHTPLRDALTAQAARRVLDLTVERGNYMPIGHVIDEKAIVNGIVGLLATGGSTNHTLHLVAIARAAGII
IDWDDFDTLSASVPLLAKVYPNGKADVNHFHAAGGMAFLTRNLLEGGLLHDDVNTVAGKGLSHYTEEPKLLDGKLTWVPG
VSESQDSAVLRRIDEPFQPDGGLRLMQGKLGRGVIKISAVAKQHRTVKAPAIVFDSQEAVQEAFDNGELKRDFIAVVRFQ
GARANGMPELHRLTPLLGVLQDQGFHVALVTDGRMSGASGKVPAVIHVSPEALLQGPLGKVRTGDMLVIDAEAGLLDVEM
DAAEWAARPIAVSQHQAENEVGFGRELFGVFRAAAAPAELGASVFGPLVGEAASAAQHAASQPASAEAREARHAMHK

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=599, Percent_Identity=59.432387312187, Blast_Score=719, Evalue=0.0,
Organism=Escherichia coli, GI48994964, Length=548, Percent_Identity=29.9270072992701, Blast_Score=198, Evalue=9e-52,
Organism=Escherichia coli, GI2367371, Length=480, Percent_Identity=31.0416666666667, Blast_Score=153, Evalue=3e-38,
Organism=Escherichia coli, GI1786464, Length=506, Percent_Identity=32.0158102766798, Blast_Score=142, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6322476, Length=484, Percent_Identity=29.7520661157025, Blast_Score=187, Evalue=6e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 67429; Mature: 67429

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSPHSQLMKVTQRVIERSKPTREAYLARIDQAQGKFPARGALSCANLAHGFAGLEGNDK
CCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCC
LVIKQIRQPNIGIVSSYNEMLSAHAPYKDFPDIIKAAARENGGVAQFAGGVPAMCDGVTQ
HHHEECCCCCCCEEECHHHHHHCCCCCCCHHHHHHHHHCCCCCEEECCCCCCHHHCCCCC
GNAGMELSLFSREVIAMSTAVALTHNMFDAALCLGVCDKIVPGLLIGALQFGHLPTIFVP
CCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
AGPMTSGISNDAKAKVRQEFATGQCGRDALLESEAAAYHGHGTCTFYGTANSNQMLMEIM
CCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHCCCHHCCCCEEEEEEECCCCCHHHHHHH
GLHLPGSAFVHPHTPLRDALTAQAARRVLDLTVERGNYMPIGHVIDEKAIVNGIVGLLAT
CCCCCCCCEECCCCCHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHCC
GGSTNHTLHLVAIARAAGIIIDWDDFDTLSASVPLLAKVYPNGKADVNHFHAAGGMAFLT
CCCCCCEEEEEEEHHHCCEEEECCCCCCCCCCCCEEEEECCCCCCCCCHHHHCCHHHHHH
RNLLEGGLLHDDVNTVAGKGLSHYTEEPKLLDGKLTWVPGVSESQDSAVLRRIDEPFQPD
HHHHCCCCEECCHHHHHCCCCHHHCCCCCEECCEEEECCCCCCCHHHHHHHHCCCCCCCC
GGLRLMQGKLGRGVIKISAVAKQHRTVKAPAIVFDSQEAVQEAFDNGELKRDFIAVVRFQ
CCCEEECCCCCCCEEEEHHHHHHCCCEECCEEEECCHHHHHHHHCCCCHHHHHHHHHEEC
GARANGMPELHRLTPLLGVLQDQGFHVALVTDGRMSGASGKVPAVIHVSPEALLQGPLGK
CCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCEEEEECHHHHHCCCCCC
VRTGDMLVIDAEAGLLDVEMDAAEWAARPIAVSQHQAENEVGFGRELFGVFRAAAAPAEL
CCCCCEEEEECCCCEEEEECCHHHHHCCCCEECHHCCCCCCCCCHHHHHHHHHHCCCHHH
GASVFGPLVGEAASAAQHAASQPASAEAREARHAMHK
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MVSPHSQLMKVTQRVIERSKPTREAYLARIDQAQGKFPARGALSCANLAHGFAGLEGNDK
CCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCC
LVIKQIRQPNIGIVSSYNEMLSAHAPYKDFPDIIKAAARENGGVAQFAGGVPAMCDGVTQ
HHHEECCCCCCCEEECHHHHHHCCCCCCCHHHHHHHHHCCCCCEEECCCCCCHHHCCCCC
GNAGMELSLFSREVIAMSTAVALTHNMFDAALCLGVCDKIVPGLLIGALQFGHLPTIFVP
CCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
AGPMTSGISNDAKAKVRQEFATGQCGRDALLESEAAAYHGHGTCTFYGTANSNQMLMEIM
CCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHCCCHHCCCCEEEEEEECCCCCHHHHHHH
GLHLPGSAFVHPHTPLRDALTAQAARRVLDLTVERGNYMPIGHVIDEKAIVNGIVGLLAT
CCCCCCCCEECCCCCHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHCC
GGSTNHTLHLVAIARAAGIIIDWDDFDTLSASVPLLAKVYPNGKADVNHFHAAGGMAFLT
CCCCCCEEEEEEEHHHCCEEEECCCCCCCCCCCCEEEEECCCCCCCCCHHHHCCHHHHHH
RNLLEGGLLHDDVNTVAGKGLSHYTEEPKLLDGKLTWVPGVSESQDSAVLRRIDEPFQPD
HHHHCCCCEECCHHHHHCCCCHHHCCCCCEECCEEEECCCCCCCHHHHHHHHCCCCCCCC
GGLRLMQGKLGRGVIKISAVAKQHRTVKAPAIVFDSQEAVQEAFDNGELKRDFIAVVRFQ
CCCEEECCCCCCCEEEEHHHHHHCCCEECCEEEECCHHHHHHHHCCCCHHHHHHHHHEEC
GARANGMPELHRLTPLLGVLQDQGFHVALVTDGRMSGASGKVPAVIHVSPEALLQGPLGK
CCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCEEEEECHHHHHCCCCCC
VRTGDMLVIDAEAGLLDVEMDAAEWAARPIAVSQHQAENEVGFGRELFGVFRAAAAPAEL
CCCCCEEEEECCCCEEEEECCHHHHHCCCCEECHHCCCCCCCCCHHHHHHHHHHCCCHHH
GASVFGPLVGEAASAAQHAASQPASAEAREARHAMHK
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8045900; 10984043 [H]