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The map label for this gene is mmlH [H]

Identifier: 186477114

GI number: 186477114

Start: 2654930

End: 2656237

Strand: Reverse

Name: mmlH [H]

Synonym: Bphy_2363

Alternate gene names: 186477114

Gene position: 2656237-2654930 (Counterclockwise)

Preceding gene: 186477115

Following gene: 186477113

Centisome position: 76.35

GC content: 63.53

Gene sequence:

>1308_bases
ATGGACAGCAAGACACTCACGGCAAACGTCGACGATGCCGCCGACATGAACACAACGGCAGACACGCAAGCGCTTTCCTG
GTACGCCGAAGCCAGTCCGCGCGCCCGTCGCGCGTTCTGGAGTTGCAAGGTCGGCTACATGCTCGACGGCATGGACACGC
AGATGCTGTCGTTCGTCATTCCGACACTCGTCGCAACATGGGGCATCTCGCTCGCCGACGCCGGCTTCATCGGCACCATG
ACGTTGCTGTCCTCGGCGCTCGGCGGCTGGATCGCGGGAATTCTGTCCGATCGCATTGGCCGCGTGCGCACTCTGCAGCT
CACCGTGCTTTGGTTCGCGGTGTTCACTGCATTGTGCGGGCTCGCGCAGAACTACGGCCAGTTGCTGGCGGCGCGCGCGT
TGATGGGCTTTGGCTTCGGTGGCGAGTGGACGGCGGGCGCCGTGCTGATCGGCGAAGTGATCCGTGCACGCGATCGGGGC
AAGGCGGTCGGTCTCGTTCAGTCGGGCTGGGCGCTCGGCTGGGGCATGGCCGCTTTGCTCTACGCCGTGCTGTTTTCCGT
GATGGCGCCGGAAATCGCGTGGCGCGCGTTGTTCCTGATCGGCCTTGTGCCGGCGCTGCTTGTGCTTTTCATCCGCCGCT
ACGTGAAAGAACCCGAAGTATTCGAGCACGCAAAGGTCCACCAGAAACACACGCATGACACGCCGCGTTTCACCGAAATC
TTCTCGCCCAGACTGCTTTCGACGACGCTGCGCGCCGCTCTGCTCACGACGGGCGCACAGGGCGGTTACTACGCGATCAC
GACATGGCTGCCGACGTTTCTCAAGACCGAGCGTCATCTGACCGTGATGGGCACGGGCGGCTATCTCGCGATGATCATCG
CGGGTTCGTATGTGGGCTATCTGTGCAGCGCGTGGCTCACGGACCGCATTGGCCGCAAACCGAACTTCATTCTGTTCGCG
CTGGGTTCGATGGCAATTGCTTTCGCGTACACGTCTTTGCCGCTCACCAATGCGTCAATGCTGTGGCTCGGCTTTCCGCT
CGGTTTCTTCGCGTCGGGCATCTTCTCCGGGATGGGCGCGTTTCTCACCGAACTCTTTCCGACCCGTGTGCGCGGCTCCG
GCCAGGGGTTTTGCTACAACGTCGGCCGTGCGATCGGCGCACTGTTCCCCGTGCTGATCGGCACGCTGTCGAGCCGCTTC
GGCCTCGGCGCGAGCATCGGCCTGTTCGCGGTGGCCGCGTATGGCGTGCTGATCATCGCCGCGCTCACGCTGCCCGAAAC
ACGCGGCCGTGAACTCGAATCGGCCTGA

Upstream 100 bases:

>100_bases
CTCGAAGCCATCCGGCCATCCAGCCCGGAGGGAATGACGCATCCCTACGCTCGTGCGCGGCTTCGCTTGTTACTCATGCG
TCTATCCACGGGAGCAACAG

Downstream 100 bases:

>100_bases
ACCGCACGCTTTTCACCTCATTCCATTTTTCGCATCAAGCCCACGACATGATGAAGCACGATCAAGCCTCCGATGTTTGC
ACGCCGTCCCGCTGGCAGTT

Product: major facilitator transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MDSKTLTANVDDAADMNTTADTQALSWYAEASPRARRAFWSCKVGYMLDGMDTQMLSFVIPTLVATWGISLADAGFIGTM
TLLSSALGGWIAGILSDRIGRVRTLQLTVLWFAVFTALCGLAQNYGQLLAARALMGFGFGGEWTAGAVLIGEVIRARDRG
KAVGLVQSGWALGWGMAALLYAVLFSVMAPEIAWRALFLIGLVPALLVLFIRRYVKEPEVFEHAKVHQKHTHDTPRFTEI
FSPRLLSTTLRAALLTTGAQGGYYAITTWLPTFLKTERHLTVMGTGGYLAMIIAGSYVGYLCSAWLTDRIGRKPNFILFA
LGSMAIAFAYTSLPLTNASMLWLGFPLGFFASGIFSGMGAFLTELFPTRVRGSGQGFCYNVGRAIGALFPVLIGTLSSRF
GLGASIGLFAVAAYGVLIIAALTLPETRGRELESA

Sequences:

>Translated_435_residues
MDSKTLTANVDDAADMNTTADTQALSWYAEASPRARRAFWSCKVGYMLDGMDTQMLSFVIPTLVATWGISLADAGFIGTM
TLLSSALGGWIAGILSDRIGRVRTLQLTVLWFAVFTALCGLAQNYGQLLAARALMGFGFGGEWTAGAVLIGEVIRARDRG
KAVGLVQSGWALGWGMAALLYAVLFSVMAPEIAWRALFLIGLVPALLVLFIRRYVKEPEVFEHAKVHQKHTHDTPRFTEI
FSPRLLSTTLRAALLTTGAQGGYYAITTWLPTFLKTERHLTVMGTGGYLAMIIAGSYVGYLCSAWLTDRIGRKPNFILFA
LGSMAIAFAYTSLPLTNASMLWLGFPLGFFASGIFSGMGAFLTELFPTRVRGSGQGFCYNVGRAIGALFPVLIGTLSSRF
GLGASIGLFAVAAYGVLIIAALTLPETRGRELESA
>Mature_435_residues
MDSKTLTANVDDAADMNTTADTQALSWYAEASPRARRAFWSCKVGYMLDGMDTQMLSFVIPTLVATWGISLADAGFIGTM
TLLSSALGGWIAGILSDRIGRVRTLQLTVLWFAVFTALCGLAQNYGQLLAARALMGFGFGGEWTAGAVLIGEVIRARDRG
KAVGLVQSGWALGWGMAALLYAVLFSVMAPEIAWRALFLIGLVPALLVLFIRRYVKEPEVFEHAKVHQKHTHDTPRFTEI
FSPRLLSTTLRAALLTTGAQGGYYAITTWLPTFLKTERHLTVMGTGGYLAMIIAGSYVGYLCSAWLTDRIGRKPNFILFA
LGSMAIAFAYTSLPLTNASMLWLGFPLGFFASGIFSGMGAFLTELFPTRVRGSGQGFCYNVGRAIGALFPVLIGTLSSRF
GLGASIGLFAVAAYGVLIIAALTLPETRGRELESA

Specific function: Probable uptake of 4-methylmuconolactone [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=451, Percent_Identity=25.2771618625277, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI213021148, Length=444, Percent_Identity=24.0990990990991, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI87082404, Length=400, Percent_Identity=29.5, Blast_Score=151, Evalue=1e-37,
Organism=Escherichia coli, GI87082231, Length=225, Percent_Identity=30.2222222222222, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1790550, Length=388, Percent_Identity=27.0618556701031, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI87081723, Length=393, Percent_Identity=27.2264631043257, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1788292, Length=460, Percent_Identity=27.8260869565217, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1786229, Length=420, Percent_Identity=25.4761904761905, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789941, Length=388, Percent_Identity=27.8350515463918, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI87082159, Length=413, Percent_Identity=26.1501210653753, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI32564663, Length=438, Percent_Identity=23.7442922374429, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI19922874, Length=469, Percent_Identity=24.0938166311301, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 46832; Mature: 46832

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: PS50850 MFS ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSKTLTANVDDAADMNTTADTQALSWYAEASPRARRAFWSCKVGYMLDGMDTQMLSFVI
CCCCEEEECCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHCEECCEECCCHHHHHHHHH
PTLVATWGISLADAGFIGTMTLLSSALGGWIAGILSDRIGRVRTLQLTVLWFAVFTALCG
HHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
LAQNYGQLLAARALMGFGFGGEWTAGAVLIGEVIRARDRGKAVGLVQSGWALGWGMAALL
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEEHHCCCHHHHHHHHHH
YAVLFSVMAPEIAWRALFLIGLVPALLVLFIRRYVKEPEVFEHAKVHQKHTHDTPRFTEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHH
FSPRLLSTTLRAALLTTGAQGGYYAITTWLPTFLKTERHLTVMGTGGYLAMIIAGSYVGY
HCCHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHH
LCSAWLTDRIGRKPNFILFALGSMAIAFAYTSLPLTNASMLWLGFPLGFFASGIFSGMGA
HHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHCCCCCCCHHHHHCCHHHHHHHHHHHHHH
FLTELFPTRVRGSGQGFCYNVGRAIGALFPVLIGTLSSRFGLGASIGLFAVAAYGVLIIA
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
ALTLPETRGRELESA
HHHCCCCCCCCCCCC
>Mature Secondary Structure
MDSKTLTANVDDAADMNTTADTQALSWYAEASPRARRAFWSCKVGYMLDGMDTQMLSFVI
CCCCEEEECCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHCEECCEECCCHHHHHHHHH
PTLVATWGISLADAGFIGTMTLLSSALGGWIAGILSDRIGRVRTLQLTVLWFAVFTALCG
HHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
LAQNYGQLLAARALMGFGFGGEWTAGAVLIGEVIRARDRGKAVGLVQSGWALGWGMAALL
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEEHHCCCHHHHHHHHHH
YAVLFSVMAPEIAWRALFLIGLVPALLVLFIRRYVKEPEVFEHAKVHQKHTHDTPRFTEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHH
FSPRLLSTTLRAALLTTGAQGGYYAITTWLPTFLKTERHLTVMGTGGYLAMIIAGSYVGY
HCCHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHH
LCSAWLTDRIGRKPNFILFALGSMAIAFAYTSLPLTNASMLWLGFPLGFFASGIFSGMGA
HHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHCCCCCCCHHHHHCCHHHHHHHHHHHHHH
FLTELFPTRVRGSGQGFCYNVGRAIGALFPVLIGTLSSRFGLGASIGLFAVAAYGVLIIA
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
ALTLPETRGRELESA
HHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9461415 [H]