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The map label for this gene is cytR [H]

Identifier: 186476996

GI number: 186476996

Start: 2519271

End: 2520287

Strand: Reverse

Name: cytR [H]

Synonym: Bphy_2245

Alternate gene names: 186476996

Gene position: 2520287-2519271 (Counterclockwise)

Preceding gene: 186477001

Following gene: 186476995

Centisome position: 72.44

GC content: 68.04

Gene sequence:

>1017_bases
TTGCCGGGGAGTGCACGCGGCGGGGAAGGGCTGTCCATTGCGGGCGTGGCGCAACGGGCGGGTGTGTCCGTCGCCACGGT
GTCGCGCGTGCTGAACGGCCATTCGAACGTGCGCCCGGAAACGCGCGACAAGGTGCTGACCGCTGTCGCGACGAGCGGCT
ACCGGGTGAACGAACTCGCGCGCAACCTGCGCACGGCCGAAAGCCGCCTGTTGCTGACGATGGTGCCCGACGTCGGCAAC
CCGTTCTACGCGGAAGTGATACGGGGAATCGATTTCGTCGCGCGCCAGCACGGCTATTTCATGCTGCTCTGCGACACGGG
TGCCGATCCGGGCCGCGAGCGCAGCTATTTCGACCTGCTGCGCCGCCGCCGCGCGGACGGGGCGATCTGCCTGGATCCCG
CCACCGTGCAGCAGGCGCTCGCTGAGGAATCGAACGCGCTGCCGTGGGTCGCGTGCTGCGAATTCGATTCGTCGGTCGGC
GTGCCGTACGTCGGCATCGACAACTACCGCGCAGCGGGCGACGCCGTGCGCCATCTGCTCGCGCGCGGCCACCGGCGCGT
TGCGCTGATCAATTCCGACGATCACTACCTTTACGCGCAGCAGCGTCAGCAAGGCTATATGGACGCGCTGCGGGACGCCG
GCATTGCGCCCGACGAGCGCTGGCGCATCAACGTGAACAGCCTCGACTATGAAGCGGGCGCGTCGGCCGCCGCGCTGCTG
ATGACGTATGCCGACGCGCCGACGGCCGTGTTCGCCGTATCCGACACGCTTGCCATCGGCGTGATGAGCGGCTTGCGCCG
CGTCGGCAAGCGTGTGCCGCACGACGTGGCCGTCGTCGGCTTCGACGATATCTCGCTGGCCGCGCAGATCGATCCGCCGC
TCACGACGATCGCGCAGCCGATGCGCGAGCTTGGCGAAACGGCTGCGCGTCTGCTGTTGCAGCGGCTCGCGAATCGGAAC
GAAAACGTGCCGGGCGTGCTTCTGCCGCATCGGCTTGTCGTCAGACAGAGCGCTTGA

Upstream 100 bases:

>100_bases
ATCGATTACATTTCGGGGGCAGAGCCCGGTGGACACATCGTCCCAGCGCACATCTCGGCATGACTCGCACGCAACGTCGT
CCGATGCGGCTGAGCCCGAC

Downstream 100 bases:

>100_bases
GGGGAAGCCGCGATGAGCCTCGCCGTGCGTTTCGACGATGTCCGCAAAGATTTCGGCCCGGTGCGCGTGCTACACGGCGT
GAGCTTCGATCTCGCGCCGG

Product: LacI family transcription regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 338; Mature: 337

Protein sequence:

>338_residues
MPGSARGGEGLSIAGVAQRAGVSVATVSRVLNGHSNVRPETRDKVLTAVATSGYRVNELARNLRTAESRLLLTMVPDVGN
PFYAEVIRGIDFVARQHGYFMLLCDTGADPGRERSYFDLLRRRRADGAICLDPATVQQALAEESNALPWVACCEFDSSVG
VPYVGIDNYRAAGDAVRHLLARGHRRVALINSDDHYLYAQQRQQGYMDALRDAGIAPDERWRINVNSLDYEAGASAAALL
MTYADAPTAVFAVSDTLAIGVMSGLRRVGKRVPHDVAVVGFDDISLAAQIDPPLTTIAQPMRELGETAARLLLQRLANRN
ENVPGVLLPHRLVVRQSA

Sequences:

>Translated_338_residues
MPGSARGGEGLSIAGVAQRAGVSVATVSRVLNGHSNVRPETRDKVLTAVATSGYRVNELARNLRTAESRLLLTMVPDVGN
PFYAEVIRGIDFVARQHGYFMLLCDTGADPGRERSYFDLLRRRRADGAICLDPATVQQALAEESNALPWVACCEFDSSVG
VPYVGIDNYRAAGDAVRHLLARGHRRVALINSDDHYLYAQQRQQGYMDALRDAGIAPDERWRINVNSLDYEAGASAAALL
MTYADAPTAVFAVSDTLAIGVMSGLRRVGKRVPHDVAVVGFDDISLAAQIDPPLTTIAQPMRELGETAARLLLQRLANRN
ENVPGVLLPHRLVVRQSA
>Mature_337_residues
PGSARGGEGLSIAGVAQRAGVSVATVSRVLNGHSNVRPETRDKVLTAVATSGYRVNELARNLRTAESRLLLTMVPDVGNP
FYAEVIRGIDFVARQHGYFMLLCDTGADPGRERSYFDLLRRRRADGAICLDPATVQQALAEESNALPWVACCEFDSSVGV
PYVGIDNYRAAGDAVRHLLARGHRRVALINSDDHYLYAQQRQQGYMDALRDAGIAPDERWRINVNSLDYEAGASAAALLM
TYADAPTAVFAVSDTLAIGVMSGLRRVGKRVPHDVAVVGFDDISLAAQIDPPLTTIAQPMRELGETAARLLLQRLANRNE
NVPGVLLPHRLVVRQSA

Specific function: This protein negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins. Binds cytidine and adenosine as effectors [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=328, Percent_Identity=37.5, Blast_Score=222, Evalue=3e-59,
Organism=Escherichia coli, GI1788474, Length=335, Percent_Identity=32.8358208955224, Blast_Score=161, Evalue=5e-41,
Organism=Escherichia coli, GI1790194, Length=313, Percent_Identity=32.9073482428115, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI1787948, Length=329, Percent_Identity=30.3951367781155, Blast_Score=158, Evalue=4e-40,
Organism=Escherichia coli, GI1789202, Length=295, Percent_Identity=29.8305084745763, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI48994940, Length=317, Percent_Identity=30.2839116719243, Blast_Score=124, Evalue=7e-30,
Organism=Escherichia coli, GI1789068, Length=304, Percent_Identity=31.9078947368421, Blast_Score=124, Evalue=9e-30,
Organism=Escherichia coli, GI1787906, Length=334, Percent_Identity=28.1437125748503, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1787580, Length=322, Percent_Identity=27.639751552795, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI1786540, Length=329, Percent_Identity=31.306990881459, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1790715, Length=331, Percent_Identity=26.2839879154079, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1786268, Length=328, Percent_Identity=26.8292682926829, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1789456, Length=336, Percent_Identity=24.702380952381, Blast_Score=84, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 36642; Mature: 36511

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGSARGGEGLSIAGVAQRAGVSVATVSRVLNGHSNVRPETRDKVLTAVATSGYRVNELA
CCCCCCCCCCCEEEHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCEEHHHHH
RNLRTAESRLLLTMVPDVGNPFYAEVIRGIDFVARQHGYFMLLCDTGADPGRERSYFDLL
HHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHH
RRRRADGAICLDPATVQQALAEESNALPWVACCEFDSSVGVPYVGIDNYRAAGDAVRHLL
HHHCCCCCEEECHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEECCCCCCHHHHHHHHHH
ARGHRRVALINSDDHYLYAQQRQQGYMDALRDAGIAPDERWRINVNSLDYEAGASAAALL
HCCCCEEEEEECCCCEEEHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCHHHHHH
MTYADAPTAVFAVSDTLAIGVMSGLRRVGKRVPHDVAVVGFDDISLAAQIDPPLTTIAQP
HHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEECCCCHHHHHHH
MRELGETAARLLLQRLANRNENVPGVLLPHRLVVRQSA
HHHHHHHHHHHHHHHHHCCCCCCCCEECCCCEEEECCC
>Mature Secondary Structure 
PGSARGGEGLSIAGVAQRAGVSVATVSRVLNGHSNVRPETRDKVLTAVATSGYRVNELA
CCCCCCCCCCEEEHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCEEHHHHH
RNLRTAESRLLLTMVPDVGNPFYAEVIRGIDFVARQHGYFMLLCDTGADPGRERSYFDLL
HHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHH
RRRRADGAICLDPATVQQALAEESNALPWVACCEFDSSVGVPYVGIDNYRAAGDAVRHLL
HHHCCCCCEEECHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEECCCCCCHHHHHHHHHH
ARGHRRVALINSDDHYLYAQQRQQGYMDALRDAGIAPDERWRINVNSLDYEAGASAAALL
HCCCCEEEEEECCCCEEEHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCHHHHHH
MTYADAPTAVFAVSDTLAIGVMSGLRRVGKRVPHDVAVVGFDDISLAAQIDPPLTTIAQP
HHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEECCCCHHHHHHH
MRELGETAARLLLQRLANRNENVPGVLLPHRLVVRQSA
HHHHHHHHHHHHHHHHHCCCCCCCCEECCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]