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The map label for this gene is nuoN

Identifier: 186476751

GI number: 186476751

Start: 2245303

End: 2246781

Strand: Reverse

Name: nuoN

Synonym: Bphy_1996

Alternate gene names: 186476751

Gene position: 2246781-2245303 (Counterclockwise)

Preceding gene: 186476752

Following gene: 186476750

Centisome position: 64.58

GC content: 62.27

Gene sequence:

>1479_bases
ATGCAAAACGCACCTATGACCGCCTTGTTACCCGACGCGCTGGTGATGGCCGCTATCGTCGTCGCGTGGCTCATCGACAC
GTTCGTTGGCCCGAACAGCCGCCGCACGACGTATTTCATCGCGCTGCTTTCCACGGTCGTGGCCGGCATCTGGTTCGCCA
TCGATGCCCTCACGCCGGGCGCCGGGCCGCAATACTTCTTCTCGCGCATGTACGTGGTGGACCCGTTCGCCAGCGTGATG
AAGGCGGTCGTGTCGCTGGGCTACGCGGTGTCGATCGTGTACTCGCGCAAGTATCTGGAAGACCGCGGCCTCTACGAAGG
CAACTTCTTCCTGCTCGGCATGTTCTCGCTGCTCGGCCAGCTGGTGATGATCTCGGGCAACAACTTCCTGACGCTGTATC
TCGGCCTGGAACTGATGTCGCTGTCGCTCTATGCGGCAATTGCGCTTCGTCGCGAGAACGCGCCGTCGACCGAAGCCGCG
ATGAAGTACTACGTGCTGGGCGCGCTGGCTTCGGGCTTCCTGCTGTACGGCATCTCGATGCTGTACGGCGCGACGGGCTC
GCTGGAACTGAACGAAGTGCTGAAGGCCGTCGCATCGGGCCGCATCAACGACGTCGTGCTGCTGTTCGGCGTGATCTTCA
TCGTCGCGGGTGTCGCGTTCAAGATGGGTGCAGTGCCCTTCCACATGTGGGTACCGGACGTGTATCAGGGCGCGCCGACT
GCAATGACGCTGATCGTCGGCGGCGGTCCAAAGGTCGCTGCGTTCGCATGGGGGCTGCGCTTCCTGGTGATGGGCCTGCT
GCCGCTCGCCGTCGACTGGCAGGAAATGCTGGTCATTCTGGCTGCGCTGTCGCTGATCGTCGGCAATATCACGGGGATCG
TCCAGCGCAACGTCAAGCGGATGCTGGCGTACTCGGCCATCTCGAACATGGGCTTCGTGCTGCTCGGGCTGCTGGCCGGC
GTGGTCGACGGCAAGACGGGCGCGGCTGCGAGCGCCTACGGTTCCGCGATGTTCTACAGCATCGTCTATCTGATCACCAC
GCTCGGCTCGTTCGGCGTCGTGATGCTGCTCGCGCGCCGCGAATTCGAAGCCGAAACGCTCGACGACTTCAAGGGTCTCA
ATCAGCGTAGTCCGGTGTTCGCGTTCGTGATGATGGTGATGATGTTCTCGCTCGCAGGCATTCCGCCGGCAGTCGGTTTC
TACGCGAAGCTGGCCGTCCTCGAAGCGACGATGAACGCGGGTCTCACGTGGCTCGCCGTGCTGGCTGTGATCACGTCGCT
GTTTGGCGCGTTCTATTACCTGCGTATCGTCAAGTTGATGTACTTCGACGATCCCGTCGACACGACGCCGATCGTCGGCG
ACGCCTGCAAGCGCACGCTGCTCGCACTCAATGGTGTGGCCGTGCTCGTGCTCGGTATCGTTCCGGGTCCACTGATGTCG
ATCTGCCTCAACGCGATTTCCCATACGCTGCCGCTGTAA

Upstream 100 bases:

>100_bases
ACCGAAGTAATGCACGTGTCGGTGGAAAATCTCCTGTCCCACGTTGCGCAGTCGAAGCTGCCGCTACCGCAGTAATGCGA
AGCGGAGGAATTTAAAGATC

Downstream 100 bases:

>100_bases
TGTCGGCAGCGGGGTGGTTCATCGTGCTGTTGGCGCTCGTCGGCGCCAACCTGCCGTTCCTGAACCAGCGCGTATTCGGT
GTCGTGCCTTTGCGGGCCGC

Product: NADH dehydrogenase subunit N

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N; NDH-1 subunit N

Number of amino acids: Translated: 492; Mature: 492

Protein sequence:

>492_residues
MQNAPMTALLPDALVMAAIVVAWLIDTFVGPNSRRTTYFIALLSTVVAGIWFAIDALTPGAGPQYFFSRMYVVDPFASVM
KAVVSLGYAVSIVYSRKYLEDRGLYEGNFFLLGMFSLLGQLVMISGNNFLTLYLGLELMSLSLYAAIALRRENAPSTEAA
MKYYVLGALASGFLLYGISMLYGATGSLELNEVLKAVASGRINDVVLLFGVIFIVAGVAFKMGAVPFHMWVPDVYQGAPT
AMTLIVGGGPKVAAFAWGLRFLVMGLLPLAVDWQEMLVILAALSLIVGNITGIVQRNVKRMLAYSAISNMGFVLLGLLAG
VVDGKTGAAASAYGSAMFYSIVYLITTLGSFGVVMLLARREFEAETLDDFKGLNQRSPVFAFVMMVMMFSLAGIPPAVGF
YAKLAVLEATMNAGLTWLAVLAVITSLFGAFYYLRIVKLMYFDDPVDTTPIVGDACKRTLLALNGVAVLVLGIVPGPLMS
ICLNAISHTLPL

Sequences:

>Translated_492_residues
MQNAPMTALLPDALVMAAIVVAWLIDTFVGPNSRRTTYFIALLSTVVAGIWFAIDALTPGAGPQYFFSRMYVVDPFASVM
KAVVSLGYAVSIVYSRKYLEDRGLYEGNFFLLGMFSLLGQLVMISGNNFLTLYLGLELMSLSLYAAIALRRENAPSTEAA
MKYYVLGALASGFLLYGISMLYGATGSLELNEVLKAVASGRINDVVLLFGVIFIVAGVAFKMGAVPFHMWVPDVYQGAPT
AMTLIVGGGPKVAAFAWGLRFLVMGLLPLAVDWQEMLVILAALSLIVGNITGIVQRNVKRMLAYSAISNMGFVLLGLLAG
VVDGKTGAAASAYGSAMFYSIVYLITTLGSFGVVMLLARREFEAETLDDFKGLNQRSPVFAFVMMVMMFSLAGIPPAVGF
YAKLAVLEATMNAGLTWLAVLAVITSLFGAFYYLRIVKLMYFDDPVDTTPIVGDACKRTLLALNGVAVLVLGIVPGPLMS
ICLNAISHTLPL
>Mature_492_residues
MQNAPMTALLPDALVMAAIVVAWLIDTFVGPNSRRTTYFIALLSTVVAGIWFAIDALTPGAGPQYFFSRMYVVDPFASVM
KAVVSLGYAVSIVYSRKYLEDRGLYEGNFFLLGMFSLLGQLVMISGNNFLTLYLGLELMSLSLYAAIALRRENAPSTEAA
MKYYVLGALASGFLLYGISMLYGATGSLELNEVLKAVASGRINDVVLLFGVIFIVAGVAFKMGAVPFHMWVPDVYQGAPT
AMTLIVGGGPKVAAFAWGLRFLVMGLLPLAVDWQEMLVILAALSLIVGNITGIVQRNVKRMLAYSAISNMGFVLLGLLAG
VVDGKTGAAASAYGSAMFYSIVYLITTLGSFGVVMLLARREFEAETLDDFKGLNQRSPVFAFVMMVMMFSLAGIPPAVGF
YAKLAVLEATMNAGLTWLAVLAVITSLFGAFYYLRIVKLMYFDDPVDTTPIVGDACKRTLLALNGVAVLVLGIVPGPLMS
ICLNAISHTLPL

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1007

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 2 (chain N)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family

Homologues:

Organism=Homo sapiens, GI251831108, Length=330, Percent_Identity=25.1515151515152, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI145693160, Length=492, Percent_Identity=32.7235772357724, Blast_Score=224, Evalue=8e-60,
Organism=Escherichia coli, GI1788614, Length=411, Percent_Identity=23.6009732360097, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1788831, Length=297, Percent_Identity=26.9360269360269, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1788827, Length=329, Percent_Identity=24.6200607902736, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788613, Length=280, Percent_Identity=28.9285714285714, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI2367154, Length=270, Percent_Identity=24.0740740740741, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUON_BURP8 (B2JDL5)

Other databases:

- EMBL:   CP001043
- RefSeq:   YP_001858221.1
- GeneID:   6243485
- GenomeReviews:   CP001043_GR
- KEGG:   bph:Bphy_1996
- HOGENOM:   HBG747830
- OMA:   MDMNTLL
- ProtClustDB:   PRK05777
- GO:   GO:0006810
- HAMAP:   MF_00445
- InterPro:   IPR010096
- InterPro:   IPR001750
- TIGRFAMs:   TIGR01770

Pfam domain/function: PF00361 Oxidored_q1

EC number: =1.6.99.5

Molecular weight: Translated: 52802; Mature: 52802

Theoretical pI: Translated: 8.10; Mature: 8.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1ed9e35c)-; HASH(0x1c61671c)-; HASH(0x1f350fbc)-; HASH(0x1e354034)-; HASH(0x1f276414)-; HASH(0x1e38110c)-; HASH(0x1f25335c)-; HASH(0x1f25a0f0)-; HASH(0x1f3538c0)-; HASH(0x1f271e80)-; HASH(0x1f313454)-; HASH(0x1efc7304)-; HASH(0x1eb94514)-; HASH(0x1f351010)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHCCH
>Mature Secondary Structure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HHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA