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The map label for this gene is uvrB [H]

Identifier: 186476713

GI number: 186476713

Start: 2200365

End: 2202458

Strand: Reverse

Name: uvrB [H]

Synonym: Bphy_1958

Alternate gene names: 186476713

Gene position: 2202458-2200365 (Counterclockwise)

Preceding gene: 186476715

Following gene: 186476712

Centisome position: 63.3

GC content: 61.03

Gene sequence:

>2094_bases
ATGTCCGAACATCATCTGAGTGAAGTCCAAGACGCTCTCGACGAATCCAAATTCGTGACGTTCGACGGCTCACCGTTCCG
GCTGTACCAGCCGTATCCGCCTGCGGGCGACCAGCCGGCGGCGATCCAGACGCTCGTCGAGGGTGTCGAGGACGGTCTGT
CGTTCCAGACGCTGCTCGGCGTGACGGGCTCTGGCAAGACCTACACGATGGCGAACACGATCGCGCGTCTGGGCCGCCCG
GCCATCGTTTTCGCGCCCAACAAGACACTTGCCGCGCAGCTGTACGCGGAGTTTCGCGAGTTTTTCCCACGCAATGCCGT
CGAGTACTTCGTCTCGTACTACGACTATTACCAGCCGGAAGCGTACGTCCCGCAGCGCGACCTGTTCATCGAAAAGGACT
CGTCGATTAACGAGCATATCGAGCAGATGCGTCTATCCGCAACCAAGAGTCTGATGGAACGGCGCGATGTCGTGATCGTG
GCGACGGTGTCGGCGATTTACGGTATCGGGAATCCGTCGGAATACCACCAGATGATTCTGACGCTGCGTACGGGCGACAA
GATGGGACAGCGTGACATCATCGCGCGTCTGATTGCGATGCAGTACAACCGCAACGAAGCCGATTTTCAGCGCGGCTCTT
TCCGCGTGCGGGGCGACACGATCGATATTTTCCCGGCCGAGCATGCCGAAATGGCCGTGCGCGTTGAACTGTTCGACGAC
GAAATCGATACGCTGCAACTGTTCGATCCGCTGACAGGCCGCGTGCGTCAGAAGATTCCGCGCTTCACCGTCTATCCGTC
GTCGCACTACGTGACGCCGCGTGAGACCGTGATGCGCGCCGTCGAGACGATCAAGTCGGAACTCCGAGACCGTCTTGAGT
TCTTCTACAACGACGGCAAGCTCGTCGAAGCGCAGCGGCTTGAGCAGCGCACGCGCTTCGACCTTGAAATGCTGCAGGAA
CTGGGCTTCTGCAAGGGCATCGAGAATTACTCGCGGCACTTCTCGGGCGCCGCGCCCGGTGAGCCGCCGCCGACGCTGGT
GGACTATCTCCCGACGGATGCCATCATGTTCCTCGACGAATCGCACGTGCTGATCGGCCAGTTGAACGGCATGTACAACG
GCGACCGCGCGCGCAAGGAAAATCTCGTCGACTACGGCTTCCGGCTGCCGTCCGCGCTCGACAACCGGCCGCTCAAGTTC
AACGAATTCGAGCGCAAGATGCGCCAGGTCGTGTTCGTGTCGGCGACGCCCGCCGACTACGAGAAGAAGACGGCGGGGCA
GGTGGCCGAGCAGGTCGTGCGTCCGACGGGCCTCGTCGATCCTGAAATCGACGTGCGGCCGGCACGCACGCAGGTCGACG
ACGTGCTGGCCGAGATCAACGAACGCGTTGCCGCGGGCGACCGCGTGCTGGTCACAGTGCTGACCAAGCGAATGGCCGAG
CAGCTGACCGAGTTTCTCGCCGATCACGGCGTGAAGGTGCGCTATCTGCATAGCGACATCGACACCGTCGAGCGTGTCGA
GATCATCCGCGACCTGCGGCTCGGTACGTTCGACGTGCTGGTCGGGATCAACCTGTTGCGCGAAGGTCTTGATATTCCCG
AGGTCTCGCTGGTCGCGATCCTCGATGCCGACAAGGAAGGCTTCCTGCGCGCCGAGCGCTCGCTGATCCAGACGATCGGC
CGCGCCGCGCGTAACGTGAACGGTAAGGCCATTCTCTACGCGGACAAGATCACGGATTCGATGAAGCGCGCCATCGACGA
AACCGAGCGGCGGCGCGCGAAGCAGATCGCGTTCAACGAACAGATGGGCATCGTGCCGCGGGGTGTGGTCAAGCGGATCA
AGGACATCATCGACGGCGTCTATAACGTCGACGAAGCCCGCGCCGAGCTGAAGGAACAGCAGGTCCGTGCGAAGTTCGAA
GATATGTCCGAGAAGCAGATCGCCAAGGAAATCAAGCGTCTAGAGAAGCAGATGATGGAGCACGCGAAAAATCTCGAATT
CGAAAAGGCGGCTCAGATGCGCGACCAGCTTGCGCTGCTGCGCGAGCGGGTATTCGGCGCGAATGTCGGCGATCATTTGA
CGGGCACGAACTAA

Upstream 100 bases:

>100_bases
CCAGGCGCCGGAAGCCGTCGCGGCCGCCAGGCGAGCCCTCAGCCCGCACGTTCGCAAAACGCTAAAATAGTCGTTTGCTC
CCGGCCGAGGTGCTGCTTCC

Downstream 100 bases:

>100_bases
ACGGCTTCCAGAAAGGGTCGGCCGCGCGGCCGATTGTCGCCGCGCGTCGTCCAAAACCGGCTTGGCGCCGCGATGCCTTC
CGAAAACTTCGCTTAAGCTC

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 697; Mature: 696

Protein sequence:

>697_residues
MSEHHLSEVQDALDESKFVTFDGSPFRLYQPYPPAGDQPAAIQTLVEGVEDGLSFQTLLGVTGSGKTYTMANTIARLGRP
AIVFAPNKTLAAQLYAEFREFFPRNAVEYFVSYYDYYQPEAYVPQRDLFIEKDSSINEHIEQMRLSATKSLMERRDVVIV
ATVSAIYGIGNPSEYHQMILTLRTGDKMGQRDIIARLIAMQYNRNEADFQRGSFRVRGDTIDIFPAEHAEMAVRVELFDD
EIDTLQLFDPLTGRVRQKIPRFTVYPSSHYVTPRETVMRAVETIKSELRDRLEFFYNDGKLVEAQRLEQRTRFDLEMLQE
LGFCKGIENYSRHFSGAAPGEPPPTLVDYLPTDAIMFLDESHVLIGQLNGMYNGDRARKENLVDYGFRLPSALDNRPLKF
NEFERKMRQVVFVSATPADYEKKTAGQVAEQVVRPTGLVDPEIDVRPARTQVDDVLAEINERVAAGDRVLVTVLTKRMAE
QLTEFLADHGVKVRYLHSDIDTVERVEIIRDLRLGTFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRAERSLIQTIG
RAARNVNGKAILYADKITDSMKRAIDETERRRAKQIAFNEQMGIVPRGVVKRIKDIIDGVYNVDEARAELKEQQVRAKFE
DMSEKQIAKEIKRLEKQMMEHAKNLEFEKAAQMRDQLALLRERVFGANVGDHLTGTN

Sequences:

>Translated_697_residues
MSEHHLSEVQDALDESKFVTFDGSPFRLYQPYPPAGDQPAAIQTLVEGVEDGLSFQTLLGVTGSGKTYTMANTIARLGRP
AIVFAPNKTLAAQLYAEFREFFPRNAVEYFVSYYDYYQPEAYVPQRDLFIEKDSSINEHIEQMRLSATKSLMERRDVVIV
ATVSAIYGIGNPSEYHQMILTLRTGDKMGQRDIIARLIAMQYNRNEADFQRGSFRVRGDTIDIFPAEHAEMAVRVELFDD
EIDTLQLFDPLTGRVRQKIPRFTVYPSSHYVTPRETVMRAVETIKSELRDRLEFFYNDGKLVEAQRLEQRTRFDLEMLQE
LGFCKGIENYSRHFSGAAPGEPPPTLVDYLPTDAIMFLDESHVLIGQLNGMYNGDRARKENLVDYGFRLPSALDNRPLKF
NEFERKMRQVVFVSATPADYEKKTAGQVAEQVVRPTGLVDPEIDVRPARTQVDDVLAEINERVAAGDRVLVTVLTKRMAE
QLTEFLADHGVKVRYLHSDIDTVERVEIIRDLRLGTFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRAERSLIQTIG
RAARNVNGKAILYADKITDSMKRAIDETERRRAKQIAFNEQMGIVPRGVVKRIKDIIDGVYNVDEARAELKEQQVRAKFE
DMSEKQIAKEIKRLEKQMMEHAKNLEFEKAAQMRDQLALLRERVFGANVGDHLTGTN
>Mature_696_residues
SEHHLSEVQDALDESKFVTFDGSPFRLYQPYPPAGDQPAAIQTLVEGVEDGLSFQTLLGVTGSGKTYTMANTIARLGRPA
IVFAPNKTLAAQLYAEFREFFPRNAVEYFVSYYDYYQPEAYVPQRDLFIEKDSSINEHIEQMRLSATKSLMERRDVVIVA
TVSAIYGIGNPSEYHQMILTLRTGDKMGQRDIIARLIAMQYNRNEADFQRGSFRVRGDTIDIFPAEHAEMAVRVELFDDE
IDTLQLFDPLTGRVRQKIPRFTVYPSSHYVTPRETVMRAVETIKSELRDRLEFFYNDGKLVEAQRLEQRTRFDLEMLQEL
GFCKGIENYSRHFSGAAPGEPPPTLVDYLPTDAIMFLDESHVLIGQLNGMYNGDRARKENLVDYGFRLPSALDNRPLKFN
EFERKMRQVVFVSATPADYEKKTAGQVAEQVVRPTGLVDPEIDVRPARTQVDDVLAEINERVAAGDRVLVTVLTKRMAEQ
LTEFLADHGVKVRYLHSDIDTVERVEIIRDLRLGTFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRAERSLIQTIGR
AARNVNGKAILYADKITDSMKRAIDETERRRAKQIAFNEQMGIVPRGVVKRIKDIIDGVYNVDEARAELKEQQVRAKFED
MSEKQIAKEIKRLEKQMMEHAKNLEFEKAAQMRDQLALLRERVFGANVGDHLTGTN

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=671, Percent_Identity=65.7228017883756, Blast_Score=877, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=306, Percent_Identity=23.5294117647059, Blast_Score=76, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 79454; Mature: 79322

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEHHLSEVQDALDESKFVTFDGSPFRLYQPYPPAGDQPAAIQTLVEGVEDGLSFQTLLG
CCCCHHHHHHHHHCCCCEEEECCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCHHHHHC
VTGSGKTYTMANTIARLGRPAIVFAPNKTLAAQLYAEFREFFPRNAVEYFVSYYDYYQPE
CCCCCCEEHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCC
AYVPQRDLFIEKDSSINEHIEQMRLSATKSLMERRDVVIVATVSAIYGIGNPSEYHQMIL
CCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHCCCCHHHHHHEEE
TLRTGDKMGQRDIIARLIAMQYNRNEADFQRGSFRVRGDTIDIFPAEHAEMAVRVELFDD
EEECCCCCCHHHHHHHHHHHHCCCCHHHHCCCCEEEECCEEEECCCCCCCEEEEEEEECC
EIDTLQLFDPLTGRVRQKIPRFTVYPSSHYVTPRETVMRAVETIKSELRDRLEFFYNDGK
CCCHHHHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
LVEAQRLEQRTRFDLEMLQELGFCKGIENYSRHFSGAAPGEPPPTLVDYLPTDAIMFLDE
EEHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCHHHHHCCCCEEEEECC
SHVLIGQLNGMYNGDRARKENLVDYGFRLPSALDNRPLKFNEFERKMRQVVFVSATPADY
CCEEEEECCCCCCCCHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHEEEEECCCCCC
EKKTAGQVAEQVVRPTGLVDPEIDVRPARTQVDDVLAEINERVAAGDRVLVTVLTKRMAE
HHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
QLTEFLADHGVKVRYLHSDIDTVERVEIIRDLRLGTFDVLVGINLLREGLDIPEVSLVAI
HHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEEEE
LDADKEGFLRAERSLIQTIGRAARNVNGKAILYADKITDSMKRAIDETERRRAKQIAFNE
EECCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHC
QMGIVPRGVVKRIKDIIDGVYNVDEARAELKEQQVRAKFEDMSEKQIAKEIKRLEKQMME
CCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
HAKNLEFEKAAQMRDQLALLRERVFGANVGDHLTGTN
HHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SEHHLSEVQDALDESKFVTFDGSPFRLYQPYPPAGDQPAAIQTLVEGVEDGLSFQTLLG
CCCHHHHHHHHHCCCCEEEECCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCHHHHHC
VTGSGKTYTMANTIARLGRPAIVFAPNKTLAAQLYAEFREFFPRNAVEYFVSYYDYYQPE
CCCCCCEEHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCC
AYVPQRDLFIEKDSSINEHIEQMRLSATKSLMERRDVVIVATVSAIYGIGNPSEYHQMIL
CCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHCCCCHHHHHHEEE
TLRTGDKMGQRDIIARLIAMQYNRNEADFQRGSFRVRGDTIDIFPAEHAEMAVRVELFDD
EEECCCCCCHHHHHHHHHHHHCCCCHHHHCCCCEEEECCEEEECCCCCCCEEEEEEEECC
EIDTLQLFDPLTGRVRQKIPRFTVYPSSHYVTPRETVMRAVETIKSELRDRLEFFYNDGK
CCCHHHHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
LVEAQRLEQRTRFDLEMLQELGFCKGIENYSRHFSGAAPGEPPPTLVDYLPTDAIMFLDE
EEHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCHHHHHCCCCEEEEECC
SHVLIGQLNGMYNGDRARKENLVDYGFRLPSALDNRPLKFNEFERKMRQVVFVSATPADY
CCEEEEECCCCCCCCHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHEEEEECCCCCC
EKKTAGQVAEQVVRPTGLVDPEIDVRPARTQVDDVLAEINERVAAGDRVLVTVLTKRMAE
HHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
QLTEFLADHGVKVRYLHSDIDTVERVEIIRDLRLGTFDVLVGINLLREGLDIPEVSLVAI
HHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEEEE
LDADKEGFLRAERSLIQTIGRAARNVNGKAILYADKITDSMKRAIDETERRRAKQIAFNE
EECCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHC
QMGIVPRGVVKRIKDIIDGVYNVDEARAELKEQQVRAKFEDMSEKQIAKEIKRLEKQMME
CCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
HAKNLEFEKAAQMRDQLALLRERVFGANVGDHLTGTN
HHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA