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The map label for this gene is hutH [H]

Identifier: 186476572

GI number: 186476572

Start: 2073749

End: 2075272

Strand: Reverse

Name: hutH [H]

Synonym: Bphy_1814

Alternate gene names: 186476572

Gene position: 2075272-2073749 (Counterclockwise)

Preceding gene: 186476573

Following gene: 186476571

Centisome position: 59.65

GC content: 66.27

Gene sequence:

>1524_bases
ATGATCCTTACACCCGGCTCCCTGACTCTGTCCCAACTGCGCCAGATCGCTCGCGAACAGGTCACCCTCGAACTCGATCC
CGCGAGCTTCGCCGCCATCGACGCCTGCGCTCAAGCCGTCGCGGACATCGCCGCGAAGGGCGAGCCGGCGTACGGTATCA
ACACGGGCTTCGGTCGCCTTGCCAGCACGCATATTCCGCATGACCAGCTCGAACTGCTGCAGCGCAATCTGGTGCTCTCG
CATGCGGTTGGCGTGGGTGAGCCGATGTCGCCGCCCGTCGTGCGCCTGCTGATGGCGCTCAAGCTGTCGAGCCTTGGCCG
CGGCCACTCGGGCATCCGCCGCGAAGTGATGGACGCGCTGATCAAGCTGTTCAACGCCGACGTGCTGCCCGTGATCCCCG
TGAAGGGTTCCGTCGGCGCATCGGGCGACCTCGCGCCGCTCGCGCATATGTCGGCCGTGCTGCTCGGCGTCGGCGAAGTG
TTCGCGAAGGGTGAGCGCGTCGCGGCGACGGAAGGTCTGCGTCTCGTCGGCCTCAAGCCGTTGACGCTGCAAGCGAAGGA
AGGTCTCGCGCTGCTCAACGGCACGCAGGCATCGGCGGCACTCGCGCTGTACAACATGTTCGCGATCGAAGACCTGTACC
GCGTCGGCCTCGTCGCGGGTGCACTGTCCGTCGACGCAGCGGCTGGTTCCGTCAAGCCGTTCGATGCGCGCATCCACGCG
CTGCGCGGCCATCAAGGCCAGATCGATGCGGCCGAGTCGTATCGCACCCTGCTCGACGGTTCGGCGATCAACCTGTCGCA
CCGCGATTGCGGCAAGGTACAGGACCCGTACAGCCTGCGCTGCCAGCCGCAGGTGATGGGCGCGTGTCTCGACCAGATGC
GTGCCGCCGCGCAAGTGCTGCTCGTCGAAGCGAACGCCGTGTCGGACAACCCGCTGATCTTCCCGGATACGGGCGAAGTG
CTGTCGGGCGGCAACTTCCACGCCGAGCCTGTCGCATTCGCCGCCGACAATCTCGCGCTCGCCGCAGCGGAAATCGGTGC
GCTCGCCGAACGCCGCATCGCGCTGCTGATCGACGCGACGCTGTCGGGTCTGCCGCCGTTCCTCGTCAAGGATGGCGGCG
TGAACTCGGGCTTCATGATCGCGCACGTCACGGCCGCCGCGCTCGCATCCGAGAACAAGACGCTGGCTCACCCGGCTTCC
GTCGATTCGCTGCCCACGTCGGCGAACCAGGAAGACCATGTGTCGATGGCGACGTTCGCCGCGCGCAAGCTCGCCGATAT
CGCCGACAACACCGCGAACATCCTGTCGATCGAACTGCTCGCCGCTGCGCAAGGTGTCGATCTGCGCGCGCCGCACAAGA
CAAGCCCGGCGCTGCAGAAGGTGATGGAGACCGTGCGCGCGCACGTCGCGCACTACGAGCTTGACCATTACTTCGCGCCC
GATATCGCCGCGATCACCAAGCTCGTGCAGGACGGCACGATCGCGAAGCACAGCCCGTTCTCGTTCATTTCCGAGCAACG
CTAA

Upstream 100 bases:

>100_bases
ATCTAGTGGAAACCCCTAACGACGATCTGCATAATTCGAGTTGTATATACAAGATGATGCCGCTACACTTCTCGAAATTG
TATAGACAGGAACTCACATC

Downstream 100 bases:

>100_bases
CTCCATCTGCTCAACGGCAGCGCGCCAGAGATGCCCAGCATGAACGCACCGGCTTATCAGGGAATCAAGGACTTCATCCT
CGCCCGCATTCACGCGGGCG

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 507; Mature: 507

Protein sequence:

>507_residues
MILTPGSLTLSQLRQIAREQVTLELDPASFAAIDACAQAVADIAAKGEPAYGINTGFGRLASTHIPHDQLELLQRNLVLS
HAVGVGEPMSPPVVRLLMALKLSSLGRGHSGIRREVMDALIKLFNADVLPVIPVKGSVGASGDLAPLAHMSAVLLGVGEV
FAKGERVAATEGLRLVGLKPLTLQAKEGLALLNGTQASAALALYNMFAIEDLYRVGLVAGALSVDAAAGSVKPFDARIHA
LRGHQGQIDAAESYRTLLDGSAINLSHRDCGKVQDPYSLRCQPQVMGACLDQMRAAAQVLLVEANAVSDNPLIFPDTGEV
LSGGNFHAEPVAFAADNLALAAAEIGALAERRIALLIDATLSGLPPFLVKDGGVNSGFMIAHVTAAALASENKTLAHPAS
VDSLPTSANQEDHVSMATFAARKLADIADNTANILSIELLAAAQGVDLRAPHKTSPALQKVMETVRAHVAHYELDHYFAP
DIAAITKLVQDGTIAKHSPFSFISEQR

Sequences:

>Translated_507_residues
MILTPGSLTLSQLRQIAREQVTLELDPASFAAIDACAQAVADIAAKGEPAYGINTGFGRLASTHIPHDQLELLQRNLVLS
HAVGVGEPMSPPVVRLLMALKLSSLGRGHSGIRREVMDALIKLFNADVLPVIPVKGSVGASGDLAPLAHMSAVLLGVGEV
FAKGERVAATEGLRLVGLKPLTLQAKEGLALLNGTQASAALALYNMFAIEDLYRVGLVAGALSVDAAAGSVKPFDARIHA
LRGHQGQIDAAESYRTLLDGSAINLSHRDCGKVQDPYSLRCQPQVMGACLDQMRAAAQVLLVEANAVSDNPLIFPDTGEV
LSGGNFHAEPVAFAADNLALAAAEIGALAERRIALLIDATLSGLPPFLVKDGGVNSGFMIAHVTAAALASENKTLAHPAS
VDSLPTSANQEDHVSMATFAARKLADIADNTANILSIELLAAAQGVDLRAPHKTSPALQKVMETVRAHVAHYELDHYFAP
DIAAITKLVQDGTIAKHSPFSFISEQR
>Mature_507_residues
MILTPGSLTLSQLRQIAREQVTLELDPASFAAIDACAQAVADIAAKGEPAYGINTGFGRLASTHIPHDQLELLQRNLVLS
HAVGVGEPMSPPVVRLLMALKLSSLGRGHSGIRREVMDALIKLFNADVLPVIPVKGSVGASGDLAPLAHMSAVLLGVGEV
FAKGERVAATEGLRLVGLKPLTLQAKEGLALLNGTQASAALALYNMFAIEDLYRVGLVAGALSVDAAAGSVKPFDARIHA
LRGHQGQIDAAESYRTLLDGSAINLSHRDCGKVQDPYSLRCQPQVMGACLDQMRAAAQVLLVEANAVSDNPLIFPDTGEV
LSGGNFHAEPVAFAADNLALAAAEIGALAERRIALLIDATLSGLPPFLVKDGGVNSGFMIAHVTAAALASENKTLAHPAS
VDSLPTSANQEDHVSMATFAARKLADIADNTANILSIELLAAAQGVDLRAPHKTSPALQKVMETVRAHVAHYELDHYFAP
DIAAITKLVQDGTIAKHSPFSFISEQR

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=494, Percent_Identity=44.7368421052632, Blast_Score=416, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI17567831, Length=501, Percent_Identity=41.1177644710579, Blast_Score=372, Evalue=1e-103,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 53121; Mature: 53121

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILTPGSLTLSQLRQIAREQVTLELDPASFAAIDACAQAVADIAAKGEPAYGINTGFGRL
CEECCCCCHHHHHHHHHHHCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
ASTHIPHDQLELLQRNLVLSHAVGVGEPMSPPVVRLLMALKLSSLGRGHSGIRREVMDAL
HHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
IKLFNADVLPVIPVKGSVGASGDLAPLAHMSAVLLGVGEVFAKGERVAATEGLRLVGLKP
HHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEECCCCEEEEECCC
LTLQAKEGLALLNGTQASAALALYNMFAIEDLYRVGLVAGALSVDAAAGSVKPFDARIHA
EEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
LRGHQGQIDAAESYRTLLDGSAINLSHRDCGKVQDPYSLRCQPQVMGACLDQMRAAAQVL
HCCCCCCCCHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEE
LVEANAVSDNPLIFPDTGEVLSGGNFHAEPVAFAADNLALAAAEIGALAERRIALLIDAT
EEEECCCCCCCEEECCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHEEEEEECH
LSGLPPFLVKDGGVNSGFMIAHVTAAALASENKTLAHPASVDSLPTSANQEDHVSMATFA
HCCCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
ARKLADIADNTANILSIELLAAAQGVDLRAPHKTSPALQKVMETVRAHVAHYELDHYFAP
HHHHHHHHCCCCCEEEEEEEHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
DIAAITKLVQDGTIAKHSPFSFISEQR
CHHHHHHHHHCCCCCCCCCHHHHCCCC
>Mature Secondary Structure
MILTPGSLTLSQLRQIAREQVTLELDPASFAAIDACAQAVADIAAKGEPAYGINTGFGRL
CEECCCCCHHHHHHHHHHHCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
ASTHIPHDQLELLQRNLVLSHAVGVGEPMSPPVVRLLMALKLSSLGRGHSGIRREVMDAL
HHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
IKLFNADVLPVIPVKGSVGASGDLAPLAHMSAVLLGVGEVFAKGERVAATEGLRLVGLKP
HHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEECCCCEEEEECCC
LTLQAKEGLALLNGTQASAALALYNMFAIEDLYRVGLVAGALSVDAAAGSVKPFDARIHA
EEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
LRGHQGQIDAAESYRTLLDGSAINLSHRDCGKVQDPYSLRCQPQVMGACLDQMRAAAQVL
HCCCCCCCCHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEE
LVEANAVSDNPLIFPDTGEVLSGGNFHAEPVAFAADNLALAAAEIGALAERRIALLIDAT
EEEECCCCCCCEEECCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHEEEEEECH
LSGLPPFLVKDGGVNSGFMIAHVTAAALASENKTLAHPASVDSLPTSANQEDHVSMATFA
HCCCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
ARKLADIADNTANILSIELLAAAQGVDLRAPHKTSPALQKVMETVRAHVAHYELDHYFAP
HHHHHHHHCCCCCEEEEEEEHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
DIAAITKLVQDGTIAKHSPFSFISEQR
CHHHHHHHHHCCCCCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA