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The map label for this gene is hisQ [H]

Identifier: 186476549

GI number: 186476549

Start: 2046648

End: 2047337

Strand: Reverse

Name: hisQ [H]

Synonym: Bphy_1791

Alternate gene names: 186476549

Gene position: 2047337-2046648 (Counterclockwise)

Preceding gene: 186476551

Following gene: 186476548

Centisome position: 58.85

GC content: 63.33

Gene sequence:

>690_bases
GTGTTCCTCTATGGCTTTGGCCCGGTGCTCCTCGACGGTACGATCAAGACGGTCGAGCTGTCCGTTCTTTCGCTGGCGAC
GTCCGTCGTGCTCGGCCTGGTCGGCGCGGCGGCGAAGCTCTCGCTCAACCGGCCGCTGCGGGCACTCGCGACGGGCTATA
CGACGCTGATCCGTTCGGTGCCCGATCTGGTGCTGATGCTGCTGCTGTTCTACAGCATCCAGATCGCGGTCAACAACCTG
ACCGACGCGCTCGACCTGCCGCAATTCGACATCGATCCGTTCATCGCGGGCGTGCTGACGCTCGGCTTCATCTACGGCGC
GTACTTCACCGAGACCTTTCGCGGTGCGTTTCTCGCCGTGCCGCGCGGCCAGCTCGAAGCGGGCGCGGCGTACGGCATGA
GCGGCGCGCGGGTATTTGCGCGCATCCTGTTTCCGCAGATGATGCGCTTCGCGCTGCCCGGCATCGGCAACAACTGGCAG
GTGCTGGTGAAGGCAACGGCGCTCGTGTCGATCATCGGTCTCGCCGATGTCGTCAAGGCCGCGCAGGACGCGGGCAAGAG
CACGTTCAACATGTTCTTCTTCATTCTCGTCGCCGCGCTGATCTATCTGGCCATTACGACCGTGTCGAATCTCGTGCTGA
TCTGGCTGGAAAAGCGCTATTCGATCGGCGTGCGGCACGCCGAACTCTAA

Upstream 100 bases:

>100_bases
GTTTGAGCAAATCATTTTCGCTTGCCAGTATCCGCGCCATGCCGCAGCGGGTGCGGCTTTCCGATCCACCTCTCGCTTTG
CTTCGACACAGGAGACACAC

Downstream 100 bases:

>100_bases
CTCGCGCAACGTGCAGGAGACGACGTTCATGATCGACATTCTCAATCAGTTCTGGCGCGCGTTCCTTTACTGGGACGGTC
AGCGCCTCTCGGGACTTGCG

Product: polar amino acid ABC transporter inner membrane subunit

Products: ADP; phosphate; L-histidine [Cytoplasm]; ADP; L-ornithine [Cytoplasm]; L-arginine [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MFLYGFGPVLLDGTIKTVELSVLSLATSVVLGLVGAAAKLSLNRPLRALATGYTTLIRSVPDLVLMLLLFYSIQIAVNNL
TDALDLPQFDIDPFIAGVLTLGFIYGAYFTETFRGAFLAVPRGQLEAGAAYGMSGARVFARILFPQMMRFALPGIGNNWQ
VLVKATALVSIIGLADVVKAAQDAGKSTFNMFFFILVAALIYLAITTVSNLVLIWLEKRYSIGVRHAEL

Sequences:

>Translated_229_residues
MFLYGFGPVLLDGTIKTVELSVLSLATSVVLGLVGAAAKLSLNRPLRALATGYTTLIRSVPDLVLMLLLFYSIQIAVNNL
TDALDLPQFDIDPFIAGVLTLGFIYGAYFTETFRGAFLAVPRGQLEAGAAYGMSGARVFARILFPQMMRFALPGIGNNWQ
VLVKATALVSIIGLADVVKAAQDAGKSTFNMFFFILVAALIYLAITTVSNLVLIWLEKRYSIGVRHAEL
>Mature_229_residues
MFLYGFGPVLLDGTIKTVELSVLSLATSVVLGLVGAAAKLSLNRPLRALATGYTTLIRSVPDLVLMLLLFYSIQIAVNNL
TDALDLPQFDIDPFIAGVLTLGFIYGAYFTETFRGAFLAVPRGQLEAGAAYGMSGARVFARILFPQMMRFALPGIGNNWQ
VLVKATALVSIIGLADVVKAAQDAGKSTFNMFFFILVAALIYLAITTVSNLVLIWLEKRYSIGVRHAEL

Specific function: Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG4215

COG function: function code E; ABC-type arginine transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788646, Length=227, Percent_Identity=61.2334801762115, Blast_Score=291, Evalue=3e-80,
Organism=Escherichia coli, GI1787087, Length=210, Percent_Identity=35.7142857142857, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI1787030, Length=215, Percent_Identity=32.093023255814, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1788226, Length=203, Percent_Identity=32.0197044334975, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1786873, Length=213, Percent_Identity=30.5164319248826, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1788645, Length=213, Percent_Identity=31.4553990610329, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1787086, Length=218, Percent_Identity=28.4403669724771, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI1786874, Length=215, Percent_Identity=26.9767441860465, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI87082239, Length=223, Percent_Identity=28.2511210762332, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 24744; Mature: 24744

Theoretical pI: Translated: 9.55; Mature: 9.55

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLYGFGPVLLDGTIKTVELSVLSLATSVVLGLVGAAAKLSLNRPLRALATGYTTLIRSV
CEEEECCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
PDLVLMLLLFYSIQIAVNNLTDALDLPQFDIDPFIAGVLTLGFIYGAYFTETFRGAFLAV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEC
PRGQLEAGAAYGMSGARVFARILFPQMMRFALPGIGNNWQVLVKATALVSIIGLADVVKA
CCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AQDAGKSTFNMFFFILVAALIYLAITTVSNLVLIWLEKRYSIGVRHAEL
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHCCCCCCCC
>Mature Secondary Structure
MFLYGFGPVLLDGTIKTVELSVLSLATSVVLGLVGAAAKLSLNRPLRALATGYTTLIRSV
CEEEECCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
PDLVLMLLLFYSIQIAVNNLTDALDLPQFDIDPFIAGVLTLGFIYGAYFTETFRGAFLAV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEC
PRGQLEAGAAYGMSGARVFARILFPQMMRFALPGIGNNWQVLVKATALVSIIGLADVVKA
CCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AQDAGKSTFNMFFFILVAALIYLAITTVSNLVLIWLEKRYSIGVRHAEL
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-histidine [Periplasm]; H2O; ATP; L-ornithine [Periplasm]; L-arginine [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: ATP + L-histidine [Periplasm] + H2O = ADP + phosphate + L-histidine [Cytoplasm] ATP + L-ornithine [Periplasm] + H2O = ADP + phosphate + L-ornithine [Cytoplasm] ATP + L-arginine [Periplasm] + H2O = ADP + phosphate + L-arginine [Cytoplasm] ATP + L-lysine [P

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]