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The map label for this gene is hisM [H]

Identifier: 186476548

GI number: 186476548

Start: 2045906

End: 2046619

Strand: Reverse

Name: hisM [H]

Synonym: Bphy_1790

Alternate gene names: 186476548

Gene position: 2046619-2045906 (Counterclockwise)

Preceding gene: 186476549

Following gene: 186476547

Centisome position: 58.82

GC content: 63.87

Gene sequence:

>714_bases
ATGATCGACATTCTCAATCAGTTCTGGCGCGCGTTCCTTTACTGGGACGGTCAGCGCCTCTCGGGACTTGCGGTGACGCT
GTGGCTGCTGGTCGCCTCGATCGGCATCGGCTTCGTGGCCTCGATCCCTCTCGCCGTGGCGCGCGTGTCGAAGAAGCGCT
GGCTGTCTACGCCCGTGCGCCTCTACACCTATGTGTTTCGCGGCACGCCGCTCTACGTGCAGCTGCTGCTGATCTACACG
GGCATGTACAGCCTCGAATTCGTGCGCTCGCACGCGCTGCTCGATGCGTTCTTCCGCAGCGGCTTTCACTGCGCGATTCT
CGCGTTCGCGTTGAACACCTGTGCGTACACGACAGAGATTTTCGCGGGCGCGATTCGCGCGACGCCGCATGGCGAAGTCG
AAGCCGCGCGCGCTTACGGGATGAGCTGGCTCACGATGTACAGGCGGATTGTGATACCGTCCGCGCTGCGCCGGGCGCTG
CCGTTGTACAGTAACGAGGTAATCCTGATGCTGCACGCGACCACCGTCGCATTCACGGCCACCGTGCCCGACGTGCTGAA
GGTGGCGCGCGATGCGAACTCGGCAACCTATCGCTCGTTCGAGGCATTCGGCCTCGCGGCGCTGATCTATCTTGCTGTAT
CGTTCGCGCTGGTTGCGCTGTTCCGGCGCGCGGAGCGCCACTGGCTCGCCTACCTGGCCGTGCGCCGGCATTGA

Upstream 100 bases:

>100_bases
ACCGTGTCGAATCTCGTGCTGATCTGGCTGGAAAAGCGCTATTCGATCGGCGTGCGGCACGCCGAACTCTAACTCGCGCA
ACGTGCAGGAGACGACGTTC

Downstream 100 bases:

>100_bases
CCACGCTGCGTGCCGCGGCGCAATGCAACATGGACGGCGGCACGACTTCACTTCAGCATCCCGTTTCACCCGTCTTCACT
CTGGGAGAGCAACTTGCTCC

Product: polar amino acid ABC transporter inner membrane subunit

Products: ADP; phosphate; L-histidine [Cytoplasm]; ADP; L-ornithine [Cytoplasm]; L-arginine [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MIDILNQFWRAFLYWDGQRLSGLAVTLWLLVASIGIGFVASIPLAVARVSKKRWLSTPVRLYTYVFRGTPLYVQLLLIYT
GMYSLEFVRSHALLDAFFRSGFHCAILAFALNTCAYTTEIFAGAIRATPHGEVEAARAYGMSWLTMYRRIVIPSALRRAL
PLYSNEVILMLHATTVAFTATVPDVLKVARDANSATYRSFEAFGLAALIYLAVSFALVALFRRAERHWLAYLAVRRH

Sequences:

>Translated_237_residues
MIDILNQFWRAFLYWDGQRLSGLAVTLWLLVASIGIGFVASIPLAVARVSKKRWLSTPVRLYTYVFRGTPLYVQLLLIYT
GMYSLEFVRSHALLDAFFRSGFHCAILAFALNTCAYTTEIFAGAIRATPHGEVEAARAYGMSWLTMYRRIVIPSALRRAL
PLYSNEVILMLHATTVAFTATVPDVLKVARDANSATYRSFEAFGLAALIYLAVSFALVALFRRAERHWLAYLAVRRH
>Mature_237_residues
MIDILNQFWRAFLYWDGQRLSGLAVTLWLLVASIGIGFVASIPLAVARVSKKRWLSTPVRLYTYVFRGTPLYVQLLLIYT
GMYSLEFVRSHALLDAFFRSGFHCAILAFALNTCAYTTEIFAGAIRATPHGEVEAARAYGMSWLTMYRRIVIPSALRRAL
PLYSNEVILMLHATTVAFTATVPDVLKVARDANSATYRSFEAFGLAALIYLAVSFALVALFRRAERHWLAYLAVRRH

Specific function: Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG4160

COG function: function code E; ABC-type arginine/histidine transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788645, Length=232, Percent_Identity=61.6379310344828, Blast_Score=310, Evalue=4e-86,
Organism=Escherichia coli, GI1787086, Length=214, Percent_Identity=35.5140186915888, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1788226, Length=214, Percent_Identity=34.5794392523364, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI1787030, Length=209, Percent_Identity=28.7081339712919, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1788646, Length=198, Percent_Identity=30.3030303030303, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI1787087, Length=219, Percent_Identity=26.027397260274, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1786873, Length=208, Percent_Identity=27.4038461538462, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1786874, Length=212, Percent_Identity=26.8867924528302, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 26754; Mature: 26754

Theoretical pI: Translated: 10.33; Mature: 10.33

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDILNQFWRAFLYWDGQRLSGLAVTLWLLVASIGIGFVASIPLAVARVSKKRWLSTPVR
CHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
LYTYVFRGTPLYVQLLLIYTGMYSLEFVRSHALLDAFFRSGFHCAILAFALNTCAYTTEI
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
FAGAIRATPHGEVEAARAYGMSWLTMYRRIVIPSALRRALPLYSNEVILMLHATTVAFTA
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHH
TVPDVLKVARDANSATYRSFEAFGLAALIYLAVSFALVALFRRAERHWLAYLAVRRH
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIDILNQFWRAFLYWDGQRLSGLAVTLWLLVASIGIGFVASIPLAVARVSKKRWLSTPVR
CHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
LYTYVFRGTPLYVQLLLIYTGMYSLEFVRSHALLDAFFRSGFHCAILAFALNTCAYTTEI
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
FAGAIRATPHGEVEAARAYGMSWLTMYRRIVIPSALRRALPLYSNEVILMLHATTVAFTA
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHH
TVPDVLKVARDANSATYRSFEAFGLAALIYLAVSFALVALFRRAERHWLAYLAVRRH
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-histidine [Periplasm]; H2O; ATP; L-ornithine [Periplasm]; L-arginine [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: ATP + L-histidine [Periplasm] + H2O = ADP + phosphate + L-histidine [Cytoplasm] ATP + L-ornithine [Periplasm] + H2O = ADP + phosphate + L-ornithine [Cytoplasm] ATP + L-arginine [Periplasm] + H2O = ADP + phosphate + L-arginine [Cytoplasm] ATP + L-lysine [P

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]