Click here to switch to the map view.

The map label for this gene is lepB [H]

Identifier: 186476423

GI number: 186476423

Start: 1879954

End: 1880658

Strand: Reverse

Name: lepB [H]

Synonym: Bphy_1665

Alternate gene names: 186476423

Gene position: 1880658-1879954 (Counterclockwise)

Preceding gene: 186476424

Following gene: 186476418

Centisome position: 54.05

GC content: 66.81

Gene sequence:

>705_bases
ATGATGCGCATGCTGGCCAGATTGTGGCGCGAGTACAAGAGTCTCGCCACGTTCATTTTCCTGATGGTGCTGTTTCGCAG
CGCGATCGCCGACTGGAACGTGGTGCCGAGCGGCTCGATGCTGCCGACCATCCGCGAGGGCGATCGCATCCTCGTCGACA
AGATGGCTTACGACCTGCGCATCCCGCTCACGCACATCGCGATAGCGCATCTGCATGAACCGCAGCGCGGCGATATCGTG
ACGATCGATTCCTCCGCCGCGCGCGAGCTGATCGTCAAGCGCGTGATCGGGCTGCCTGGCGATGTCGTCGCGATGCGTGA
CAACGTGCTGTACGTGAACGGTGCGCGAGCGAGCTATCAACCGCTCGCGCTCGCGCCGCTGCCCGGCGATGCCGTGTCGC
CCGGCGACTACCTGACCGAGCGTGTTGCGGGCGCGTCGCCGGGCTCGCCGCACGCGGTGCGGCTGTCCGAACTGGCGCCG
AGTCCGCGCCGCTCATTCGGTCCGGTGACGGTGCCGGCGGGCGAGTATCTGATGCTCGGCGACAATCGCGACGATAGCGC
GGATTCGCGCTATTTCGGTTTCTTTCCACGCGCCGAGCTGATGGGGCGCACGCGCCGCGTCGCGTTCTCGCTCGACCCGG
ATCACGCGTACCGGCCGCGTTTCGAGCGGTTCGGTGTGCGGCTCGATGCGGTGGCGGCGCACTGA

Upstream 100 bases:

>100_bases
CGGACCGATGCGCAGTTGAGCGGATGAGAAGCCGGCTGGCCGCTTTCGTTTTCCGCATCATGTATGCAGGTTGTTATCCA
TGTTGTTTGCGAGGAGCGCA

Downstream 100 bases:

>100_bases
GGCCCGGCTACGCGCCTGACGTCGTCCCCGTGCGCCGCGGCTGCGCAAAGGCCTACGCTGCGCGCATCGCCAGCGCCTGT
GCGCATTCGGCGACGAGGGC

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MMRMLARLWREYKSLATFIFLMVLFRSAIADWNVVPSGSMLPTIREGDRILVDKMAYDLRIPLTHIAIAHLHEPQRGDIV
TIDSSAARELIVKRVIGLPGDVVAMRDNVLYVNGARASYQPLALAPLPGDAVSPGDYLTERVAGASPGSPHAVRLSELAP
SPRRSFGPVTVPAGEYLMLGDNRDDSADSRYFGFFPRAELMGRTRRVAFSLDPDHAYRPRFERFGVRLDAVAAH

Sequences:

>Translated_234_residues
MMRMLARLWREYKSLATFIFLMVLFRSAIADWNVVPSGSMLPTIREGDRILVDKMAYDLRIPLTHIAIAHLHEPQRGDIV
TIDSSAARELIVKRVIGLPGDVVAMRDNVLYVNGARASYQPLALAPLPGDAVSPGDYLTERVAGASPGSPHAVRLSELAP
SPRRSFGPVTVPAGEYLMLGDNRDDSADSRYFGFFPRAELMGRTRRVAFSLDPDHAYRPRFERFGVRLDAVAAH
>Mature_234_residues
MMRMLARLWREYKSLATFIFLMVLFRSAIADWNVVPSGSMLPTIREGDRILVDKMAYDLRIPLTHIAIAHLHEPQRGDIV
TIDSSAARELIVKRVIGLPGDVVAMRDNVLYVNGARASYQPLALAPLPGDAVSPGDYLTERVAGASPGSPHAVRLSELAP
SPRRSFGPVTVPAGEYLMLGDNRDDSADSRYFGFFPRAELMGRTRRVAFSLDPDHAYRPRFERFGVRLDAVAAH

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=249, Percent_Identity=32.1285140562249, Blast_Score=106, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 25973; Mature: 25973

Theoretical pI: Translated: 9.59; Mature: 9.59

Prosite motif: PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMRMLARLWREYKSLATFIFLMVLFRSAIADWNVVPSGSMLPTIREGDRILVDKMAYDLR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEHHHHHEE
IPLTHIAIAHLHEPQRGDIVTIDSSAARELIVKRVIGLPGDVVAMRDNVLYVNGARASYQ
CCHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHCCCCCEEEEECCEEEEECCCCCCC
PLALAPLPGDAVSPGDYLTERVAGASPGSPHAVRLSELAPSPRRSFGPVTVPAGEYLMLG
CEEEECCCCCCCCCHHHHHHHHCCCCCCCCCEEEHHHCCCCCCCCCCCEEECCCCEEEEE
DNRDDSADSRYFGFFPRAELMGRTRRVAFSLDPDHAYRPRFERFGVRLDAVAAH
CCCCCCCCCCEEECCCCHHHCCCCEEEEEEECCCCCCCCCHHHHCEEEEEEECC
>Mature Secondary Structure
MMRMLARLWREYKSLATFIFLMVLFRSAIADWNVVPSGSMLPTIREGDRILVDKMAYDLR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEHHHHHEE
IPLTHIAIAHLHEPQRGDIVTIDSSAARELIVKRVIGLPGDVVAMRDNVLYVNGARASYQ
CCHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHCCCCCEEEEECCEEEEECCCCCCC
PLALAPLPGDAVSPGDYLTERVAGASPGSPHAVRLSELAPSPRRSFGPVTVPAGEYLMLG
CEEEECCCCCCCCCHHHHHHHHCCCCCCCCCEEEHHHCCCCCCCCCCCEEECCCCEEEEE
DNRDDSADSRYFGFFPRAELMGRTRRVAFSLDPDHAYRPRFERFGVRLDAVAAH
CCCCCCCCCCEEECCCCHHHCCCCEEEEEEECCCCCCCCCHHHHCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]