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The map label for this gene is crt [H]

Identifier: 186476410

GI number: 186476410

Start: 1870245

End: 1871375

Strand: Reverse

Name: crt [H]

Synonym: Bphy_1652

Alternate gene names: 186476410

Gene position: 1871375-1870245 (Counterclockwise)

Preceding gene: 186476411

Following gene: 186476407

Centisome position: 53.79

GC content: 65.69

Gene sequence:

>1131_bases
ATGTCGACATCCGAACCGCGCCTCGCCTCCGACGAACTCATCGCCTATGTCGCCAACGGCATCGGTTTCATCGAGCTGAA
CCGGCCGAAGGCGCTCAATGCGCTGTCGCTGGACATGATGCGCGCGATGCAGGCGGCGCTCGACCAATGGCGCGACGAGC
CCGGCGTGCTTGCCGTCGTCGTGCGCAGCACGAGCGAACGTGCGTTCTGTGCGGGCGGCGACATCCGCTATCTGTACGAC
GCGTTTCGGCGCGGCGACGGTGATGCCGTGGACACGTTCTTCATCGACGAGTACCGGCTCGATCACGCGATCTTCACATA
CACGAAACCGTATATCGCGTTGATGAACGGCATCGTGATGGGCGGCGGCATGGGTATTTCGCAAGGCGCGCACCGGACGG
GTGGTTTGCGCGTCGTGACGTCGTCGACACGTATGGCGATGCCGGAAACGCGCATCGGTTTGTTTCCCGATGTCGGCGCC
GGATGGTTTCTCGCGCGAACGCCGGGTGCGATCGGCCGCTATCTGGCGGTGACGGGCACGACGATCGGCGCCGCCGATGC
ACTTTACGCGGGTCTCGCCGACGCGTATCTGCCCGACGAAGTCATCCCCGCGCTGATCGATCGCCTGAAGTCGCAGACGT
TCGAGCAGGGCGCGGAAGTGGTGGCGTGCGTGCGGCAGGAAGCGGACGCGCATCGGGTCACGCCGTTGCCCGACGTCTCG
CCGCTCGCCGATGCCCGCATGCTGATCGACAAACACTTCGCGCGGGCGGACGTCGCGCAGATCATCCGTTCACTCGACCT
CGAAGGTGATTGCGCCTATGCCGACTGGGCGGAGCAGGCGGGCGCGATGCTGCGCGAGCGTTCGCCGCTGTCGATGGCGG
TATCGCTGGAAGTGGTGACGCGCGCCGAAGGCACAATGGCCGAGTGCCTGCGCCGCGATCTCGATCTGACGCGTTCGTCG
TTCGAACGCGGCGACGCGCCGGAAGGCATCCGCGCGCGCATCATCGACAAGGACAACCAGCCGCACTGGCGCTTTGCGCG
AATCGAAGACGTGAAGCGCGCGGACGTCGACGCGATGTTCGACAGCCCGTGGCCCGCGAACGAACATCCGCTGCGGGATC
TGCAAGGCTGA

Upstream 100 bases:

>100_bases
AACGCGGGCCACCCGTTGCGCTGCCGGTTTTACTGAACAAGTCGATGACGCGTGTTACCGTTGGCGTCGCATCTCCATCG
AACCGCTTCACACCCACGCC

Downstream 100 bases:

>100_bases
CGCGAAGAAGCGGGAAAACGCCGTAACGAAGCTGAAAAGAAGCGCAGAGGCAGCAGATGCGGGTGGGGCGCTCAGTTCTC
GCTCGCCATGAAGGCGCGCA

Product: 3-hydroxyisobutyryl-CoA hydrolase

Products: NA

Alternate protein names: Crotonase [H]

Number of amino acids: Translated: 376; Mature: 375

Protein sequence:

>376_residues
MSTSEPRLASDELIAYVANGIGFIELNRPKALNALSLDMMRAMQAALDQWRDEPGVLAVVVRSTSERAFCAGGDIRYLYD
AFRRGDGDAVDTFFIDEYRLDHAIFTYTKPYIALMNGIVMGGGMGISQGAHRTGGLRVVTSSTRMAMPETRIGLFPDVGA
GWFLARTPGAIGRYLAVTGTTIGAADALYAGLADAYLPDEVIPALIDRLKSQTFEQGAEVVACVRQEADAHRVTPLPDVS
PLADARMLIDKHFARADVAQIIRSLDLEGDCAYADWAEQAGAMLRERSPLSMAVSLEVVTRAEGTMAECLRRDLDLTRSS
FERGDAPEGIRARIIDKDNQPHWRFARIEDVKRADVDAMFDSPWPANEHPLRDLQG

Sequences:

>Translated_376_residues
MSTSEPRLASDELIAYVANGIGFIELNRPKALNALSLDMMRAMQAALDQWRDEPGVLAVVVRSTSERAFCAGGDIRYLYD
AFRRGDGDAVDTFFIDEYRLDHAIFTYTKPYIALMNGIVMGGGMGISQGAHRTGGLRVVTSSTRMAMPETRIGLFPDVGA
GWFLARTPGAIGRYLAVTGTTIGAADALYAGLADAYLPDEVIPALIDRLKSQTFEQGAEVVACVRQEADAHRVTPLPDVS
PLADARMLIDKHFARADVAQIIRSLDLEGDCAYADWAEQAGAMLRERSPLSMAVSLEVVTRAEGTMAECLRRDLDLTRSS
FERGDAPEGIRARIIDKDNQPHWRFARIEDVKRADVDAMFDSPWPANEHPLRDLQG
>Mature_375_residues
STSEPRLASDELIAYVANGIGFIELNRPKALNALSLDMMRAMQAALDQWRDEPGVLAVVVRSTSERAFCAGGDIRYLYDA
FRRGDGDAVDTFFIDEYRLDHAIFTYTKPYIALMNGIVMGGGMGISQGAHRTGGLRVVTSSTRMAMPETRIGLFPDVGAG
WFLARTPGAIGRYLAVTGTTIGAADALYAGLADAYLPDEVIPALIDRLKSQTFEQGAEVVACVRQEADAHRVTPLPDVSP
LADARMLIDKHFARADVAQIIRSLDLEGDCAYADWAEQAGAMLRERSPLSMAVSLEVVTRAEGTMAECLRRDLDLTRSSF
ERGDAPEGIRARIIDKDNQPHWRFARIEDVKRADVDAMFDSPWPANEHPLRDLQG

Specific function: Catalyzes The Reversible Dehydration Of L-Carnitinyl-CoA To Crotobetainyl-CoA. [C]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI37594471, Length=359, Percent_Identity=34.8189415041783, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI37594469, Length=316, Percent_Identity=34.4936708860759, Blast_Score=178, Evalue=9e-45,
Organism=Homo sapiens, GI194097323, Length=229, Percent_Identity=30.5676855895196, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI221142681, Length=173, Percent_Identity=30.0578034682081, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI25144157, Length=375, Percent_Identity=35.7333333333333, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI25144160, Length=375, Percent_Identity=35.7333333333333, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17554946, Length=207, Percent_Identity=29.4685990338164, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17540714, Length=177, Percent_Identity=25.9887005649718, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320241, Length=344, Percent_Identity=31.6860465116279, Blast_Score=144, Evalue=2e-35,
Organism=Drosophila melanogaster, GI28571730, Length=355, Percent_Identity=36.056338028169, Blast_Score=207, Evalue=8e-54,
Organism=Drosophila melanogaster, GI28571729, Length=355, Percent_Identity=36.056338028169, Blast_Score=207, Evalue=8e-54,
Organism=Drosophila melanogaster, GI20129971, Length=190, Percent_Identity=30, Blast_Score=78, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24653477, Length=190, Percent_Identity=30, Blast_Score=78, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24653139, Length=179, Percent_Identity=32.4022346368715, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.55 [H]

Molecular weight: Translated: 41255; Mature: 41124

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTSEPRLASDELIAYVANGIGFIELNRPKALNALSLDMMRAMQAALDQWRDEPGVLAVV
CCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEE
VRSTSERAFCAGGDIRYLYDAFRRGDGDAVDTFFIDEYRLDHAIFTYTKPYIALMNGIVM
EECCCCCEEECCCCHHHHHHHHHCCCCCEEEEEEEHHHHHCHHHEECCCHHHHHHHHHHC
GGGMGISQGAHRTGGLRVVTSSTRMAMPETRIGLFPDVGAGWFLARTPGAIGRYLAVTGT
CCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCHHHCEEEEECC
TIGAADALYAGLADAYLPDEVIPALIDRLKSQTFEQGAEVVACVRQEADAHRVTPLPDVS
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
PLADARMLIDKHFARADVAQIIRSLDLEGDCAYADWAEQAGAMLRERSPLSMAVSLEVVT
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEEC
RAEGTMAECLRRDLDLTRSSFERGDAPEGIRARIIDKDNQPHWRFARIEDVKRADVDAMF
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCEEEHHHHHHHHHCHHHHC
DSPWPANEHPLRDLQG
CCCCCCCCCCCHHCCC
>Mature Secondary Structure 
STSEPRLASDELIAYVANGIGFIELNRPKALNALSLDMMRAMQAALDQWRDEPGVLAVV
CCCCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEE
VRSTSERAFCAGGDIRYLYDAFRRGDGDAVDTFFIDEYRLDHAIFTYTKPYIALMNGIVM
EECCCCCEEECCCCHHHHHHHHHCCCCCEEEEEEEHHHHHCHHHEECCCHHHHHHHHHHC
GGGMGISQGAHRTGGLRVVTSSTRMAMPETRIGLFPDVGAGWFLARTPGAIGRYLAVTGT
CCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCHHHCEEEEECC
TIGAADALYAGLADAYLPDEVIPALIDRLKSQTFEQGAEVVACVRQEADAHRVTPLPDVS
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
PLADARMLIDKHFARADVAQIIRSLDLEGDCAYADWAEQAGAMLRERSPLSMAVSLEVVT
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEEC
RAEGTMAECLRRDLDLTRSSFERGDAPEGIRARIIDKDNQPHWRFARIEDVKRADVDAMF
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCEEEHHHHHHHHHCHHHHC
DSPWPANEHPLRDLQG
CCCCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]