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The map label for this gene is glxR [H]

Identifier: 186476380

GI number: 186476380

Start: 1843801

End: 1844709

Strand: Direct

Name: glxR [H]

Synonym: Bphy_1622

Alternate gene names: 186476380

Gene position: 1843801-1844709 (Clockwise)

Preceding gene: 186476379

Following gene: 186476388

Centisome position: 53.0

GC content: 63.59

Gene sequence:

>909_bases
ATGGCAAAGATCGGTTTCATCGGCCTCGGCATCATGGGCGCGCACATGGCGCGCAACCTCATCAAGGGCGGCCACGCGCT
GGTCGTGAATGGCGCGTATCCCGTGCCGGAAGATCTCGCCCGGACGACGACGGTCGTTGCCGATTCGACGGCTGTCGCGC
AGGCCGCCGACATCGTCGTGATCATGGTTCCCGACACGCCCGACGTCGCGAACGTGCTGTTCGCCGATGACGGCGTCGCG
AAGGGCCTGACGAAGGGCAAGCTCGTGATCGACATGAGCTCGATCTCGCCGCTCGACACGCAGGCGTTCGCAAAGAAAAT
CAACGAACTGGGCTGCGACTATCTCGACGCGCCAGTTTCCGGCGGTGAGATCGGCGCACGGGATGCGACGCTGACAATCA
TGGTCGGCGGCCCGCAGAAGTCGTTCGATCTCGCCAAGCCGTTGTTCGAGCTGATGGGGAAGAACATTTCGCTGATCGGC
GAGAACGGTGCGGGCCAGACGTGCAAGGTCGCGAACCAGATCATCGTCGCGCTGAACATCGAGGCTGTCGCCGAAGCGCT
GCTCTTCGCGGCACGCTCGGGTGCCGATCCGGAGCGCGTACGCAAGGCATTGATGGGTGGCTTCGCATCGTCGCGCATTC
TCGAAGTGCATGGCGAGCGCATGACGAAGCGCACGTTCAACCCGGGCTTCCGAATCGAGTTGCACCAGAAGGATCTGAAC
CTCGCACTTGACGGCGCACGCAAGCTCGGCATCGCACTGCCCCATACGGCGAGCGCGCAGCAGTTGTTCAGCGTGTGCGC
GGCGAACGGCGGCAAGGCGTGGGATCACTCGGCGATGGTGCGCGCGCTTGAAATCATGGCGAATTTCGAAGTGGCGCAGG
CGCCGGCGGCCGATCAGAAGGCTGCTTGA

Upstream 100 bases:

>100_bases
GGTGTGAAGCGCGCGCATGCATCGGCCTGACGCGGCCCGCTGAACCCGGCGGCATCGCACACGAGCACATTTCGAACCTC
ATTCACTGGAGACTTACCCA

Downstream 100 bases:

>100_bases
CGAAACGAACGCCGCCGTGACGGGTTCACGGCGGCGCGCAGGTGGGGCGCCTGGTCCGGCGCGCGGCACGCATCGGATCG
GGCAAATCATGTCGCTCTGG

Product: 2-hydroxy-3-oxopropionate reductase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MAKIGFIGLGIMGAHMARNLIKGGHALVVNGAYPVPEDLARTTTVVADSTAVAQAADIVVIMVPDTPDVANVLFADDGVA
KGLTKGKLVIDMSSISPLDTQAFAKKINELGCDYLDAPVSGGEIGARDATLTIMVGGPQKSFDLAKPLFELMGKNISLIG
ENGAGQTCKVANQIIVALNIEAVAEALLFAARSGADPERVRKALMGGFASSRILEVHGERMTKRTFNPGFRIELHQKDLN
LALDGARKLGIALPHTASAQQLFSVCAANGGKAWDHSAMVRALEIMANFEVAQAPAADQKAA

Sequences:

>Translated_302_residues
MAKIGFIGLGIMGAHMARNLIKGGHALVVNGAYPVPEDLARTTTVVADSTAVAQAADIVVIMVPDTPDVANVLFADDGVA
KGLTKGKLVIDMSSISPLDTQAFAKKINELGCDYLDAPVSGGEIGARDATLTIMVGGPQKSFDLAKPLFELMGKNISLIG
ENGAGQTCKVANQIIVALNIEAVAEALLFAARSGADPERVRKALMGGFASSRILEVHGERMTKRTFNPGFRIELHQKDLN
LALDGARKLGIALPHTASAQQLFSVCAANGGKAWDHSAMVRALEIMANFEVAQAPAADQKAA
>Mature_301_residues
AKIGFIGLGIMGAHMARNLIKGGHALVVNGAYPVPEDLARTTTVVADSTAVAQAADIVVIMVPDTPDVANVLFADDGVAK
GLTKGKLVIDMSSISPLDTQAFAKKINELGCDYLDAPVSGGEIGARDATLTIMVGGPQKSFDLAKPLFELMGKNISLIGE
NGAGQTCKVANQIIVALNIEAVAEALLFAARSGADPERVRKALMGGFASSRILEVHGERMTKRTFNPGFRIELHQKDLNL
ALDGARKLGIALPHTASAQQLFSVCAANGGKAWDHSAMVRALEIMANFEVAQAPAADQKAA

Specific function: Glyoxylate catabolism. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=304, Percent_Identity=32.2368421052632, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI40556376, Length=286, Percent_Identity=27.972027972028, Blast_Score=102, Evalue=4e-22,
Organism=Escherichia coli, GI1786719, Length=291, Percent_Identity=65.6357388316151, Blast_Score=391, Evalue=1e-110,
Organism=Escherichia coli, GI145693186, Length=293, Percent_Identity=41.296928327645, Blast_Score=227, Evalue=6e-61,
Organism=Escherichia coli, GI1790315, Length=292, Percent_Identity=32.5342465753425, Blast_Score=127, Evalue=9e-31,
Organism=Escherichia coli, GI1789092, Length=284, Percent_Identity=28.5211267605634, Blast_Score=98, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17557316, Length=287, Percent_Identity=34.4947735191638, Blast_Score=127, Evalue=6e-30,
Organism=Drosophila melanogaster, GI24655230, Length=273, Percent_Identity=36.996336996337, Blast_Score=142, Evalue=2e-34,
Organism=Drosophila melanogaster, GI19922568, Length=273, Percent_Identity=36.996336996337, Blast_Score=142, Evalue=2e-34,
Organism=Drosophila melanogaster, GI28574115, Length=282, Percent_Identity=29.0780141843972, Blast_Score=98, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 31569; Mature: 31438

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIGFIGLGIMGAHMARNLIKGGHALVVNGAYPVPEDLARTTTVVADSTAVAQAADIVV
CCCEEEEEHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHEEEEECCHHHHHHCCEEE
IMVPDTPDVANVLFADDGVAKGLTKGKLVIDMSSISPLDTQAFAKKINELGCDYLDAPVS
EEECCCCCHHHEEECCCCHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCC
GGEIGARDATLTIMVGGPQKSFDLAKPLFELMGKNISLIGENGAGQTCKVANQIIVALNI
CCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCEEEEECCCCCCHHHHCCEEEEEEEH
EAVAEALLFAARSGADPERVRKALMGGFASSRILEVHGERMTKRTFNPGFRIELHQKDLN
HHHHHHHHHHHHCCCCHHHHHHHHHCCHHHCCEEEHHCHHHHHHCCCCCEEEEEECCCCC
LALDGARKLGIALPHTASAQQLFSVCAANGGKAWDHSAMVRALEIMANFEVAQAPAADQK
EEECCCHHCCEECCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHCCCCCCCC
AA
CC
>Mature Secondary Structure 
AKIGFIGLGIMGAHMARNLIKGGHALVVNGAYPVPEDLARTTTVVADSTAVAQAADIVV
CCEEEEEHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHEEEEECCHHHHHHCCEEE
IMVPDTPDVANVLFADDGVAKGLTKGKLVIDMSSISPLDTQAFAKKINELGCDYLDAPVS
EEECCCCCHHHEEECCCCHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCC
GGEIGARDATLTIMVGGPQKSFDLAKPLFELMGKNISLIGENGAGQTCKVANQIIVALNI
CCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCEEEEECCCCCCHHHHCCEEEEEEEH
EAVAEALLFAARSGADPERVRKALMGGFASSRILEVHGERMTKRTFNPGFRIELHQKDLN
HHHHHHHHHHHHCCCCHHHHHHHHHCCHHHCCEEEHHCHHHHHHCCCCCEEEEEECCCCC
LALDGARKLGIALPHTASAQQLFSVCAANGGKAWDHSAMVRALEIMANFEVAQAPAADQK
EEECCCHHCCEECCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHCCCCCCCC
AA
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10601204; 9278503 [H]