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The map label for this gene is hyi [H]

Identifier: 186476379

GI number: 186476379

Start: 1842930

End: 1843730

Strand: Direct

Name: hyi [H]

Synonym: Bphy_1621

Alternate gene names: 186476379

Gene position: 1842930-1843730 (Clockwise)

Preceding gene: 186476378

Following gene: 186476380

Centisome position: 52.97

GC content: 61.67

Gene sequence:

>801_bases
ATGCCGAAATTTGCCGCGAATCTCACGATGCTGTTCAACGAAGTCCCGTTCCTCGACCGCTTTGCTGCCGCTGCCGATGC
GGGCTTCGATGCCGTCGAATTTCTGTTCCCCTACCCGTATCAGATCGCCGACCTGTCGGAGCGCCTCGAGCAGAACAAGC
TGAAGCTGGTGCTGCACAACCTGCCCGCCGGCAACTGGGAAGCGGGCGAGCGCGGTATCGCGTCGCTGCCGGATCGCGTG
AGCGAGTTCCAGGAAGGCGTCGGCCGCGCGATCGAATACGCAAAGGCACTGAAGGTGCCGCAATTGAACTGCCTTGTCGG
CATTCCAAAGAACGTCGAGGCCGACAAGGCTCGCGCGACGATCGTCGACAACCTGCGCTTCGCCGCTGCCGCGCTGAAGA
AAGAAGGCATCCGGCTGCTGGTCGAACCGTGCAACTCGTACGACATTCCGGGCTTCGCGCTGAACCGTTCGTCGGAAGGA
CTGGACGTGATTCAGGCCGTCGGATCCGACAACCTGTTCCTGCAATACGACATCTATCACATGCAACGGATGGAAGGCGA
ACTCGCTGCGACGATCAAGAAGCACTTCGCGCAGATCGCGCACATCCAGCTCGCCGACAACCCGGGCCGCAACGAACCGG
GCACGGGCGAAATCAACTATCCGTTCCTGTTCGATCTGCTCGATTCGCTCGGCTACCAGGGCTACGTCGGCTGCGAGTAC
AAGCCGCGCACGACGACGTCCGAAGGCCTCGGCTGGCTGGAAAGCATCGCGGGTGTGAAGCGCGCGCATGCATCGGCCTG
A

Upstream 100 bases:

>100_bases
TATCCGCTTCACCGGGATGGGTGCGCTTCGCACGAAGCGCATTCGTCCGCGTCACGCTGTTCACGCCGTTCAATTTGACC
GACCAGAGAGAAAAAGCAAC

Downstream 100 bases:

>100_bases
CGCGGCCCGCTGAACCCGGCGGCATCGCACACGAGCACATTTCGAACCTCATTCACTGGAGACTTACCCAATGGCAAAGA
TCGGTTTCATCGGCCTCGGC

Product: hydroxypyruvate isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 266; Mature: 265

Protein sequence:

>266_residues
MPKFAANLTMLFNEVPFLDRFAAAADAGFDAVEFLFPYPYQIADLSERLEQNKLKLVLHNLPAGNWEAGERGIASLPDRV
SEFQEGVGRAIEYAKALKVPQLNCLVGIPKNVEADKARATIVDNLRFAAAALKKEGIRLLVEPCNSYDIPGFALNRSSEG
LDVIQAVGSDNLFLQYDIYHMQRMEGELAATIKKHFAQIAHIQLADNPGRNEPGTGEINYPFLFDLLDSLGYQGYVGCEY
KPRTTTSEGLGWLESIAGVKRAHASA

Sequences:

>Translated_266_residues
MPKFAANLTMLFNEVPFLDRFAAAADAGFDAVEFLFPYPYQIADLSERLEQNKLKLVLHNLPAGNWEAGERGIASLPDRV
SEFQEGVGRAIEYAKALKVPQLNCLVGIPKNVEADKARATIVDNLRFAAAALKKEGIRLLVEPCNSYDIPGFALNRSSEG
LDVIQAVGSDNLFLQYDIYHMQRMEGELAATIKKHFAQIAHIQLADNPGRNEPGTGEINYPFLFDLLDSLGYQGYVGCEY
KPRTTTSEGLGWLESIAGVKRAHASA
>Mature_265_residues
PKFAANLTMLFNEVPFLDRFAAAADAGFDAVEFLFPYPYQIADLSERLEQNKLKLVLHNLPAGNWEAGERGIASLPDRVS
EFQEGVGRAIEYAKALKVPQLNCLVGIPKNVEADKARATIVDNLRFAAAALKKEGIRLLVEPCNSYDIPGFALNRSSEGL
DVIQAVGSDNLFLQYDIYHMQRMEGELAATIKKHFAQIAHIQLADNPGRNEPGTGEINYPFLFDLLDSLGYQGYVGCEYK
PRTTTSEGLGWLESIAGVKRAHASA

Specific function: Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) [H]

COG id: COG3622

COG function: function code G; Hydroxypyruvate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hyi family [H]

Homologues:

Organism=Homo sapiens, GI300068962, Length=272, Percent_Identity=41.1764705882353, Blast_Score=194, Evalue=7e-50,
Organism=Homo sapiens, GI300068964, Length=243, Percent_Identity=39.917695473251, Blast_Score=166, Evalue=2e-41,
Organism=Escherichia coli, GI1786718, Length=255, Percent_Identity=55.2941176470588, Blast_Score=293, Evalue=8e-81,
Organism=Escherichia coli, GI1789095, Length=256, Percent_Identity=46.09375, Blast_Score=249, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI17552022, Length=257, Percent_Identity=40.0778210116732, Blast_Score=187, Evalue=3e-48,
Organism=Drosophila melanogaster, GI17530883, Length=259, Percent_Identity=33.976833976834, Blast_Score=158, Evalue=4e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017643
- InterPro:   IPR013022
- InterPro:   IPR012307 [H]

Pfam domain/function: PF01261 AP_endonuc_2 [H]

EC number: =5.3.1.22 [H]

Molecular weight: Translated: 29308; Mature: 29176

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKFAANLTMLFNEVPFLDRFAAAADAGFDAVEFLFPYPYQIADLSERLEQNKLKLVLHN
CCCHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHEEC
LPAGNWEAGERGIASLPDRVSEFQEGVGRAIEYAKALKVPQLNCLVGIPKNVEADKARAT
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHH
IVDNLRFAAAALKKEGIRLLVEPCNSYDIPGFALNRSSEGLDVIQAVGSDNLFLQYDIYH
HHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEEECCCCCCHHHHHHCCCCCEEEEEHHHH
MQRMEGELAATIKKHFAQIAHIQLADNPGRNEPGTGEINYPFLFDLLDSLGYQGYVGCEY
HHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCEECCCC
KPRTTTSEGLGWLESIAGVKRAHASA
CCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PKFAANLTMLFNEVPFLDRFAAAADAGFDAVEFLFPYPYQIADLSERLEQNKLKLVLHN
CCHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHEEC
LPAGNWEAGERGIASLPDRVSEFQEGVGRAIEYAKALKVPQLNCLVGIPKNVEADKARAT
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHH
IVDNLRFAAAALKKEGIRLLVEPCNSYDIPGFALNRSSEGLDVIQAVGSDNLFLQYDIYH
HHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEEECCCCCCHHHHHHCCCCCEEEEEHHHH
MQRMEGELAATIKKHFAQIAHIQLADNPGRNEPGTGEINYPFLFDLLDSLGYQGYVGCEY
HHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCEECCCC
KPRTTTSEGLGWLESIAGVKRAHASA
CCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8440684; 10561547; 9278503 [H]