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The map label for this gene is lutP [H]

Identifier: 186476279

GI number: 186476279

Start: 1715909

End: 1717507

Strand: Direct

Name: lutP [H]

Synonym: Bphy_1521

Alternate gene names: 186476279

Gene position: 1715909-1717507 (Clockwise)

Preceding gene: 186476278

Following gene: 186476280

Centisome position: 49.32

GC content: 62.29

Gene sequence:

>1599_bases
ATGTTTCACCAGTTATTGACGCCCATCGGCAACTCGCTGTTGCCGTCGTTCATCGTTGCCGCCTTGCCTATCATCGTCGT
GCTCGTGCTGCTTGGGTGGGCGCGGCGCCCGGCATGGCAGGCCTCGCTCGCGGGTCTTGCAGTCGGCCTGCTGATCGCGA
TTTTCGGCTGGCACTTCCCCATTGGTCTCGCGCTCAATTCCGTCGCTGCCGGCGCCGTGTTCGCGTGCTGGCCCGTGATG
TGGATCGTCGTGACGGCGATCCTGCTCTACAACATCGCGCAGTATTCGGGACGCTTCGCGGCCTTCCGCATGTGGATGAT
CGACAATCTGCCGAACGACCGGCGCATCGTATTGGTCGTAATCGGCTTTTCGTTCGGCGCGCTGTTCGAAGGCATCTCCG
GCTTCGGCACGCCGATCGCGATCACCAGTTCTCTGCTGATCCTGCTCGGTTTCCCCGCTCTCGAAGCGCTGACCTTCACG
CTGATCTTCAACACGGCGCCCGTCGCGTTTGGGGCGCTCGGCGTGCCTATCACGGTGCTCGGCGCAGTCACGCACCTGCC
CACCGATGCCCTCGCCAAGATGGTCGGCCGGCAGTTGCCGTTCTTCGCGCTGATGCTGCCGTTCTACGTGATCGGCGTAT
ACGCGGGCTTTCGCAATATGCTGCGTGTGTGGCCCGTGCTGCTCGTGTCGGGCGGCAGCTTCGCGCTCACACAGTTCGTC
ACGTCCAACTTCATCAACTACAGCCTGACGGACGTGCTGTCGTCGCTGGTGTCGCTGATCCTGACCATCGCCTTCCTGCG
CGTCTGGCGCCCCGCCGTCGATCCCGCGTTCGCGATCAACGTCGATCGCGTGAACGAGACGCGCGGCAAGATCACGGGCA
CGCAGGGCTGGTATCCGTGGCTGATCGTGTCCGCCGTCGTGATCGTCTGGACGATTGCGAAGATCTTCATGATCGGCGAC
GTGAAGGTGCCGTGGCCGGGTCTCGACAAAGCCGTCTACATCACGCTGTACAACACACCGTACGGCGCGATCTGGGACTT
CCAGCCGCTCGCGACAGGCACGGCGATCCTCGTAGCGGCGATTATCACGGCACTCGTCGTGAAGCTGTCAGTAGCCGACT
TCGGGCGCGCGATCGTCGATACCTGGGTGCAGACGCGCATCGCCATTCTCACGGTGGCCACCATTGTCGGCCTCGCGTAC
CTGATGAATTACTCAGGGATGAATTACACGCTGGGGCTCGGCGTGGCGTCCGTCGGGGCGCTCTTTCCGCTGGTGTCGGC
GTTCCTCGGCTGGGTGGCCGTATTCCTGTCGGGGAGCGACACGTCGGGTAACGCACTGTTCGGCAATCTGCAGGTGGTGG
CCGCCAATCAGCTGAACCTGAACCCCGTGCTGATGGCCGCGACGAACTCGTCGGGCGGCGTAATGGGCAAGATGATCTCA
CCGCAGAACATCTCGACGGGCGTCGCGACAACCGATCTCAAAGGCAAGGAAGGCTATGTGTTCGCGAAGACCTTCAAGCA
TTCGATCCTGCTGACCGTCCTGCTCGGCATTCTCGTGTGGCTGCAGCAGAACGTGCTGCAATGGATGATTCCGCATTGA

Upstream 100 bases:

>100_bases
TCCGCTGCGCGGCGGCCACAGCCTTCATCCGTCCAGCCCTGCCGCTTCGCCGCGTAGGCGCAGTCTTCGCGTCGAATCGA
ACAACAACGAAGGAGACGTG

Downstream 100 bases:

>100_bases
CGAGCACTGCCGAAGCGGGCGCGATCCACGCACGCCCGCTTCGCTGTACGTACGTGCGCGCGACGCGCATGCGCGATAAA
CCGCATCCCCGCCGGCCGGT

Product: L-lactate transport

Products: lactate [Cytoplasm]; Proton [Cytoplasm]; glycolate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 532; Mature: 532

Protein sequence:

>532_residues
MFHQLLTPIGNSLLPSFIVAALPIIVVLVLLGWARRPAWQASLAGLAVGLLIAIFGWHFPIGLALNSVAAGAVFACWPVM
WIVVTAILLYNIAQYSGRFAAFRMWMIDNLPNDRRIVLVVIGFSFGALFEGISGFGTPIAITSSLLILLGFPALEALTFT
LIFNTAPVAFGALGVPITVLGAVTHLPTDALAKMVGRQLPFFALMLPFYVIGVYAGFRNMLRVWPVLLVSGGSFALTQFV
TSNFINYSLTDVLSSLVSLILTIAFLRVWRPAVDPAFAINVDRVNETRGKITGTQGWYPWLIVSAVVIVWTIAKIFMIGD
VKVPWPGLDKAVYITLYNTPYGAIWDFQPLATGTAILVAAIITALVVKLSVADFGRAIVDTWVQTRIAILTVATIVGLAY
LMNYSGMNYTLGLGVASVGALFPLVSAFLGWVAVFLSGSDTSGNALFGNLQVVAANQLNLNPVLMAATNSSGGVMGKMIS
PQNISTGVATTDLKGKEGYVFAKTFKHSILLTVLLGILVWLQQNVLQWMIPH

Sequences:

>Translated_532_residues
MFHQLLTPIGNSLLPSFIVAALPIIVVLVLLGWARRPAWQASLAGLAVGLLIAIFGWHFPIGLALNSVAAGAVFACWPVM
WIVVTAILLYNIAQYSGRFAAFRMWMIDNLPNDRRIVLVVIGFSFGALFEGISGFGTPIAITSSLLILLGFPALEALTFT
LIFNTAPVAFGALGVPITVLGAVTHLPTDALAKMVGRQLPFFALMLPFYVIGVYAGFRNMLRVWPVLLVSGGSFALTQFV
TSNFINYSLTDVLSSLVSLILTIAFLRVWRPAVDPAFAINVDRVNETRGKITGTQGWYPWLIVSAVVIVWTIAKIFMIGD
VKVPWPGLDKAVYITLYNTPYGAIWDFQPLATGTAILVAAIITALVVKLSVADFGRAIVDTWVQTRIAILTVATIVGLAY
LMNYSGMNYTLGLGVASVGALFPLVSAFLGWVAVFLSGSDTSGNALFGNLQVVAANQLNLNPVLMAATNSSGGVMGKMIS
PQNISTGVATTDLKGKEGYVFAKTFKHSILLTVLLGILVWLQQNVLQWMIPH
>Mature_532_residues
MFHQLLTPIGNSLLPSFIVAALPIIVVLVLLGWARRPAWQASLAGLAVGLLIAIFGWHFPIGLALNSVAAGAVFACWPVM
WIVVTAILLYNIAQYSGRFAAFRMWMIDNLPNDRRIVLVVIGFSFGALFEGISGFGTPIAITSSLLILLGFPALEALTFT
LIFNTAPVAFGALGVPITVLGAVTHLPTDALAKMVGRQLPFFALMLPFYVIGVYAGFRNMLRVWPVLLVSGGSFALTQFV
TSNFINYSLTDVLSSLVSLILTIAFLRVWRPAVDPAFAINVDRVNETRGKITGTQGWYPWLIVSAVVIVWTIAKIFMIGD
VKVPWPGLDKAVYITLYNTPYGAIWDFQPLATGTAILVAAIITALVVKLSVADFGRAIVDTWVQTRIAILTVATIVGLAY
LMNYSGMNYTLGLGVASVGALFPLVSAFLGWVAVFLSGSDTSGNALFGNLQVVAANQLNLNPVLMAATNSSGGVMGKMIS
PQNISTGVATTDLKGKEGYVFAKTFKHSILLTVLLGILVWLQQNVLQWMIPH

Specific function: Is the principal permease for the uptake of L-lactate in B.subtilis [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1789347, Length=558, Percent_Identity=40.3225806451613, Blast_Score=352, Evalue=5e-98,
Organism=Escherichia coli, GI1790031, Length=551, Percent_Identity=38.8384754990926, Blast_Score=340, Evalue=1e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 57240; Mature: 57240

Theoretical pI: Translated: 9.98; Mature: 9.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFHQLLTPIGNSLLPSFIVAALPIIVVLVLLGWARRPAWQASLAGLAVGLLIAIFGWHFP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
IGLALNSVAAGAVFACWPVMWIVVTAILLYNIAQYSGRFAAFRMWMIDNLPNDRRIVLVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEEE
IGFSFGALFEGISGFGTPIAITSSLLILLGFPALEALTFTLIFNTAPVAFGALGVPITVL
ECCHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHCCCHHHHH
GAVTHLPTDALAKMVGRQLPFFALMLPFYVIGVYAGFRNMLRVWPVLLVSGGSFALTQFV
HHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
TSNFINYSLTDVLSSLVSLILTIAFLRVWRPAVDPAFAINVDRVNETRGKITGTQGWYPW
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHCCCCCCCCCCCCCCHHH
LIVSAVVIVWTIAKIFMIGDVKVPWPGLDKAVYITLYNTPYGAIWDFQPLATGTAILVAA
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHH
IITALVVKLSVADFGRAIVDTWVQTRIAILTVATIVGLAYLMNYSGMNYTLGLGVASVGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHH
LFPLVSAFLGWVAVFLSGSDTSGNALFGNLQVVAANQLNLNPVLMAATNSSGGVMGKMIS
HHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEEECCCCCCEEEEEEECCCCCEEEECCC
PQNISTGVATTDLKGKEGYVFAKTFKHSILLTVLLGILVWLQQNVLQWMIPH
CCCCCCCCEECCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFHQLLTPIGNSLLPSFIVAALPIIVVLVLLGWARRPAWQASLAGLAVGLLIAIFGWHFP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
IGLALNSVAAGAVFACWPVMWIVVTAILLYNIAQYSGRFAAFRMWMIDNLPNDRRIVLVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEEE
IGFSFGALFEGISGFGTPIAITSSLLILLGFPALEALTFTLIFNTAPVAFGALGVPITVL
ECCHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHCCCHHHHH
GAVTHLPTDALAKMVGRQLPFFALMLPFYVIGVYAGFRNMLRVWPVLLVSGGSFALTQFV
HHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
TSNFINYSLTDVLSSLVSLILTIAFLRVWRPAVDPAFAINVDRVNETRGKITGTQGWYPW
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHCCCCCCCCCCCCCCHHH
LIVSAVVIVWTIAKIFMIGDVKVPWPGLDKAVYITLYNTPYGAIWDFQPLATGTAILVAA
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHH
IITALVVKLSVADFGRAIVDTWVQTRIAILTVATIVGLAYLMNYSGMNYTLGLGVASVGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHH
LFPLVSAFLGWVAVFLSGSDTSGNALFGNLQVVAANQLNLNPVLMAATNSSGGVMGKMIS
HHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEEECCCCCCEEEEEEECCCCCEEEECCC
PQNISTGVATTDLKGKEGYVFAKTFKHSILLTVLLGILVWLQQNVLQWMIPH
CCCCCCCCEECCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: lactate [Periplasm]; Proton [Periplasm]; glycolate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] Proton [Periplasm] + glycolate [Periplasm] = Proton [Cytoplasm] + glycolate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 8969506 [H]