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The map label for this gene is uvrY [H]

Identifier: 186476266

GI number: 186476266

Start: 1703044

End: 1703754

Strand: Reverse

Name: uvrY [H]

Synonym: Bphy_1508

Alternate gene names: 186476266

Gene position: 1703754-1703044 (Counterclockwise)

Preceding gene: 186476267

Following gene: 186476265

Centisome position: 48.97

GC content: 62.59

Gene sequence:

>711_bases
ATGTGTGCCGCTGCACGTTCGGCCGTCAGCGCGTTCCTGCTTTTTCACTGCGTTGAGCCACGAACGATGATTCGAGTGCT
GATAGCGGACGATCACGCGATAGTCCGGGGCGGATTCAGGCAGTTCGTCGCCGACGAGCCGGATATGTGCGTCGCGGCGG
AAGCGGCGACGGGCGACGAGACGATACGCCTCGTGCGCGAGCAGGCGGACAGCGAGCCGTTCGACGTGGTGCTGCTCGAT
ATCGCGATGCCCGACAAGAACGGCATCGACACGCTGCGCGTGATCCGCCAGTTGCGTCCGGAGCAGAACGTGCTGATCCT
GTCCGGCTACCCGGAGAGCCAGTACGCGATCAATCTGCTGCGCGCGGGCGCGAACGGCTATCTGAACAAGGATTGCGAGC
CCGGCGAGATCGTGCGCGCGATCCGCTCGGTGGCGCGCGGGCATCGCTATCTGTCGGAGGCCGTTGCCGATACGCTCGCG
AACAGTCTCGACAGGCCCGCGTCTTCGCATCCGCACGAGTTGCTGTCGGAGCGCGAATTCCAGATTTTCTGCAAGCTCGC
GTCCGGGCAGATTCCCACCGACATCGCGGACGAACTGCATTTGTCGGTGAAGACGGTCAGCACCTATCGCGCGCGCGTGC
TGGAGAAAATGCACATGACGAACAACGCGGACATCACGTACTACGCGATCAAGAACGGCTTGATCGAATGA

Upstream 100 bases:

>100_bases
GGCCGTCGAGGAAGAACACGCGGACGACATGGCCGATCTGTTGACGGGCCGCGAATAAGCGGCTGATTGATGCCTGGCGC
GAACGCTGCGAGCGGCATGC

Downstream 100 bases:

>100_bases
CGGTTTGACAACCCGCGCATGGAACGCCACCGATGACCCCCGACTCCGCCACCGCACACGACGACGCCCGCCGCGCGCCG
CTGCGTGTACTGCTGATCGA

Product: two component LuxR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MCAAARSAVSAFLLFHCVEPRTMIRVLIADDHAIVRGGFRQFVADEPDMCVAAEAATGDETIRLVREQADSEPFDVVLLD
IAMPDKNGIDTLRVIRQLRPEQNVLILSGYPESQYAINLLRAGANGYLNKDCEPGEIVRAIRSVARGHRYLSEAVADTLA
NSLDRPASSHPHELLSEREFQIFCKLASGQIPTDIADELHLSVKTVSTYRARVLEKMHMTNNADITYYAIKNGLIE

Sequences:

>Translated_236_residues
MCAAARSAVSAFLLFHCVEPRTMIRVLIADDHAIVRGGFRQFVADEPDMCVAAEAATGDETIRLVREQADSEPFDVVLLD
IAMPDKNGIDTLRVIRQLRPEQNVLILSGYPESQYAINLLRAGANGYLNKDCEPGEIVRAIRSVARGHRYLSEAVADTLA
NSLDRPASSHPHELLSEREFQIFCKLASGQIPTDIADELHLSVKTVSTYRARVLEKMHMTNNADITYYAIKNGLIE
>Mature_236_residues
MCAAARSAVSAFLLFHCVEPRTMIRVLIADDHAIVRGGFRQFVADEPDMCVAAEAATGDETIRLVREQADSEPFDVVLLD
IAMPDKNGIDTLRVIRQLRPEQNVLILSGYPESQYAINLLRAGANGYLNKDCEPGEIVRAIRSVARGHRYLSEAVADTLA
NSLDRPASSHPHELLSEREFQIFCKLASGQIPTDIADELHLSVKTVSTYRARVLEKMHMTNNADITYYAIKNGLIE

Specific function: Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. UvrY activates the transcription of the untranslated csrB RNA and of barA, in an autoregulatory loop. Mediates the

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=213, Percent_Identity=36.6197183098592, Blast_Score=147, Evalue=6e-37,
Organism=Escherichia coli, GI1790102, Length=203, Percent_Identity=36.4532019704434, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1788521, Length=198, Percent_Identity=34.8484848484849, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1787473, Length=193, Percent_Identity=33.6787564766839, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI1786747, Length=205, Percent_Identity=28.780487804878, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI1788712, Length=211, Percent_Identity=26.5402843601896, Blast_Score=82, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 26181; Mature: 26181

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCAAARSAVSAFLLFHCVEPRTMIRVLIADDHAIVRGGFRQFVADEPDMCVAAEAATGDE
CCCHHHHHHHHHHHHHHCCCHHEEEEEEECCCHHHHHHHHHHHCCCCCCEEEECCCCCHH
TIRLVREQADSEPFDVVLLDIAMPDKNGIDTLRVIRQLRPEQNVLILSGYPESQYAINLL
HHHHHHHHCCCCCCEEEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHH
RAGANGYLNKDCEPGEIVRAIRSVARGHRYLSEAVADTLANSLDRPASSHPHELLSEREF
HCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCC
QIFCKLASGQIPTDIADELHLSVKTVSTYRARVLEKMHMTNNADITYYAIKNGLIE
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCC
>Mature Secondary Structure
MCAAARSAVSAFLLFHCVEPRTMIRVLIADDHAIVRGGFRQFVADEPDMCVAAEAATGDE
CCCHHHHHHHHHHHHHHCCCHHEEEEEEECCCHHHHHHHHHHHCCCCCCEEEECCCCCHH
TIRLVREQADSEPFDVVLLDIAMPDKNGIDTLRVIRQLRPEQNVLILSGYPESQYAINLL
HHHHHHHHCCCCCCEEEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHH
RAGANGYLNKDCEPGEIVRAIRSVARGHRYLSEAVADTLANSLDRPASSHPHELLSEREF
HCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCC
QIFCKLASGQIPTDIADELHLSVKTVSTYRARVLEKMHMTNNADITYYAIKNGLIE
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]