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The map label for this gene is pyrG [H]

Identifier: 186476199

GI number: 186476199

Start: 1619804

End: 1621465

Strand: Reverse

Name: pyrG [H]

Synonym: Bphy_1441

Alternate gene names: 186476199

Gene position: 1621465-1619804 (Counterclockwise)

Preceding gene: 186476200

Following gene: 186476198

Centisome position: 46.6

GC content: 60.77

Gene sequence:

>1662_bases
ATGACCAAATATGTTTTCGTCACCGGCGGCGTAGTTTCTTCCCTCGGCAAGGGTATTGCCGCCGCTTCCCTCGCCGCGAT
CCTCGAATCGCGCGGTCTGAAAGTCACCCTCCTCAAGCTTGATCCTTACATCAACGTCGACCCCGGCACGATGAGTCCGT
TTCAACACGGCGAAGTGTTCGTGACGGAAGATGGCGCTGAGACGGACCTCGACCTCGGCCACTACGAGCGCTTCATCAGC
ACGAAGATGCGCAAGGCCAACAACTTCACCACGGGCCAGATCTACGAATCGGTGATCCGCAAGGAACGCCGTGGCGATTA
TCTCGGCAAGACGGTCCAGGTCATCCCCCACATCACGAACGAAATCCAGGCATTCGTCGAACGCGGCGCGGCATCCGCGA
CGTGCGGCGAGCCGGATGTCGCAATCGTCGAAGTGGGCGGCACGGTGGGTGACATCGAATCGCTGCCGTTCCTCGAAGCC
GCGCGTCAGATGAGCCTGCGCCTCGGCCGCAACAGCGCGTGTTTCGTGCACCTCACGCTGGTTCCGTTCATCGCCACCGC
GGGCGAGCTGAAAACCAAGCCGACGCAGCACAGCGTGCAGAAGCTGCGCGAAATCGGCATCTACCCGAATGTGCTGTTGT
GCCGTGCCGACCGCCGCATCCCTGACGACGAGCGCGCGAAGATTTCGATGTTCTCGAACGTGCCGGAAGACGCCGTGATC
TCGGTGTGGGACGTCGACAGCATCTACAAGATTCCGCAGATGCTGCACGACCAGGGCCTCGACGAGCTGATCTGCGAAGA
GCTGAAGCTCACCGCCAGGCCGGCTGATCTGTCGATCTGGTCGGAAATGGTCGAGAAGCTCGAGAACCCGAAGAGTGAAG
TGACGATCGGCATGGTCGGCAAGTACGTCGAACTGACCGAGTCGTACAAGTCGCTGATCGAAGCGCTGCGCCATGCGTCG
ATCCACACGTCGACGAAGGTCAACATCGAATACATCGACTCGGAAGAGCTGGAAGAGAACGGCGTCGACAGCCTCAAGCA
TCTGGATGCCGTGCTGGTTCCGGGTGGTTTCGGCCGCCGCGGCACGGAAGGCAAGATCAAGGCCATCCGCTATGCACGCG
AAGCAAAGGTGCCGTACCTCGGCATTTGCCTCGGCATGCAGCTGGCGGTGATCGAATTCGCGCGCGACGTCGTCGGCCTC
AAGGATGCGAATAGCACGGAATTCGACCAGGACACGCCGAACCGCGTCGTCGCGCTAATCACCGAGTGGTACGACCGCGA
AGGTAAGGTCGAGAAGCGCACGGAAGAATCCGATCTGGGCGGCACGATGCGCCTCGGTTCGCAGCGTTGCCCGATCAAGC
CGGGCACGATGGCTGAAGAGATCTACGGCAAGGATGTGAACGAGCGTCACCGTCACCGTTATGAAGTCAATAACCGCTTC
GTGCCCCAGCTCGAAGGCGGTGGCCTTATCATCAGCGCCCGTACCCCGAGCGAAGATCTGCCGGAAATGATGGAACTGCC
GCGTTCGATGCACCCTTGGTTCGTCGGCGTCCAGTTCCACCCCGAATTCACGTCGACGCCTCGTGACGGCCATCCGCTGT
TCAAGGCGTTCGTCGAAGCGGCGCGCGCTCACCACGAAGCGAGCGTCGAGGAGAAAGTATGA

Upstream 100 bases:

>100_bases
GCGCTGAAAAGCACGTTCGATCGGTGCGGACGGGCCGCCCCAGGTATGGGCTGGAAGCACGCGTTCGGGTATAATCCGTT
TTTCCCGCGAGCATCCAGCG

Downstream 100 bases:

>100_bases
AACTGGGCGATTTCGAAATCGGCCTCGACAAGCCGTTTTTCCTGATCGCGGGCACCTGTGTCGTCGAATCCGAACAGATG
ACGATCGACACGGCCGGCAA

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase [H]

Number of amino acids: Translated: 553; Mature: 552

Protein sequence:

>553_residues
MTKYVFVTGGVVSSLGKGIAAASLAAILESRGLKVTLLKLDPYINVDPGTMSPFQHGEVFVTEDGAETDLDLGHYERFIS
TKMRKANNFTTGQIYESVIRKERRGDYLGKTVQVIPHITNEIQAFVERGAASATCGEPDVAIVEVGGTVGDIESLPFLEA
ARQMSLRLGRNSACFVHLTLVPFIATAGELKTKPTQHSVQKLREIGIYPNVLLCRADRRIPDDERAKISMFSNVPEDAVI
SVWDVDSIYKIPQMLHDQGLDELICEELKLTARPADLSIWSEMVEKLENPKSEVTIGMVGKYVELTESYKSLIEALRHAS
IHTSTKVNIEYIDSEELEENGVDSLKHLDAVLVPGGFGRRGTEGKIKAIRYAREAKVPYLGICLGMQLAVIEFARDVVGL
KDANSTEFDQDTPNRVVALITEWYDREGKVEKRTEESDLGGTMRLGSQRCPIKPGTMAEEIYGKDVNERHRHRYEVNNRF
VPQLEGGGLIISARTPSEDLPEMMELPRSMHPWFVGVQFHPEFTSTPRDGHPLFKAFVEAARAHHEASVEEKV

Sequences:

>Translated_553_residues
MTKYVFVTGGVVSSLGKGIAAASLAAILESRGLKVTLLKLDPYINVDPGTMSPFQHGEVFVTEDGAETDLDLGHYERFIS
TKMRKANNFTTGQIYESVIRKERRGDYLGKTVQVIPHITNEIQAFVERGAASATCGEPDVAIVEVGGTVGDIESLPFLEA
ARQMSLRLGRNSACFVHLTLVPFIATAGELKTKPTQHSVQKLREIGIYPNVLLCRADRRIPDDERAKISMFSNVPEDAVI
SVWDVDSIYKIPQMLHDQGLDELICEELKLTARPADLSIWSEMVEKLENPKSEVTIGMVGKYVELTESYKSLIEALRHAS
IHTSTKVNIEYIDSEELEENGVDSLKHLDAVLVPGGFGRRGTEGKIKAIRYAREAKVPYLGICLGMQLAVIEFARDVVGL
KDANSTEFDQDTPNRVVALITEWYDREGKVEKRTEESDLGGTMRLGSQRCPIKPGTMAEEIYGKDVNERHRHRYEVNNRF
VPQLEGGGLIISARTPSEDLPEMMELPRSMHPWFVGVQFHPEFTSTPRDGHPLFKAFVEAARAHHEASVEEKV
>Mature_552_residues
TKYVFVTGGVVSSLGKGIAAASLAAILESRGLKVTLLKLDPYINVDPGTMSPFQHGEVFVTEDGAETDLDLGHYERFIST
KMRKANNFTTGQIYESVIRKERRGDYLGKTVQVIPHITNEIQAFVERGAASATCGEPDVAIVEVGGTVGDIESLPFLEAA
RQMSLRLGRNSACFVHLTLVPFIATAGELKTKPTQHSVQKLREIGIYPNVLLCRADRRIPDDERAKISMFSNVPEDAVIS
VWDVDSIYKIPQMLHDQGLDELICEELKLTARPADLSIWSEMVEKLENPKSEVTIGMVGKYVELTESYKSLIEALRHASI
HTSTKVNIEYIDSEELEENGVDSLKHLDAVLVPGGFGRRGTEGKIKAIRYAREAKVPYLGICLGMQLAVIEFARDVVGLK
DANSTEFDQDTPNRVVALITEWYDREGKVEKRTEESDLGGTMRLGSQRCPIKPGTMAEEIYGKDVNERHRHRYEVNNRFV
PQLEGGGLIISARTPSEDLPEMMELPRSMHPWFVGVQFHPEFTSTPRDGHPLFKAFVEAARAHHEASVEEKV

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen [H]

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI28559085, Length=569, Percent_Identity=44.6397188049209, Blast_Score=486, Evalue=1e-137,
Organism=Homo sapiens, GI28559083, Length=569, Percent_Identity=44.6397188049209, Blast_Score=486, Evalue=1e-137,
Organism=Homo sapiens, GI221316689, Length=569, Percent_Identity=44.6397188049209, Blast_Score=486, Evalue=1e-137,
Organism=Homo sapiens, GI148491070, Length=559, Percent_Identity=45.9749552772809, Blast_Score=482, Evalue=1e-136,
Organism=Escherichia coli, GI1789142, Length=541, Percent_Identity=63.4011090573013, Blast_Score=690, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25148299, Length=609, Percent_Identity=40.0656814449918, Blast_Score=432, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6319432, Length=581, Percent_Identity=42.512908777969, Blast_Score=456, Evalue=1e-129,
Organism=Saccharomyces cerevisiae, GI6322563, Length=574, Percent_Identity=42.3344947735192, Blast_Score=454, Evalue=1e-128,
Organism=Drosophila melanogaster, GI24664469, Length=559, Percent_Identity=45.7960644007156, Blast_Score=486, Evalue=1e-137,
Organism=Drosophila melanogaster, GI21357815, Length=504, Percent_Identity=44.4444444444444, Blast_Score=413, Evalue=1e-115,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase [H]

EC number: =6.3.4.2 [H]

Molecular weight: Translated: 61566; Mature: 61435

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKYVFVTGGVVSSLGKGIAAASLAAILESRGLKVTLLKLDPYINVDPGTMSPFQHGEVF
CCEEEEEECHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEECCEEECCCCCCCCCCCCEEE
VTEDGAETDLDLGHYERFISTKMRKANNFTTGQIYESVIRKERRGDYLGKTVQVIPHITN
EECCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHCCHHHHHHHHHH
EIQAFVERGAASATCGEPDVAIVEVGGTVGDIESLPFLEAARQMSLRLGRNSACFVHLTL
HHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEH
VPFIATAGELKTKPTQHSVQKLREIGIYPNVLLCRADRRIPDDERAKISMFSNVPEDAVI
HHHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHCCCCCCCEE
SVWDVDSIYKIPQMLHDQGLDELICEELKLTARPADLSIWSEMVEKLENPKSEVTIGMVG
EEECCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHEEEHHHHH
KYVELTESYKSLIEALRHASIHTSTKVNIEYIDSEELEENGVDSLKHLDAVLVPGGFGRR
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHCCHHHHHHCCEEEECCCCCCC
GTEGKIKAIRYAREAKVPYLGICLGMQLAVIEFARDVVGLKDANSTEFDQDTPNRVVALI
CCCCHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
TEWYDREGKVEKRTEESDLGGTMRLGSQRCPIKPGTMAEEIYGKDVNERHRHRYEVNNRF
HHHHCCCCCCHHCCCHHCCCCEEECCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHCCCCC
VPQLEGGGLIISARTPSEDLPEMMELPRSMHPWFVGVQFHPEFTSTPRDGHPLFKAFVEA
CCEECCCCEEEECCCCCCCHHHHHHCCHHCCCEEEEEEECCCCCCCCCCCCHHHHHHHHH
ARAHHEASVEEKV
HHHHHHCCHHCCC
>Mature Secondary Structure 
TKYVFVTGGVVSSLGKGIAAASLAAILESRGLKVTLLKLDPYINVDPGTMSPFQHGEVF
CEEEEEECHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEECCEEECCCCCCCCCCCCEEE
VTEDGAETDLDLGHYERFISTKMRKANNFTTGQIYESVIRKERRGDYLGKTVQVIPHITN
EECCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHCCHHHHHHHHHH
EIQAFVERGAASATCGEPDVAIVEVGGTVGDIESLPFLEAARQMSLRLGRNSACFVHLTL
HHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEH
VPFIATAGELKTKPTQHSVQKLREIGIYPNVLLCRADRRIPDDERAKISMFSNVPEDAVI
HHHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHCCCCCCCEE
SVWDVDSIYKIPQMLHDQGLDELICEELKLTARPADLSIWSEMVEKLENPKSEVTIGMVG
EEECCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHEEEHHHHH
KYVELTESYKSLIEALRHASIHTSTKVNIEYIDSEELEENGVDSLKHLDAVLVPGGFGRR
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHCCHHHHHHCCEEEECCCCCCC
GTEGKIKAIRYAREAKVPYLGICLGMQLAVIEFARDVVGLKDANSTEFDQDTPNRVVALI
CCCCHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
TEWYDREGKVEKRTEESDLGGTMRLGSQRCPIKPGTMAEEIYGKDVNERHRHRYEVNNRF
HHHHCCCCCCHHCCCHHCCCCEEECCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHCCCCC
VPQLEGGGLIISARTPSEDLPEMMELPRSMHPWFVGVQFHPEFTSTPRDGHPLFKAFVEA
CCEECCCCEEEECCCCCCCHHHHHHCCHHCCCEEEEEEECCCCCCCCCCCCHHHHHHHHH
ARAHHEASVEEKV
HHHHHHCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA