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The map label for this gene is map [H]

Identifier: 186476097

GI number: 186476097

Start: 1498842

End: 1499654

Strand: Direct

Name: map [H]

Synonym: Bphy_1339

Alternate gene names: 186476097

Gene position: 1498842-1499654 (Clockwise)

Preceding gene: 186476080

Following gene: 186476098

Centisome position: 43.08

GC content: 63.47

Gene sequence:

>813_bases
ATGGCTATTACGCTCAAAAACGAAGACGATATCGCGCAGATGCGCATCGCCGGACGGCTCGCGAGCGAGGTGCTCGACTA
CATCACGCCGTTCGTCAAGCCCGGCGTCACGACGGGCGAACTCGACCGTCTTTGCCACGAATACATGACGAACGTGCAAG
GCACGGTTCCCGCGCCGCTGAATTACCAGCCGCCCGGCTATCCGCCTTTCCCGAAGGCCGTCTGCACGTCCGTCAACGAC
GTGATCTGCCACGGCATCCCCGGCGACAAGGCGCTGAAGAACGGCGACGCGCTGAATATCGACGTCACCGTGATCAAGAA
CGGCTATTACGGCGACACGAGCCGCATGTTCATCGTCGGCGAGGGCTCGATCATGGCGAAGCGCCTCGTCCAGACCACGT
ATGAATGCATGTGGCTCGGCATCGAGCAGGTGCGCCCCGGCGCGCATCTCGGCGACATCGGCCATGCGATCCAGAAACAT
GCGGAAAGCCTCGGCTACAGCGTCGTGCGCGAATATTGCGGGCACGGCATCGGCAAGGTCTTCCACGACGAGCCGCAAAT
CCTGCACTACGGCCGCCCTGGCACGGGCATCGAACTGCAGGCGGGCATGATTTTCACGATCGAGCCGATGATCAATGCCG
GCCGCCGCGATATCCGCACGATGCCCGACCAGTGGACCGTCAAGACCAAGGACCGCAGCCTGTCCGCCCAATGGGAGCAC
ACGATCCTCGTCACGCCGACGGGCTACGAAGTGCTGACCGTGTCGGAAGGCACGCCCGCGCGTCCGCAAATCGTCGCCGC
CGCCACGGCCTGA

Upstream 100 bases:

>100_bases
GCGTGCGTCGCCCGTCAGGCCCAATCATCCCCGCAAACCCCAGCGATCGCGCGAATAAGGTGCGATAATTCCGCGATAAA
CCGCATTTCAGGCCCGACTC

Downstream 100 bases:

>100_bases
TCACTTTCGCCGCCACCCGCCGCCTATGAGTAGCGTTCACGCTGTCGCCCATTCCGATGCCACGTCTCTCAAGGCGGATT
ACAAGGTGGCCAAGACCCCG

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 270; Mature: 269

Protein sequence:

>270_residues
MAITLKNEDDIAQMRIAGRLASEVLDYITPFVKPGVTTGELDRLCHEYMTNVQGTVPAPLNYQPPGYPPFPKAVCTSVND
VICHGIPGDKALKNGDALNIDVTVIKNGYYGDTSRMFIVGEGSIMAKRLVQTTYECMWLGIEQVRPGAHLGDIGHAIQKH
AESLGYSVVREYCGHGIGKVFHDEPQILHYGRPGTGIELQAGMIFTIEPMINAGRRDIRTMPDQWTVKTKDRSLSAQWEH
TILVTPTGYEVLTVSEGTPARPQIVAAATA

Sequences:

>Translated_270_residues
MAITLKNEDDIAQMRIAGRLASEVLDYITPFVKPGVTTGELDRLCHEYMTNVQGTVPAPLNYQPPGYPPFPKAVCTSVND
VICHGIPGDKALKNGDALNIDVTVIKNGYYGDTSRMFIVGEGSIMAKRLVQTTYECMWLGIEQVRPGAHLGDIGHAIQKH
AESLGYSVVREYCGHGIGKVFHDEPQILHYGRPGTGIELQAGMIFTIEPMINAGRRDIRTMPDQWTVKTKDRSLSAQWEH
TILVTPTGYEVLTVSEGTPARPQIVAAATA
>Mature_269_residues
AITLKNEDDIAQMRIAGRLASEVLDYITPFVKPGVTTGELDRLCHEYMTNVQGTVPAPLNYQPPGYPPFPKAVCTSVNDV
ICHGIPGDKALKNGDALNIDVTVIKNGYYGDTSRMFIVGEGSIMAKRLVQTTYECMWLGIEQVRPGAHLGDIGHAIQKHA
ESLGYSVVREYCGHGIGKVFHDEPQILHYGRPGTGIELQAGMIFTIEPMINAGRRDIRTMPDQWTVKTKDRSLSAQWEHT
ILVTPTGYEVLTVSEGTPARPQIVAAATA

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=264, Percent_Identity=47.7272727272727, Blast_Score=245, Evalue=3e-65,
Organism=Homo sapiens, GI40385867, Length=252, Percent_Identity=41.6666666666667, Blast_Score=194, Evalue=6e-50,
Organism=Escherichia coli, GI1786364, Length=257, Percent_Identity=59.9221789883268, Blast_Score=325, Evalue=2e-90,
Organism=Escherichia coli, GI1788728, Length=254, Percent_Identity=25.1968503937008, Blast_Score=71, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI71996291, Length=257, Percent_Identity=43.9688715953307, Blast_Score=219, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6323273, Length=263, Percent_Identity=44.8669201520913, Blast_Score=222, Evalue=5e-59,
Organism=Drosophila melanogaster, GI21355531, Length=263, Percent_Identity=46.3878326996198, Blast_Score=228, Evalue=3e-60,
Organism=Drosophila melanogaster, GI24583427, Length=249, Percent_Identity=40.5622489959839, Blast_Score=192, Evalue=2e-49,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 29562; Mature: 29431

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAITLKNEDDIAQMRIAGRLASEVLDYITPFVKPGVTTGELDRLCHEYMTNVQGTVPAPL
CEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCC
NYQPPGYPPFPKAVCTSVNDVICHGIPGDKALKNGDALNIDVTVIKNGYYGDTSRMFIVG
CCCCCCCCCCCHHHHCCCCHHEEECCCCCHHHCCCCEEEEEEEEEECCEECCCCEEEEEE
EGSIMAKRLVQTTYECMWLGIEQVRPGAHLGDIGHAIQKHAESLGYSVVREYCGHGIGKV
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
FHDEPQILHYGRPGTGIELQAGMIFTIEPMINAGRRDIRTMPDQWTVKTKDRSLSAQWEH
CCCCCCEEEECCCCCCEEEECCEEEEEEHHHCCCCHHHHCCCCCEEEEECCCCCCCCCCE
TILVTPTGYEVLTVSEGTPARPQIVAAATA
EEEECCCCCEEEEECCCCCCCCEEEEEECC
>Mature Secondary Structure 
AITLKNEDDIAQMRIAGRLASEVLDYITPFVKPGVTTGELDRLCHEYMTNVQGTVPAPL
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCC
NYQPPGYPPFPKAVCTSVNDVICHGIPGDKALKNGDALNIDVTVIKNGYYGDTSRMFIVG
CCCCCCCCCCCHHHHCCCCHHEEECCCCCHHHCCCCEEEEEEEEEECCEECCCCEEEEEE
EGSIMAKRLVQTTYECMWLGIEQVRPGAHLGDIGHAIQKHAESLGYSVVREYCGHGIGKV
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
FHDEPQILHYGRPGTGIELQAGMIFTIEPMINAGRRDIRTMPDQWTVKTKDRSLSAQWEH
CCCCCCEEEECCCCCCEEEECCEEEEEEHHHCCCCHHHHCCCCCEEEEECCCCCCCCCCE
TILVTPTGYEVLTVSEGTPARPQIVAAATA
EEEECCCCCEEEEECCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]