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The map label for this gene is guaB [H]

Identifier: 186476072

GI number: 186476072

Start: 1472732

End: 1474192

Strand: Reverse

Name: guaB [H]

Synonym: Bphy_1314

Alternate gene names: 186476072

Gene position: 1474192-1472732 (Counterclockwise)

Preceding gene: 186476074

Following gene: 186476071

Centisome position: 42.37

GC content: 64.75

Gene sequence:

>1461_bases
ATGCGTCTGATCCAAAAAGCACTCACGTTCGATGACGTGCTCCTCGTCCCGGCTTTCTCCGACGTTCTGCCGCGCGACAC
CAGCCTCAAAACCCGGCTGACCCGCAACATCTCCCTCAATATGCCGCTCGTGTCCGCCGCCATGGACACCGTCACGGAGG
CTCGCCTTGCCATCGCGATGGCGCAGATGGGTGGCGTCGGCATCATCCACAAGAATCTCACGCCGGCCGAGCAGGCTCGC
GAAGTCGCGAAGGTCAAGCGTTTCGAATCGGGCGTCGTGCGCGATCCGATCACCGTTCCGCCGCAAATGAAGGTGAGCGA
CGTGATCGCACTGTCGCGCCAGCATGGCATTTCGGGCTTCCCCGTGGTGGAAGGGGCGCAGCTGATCGGCATCGTCACGA
ACCGCGACCTGCGTTTCGAAACGCGTCTGGACGAGCCCGTGCGCACGATCATGACGCCGCGCGAACGCCTCGTTACGGTG
AAGGAAGGTACGCCGCTCGCCGAAGCGAAGGCGCTGATGCACAGCCACCGCCTCGAGCGCGTGCTGGTCGTCAACGACGC
GTTCGAACTGCGCGGCCTGATGACGGTGAAGGACATCACCAAGCAGACGGAGCATCCGGACGCCTGTAAGGACGAGCATG
GCAAGCTGCGCGCAGGCGCCGCGGTCGGCGTCGGCCCGGACAACGAGGAGCGCGTGTCGCTGCTGGTGCAGGCGGGCGTG
GACGTAATCGTCGTCGATACGGCGCACGGCCACAGCAAGGGTGTGCTGGAGCGCGTCCAGTGGGTCAAGAAGAGCTTCCC
GCACGTCGAGGTGATCGGCGGCAACATCGCCACGGCCGATGCGGCCAAGGCGCTCGTTGAATACGGCGCGGATGGCGTGA
AGGTCGGTATCGGCCCCGGTTCGATCTGTACGACGCGTATTGTGGCTGGCGTGGGCGTGCCGCAAATCTCGGCGATCGCC
AACGTGTCGGCCGCGCTCAAGGGCACGGGCATCCCCGTGATCGCGGACGGCGGCGTGCGCTTCTCTGGCGACGTCAGCAA
GGCGCTGGCCGCGGGCGCCAATGCGGTGATGATGGGTAGCATGTTCGCTGGCACGGAAGAAGCGCCAGGCGACGTGTTTC
TCTATCAAGGCCGCCAGTACAAGTCGTACCGCGGCATGGGTTCCGTCGGCGCGATGAAGGACGGCGCGGCTGACCGCTAC
TTCCAGGACAATTCCGCGAACATCGACAAGCTCGTGCCGGAAGGCATCGAAGGCCGCGTCGCGTACAAGGGCTCGGTTGG
CGCGATCCTGTTCCAGTTGATCGGCGGCGTGCGCGCGTCAATGGGCTACTGCGGCTGCCGCACGATCGACGAACTGCACG
AGAAGGCCTCGTTCGTCGAAATCACCGCGGCGGGCATGCGCGAATCCCACGTGCACGATGTGCAGATCACGAAGGAAGCC
CCTAACTACCACGTGGACTAA

Upstream 100 bases:

>100_bases
GACGCGAAAGAACATTGAAGAATTTCGCTAACTGACTGTTCGCGCAGTGAAAACCGGGAGGTATCGCGTATAATTCGCTT
TTGCGCCTATAGGATTTGCC

Downstream 100 bases:

>100_bases
TTGCCGATGAAGCCGCTGCTGCGTGCCGTACTGATCATCGATGCCTTGTTGTTGCTGGCATTCGGGCTGCTACTCCTGCT
CACGCCGTGGAAGTCGCTGT

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 486; Mature: 486

Protein sequence:

>486_residues
MRLIQKALTFDDVLLVPAFSDVLPRDTSLKTRLTRNISLNMPLVSAAMDTVTEARLAIAMAQMGGVGIIHKNLTPAEQAR
EVAKVKRFESGVVRDPITVPPQMKVSDVIALSRQHGISGFPVVEGAQLIGIVTNRDLRFETRLDEPVRTIMTPRERLVTV
KEGTPLAEAKALMHSHRLERVLVVNDAFELRGLMTVKDITKQTEHPDACKDEHGKLRAGAAVGVGPDNEERVSLLVQAGV
DVIVVDTAHGHSKGVLERVQWVKKSFPHVEVIGGNIATADAAKALVEYGADGVKVGIGPGSICTTRIVAGVGVPQISAIA
NVSAALKGTGIPVIADGGVRFSGDVSKALAAGANAVMMGSMFAGTEEAPGDVFLYQGRQYKSYRGMGSVGAMKDGAADRY
FQDNSANIDKLVPEGIEGRVAYKGSVGAILFQLIGGVRASMGYCGCRTIDELHEKASFVEITAAGMRESHVHDVQITKEA
PNYHVD

Sequences:

>Translated_486_residues
MRLIQKALTFDDVLLVPAFSDVLPRDTSLKTRLTRNISLNMPLVSAAMDTVTEARLAIAMAQMGGVGIIHKNLTPAEQAR
EVAKVKRFESGVVRDPITVPPQMKVSDVIALSRQHGISGFPVVEGAQLIGIVTNRDLRFETRLDEPVRTIMTPRERLVTV
KEGTPLAEAKALMHSHRLERVLVVNDAFELRGLMTVKDITKQTEHPDACKDEHGKLRAGAAVGVGPDNEERVSLLVQAGV
DVIVVDTAHGHSKGVLERVQWVKKSFPHVEVIGGNIATADAAKALVEYGADGVKVGIGPGSICTTRIVAGVGVPQISAIA
NVSAALKGTGIPVIADGGVRFSGDVSKALAAGANAVMMGSMFAGTEEAPGDVFLYQGRQYKSYRGMGSVGAMKDGAADRY
FQDNSANIDKLVPEGIEGRVAYKGSVGAILFQLIGGVRASMGYCGCRTIDELHEKASFVEITAAGMRESHVHDVQITKEA
PNYHVD
>Mature_486_residues
MRLIQKALTFDDVLLVPAFSDVLPRDTSLKTRLTRNISLNMPLVSAAMDTVTEARLAIAMAQMGGVGIIHKNLTPAEQAR
EVAKVKRFESGVVRDPITVPPQMKVSDVIALSRQHGISGFPVVEGAQLIGIVTNRDLRFETRLDEPVRTIMTPRERLVTV
KEGTPLAEAKALMHSHRLERVLVVNDAFELRGLMTVKDITKQTEHPDACKDEHGKLRAGAAVGVGPDNEERVSLLVQAGV
DVIVVDTAHGHSKGVLERVQWVKKSFPHVEVIGGNIATADAAKALVEYGADGVKVGIGPGSICTTRIVAGVGVPQISAIA
NVSAALKGTGIPVIADGGVRFSGDVSKALAAGANAVMMGSMFAGTEEAPGDVFLYQGRQYKSYRGMGSVGAMKDGAADRY
FQDNSANIDKLVPEGIEGRVAYKGSVGAILFQLIGGVRASMGYCGCRTIDELHEKASFVEITAAGMRESHVHDVQITKEA
PNYHVD

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=454, Percent_Identity=42.9515418502203, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI156616279, Length=454, Percent_Identity=42.9515418502203, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI34328928, Length=454, Percent_Identity=42.9515418502203, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI34328930, Length=454, Percent_Identity=42.9515418502203, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI217035152, Length=450, Percent_Identity=42.8888888888889, Blast_Score=359, Evalue=3e-99,
Organism=Homo sapiens, GI217035148, Length=454, Percent_Identity=42.0704845814978, Blast_Score=354, Evalue=9e-98,
Organism=Homo sapiens, GI66933016, Length=482, Percent_Identity=39.6265560165975, Blast_Score=349, Evalue=3e-96,
Organism=Homo sapiens, GI217035150, Length=454, Percent_Identity=39.4273127753304, Blast_Score=322, Evalue=5e-88,
Organism=Homo sapiens, GI156104880, Length=262, Percent_Identity=35.1145038167939, Blast_Score=163, Evalue=4e-40,
Organism=Homo sapiens, GI50541954, Length=245, Percent_Identity=36.734693877551, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI50541952, Length=245, Percent_Identity=36.734693877551, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI50541948, Length=245, Percent_Identity=36.734693877551, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI50541956, Length=245, Percent_Identity=36.734693877551, Blast_Score=157, Evalue=3e-38,
Organism=Escherichia coli, GI1788855, Length=487, Percent_Identity=61.8069815195072, Blast_Score=569, Evalue=1e-163,
Organism=Escherichia coli, GI1786293, Length=230, Percent_Identity=33.4782608695652, Blast_Score=137, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI71994385, Length=475, Percent_Identity=38.3157894736842, Blast_Score=304, Evalue=9e-83,
Organism=Caenorhabditis elegans, GI71994389, Length=424, Percent_Identity=39.3867924528302, Blast_Score=288, Evalue=4e-78,
Organism=Caenorhabditis elegans, GI17560440, Length=239, Percent_Identity=35.1464435146443, Blast_Score=157, Evalue=8e-39,
Organism=Saccharomyces cerevisiae, GI6322012, Length=488, Percent_Identity=38.7295081967213, Blast_Score=352, Evalue=7e-98,
Organism=Saccharomyces cerevisiae, GI6323585, Length=484, Percent_Identity=39.2561983471074, Blast_Score=349, Evalue=6e-97,
Organism=Saccharomyces cerevisiae, GI6323464, Length=484, Percent_Identity=39.0495867768595, Blast_Score=340, Evalue=3e-94,
Organism=Saccharomyces cerevisiae, GI6319352, Length=342, Percent_Identity=38.3040935672515, Blast_Score=261, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6319353, Length=142, Percent_Identity=35.9154929577465, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24641071, Length=485, Percent_Identity=40.4123711340206, Blast_Score=354, Evalue=9e-98,
Organism=Drosophila melanogaster, GI24641073, Length=485, Percent_Identity=40.4123711340206, Blast_Score=354, Evalue=9e-98,
Organism=Drosophila melanogaster, GI28571163, Length=443, Percent_Identity=41.0835214446953, Blast_Score=320, Evalue=2e-87,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 51827; Mature: 51827

Theoretical pI: Translated: 7.42; Mature: 7.42

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLIQKALTFDDVLLVPAFSDVLPRDTSLKTRLTRNISLNMPLVSAAMDTVTEARLAIAM
CCHHHHHCCCCCEEEECCHHHHCCCCCCHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHH
AQMGGVGIIHKNLTPAEQAREVAKVKRFESGVVRDPITVPPQMKVSDVIALSRQHGISGF
HHHCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCC
PVVEGAQLIGIVTNRDLRFETRLDEPVRTIMTPRERLVTVKEGTPLAEAKALMHSHRLER
CEECCCEEEEEEECCCEEEECCCCHHHHHHHCCHHHEEEEECCCCHHHHHHHHHHHHCCE
VLVVNDAFELRGLMTVKDITKQTEHPDACKDEHGKLRAGAAVGVGPDNEERVSLLVQAGV
EEEEECHHHHHCCHHHHHHHHHCCCCCCCCCCCCCEEECEEECCCCCCHHHHHHHEECCC
DVIVVDTAHGHSKGVLERVQWVKKSFPHVEVIGGNIATADAAKALVEYGADGVKVGIGPG
CEEEEECCCCCCHHHHHHHHHHHHCCCEEEEECCCEEHHHHHHHHHHHCCCCEEEECCCC
SICTTRIVAGVGVPQISAIANVSAALKGTGIPVIADGGVRFSGDVSKALAAGANAVMMGS
CHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEECCCEEECCCHHHHHHCCCCEEEECH
MFAGTEEAPGDVFLYQGRQYKSYRGMGSVGAMKDGAADRYFQDNSANIDKLVPEGIEGRV
HHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCEE
AYKGSVGAILFQLIGGVRASMGYCGCRTIDELHEKASFVEITAAGMRESHVHDVQITKEA
EECCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCEEEEEECCCCCCCCEEEEEEECC
PNYHVD
CCCCCC
>Mature Secondary Structure
MRLIQKALTFDDVLLVPAFSDVLPRDTSLKTRLTRNISLNMPLVSAAMDTVTEARLAIAM
CCHHHHHCCCCCEEEECCHHHHCCCCCCHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHH
AQMGGVGIIHKNLTPAEQAREVAKVKRFESGVVRDPITVPPQMKVSDVIALSRQHGISGF
HHHCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCC
PVVEGAQLIGIVTNRDLRFETRLDEPVRTIMTPRERLVTVKEGTPLAEAKALMHSHRLER
CEECCCEEEEEEECCCEEEECCCCHHHHHHHCCHHHEEEEECCCCHHHHHHHHHHHHCCE
VLVVNDAFELRGLMTVKDITKQTEHPDACKDEHGKLRAGAAVGVGPDNEERVSLLVQAGV
EEEEECHHHHHCCHHHHHHHHHCCCCCCCCCCCCCEEECEEECCCCCCHHHHHHHEECCC
DVIVVDTAHGHSKGVLERVQWVKKSFPHVEVIGGNIATADAAKALVEYGADGVKVGIGPG
CEEEEECCCCCCHHHHHHHHHHHHCCCEEEEECCCEEHHHHHHHHHHHCCCCEEEECCCC
SICTTRIVAGVGVPQISAIANVSAALKGTGIPVIADGGVRFSGDVSKALAAGANAVMMGS
CHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEECCCEEECCCHHHHHHCCCCEEEECH
MFAGTEEAPGDVFLYQGRQYKSYRGMGSVGAMKDGAADRYFQDNSANIDKLVPEGIEGRV
HHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCEE
AYKGSVGAILFQLIGGVRASMGYCGCRTIDELHEKASFVEITAAGMRESHVHDVQITKEA
EECCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCEEEEEECCCCCCCCEEEEEEECC
PNYHVD
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA