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The map label for this gene is vllY [H]

Identifier: 186475846

GI number: 186475846

Start: 1217200

End: 1219086

Strand: Direct

Name: vllY [H]

Synonym: Bphy_1081

Alternate gene names: 186475846

Gene position: 1217200-1219086 (Clockwise)

Preceding gene: 186475845

Following gene: 186475847

Centisome position: 34.99

GC content: 61.53

Gene sequence:

>1887_bases
ATGCTCCGCTCCATTGCCACTGTGTCGGTTAGCGGCACGCTCGTCGAGAAGCTCGCTGCGATTCGCGCGGCGGGTTTCGA
TGGCGTCGAGATCTTCGAAAACGATCTGCTGTATTTCGACGGCTCGCCAGCAGATATCCGCAAGCGTTGCGCCGATCTCG
GTCTGCAGATCATGCTGTTCCAGCCGTTCCGCGATTTCGAAGGCGTCTCGAAGGAGCGGCTTGCGCAGAACCTTAACCGC
GCAAAACGCAAGTTTGATCTGATGCACGAACTCGGCACCGATCTGGTGCTCGTGTGCAGCAACGTCAACGCAAACGTGAT
TGCGGACGATGCACTGATCGTCGATCAGCTCGGCGAGCTTGCATCGCTCGCCGAACGCGAAGGTGTGCGGGTCGGCTTCG
AAGCCCTCGCGTGGGGCAAGTATGTGAATTCGTATCGCCACGCGTGGCGGCTCGTCGATGCCGTCAATCATCCGAGCCTC
GGGCTGATACTGGACAGCTTCCATACGCTGTCGATCGACGATCCTGTCGATCCCATTGCCGACATTCCGGGCGATCGGAT
TGTGTTCGTGCAGATCGCCGATGCGCCGCTGCACAAGATGGACGTTCTCGAATGGAGCCGTCATTACCGGTGCTTTCCGG
GGCAGGGCGACCTCGATGTCGCCCGCTTCGCGGACCGGGTACTGGCGACGGGCTATCAGGGCCCCTTTTCGCTGGAGATC
TTCAACGACGGCTTCCGCGCCGCGCCGACGGCGGCGACCGCCGCAGACGGCTATCGCTCGCTGCTGTACCTCGAAGAGCA
GGCGGCGCATCAGCGCACGGGGCAGAGCGCGCAGCCGCTGTTCACGCCGCCTGCGCCGCCCGCGCATTCGGGCTTTCAGT
TCATTGAGTTCGCCGTCGATTCGACCAGCGCGCCGCGTCTTGCGCAACGCTTTGCCGAAGCGGGATTTCACACGGCGGGC
AAGCATCGCTCGAAGGACGTGACGCTATATCAGCAAGGCGATGCGTCGATCGTGCTGAACGCGGAGACGGATTCATTCGC
GAGCGAGTTTTTTCATCGGCACGGTTTGTCGCTTTGCGCGTCTGCGTTTCAGGTCGACGATGCCGCGCGTGTTTTCGAAC
GCGCGACGTCGTTCGGCTACGCACCGTTTTCGGGCCGTGTCGGTCCCAACGAGCGCGTCGTGCCCGGTGTGCGTGCACCG
GACGGCAGCCTGCATTACTTCGTCGACGCGCGCCCCGACGAGCCAACGCTTTACGAAGCCGATTTCGTGCTCGACGCGCA
AGCCAACGGGCAGCCAGCCGGGCCGGGCGATCTGACGCGTATCGATCACGTCTGCCTCGACTTGCCCGCCGATACGCTCG
ACACGTGGGTGCTGTATTTCAAGGCAGTGTTCGGCTTTGAAGCCGAATCGGCCTGGTTGCTTCCCGATCCTTATGGACTG
GTGCGCAGCCGTGCGGTGCGCAGTGCCGACGGATCGGTGCGGATCGTTCTCAATGCTTCCGTGGACGGGCGTACGTCGAC
GGCGCAATCGCTGCATATATATCGCGGTTCTGGCCTGAATCATGTGGCGTTTGTCACTGACGACATCTTCGCGGCCGTCG
AACAGTTGCGCGCACGCGACGTTCGGCTATTACGAATACCGTTGAACTATTACGATGACCTTGAAGCGCGATACGATTTC
GCCGACGACATGATTGCCAGGATGAAAGACGCTCACGTGCTCTATGACCGGGATGCGCAGGGCGGCGAATTCTTCCATGT
GTACACCGAGCAGATGGACGGACGCTTCTTCCTGGAGGTCGTGCAGCGCAAGGGCGGCTACGACGGATACGGTGCAGTAA
ACGCACCTGTCAGGCTCGCCGCTCAAGCGCAGCGCAAGCATGGCTAG

Upstream 100 bases:

>100_bases
CGGCCGCCCCGTGGCGACCGCGAAACAGGCCCGCGAAATGTTGGCGCTCAGGCCCGCTGCGTGACGCGCACCCAGTCCGC
TTTCTCCTTCGAGCCATACC

Downstream 100 bases:

>100_bases
ATGCAAAGAACTGAGATTGCGCGGGGCGCTGACAGGTGATTTCCAGTAGCAATCCGCGCAGTACCAGGGTGTACCCAGGT
TTTCCCCGCCTTACCTTCAG

Product: 4-hydroxyphenylpyruvate dioxygenase

Products: homogentisate; CO2

Alternate protein names: NA

Number of amino acids: Translated: 628; Mature: 628

Protein sequence:

>628_residues
MLRSIATVSVSGTLVEKLAAIRAAGFDGVEIFENDLLYFDGSPADIRKRCADLGLQIMLFQPFRDFEGVSKERLAQNLNR
AKRKFDLMHELGTDLVLVCSNVNANVIADDALIVDQLGELASLAEREGVRVGFEALAWGKYVNSYRHAWRLVDAVNHPSL
GLILDSFHTLSIDDPVDPIADIPGDRIVFVQIADAPLHKMDVLEWSRHYRCFPGQGDLDVARFADRVLATGYQGPFSLEI
FNDGFRAAPTAATAADGYRSLLYLEEQAAHQRTGQSAQPLFTPPAPPAHSGFQFIEFAVDSTSAPRLAQRFAEAGFHTAG
KHRSKDVTLYQQGDASIVLNAETDSFASEFFHRHGLSLCASAFQVDDAARVFERATSFGYAPFSGRVGPNERVVPGVRAP
DGSLHYFVDARPDEPTLYEADFVLDAQANGQPAGPGDLTRIDHVCLDLPADTLDTWVLYFKAVFGFEAESAWLLPDPYGL
VRSRAVRSADGSVRIVLNASVDGRTSTAQSLHIYRGSGLNHVAFVTDDIFAAVEQLRARDVRLLRIPLNYYDDLEARYDF
ADDMIARMKDAHVLYDRDAQGGEFFHVYTEQMDGRFFLEVVQRKGGYDGYGAVNAPVRLAAQAQRKHG

Sequences:

>Translated_628_residues
MLRSIATVSVSGTLVEKLAAIRAAGFDGVEIFENDLLYFDGSPADIRKRCADLGLQIMLFQPFRDFEGVSKERLAQNLNR
AKRKFDLMHELGTDLVLVCSNVNANVIADDALIVDQLGELASLAEREGVRVGFEALAWGKYVNSYRHAWRLVDAVNHPSL
GLILDSFHTLSIDDPVDPIADIPGDRIVFVQIADAPLHKMDVLEWSRHYRCFPGQGDLDVARFADRVLATGYQGPFSLEI
FNDGFRAAPTAATAADGYRSLLYLEEQAAHQRTGQSAQPLFTPPAPPAHSGFQFIEFAVDSTSAPRLAQRFAEAGFHTAG
KHRSKDVTLYQQGDASIVLNAETDSFASEFFHRHGLSLCASAFQVDDAARVFERATSFGYAPFSGRVGPNERVVPGVRAP
DGSLHYFVDARPDEPTLYEADFVLDAQANGQPAGPGDLTRIDHVCLDLPADTLDTWVLYFKAVFGFEAESAWLLPDPYGL
VRSRAVRSADGSVRIVLNASVDGRTSTAQSLHIYRGSGLNHVAFVTDDIFAAVEQLRARDVRLLRIPLNYYDDLEARYDF
ADDMIARMKDAHVLYDRDAQGGEFFHVYTEQMDGRFFLEVVQRKGGYDGYGAVNAPVRLAAQAQRKHG
>Mature_628_residues
MLRSIATVSVSGTLVEKLAAIRAAGFDGVEIFENDLLYFDGSPADIRKRCADLGLQIMLFQPFRDFEGVSKERLAQNLNR
AKRKFDLMHELGTDLVLVCSNVNANVIADDALIVDQLGELASLAEREGVRVGFEALAWGKYVNSYRHAWRLVDAVNHPSL
GLILDSFHTLSIDDPVDPIADIPGDRIVFVQIADAPLHKMDVLEWSRHYRCFPGQGDLDVARFADRVLATGYQGPFSLEI
FNDGFRAAPTAATAADGYRSLLYLEEQAAHQRTGQSAQPLFTPPAPPAHSGFQFIEFAVDSTSAPRLAQRFAEAGFHTAG
KHRSKDVTLYQQGDASIVLNAETDSFASEFFHRHGLSLCASAFQVDDAARVFERATSFGYAPFSGRVGPNERVVPGVRAP
DGSLHYFVDARPDEPTLYEADFVLDAQANGQPAGPGDLTRIDHVCLDLPADTLDTWVLYFKAVFGFEAESAWLLPDPYGL
VRSRAVRSADGSVRIVLNASVDGRTSTAQSLHIYRGSGLNHVAFVTDDIFAAVEQLRARDVRLLRIPLNYYDDLEARYDF
ADDMIARMKDAHVLYDRDAQGGEFFHVYTEQMDGRFFLEVVQRKGGYDGYGAVNAPVRLAAQAQRKHG

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Caenorhabditis elegans, GI17555220, Length=193, Percent_Identity=30.0518134715026, Blast_Score=82, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17550752, Length=216, Percent_Identity=27.3148148148148, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI21356105, Length=287, Percent_Identity=26.8292682926829, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24667510, Length=302, Percent_Identity=26.8211920529801, Blast_Score=82, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: 1.13.11.27

Molecular weight: Translated: 69349; Mature: 69349

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRSIATVSVSGTLVEKLAAIRAAGFDGVEIFENDLLYFDGSPADIRKRCADLGLQIMLF
CCCCEEEEEECHHHHHHHHHHHHCCCCCCEEECCCEEEECCCCHHHHHHHHHCCEEEEEE
QPFRDFEGVSKERLAQNLNRAKRKFDLMHELGTDLVLVCSNVNANVIADDALIVDQLGEL
CCCHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEECCHHHHHHHHHH
ASLAEREGVRVGFEALAWGKYVNSYRHAWRLVDAVNHPSLGLILDSFHTLSIDDPVDPIA
HHHHHHCCCEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCEEEECCCCCCHHH
DIPGDRIVFVQIADAPLHKMDVLEWSRHYRCFPGQGDLDVARFADRVLATGYQGPFSLEI
CCCCCEEEEEEECCCCCHHHHHHHHHCCEEECCCCCCCHHHHHHHHHHHCCCCCCEEEEE
FNDGFRAAPTAATAADGYRSLLYLEEQAAHQRTGQSAQPLFTPPAPPAHSGFQFIEFAVD
ECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEEC
STSAPRLAQRFAEAGFHTAGKHRSKDVTLYQQGDASIVLNAETDSFASEFFHRHGLSLCA
CCCCHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHH
SAFQVDDAARVFERATSFGYAPFSGRVGPNERVVPGVRAPDGSLHYFVDARPDEPTLYEA
HHHHCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEE
DFVLDAQANGQPAGPGDLTRIDHVCLDLPADTLDTWVLYFKAVFGFEAESAWLLPDPYGL
EEEEECCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCEEECCCCHHH
VRSRAVRSADGSVRIVLNASVDGRTSTAQSLHIYRGSGLNHVAFVTDDIFAAVEQLRARD
HHHHHHHCCCCCEEEEEECCCCCCCCCCCEEEEEECCCCCEEEEEHHHHHHHHHHHHHCC
VRLLRIPLNYYDDLEARYDFADDMIARMKDAHVLYDRDAQGGEFFHVYTEQMDGRFFLEV
EEEEEECCCCCCCCHHHHCHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCCCCHHHHHH
VQRKGGYDGYGAVNAPVRLAAQAQRKHG
HHHCCCCCCCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MLRSIATVSVSGTLVEKLAAIRAAGFDGVEIFENDLLYFDGSPADIRKRCADLGLQIMLF
CCCCEEEEEECHHHHHHHHHHHHCCCCCCEEECCCEEEECCCCHHHHHHHHHCCEEEEEE
QPFRDFEGVSKERLAQNLNRAKRKFDLMHELGTDLVLVCSNVNANVIADDALIVDQLGEL
CCCHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEECCHHHHHHHHHH
ASLAEREGVRVGFEALAWGKYVNSYRHAWRLVDAVNHPSLGLILDSFHTLSIDDPVDPIA
HHHHHHCCCEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCEEEECCCCCCHHH
DIPGDRIVFVQIADAPLHKMDVLEWSRHYRCFPGQGDLDVARFADRVLATGYQGPFSLEI
CCCCCEEEEEEECCCCCHHHHHHHHHCCEEECCCCCCCHHHHHHHHHHHCCCCCCEEEEE
FNDGFRAAPTAATAADGYRSLLYLEEQAAHQRTGQSAQPLFTPPAPPAHSGFQFIEFAVD
ECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEEC
STSAPRLAQRFAEAGFHTAGKHRSKDVTLYQQGDASIVLNAETDSFASEFFHRHGLSLCA
CCCCHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHH
SAFQVDDAARVFERATSFGYAPFSGRVGPNERVVPGVRAPDGSLHYFVDARPDEPTLYEA
HHHHCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEE
DFVLDAQANGQPAGPGDLTRIDHVCLDLPADTLDTWVLYFKAVFGFEAESAWLLPDPYGL
EEEEECCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCEEECCCCHHH
VRSRAVRSADGSVRIVLNASVDGRTSTAQSLHIYRGSGLNHVAFVTDDIFAAVEQLRARD
HHHHHHHCCCCCEEEEEECCCCCCCCCCCEEEEEECCCCCEEEEEHHHHHHHHHHHHHCC
VRLLRIPLNYYDDLEARYDFADDMIARMKDAHVLYDRDAQGGEFFHVYTEQMDGRFFLEV
EEEEEECCCCCCCCHHHHCHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCCCCHHHHHH
VQRKGGYDGYGAVNAPVRLAAQAQRKHG
HHHCCCCCCCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-hydroxyphenylpyruvate; O2

Specific reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA