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The map label for this gene is alkK [H]

Identifier: 186475792

GI number: 186475792

Start: 1156782

End: 1158464

Strand: Direct

Name: alkK [H]

Synonym: Bphy_1027

Alternate gene names: 186475792

Gene position: 1156782-1158464 (Clockwise)

Preceding gene: 186475787

Following gene: 186475793

Centisome position: 33.25

GC content: 64.47

Gene sequence:

>1683_bases
ATGACGACGCCGCTCTATGGACAGATGATGGACGTGCCACTCACGGTCTCTTCGTTGCTGGCGCATGCGTCGCGCCACTT
CGGCAGCACGGAGATCGTGTCGAGGCGCATCGAGGGCGACGTGCATCGCTACACATATCGCGATTGCGAGCGGCGCGCGA
AGCAGCTGGCGCAAGCGCTGATCGCACTCGGCGTCGAAGCGGGCGACCGCATCGGCACGCTCGCATGGAACGGCTACCGG
CATCTGGAAACCTACTACGGTACGACAGGCTTCGGCGCCGTCTGTCATACGATCAACCCGCGGCTCTTTCCCGATCAGAT
TGCCTACATCGTCAATCACGCCAATGACCGCTATGTGCTGTTCGACATCACGTTTGCAGCGCTCGTCGACGTGCTCGCGC
CGCAGTGCCCGAACGTGCGCGGCTGGATCGCGATGACGGACGAAGCGCACATGCCGTGCATGTCGACGGCCGTATCGAGC
TACGAAGCACTGCTCGCGCGCCACGACGGCGCATTCGAATGGCCCGCGATCGACGAACGTTGCGCATCCAACCTGTGCTA
CACGTCGGGGACGACGGGCAACCCGAAGGGTGCGCTGTATTCGCATCGCTCGACGGTGCTGCATGCATTCGGCGCGTCGC
TGCCGGATGCGATGGGTCTGTCCGCGCGCGACTCAGTGCTGCCCGTCGTGCCGATGTTTCATGTGAACGCCTGGGGCATC
CCGCACGCCGCGCCGCTGACGGGCGCGAAACTCGTGTTGCCGGGCAAGGATCTCGACGGCAAGTCGCTATATGAGCTGAT
GGAGGCGGAACGGGTCACATATTCGGCGGGCGTGCCGACGGTATGGCTCGGCCTGCTCAACCATGTGCGCGAGGCGGGCG
TGAAGTTTTCGTCGCTGGAGCGCACCGTGATCGGCGGCTCCGCCTGCCCGCCCGCGATGATCAAGACGTTTCGCGAAAAC
TACGGTGTCGAGGTGATCCACGCGTGGGGCATGACGGAGATGTCGCCGCTCGGCACGCTGTCGAAGCTCACATGGGAGCA
GTTGCAGCGTTCCCCCGACGAGCAGCGCAAGTTGCGCGAAAAGCAGGGTCACGCGCTGTACGGAGTCGATATGAAGATCG
TCGGCGACGACGGGCGCGAACTGCCGTGGGACGGCGTCGCATTCGGTGATCTTCATGTGCGCGGGCCGTGGGTGATCGAC
CGGTATTTCCGCAGCGACGCGTCGCCGCTCGTCGACGGCTGGTTCCCGACGGGCGATGTCGCGACGATCGACAAGGACGG
CTTCCTGAATATCACCGACCGCAGCAAGGATGTGATCAAGTCGGGCGGCGAATGGATCAGCTCGATCGATGTCGAAAACA
TCGCGGTCGCGCATCCCGCCGTCGCGGAGGCCGCGTGCATCGCGTGCGCGCATCCGAAGTGGACGGAGCGGCCGCTGCTC
GTGGTCGTCAGGCGTCCCGACGCGCACGTGACGCGCGAAGAACTGCTCGCGTTCTACGAAGGCAAGCTCGCGAAATGGTG
GATTCCCGACGACGTCGTGTTCGTCGACGAACTTCCGCACACGGCAACGGGCAAGCTCCAAAAGCTGAAGCTGCGCGCGC
AGTTCCGCACGCACGTGCTGCCGTCGGCGCTCGGCATCGAAGGCTGTCCGTTCGACGAGGCGGAGAAAAACGGCCGCGCG
TAG

Upstream 100 bases:

>100_bases
TGCAGGGCGCGCATCGGCCATGCATCACGGACGCATCGAAAGCGTCATTCGAACCATTCGAATCGAATAGAGACAACACG
CTACTGGGAGACATCCGCGT

Downstream 100 bases:

>100_bases
ATCAGGCACCTCGGGTTGACGCCCACGCCTACGGTTATCGTCTGAATTGAACGATCGTGCTTTTTTGTGTATTCTGCCAT
CTGTCGCAAATGAACGGTGA

Product: long-chain-fatty-acid--CoA ligase

Products: NA

Alternate protein names: Medium-chain acyl-CoA synthetase [H]

Number of amino acids: Translated: 560; Mature: 559

Protein sequence:

>560_residues
MTTPLYGQMMDVPLTVSSLLAHASRHFGSTEIVSRRIEGDVHRYTYRDCERRAKQLAQALIALGVEAGDRIGTLAWNGYR
HLETYYGTTGFGAVCHTINPRLFPDQIAYIVNHANDRYVLFDITFAALVDVLAPQCPNVRGWIAMTDEAHMPCMSTAVSS
YEALLARHDGAFEWPAIDERCASNLCYTSGTTGNPKGALYSHRSTVLHAFGASLPDAMGLSARDSVLPVVPMFHVNAWGI
PHAAPLTGAKLVLPGKDLDGKSLYELMEAERVTYSAGVPTVWLGLLNHVREAGVKFSSLERTVIGGSACPPAMIKTFREN
YGVEVIHAWGMTEMSPLGTLSKLTWEQLQRSPDEQRKLREKQGHALYGVDMKIVGDDGRELPWDGVAFGDLHVRGPWVID
RYFRSDASPLVDGWFPTGDVATIDKDGFLNITDRSKDVIKSGGEWISSIDVENIAVAHPAVAEAACIACAHPKWTERPLL
VVVRRPDAHVTREELLAFYEGKLAKWWIPDDVVFVDELPHTATGKLQKLKLRAQFRTHVLPSALGIEGCPFDEAEKNGRA

Sequences:

>Translated_560_residues
MTTPLYGQMMDVPLTVSSLLAHASRHFGSTEIVSRRIEGDVHRYTYRDCERRAKQLAQALIALGVEAGDRIGTLAWNGYR
HLETYYGTTGFGAVCHTINPRLFPDQIAYIVNHANDRYVLFDITFAALVDVLAPQCPNVRGWIAMTDEAHMPCMSTAVSS
YEALLARHDGAFEWPAIDERCASNLCYTSGTTGNPKGALYSHRSTVLHAFGASLPDAMGLSARDSVLPVVPMFHVNAWGI
PHAAPLTGAKLVLPGKDLDGKSLYELMEAERVTYSAGVPTVWLGLLNHVREAGVKFSSLERTVIGGSACPPAMIKTFREN
YGVEVIHAWGMTEMSPLGTLSKLTWEQLQRSPDEQRKLREKQGHALYGVDMKIVGDDGRELPWDGVAFGDLHVRGPWVID
RYFRSDASPLVDGWFPTGDVATIDKDGFLNITDRSKDVIKSGGEWISSIDVENIAVAHPAVAEAACIACAHPKWTERPLL
VVVRRPDAHVTREELLAFYEGKLAKWWIPDDVVFVDELPHTATGKLQKLKLRAQFRTHVLPSALGIEGCPFDEAEKNGRA
>Mature_559_residues
TTPLYGQMMDVPLTVSSLLAHASRHFGSTEIVSRRIEGDVHRYTYRDCERRAKQLAQALIALGVEAGDRIGTLAWNGYRH
LETYYGTTGFGAVCHTINPRLFPDQIAYIVNHANDRYVLFDITFAALVDVLAPQCPNVRGWIAMTDEAHMPCMSTAVSSY
EALLARHDGAFEWPAIDERCASNLCYTSGTTGNPKGALYSHRSTVLHAFGASLPDAMGLSARDSVLPVVPMFHVNAWGIP
HAAPLTGAKLVLPGKDLDGKSLYELMEAERVTYSAGVPTVWLGLLNHVREAGVKFSSLERTVIGGSACPPAMIKTFRENY
GVEVIHAWGMTEMSPLGTLSKLTWEQLQRSPDEQRKLREKQGHALYGVDMKIVGDDGRELPWDGVAFGDLHVRGPWVIDR
YFRSDASPLVDGWFPTGDVATIDKDGFLNITDRSKDVIKSGGEWISSIDVENIAVAHPAVAEAACIACAHPKWTERPLLV
VVRRPDAHVTREELLAFYEGKLAKWWIPDDVVFVDELPHTATGKLQKLKLRAQFRTHVLPSALGIEGCPFDEAEKNGRA

Specific function: Unknown

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=524, Percent_Identity=26.3358778625954, Blast_Score=172, Evalue=8e-43,
Organism=Homo sapiens, GI187761345, Length=533, Percent_Identity=26.078799249531, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI187761343, Length=533, Percent_Identity=26.078799249531, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI38505220, Length=506, Percent_Identity=24.3083003952569, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI157311624, Length=514, Percent_Identity=23.3463035019455, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI157311622, Length=514, Percent_Identity=23.3463035019455, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI58082049, Length=516, Percent_Identity=23.062015503876, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI42544132, Length=531, Percent_Identity=22.9755178907721, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI115511026, Length=514, Percent_Identity=21.4007782101167, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI28416953, Length=556, Percent_Identity=23.9208633093525, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI122937307, Length=529, Percent_Identity=21.5500945179584, Blast_Score=81, Evalue=3e-15,
Organism=Escherichia coli, GI145693145, Length=521, Percent_Identity=26.8714011516315, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1788107, Length=527, Percent_Identity=25.8064516129032, Blast_Score=152, Evalue=6e-38,
Organism=Escherichia coli, GI221142682, Length=512, Percent_Identity=23.046875, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1786810, Length=363, Percent_Identity=28.9256198347107, Blast_Score=108, Evalue=7e-25,
Organism=Escherichia coli, GI1789201, Length=366, Percent_Identity=23.7704918032787, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788595, Length=303, Percent_Identity=25.7425742574257, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71994703, Length=560, Percent_Identity=26.4285714285714, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI71994694, Length=560, Percent_Identity=26.4285714285714, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71994690, Length=560, Percent_Identity=26.4285714285714, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17558820, Length=507, Percent_Identity=27.0216962524655, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI32563687, Length=511, Percent_Identity=26.4187866927593, Blast_Score=136, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17560308, Length=562, Percent_Identity=25.0889679715303, Blast_Score=132, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI17531443, Length=508, Percent_Identity=23.8188976377953, Blast_Score=120, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17557194, Length=548, Percent_Identity=23.5401459854015, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17538037, Length=511, Percent_Identity=23.091976516634, Blast_Score=113, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17559526, Length=365, Percent_Identity=27.6712328767123, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71985884, Length=366, Percent_Identity=25.9562841530055, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71996755, Length=509, Percent_Identity=20.6286836935167, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319699, Length=360, Percent_Identity=27.7777777777778, Blast_Score=118, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24581924, Length=557, Percent_Identity=28.0071813285458, Blast_Score=175, Evalue=7e-44,
Organism=Drosophila melanogaster, GI18859661, Length=464, Percent_Identity=26.7241379310345, Blast_Score=127, Evalue=3e-29,
Organism=Drosophila melanogaster, GI21355181, Length=523, Percent_Identity=22.9445506692161, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI19922652, Length=502, Percent_Identity=22.1115537848606, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24648253, Length=541, Percent_Identity=20.5175600739372, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21356947, Length=498, Percent_Identity=23.6947791164659, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24648255, Length=556, Percent_Identity=20.6834532374101, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI19921316, Length=479, Percent_Identity=22.7557411273486, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24656500, Length=506, Percent_Identity=23.1225296442688, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24648260, Length=510, Percent_Identity=23.3333333333333, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24648257, Length=482, Percent_Identity=21.1618257261411, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI281365686, Length=246, Percent_Identity=21.5447154471545, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21356441, Length=508, Percent_Identity=20.2755905511811, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI21355225, Length=394, Percent_Identity=23.8578680203046, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: NA

Molecular weight: Translated: 61783; Mature: 61652

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPLYGQMMDVPLTVSSLLAHASRHFGSTEIVSRRIEGDVHRYTYRDCERRAKQLAQAL
CCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
IALGVEAGDRIGTLAWNGYRHLETYYGTTGFGAVCHTINPRLFPDQIAYIVNHANDRYVL
HHHCCCCCCCEEEEEECCCHHHHHHCCCCCHHHHHHCCCCCCCHHHHHHHHCCCCCCEEE
FDITFAALVDVLAPQCPNVRGWIAMTDEAHMPCMSTAVSSYEALLARHDGAFEWPAIDER
EEEHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHH
CASNLCYTSGTTGNPKGALYSHRSTVLHAFGASLPDAMGLSARDSVLPVVPMFHVNAWGI
HHCCCEECCCCCCCCCCCEEHHHHHHHHHHCCCCCHHCCCCCCCCCCCEEEEEEECCCCC
PHAAPLTGAKLVLPGKDLDGKSLYELMEAERVTYSAGVPTVWLGLLNHVREAGVKFSSLE
CCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHCCCHHHCC
RTVIGGSACPPAMIKTFRENYGVEVIHAWGMTEMSPLGTLSKLTWEQLQRSPDEQRKLRE
HHEECCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHH
KQGHALYGVDMKIVGDDGRELPWDGVAFGDLHVRGPWVIDRYFRSDASPLVDGWFPTGDV
HCCCEEEEEEEEEECCCCCCCCCCCEEECCEEECCCHHHHHHHHCCCCCCCCCCCCCCCE
ATIDKDGFLNITDRSKDVIKSGGEWISSIDVENIAVAHPAVAEAACIACAHPKWTERPLL
EEECCCCEEEECCCCHHHHHCCCHHHHHCCCCCEEECCCHHHHHHHHEECCCCCCCCCEE
VVVRRPDAHVTREELLAFYEGKLAKWWIPDDVVFVDELPHTATGKLQKLKLRAQFRTHVL
EEEECCCCCCCHHHHHHHHCCCEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHC
PSALGIEGCPFDEAEKNGRA
CHHCCCCCCCCCHHHCCCCC
>Mature Secondary Structure 
TTPLYGQMMDVPLTVSSLLAHASRHFGSTEIVSRRIEGDVHRYTYRDCERRAKQLAQAL
CCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
IALGVEAGDRIGTLAWNGYRHLETYYGTTGFGAVCHTINPRLFPDQIAYIVNHANDRYVL
HHHCCCCCCCEEEEEECCCHHHHHHCCCCCHHHHHHCCCCCCCHHHHHHHHCCCCCCEEE
FDITFAALVDVLAPQCPNVRGWIAMTDEAHMPCMSTAVSSYEALLARHDGAFEWPAIDER
EEEHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHH
CASNLCYTSGTTGNPKGALYSHRSTVLHAFGASLPDAMGLSARDSVLPVVPMFHVNAWGI
HHCCCEECCCCCCCCCCCEEHHHHHHHHHHCCCCCHHCCCCCCCCCCCEEEEEEECCCCC
PHAAPLTGAKLVLPGKDLDGKSLYELMEAERVTYSAGVPTVWLGLLNHVREAGVKFSSLE
CCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHCCCHHHCC
RTVIGGSACPPAMIKTFRENYGVEVIHAWGMTEMSPLGTLSKLTWEQLQRSPDEQRKLRE
HHEECCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHH
KQGHALYGVDMKIVGDDGRELPWDGVAFGDLHVRGPWVIDRYFRSDASPLVDGWFPTGDV
HCCCEEEEEEEEEECCCCCCCCCCCEEECCEEECCCHHHHHHHHCCCCCCCCCCCCCCCE
ATIDKDGFLNITDRSKDVIKSGGEWISSIDVENIAVAHPAVAEAACIACAHPKWTERPLL
EEECCCCEEEECCCCHHHHHCCCHHHHHCCCCCEEECCCHHHHHHHHEECCCCCCCCCEE
VVVRRPDAHVTREELLAFYEGKLAKWWIPDDVVFVDELPHTATGKLQKLKLRAQFRTHVL
EEEECCCCCCCHHHHHHHHCCCEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHC
PSALGIEGCPFDEAEKNGRA
CHHCCCCCCCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1453953 [H]